 |
|
Is hepatic differentiation of embryonic stem cells induced by valproic acid and cytokines?
November 18, 2009Embryonic stem (ES) cells, known for their capacity to proliferate indefinitely and differentiate into almost all types of cells including hepatocytes, have raised the hope of cellular replacement therapy for liver failure. There have been several protocols available for hepatic fate specification from ES cells, however, most of the protocols currently used result in low yield or purity of functional hepatocytes. Valproic acid (VPA), a histone deacetylase inhibitor, has been demonstrated to facilitate the hepatic differentiation of mesenchymal stem cells. However, little is know about whether VPA could induce the hepatic differentiation of ES cells.
A research team from China reported such research and the development of a protocol for direct hepatic lineage differentiation, from early developmental progenitors to a population of mature hepatocytes, based on sequential induction with VPA and cytokines. Results showed that VPA can direct the hepatic specification of ES cells and largely participates in the differentiation of ES cells into hepatic progenitors. Further differentiation of hepatic progenitors into mature hepatocytes requires supplementation with cytokines. Their study will be published on November 7, 2009 in the World Journal of Gastroenterology.
Their research may not only be helpful for the clinical application of hepatocyte transplantation, but also provide an in vitro research model for the better investigation and understanding of the entire developmental process of hepatocytes, from ES cells to hepatic progenitors, and then to mature hepatocytes. Furthermore, as VPA is an epigenetic modulator, their results may also be of benefit to the research of mechanisms of epigenetic modifications during liver development.
World Journal of Gastroenterology
World Journal of Gastroenterology
Embryonic Stem Cells Current Events and Embryonic Stem Cells News RSSGene that improves quality of reprogrammed stem cells identified by Singapore scientists
In the 7 Feb. 2010 issue of the journal Nature, scientists at the Genome Institute of Singapore (GIS), report that a genetic molecule, called Tbx3, which is crucial for many aspects of early developmental processes in mammals, significantly improves the quality of stem cells that have been reprogrammed from differentiated cells.
Scientists map epigenome of human stem cells during development
Scientists at The Genome Institute of Singapore (GIS) and The Scripps Research Institute (TSRI) led an international effort to build a map that shows in detail how the human genome is modified during embryonic development.
Stanford researchers explore link between human birth defect syndrome, cancer metastasis
Some cells are natural rule-breakers. Neural crest cells for example, not only migrate throughout the body during development (most cells are more selective in their wandering), they are also more developmentally flexible than their predecessors (a no-no for nearly all cell types).
Scripps Research and GIS scientists map epigenome of human stem cells during development
Scientists at The Scripps Research Institute and The Genome Institute of Singapore (GIS) led an international effort to build a map that shows in detail how the human genome is modified during embryonic development.
Disarming specialized stem cells might combat deadly ovarian cancer
Eliminating cancer stem cells (CSCs) within a tumor could hold the key to successful treatments for ovarian cancer, which has been notoriously difficult to detect and treat, according to new findings published this week in the journal Oncogene by Yale School of Medicine researchers.
Stem cell breakthrough: Bone marrow cells are the answer
Using cells from mice, scientists from Iowa and Iran have discovered a new strategy for making embryonic stem cell transplants less likely to be rejected by a recipient's immune system.
New concoction reprograms differentiated cells into pluripotent stem cells
In the new issue of the journal Cell Stem Cell, Singapore scientists report the surprising discovery that a novel transcription factor, Nr5a2, can replace one of the classical reprogramming factors, Oct 4, to significantly increase the efficiency of reprogramming differentiated stem cells into induced pluripotent stem cells (iPS cells).
NYSCF Fellow lead author on study that creates blood vessel cells from stem cells
New York Stem Cell Foundation (NYSCF)-Druckenmiller Fellow, Daylon James, PhD, of Weill Cornell Medial College, is lead author on a study defining conditions for generating a plentiful supply of endothelial (vessel lining) cells that are suitable for therapeutic use.
New way to generate abundant functional blood vessel cells from human stem cells discovered
In a significant step toward restoring healthy blood circulation to treat a variety of diseases, a team of scientists at Weill Cornell Medical College has developed a new technique and described a novel mechanism for turning human embryonic and pluripotent stem cells into plentiful, functional endothelial cells, which are critical to the formation of blood vessels.
The viruses within -- and what keeps them there
It is known that viral "squatters" comprise nearly half of our genetic code. These genomic invaders inserted their DNA into our own millions of years ago when they infected our ancestors. But just how we keep them quiet and prevent them from attack was more of a mystery until EPFL researchers revived them.
