Vardenafil: A potential drug to protect gastric mucosaNovember 18, 2009Indomethacin has been proved by epidemiological and experimental studies to be closely associated with peptic ulcer development. Vardenafil is a potent phosphodiesterase 5 inhibitor and its effects on the gastric mucosa havenot been reported. A research article to be published in October 28, 2009 in the World Journal of Gastroenterology addresses this question. The research team, led by Dr. Karakaya MD from Zonguldak Karaelmas University, designed an experimental study in rat which they used vardenafil to study gastric mucosal protection against the harmful effects of indomethacin. Multiple agents have been used to prevent NSAID-induced peptic ulcer. This work is the first experimental study that show the beneficial effects of Vardenafil (a phosphodiesterase type V inhibitor) on NSAID-induced gastric ulcer. The gastroprotective effect of vardenafil against NSAID-induced peptic ulcer is dose-dependent. The study results suggest that vardenafil might be used as a potential therapeutic drug to prevent NSAID-induced gastric ulcer formation. World Journal of Gastroenterology |
|||||||||||||||||||||
| Related Peptic Ulcer Current Events and Peptic Ulcer News Articles Is short-term Celecoxib intervention a effective method for preventing gastric carcinogenesis? Since the isolation and culture of Helicobacter pylori (H. pylori) in 1983, this bacterium has become accepted as an important human pathogen for the development of gastritis, peptic ulcer, and gastric cancer. Neurologists Investigate Possible New Underlying Cause of MS Neurologists at the University at Buffalo are beginning a research study that could overturn the prevailing wisdom on the cause of multiple sclerosis (MS). Cogent trial shows lack of adverse interaction between clopidogrel and stomach medicine Results from a late breaking clinical trial called COGENT demonstrate that the combination of giving patients clopidogrel, a blood thinner commonly prescribed to patients with cardiovascular disease, and stomach medicines such as omeprazole, known as proton pump inhibitors (PPIs), did not lead to adverse events, as some prior studies had suggested. Does Helicobacter pylori eradication therapy prevent gastric cancer? Although it has been demonstrated that Helicobacter pylori causes gastric cancer, it is still controversial that whether H. pylori eradication therapy is effective in primary prevention of gastric cancer. Endoscopy within 24 hours shows better outcomes in elderly with peptic ulcer bleeding A new study shows that elderly patients who underwent endoscopy within one day of presentation for peptic ulcer bleeding had a two-day shorter hospital stay and were less likely to require upper gastrointestinal surgery than patients who did not receive endoscopy within the first day of presentation. Childhood adversities have a predictive role in peptic ulcer Helicobacter pylori, nonsteroidal anti-inflammatory drug use and smoking are the most important risk factors for peptic ulcer. Why are tribal populations free from clinical symptoms infection with H pylori strains? Helicobacter pylori is of growing concern today because of its crucial role in the pathogenesis of chronic gastritis, peptic ulcer diseases and in the multi-step carcinogenic process of gastric cancer. However, it is still an enigma why few strains are associated with ulcer formation with relevant clinical symptoms while others are not associated with any disease manifestation. Patients with GI bleeding admitted on the weekend have higher death rate Previous studies have raised questions regarding differences in quality of care for patients hospitalized on a weekend compared to weekdays. In fact, a growing body of health services research has demonstrated an association between admission to hospitals on the weekend and increased mortality. This "weekend effect" has been attributed to reduced hospital staffing and access to specific intensive treatments and procedures. Non-invasive diagnostic tools for assessment of function and structure of the stomach mucosa Risks for gastric cancer or peptic ulcer diseases are low in subjects with healthy stomach mucosa but are remarkably high in those with "diseased" stomach mucosa: i.e., in those with H pylori gastritis or atrophic gastritis. What is the most effective therapy for low-dose aspirin induced peptic ulcer? The incidence of low-dose aspirin-induced peptic ulcer seems to be increasing in Japan in conjunction with the increasing proportion of elderly individuals, in whom metabolic syndrome frequently develops. However, a therapeutic and prevention strategy for such peptic ulcers has not yet been established. More Peptic Ulcer Current Events and Peptic Ulcer News Articles |
|||||||||||||||||||||
|
|||||||||||||||||||||
|
|||||||||||||||||||||