Science Current Events | Science News |

Researchers warn of 'fever from the forest'

June 14, 2011

Dengue virus circulating between monkeys and mosquitoes could emerge to cause human outbreaks

GALVESTON, Texas - More than a thousand years ago, somewhere in Southeast Asia, a fateful meeting occurred between a mosquito-borne virus that infected mainly monkeys and a large, susceptible group of humans.

The result: the world's first outbreak of dengue fever.

Today, dengue virus - which can produce high fever, excruciating joint pain and even death - has spread throughout tropical Asia, Africa and South America, and in 2008 it re-appeared in the Florida Keys. It could be even more widespread along the U.S. Gulf Coast but there is no surveillance in place to detect it.

Annually dengue strikes about 100 million people and causes an estimated 50,000 deaths, thriving in the urban environments infested by Aedes aegypti, the mosquito species primarily responsible for human dengue transmission.

Meanwhile, the virus' forest-dwelling counterpart - known as "sylvatic dengue" - continues to flourish in Southeast Asia and West Africa, cycling between non-human primates and the mosquitoes that feed on them. Since the 1970s, sylvatic dengue has received very little scientific attention - a situation that badly needs to be remedied, according to the authors of "Fever from the forest: Prospects for the continued emergence of sylvatic dengue virus and its impact on public health," an article published online June 13 in Nature Reviews Microbiology.

"This virus continues to circulate in the forests, and now economic and ecological pressures are driving more and more people into the forests in Africa and Southeast Asia," said University of Texas Medical Branch at Galveston assistant professor Nikos Vasilakis, lead author of the paper. "In the last 10 years we've seen a number of outbreaks of disease with real public health impact caused by what we call zoonotic viruses, viruses that start out in wild animals but can also be transmitted to humans - look at SARS, Nipah and Hendra, for example. Sylvatic dengue could be capable of a similar emergence - or rather, re-emergence, since we know previous dengue spillovers into urban and near-urban settings have occurred."

Dengue virus may also be capable of movement from the widespread urban cycles into primates and forest mosquitoes of Latin America, which would establish a new reservoir for human infections in the New World.

In the paper, Vasilakis and his collaborators identify two factors that make a dengue re-emergence a "clear and present danger": rapid human population growth near and in tropical forests, and the fact that little or no genetic change would be needed for sylvatic dengue to adapt to human hosts and urban mosquitoes.

"Experiments show that there is little or no adaptive barrier to the emergence of sylvatic dengue into human populations," Vasilakis said. "In other words, the virus can emerge from its current environment at any time, without further adaptation."

The article also presents additional reasons for boosting research into sylvatic dengue, among them the possibility that its behavior in nonhuman primate animal models might offer critical new perspectives on the pathology of human dengue. (Most monkeys tested so far show no clinical signs of the disease, limiting their usefulness as experimental models.) Another significant issue is the possibility that vaccines against human dengue, which could be licensed in as little as five years, might push the virus to the brink of eradication in the urban, human transmission cycle, leaving an ecological opening that could be filled by sylvatic dengue.

"We see a precedent for this with yellow fever, where we have a very good vaccine - urban yellow fever has been nearly eliminated in some regions - but we don't have good vector control programs, and especially in South America we now have outbreaks fueled by sylvatic yellow fever," Vasilakis said. "If we eradicate human dengue and then stop vaccinating, as we often do after the disease disappears, we could see a re-emergence of dengue from a sylvatic source."

With the exception of a research program in Malaysia that ended in 1975, fieldwork on sylvatic dengue has been minimal, according to Vasilakis. In the article, he and his fellow authors call for new surveillance programs to monitor mosquitoes, non-human primates and humans in areas where sylvatic dengue is endemic, as well as the development of new diagnostic tools that will enable researchers to more easily accomplish those studies. (One such surveillance effort is now underway in Senegal, funded by the National Institutes of Health and led by UTMB professor Scott Weaver, the paper's senior author.)

"Of all the viruses with the potential to shift from animals into humans, the most likely to do so are those that, like sylvatic dengue, are carried by the non-human primates and/or bats," Vasilakis said. "For our own good, we need to know as much as we can about this virus."


Other authors of the paper include Jane Cardosa of the Universiti Sarawak Malaysia, Kathryn Hanley of New Mexico State University and Edward Holmes of Pennsylvania State University. The National Institutes of Health supported this work.