More Embryonic Stem Cells Current Events and Embryonic Stem Cells News Articles
 |
Embryonic Stem Cells: A Practical Approach (The Practical Approach Series) by Elena Notarianni (Editor), Martin J. Evans (Editor) The groundbreaking isolation of embryonic stem cells (or 'ES cells') of the mouse in the early 1980s triggered a sustained expansion of global research into their exploitation. This led to the routine genetic engineering of the mouse and revolutionised our understanding of biological processes in the context of the whole animal. ES cell biology remains a crucial and growing area of research with far-reaching implications for developmental and comparative biology as well as for human health. This book serves as a primer to ES cells, their derivation and experimental manipulation. It contains a broad compendium of methods of direct relevance to both graduate students and specialist researchers. An introductory chapter by the principle originator of ES cell research outlines the... |
 |
Lines That Divide: The Great Stem Cell Debate Directed By: Brian Godawa Also With: Jack Hafer (Producer), Jennifer Lahl (Producer) With the Obama administration recently announcing its policy change on the issue of stem cell research and regenerative medicine, the questions surrounding this issue are increasingly more complex. This is why Lines That Divide: The Great Stem Cell Debate, a feature length documentary on stem cell research was made. Is stem cell research a potential miracle cure for diseases or a form of biological colonialism? The debate still rages over this controversial science. Supporters argue that it is our moral duty to pursue scientific progress that provides healing hope for humanity. Detractors argue that the ends don't justify the means in harvesting some human life to save others places our nations heart and soul on the same path as Germany in the late 1930's. This documentary seeks to... |
 |
USDA Embryonic Stem Cell Qualified (ESQ) FBS (100mL) by TPI Serum International Embryonic stem (ES) cell research requires the highest level possible serum purity to prevent adverse differentiation. ES-Qualified Fetal Bovine Serum (FBS) allows researchers to focus on more important tasks by providing FBS already screened and tested for toxicity, colony morphology and plating efficiency. ES-Qualified FBS is collected from our highest quality Premium Grade FBS lots from USDA approved abattoirs. |
 |
Charlie Rose (August 9, 2001) Directed By: Inc Charlie Rose Also With: Charlie Rose (Producer) |
 |
Embryonic Stem Cells navy blue silk Tie by I Awareables The Mission of every Infectious Awareables tie is to generate interest, discussion - even excitement - about serious public health issues which affect us all. Believing that humor can be a powerful educational tool, Infectious Awareables neckties take an atypical, slightly irreverent approach to some very serious subjects. A portion of the proceeds from each tie is donated to organizations that are dedicated to research, education or treatment of disease. You can do your part to help educate people about these matters by getting your tie Today. Stem Cells: Embryonic Stem Cells are precursor cells to hundreds of tissue types. Because of their unique ability to morph and differentiate, Stem Cells have the potential to play a key role in cure or treatment of a wide range of diseases and... |
 |
The Human Embryonic Stem Cell Debate: Science, Ethics, and Public Policy (Basic Bioethics) by Suzanne Holland (Editor), Karen Lebacqz (Editor), Laurie Zoloth (Editor) Human embryonic stem cells can divide indefinitely and have the potential to develop into many types of tissue. Research on these cells is essential to one of the most intriguing medical frontiers, regenerative medicine. It also raises a host of difficult ethical issues and has sparked great public interest and controversy. This book offers a foundation for thinking about the many issues involved in human embryonic stem cell research. It considers questions about the nature of human life, the limits of intervention into human cells and tissues, and the meaning of our corporeal existence. The fact that stem cells may be derived from living embryos that are destroyed in the process or from aborted fetuses ties the discussion of stem cell research to the ongoing debates on abortion. In... |
 |
Should the Government Fund Embryonic Stem Cell Research? (At Issue Series) by Amy Francis (Editor) |
 |
Embryonic Stem Cells (Human Cell Culture) by John R. Masters (Author), John R. Masters (Editor), Bernhard O. Palsson (Editor), James A. Thomson (Editor) If you wish to grow or characterize embryonic stem cells or persuade them to differentiate into a particular cell type, then this book contains information that is vital to your success. The aim is to provide clear simple instructions and protocols for growing, maintaining and characterizing embryonic stem cells and details of the various methods used to make stem cells differentiate into specific cell types. The contents will be of interest to stem cell biologists, tissue engineers and scientists wishing to use embryonic stem cells for therapeutic purposes. Each chapter has been written and edited by internationally respected scientists working at the cutting edge of technological developments in human embryonic stem cells. |
 |
Human Embryonic Stem Cells: The Practical Handbook by Stephen Sullivan (Editor), Chad A Cowan (Editor), Kevin Eggan (Editor) With this valuable practical guide, three members of the Harvard Stem Cell Institute have compiled and edited the definite handbook for the exciting new field of human embryonic stem cell research. The editors have gathered protocols from scientists with extensive reputation and expertise, describing and comparing currently used techniques for the culture of human stem cells and discussing the strengths and weaknesses of the different approaches. Human Embryonic Stem Cells: The Practical Handbook contains the first centralised collection of methods used in human embryonic stem cell biology. The book covers the derivation of human stem cell lines, the obtaining of cells from human stem cell banks, the culturing and characterisation of the cells, and the differentiation of the... |
 |
Human Embryonic Stem Cells: An Introduction to the Science and Therapeutic Potential by Ann A. Kiessling (Author), Scott. C. Anderson (Author) The social debate and resulting moratorium by the Bush Administration against federal funding for research involving the creation of human embryos for stem cell therapy prompted the writing of this text. The emerging field of human embryonic stem cell biomedicine crosses many disciplinary boundaries - cell biology, reproductive biology, embryology, molecular biology, endocrinology, immunology, fetal medicine, transplantation medicine and surgery. This single reference provides basic information from these multiple disciplines as it pertains to the science of stem cells. |
| © 2010 BrightSurf.com |