 |
|
New neuroimaging analysis technique identifies impact of Alzheimer's disease gene in healthy brains
November 18, 2009Brain imaging can offer a window into risk for diseases such as Alzheimer's disease (AD). A study conducted at the University of Kansas School of Medicine demonstrated that genetic risk is expressed in the brains of even those who are healthy, but carry some risk for AD. The results of this study are published in the November 2009 issue of the Journal of Alzheimer's Disease.
Investigators used automated neuroimaging analysis techniques to characterize the impact of an AD-risk gene, apolipoprotein E (ApoE4), on gray and white matter in the brains of cognitively healthy elderly from the KU Brain Aging Project.
They found that healthy elderly individuals carrying a risk-allele of the ApoE4 gene had reduced cognitive performance, decreased brain volume in the hippocampus and amygdala (regions important for memory processing), and decreased white matter integrity in limbic regions. These type of brain changes are also found in people with AD. Therefore, brain changes, usually found in AD patients, are also evident in nondemented individuals who have a genetic risk of later developing AD.
Lead investigator, Robyn Honea, DPhil, Research Assistant Professor, University of Kansas School of Medicine, Department of Neurology, Alzheimer's and Memory Group, comments, "It is important to note that findings of imaging phenotypes of risk variants, such as with this gene, have been shown in a number of studies. The unique element of our study is that we used several new neuroimaging analysis techniques. In addition, the individuals in our study have been well-characterized in a clinical setting."
IOS Press
Lead investigator, Robyn Honea, DPhil, Research Assistant Professor, University of Kansas School of Medicine, Department of Neurology, Alzheimer's and Memory Group, comments, "It is important to note that findings of imaging phenotypes of risk variants, such as with this gene, have been shown in a number of studies. The unique element of our study is that we used several new neuroimaging analysis techniques. In addition, the individuals in our study have been well-characterized in a clinical setting."
IOS Press
Neuroimaging Current Events and Neuroimaging News RSSBlacks with MS Have More Severe Symptoms, Decline Faster than Whites, New Study Shows
Fewer African Americans than Caucasians develop multiple sclerosis (MS), statistics show, but their disease progresses more rapidly, and they don't respond as well to therapies, a new study by neurology researchers at the University at Buffalo has found.
York study maps the effects of acupuncture on the brain
Important new research about the effects of acupuncture on the brain may provide an understanding of the complex mechanisms of acupuncture and could lead to a wider acceptability of the treatment.
Promising new neuroimaging techniques for early detection of Alzheimer's disease
Investigators from the International Center for Biomedicine and the University of Chile, in collaboration with the Center for Bioinformatics of the Universidad de Talca, have discovered that two drugs, the benzimidazole derivatives lanzoprazole and astemizole, may be suitable for use as PET (positron emission tomography) radiotracers and enable imaging for the early detection of Alzheimer's Disease.
Microcephaly genes associated with human brain size
A group of Norwegian and American researchers have shown that common variations in genes associated with microcephaly - a neuro-developmental disorder in which brain size is dramatically reduced - may explain differences in brain size in healthy individuals as well as in patients with neurological and psychiatric disorders.
UCLA study shows brain's ability to reorganize
Visually impaired people appear to be fearless, navigating busy sidewalks and crosswalks, safely finding their way using nothing more than a cane as a guide.
Neuroimaging provides insights into new treatment options for Alzheimer's disease
With about 35 million people around the world suffering from Alzheimer's disease (AD) by the year 2010 and an expectation that these numbers will double every twenty years with approximately 115 million cases by 2050, pressure on healthcare systems worldwide will be intense.
Sights and sounds of emotion trigger big brain responses
Researchers at the University of York have identified a part of the brain that responds to both facial and vocal expressions of emotion.
Precuneus region of human and monkey brain is divided into 4 distinct regions
A study published this week in PNAS provides a comprehensive comparative functional anatomy study in human and monkey brains which reveals highly similar brain networks preserved across evolution.
Neurologists Investigate Possible New Underlying Cause of MS
Neurologists at the University at Buffalo are beginning a research study that could overturn the prevailing wisdom on the cause of multiple sclerosis (MS).
Experts summarize state of the science in autism disorders
Scientific understanding and medical treatments for autism spectrum disorders (ASDs) have advanced significantly over the past several years, but much remains to be done.
More Neuroimaging Current Events and Neuroimaging News Articles
 |
Handbook of Functional Neuroimaging of Cognition, 2nd Edition (Cognitive Neuroscience) by Roberto Cabeza (Editor), Alan Kingstone (Editor) This essential resource on neuroimaging provides an accessible and user-friendly introduction to the field written by leading researchers. The book describes theoretical and methodological developments in the use of functional neuroimaging techniques to study the neural basis of cognition, from early scientific efforts to link brain and behavior to the latest applications of fMRI and PET methods. The core of the book covers fMRI and PET studies in specific domains: attention, skill learning, semantic memory, language, episodic memory, working memory, and executive functions. By introducing a technique within the description of a domain, the book offers a clear explanation of the process while highlighting its biological context. The emphasis on readability makes Handbook of Functional... |
 |
Q&A Color Review of Neuroimaging by Michael Lev (Editor), Joseph Heisserman (Editor), Sanjay Shetty (Editor), Kristen Forbes (Editor) This color review features 120 randomly organized cases in a question and answer format--perfect for honing your clinical skills and for board examination preparation. The book covers the full spectrum of neurological disease using MRI, CT, invasive, and non-invasive vascular imaging techniques, with an emphasis on diagnostic neuroimaging in adults and children. Questions, supplemented by high-quality images, appear on the right page, and answers follow on the next page with detailed explanations of differential diagnosis, complications, and management. |
 |
Windows to the Brain: Insights From Neuroimaging by Robin A. (Author), M.D. Hurley (Author), Katherine H. (Author), Ph.D. Taber (Author) Windows to the Brain is the only book to synthesize neuroanatomical and imaging research as it pertains to selected neuropsychiatric diseases, containing all of the Windows to the Brain papers published from 1999-2006 in the Journal of Neuropsychiatry and Clinical Neurosciences. They provide a basic understanding of how to apply a variety of imaging techniques to the study of adult neuropsychiatric disease and how to use neuroimaging to assist in diagnostic work-ups for conditions ranging from sleep disorders to epilepsy to borderline personality. Integrated, color-coded graphics present functional anatomical information in a manner that promotes understanding and use in clinical practice, while the text encompasses a wide range of diseases and injuries across the adult lifespan... |
 |
Neuroimaging in Neurology: An Interactive CD by David C. Preston MD (Author), Barbara E. Shapiro MD PhD (Author) Neuroimaging is playing an increasingly crucial role in all facets of neurological and neurosurgical diagnosis and treatment. Now there's an easy, interactive way to learn neuroanatomy and recognize common neurologic conditions seen on neuroimaging! This new CD-ROM enables you to explore more than 2,100 images depicting the complete spectrum of neurological disorders. Best of all, you can choose to view labels, arrows, and highlights that point out the key clinical features of each image, or turn them off as desired! The result is an ideal way to learn neuroanatomy and recognize common neurologic conditions seen on neuroimaging. Learn to recognize the full range of common neurological disorders as seen via today's imaging modalities.View neuroimaging findings the way they present... |
 |
Functional Neuroimaging: A Clinical Approach by Andrei I. Holodny (Editor) The first text designed specifically with clinical practitioners in mind, including neuroradiologists, radiologists, neurologists, neurosurgeons, and clinical psychologists, Functional Neuroimaging demonstrates the clinical application and utilization of functional neuroradiology for early diagnosis, neurological decision-making, and assessing response to cancer therapy. Edited by the Founding President of American Society of Functional Neuroradiology, this guide expertly describes the incorporation of this technology into clinical practice, and showcases high-quality color images depicting the function and mechanisms of the brain. Functional Neuroimaging: helps clinicians incorporate functional neuroradiology into their practice contains... |
 |
McGraw-Hill Specialty Board Review Clinical Neuroimaging: Cases and Key Points by David Anschel (Author), Pantaleo Romanelli (Author), Avi Mazumdar (Author) The best cases in neuroimaging--the definitive review for any type of neuroimaging examination Clinical Neuroimaging: Cases and Key Points is a must-have resource that offers one-stop, essential preparation for neuroimaging examinations. This unique review utilizes a step-by-step approach to case-based learning that assures more thorough retention of material, and reinforces your understanding of even the most difficult topics. Coverage reflects all the recent advances of clinical importance, so you can assimilate critical new information easily into your examination preparation activities and daily practice. It's the ultimate tool to prepare for certification and recertification/maintenance of certification, or for use as a clinical refresher! ... |
 |
Cranial Neuroimaging and Clinical Neuroanatomy: Magnetic Resonance Imaging and Computed Tomography (Thieme Classics) by Hans-Joachim Kretschmann (Author), Wolfgang Weinrich (Author) Written by experts in the field, this beautifully illustrated text/atlas provides the tools you need to directly visualize and interpret cranial CT and MR images. It reviews with exacting detail the normal anatomic brain structures identified on sagittal, coronal, and axial imaging planes. Use this book to make accurate and complete neurological assessments at the earliest possible stages - before reaching the sectioning or operating table. This revised and expanded third edition contains nearly 600 illustrations - most in color - that provide graphic representations of brain structures, arteries, arterial territories, veins, nerves and neurofunctional systems. The illustrations depict anatomic structures in shades of gray similar to the way they are seen in CT and MR images. ... |
 |
Neuroimaging by Jack Greenberg (Author) This superbly illustrated text demonstrates how to optimize the diagnostic yield of today's sophisticated imaging technology by correlating the neuroimaging work-up with the neurologic history and examination. In addition, three new chapters covering Magnetic Resonance Angiography, Interventional Neuroimaging, and Spectroscopy have been added. In all, over 1,200 high-quality, detail-revealing MRI, CT, PET, SPECT, ultrasound, and plain x-ray studies enhance and reinforce the succinct, clinically oriented text. |
 |
Brain Imaging Handbook by J. Douglas Bremner (Author) An easy-to-use reference on the major brain imaging technologies. The past ten years have seen an explosion in the use of brain imaging technologies to aid treatment of medical as well as mental health conditions. MRI, CT ("CAT") scans, and PET scans are now common. This will be the first quick reference to these technologies, rich in illustrations and including discussions of which techniques are best used in particular instances of care. |
 |
Pediatric Neuroimaging (Pediatric Neuroimaging (Barkovich)) by A. James Barkovich (Author) The thoroughly updated Fourth Edition of this acclaimed reference describes and illustrates the full range of pediatric disorders diagnosable by modern neuroimaging. This edition includes state-of-the-art information on the use of proton spectroscopy, diffusion imaging, and perfusion imaging in diagnosing metabolic disorders, brain tumors, abnormalities of cerebral microstructure, and abnormalities of blood flow. New entities have been added to the chapters on metabolic disorders, brain injuries, congenital malformations of the brain and skull, cerebellar disorders, brain tumors, phakomatoses, hydrocephalus, and infections. More than 2,400 images complement the text. A List of Disorders with corresponding page numbers enables readers to quickly look up a disease. "Doody's Core... |
| © 2010 BrightSurf.com |