ABOUT UTMB Health: Established in 1891, Texas' first academic health center comprises four health sciences schools, three institutes for advanced study, a research enterprise that includes one of only two national laboratories dedicated to the safe study of infectious threats to human health, and a health system offering a full range of primary and specialized medical services throughout Galveston County and the Texas Gulf Coast region. UTMB Health is a component of the University of Texas System and a member of the Texas Medical Center.

University of Texas Medical Branch at Galveston

Related Dengue Fever Current Events and Dengue Fever News Articles

Yellow fever epidemic threatens to spread from Angola to China
The spread of yellow fever (YF) is a global health threat. In response to current outbreaks in Angola, other African countries, and China, which represents the first ever documented cases of YF in Asia, the World Health Organization (WHO) convened an emergency committee on May 19, 2016 to underscore the severity of the outbreak.

A warming climate puts Europe at risk for seasonal outbreaks of dengue fever
Increasing temperatures will enlarge Europe's seasonal window for the potential spread of mosquito-borne viral disease, expanding the geographic areas at risk for a dengue epidemic to include much of Europe.

First in-human vaccine study for malaria caused by Plasmodium vivax
Walter Reed Army Institute of Research (WRAIR) researchers recently published the results of testing a Plasmodium vivax malaria vaccine candidate in a human challenge model.

Engineered gene drives and the future
Engineered gene drives, which have the potential to spread desirable genes throughout wild populations or to suppress harmful species, have received a lot of recent attention because of their potential to control organisms, such as mosquitoes that carry diseases such as Zika virus, malaria and dengue fever.

Researchers compare 'natural' mosquito repellents to DEET
Researchers at New Mexico State University tested 10 commercially available products for their effectiveness at repelling mosquitoes, and the results were published in the Journal of Insect Science.

Childhood infections associated with increased risk of early heart attack
In Indonesia there is no reliable registry data on infection related hospitalisation and prescription of antibiotics.

Comprehensive genomic study provides evidence that dengue has become endemic and diverse in China
The first-ever comprehensive genomic analysis of the virus that causes dengue fever suggests that it may survive year-round in southern China.

Researchers discover a new mechanism of proteins to block HIV
There is little doubt that the Human Immunodeficiency Virus, or HIV, is devastating. More than 1.2 million people in the United States are living with HIV and more than 47,000 people are diagnosed annually.

UQ scientists close in on first dengue treatment
Clinical trials for a dengue fever treatment could start within a year, following a discovery by University of Queensland scientists.

Study shows how climate change threatens health
Researchers at Columbia University's National Center for Disaster Preparedness (NCDP) and the University of Washington have published a new study focused on the public health implications of climate change.
More Dengue Fever Current Events and Dengue Fever News Articles

Dengue and Dengue Hemorrhagic Fever

Dengue and Dengue Hemorrhagic Fever
by Duane J. Gubler (Editor), Eng Eong Ooi (Editor), Subhash Vasudevan (Editor), Jeremy Farrar (Editor)

Continued geographic expansion of dengue viruses and their mosquito vectors has seen the magnitude and frequency of epidemic dengue/dengue hemorrhagic fever (DF/DHF) increase dramatically. Recent exciting research on dengue has resulted in major advances in our understanding of all aspects of the biology of these viruses, and this updated second edition brings together leading research and clinical scientists to review dengue virus biology, epidemiology, entomology, therapeutics, vaccinology and clinical management.

Dengue Fever (Epidemics)

Dengue Fever (Epidemics)
by Katherine White (Author)

Book by White, Katherine

Dengue Fever Natural Remedies - A Comprehensive Guide to Identifying and Treating Dengue Fever at Home

Dengue Fever Natural Remedies - A Comprehensive Guide to Identifying and Treating Dengue Fever at Home
by Green Initiative

Early Detection, Cure and Prevention: A Comprehensive Guide to Identifying and Treating Dengue Fever at Home

CHAPTER I. Understanding Dengue Fever
A. What Is Dengue Fever
B. Classifications, Signs, and Symptoms
C. The Four Strains
D. Transmission
E. How The Dengue Virus Attacks The Immune System
CHAPTER II. The Treatment Methods
A. What To Do When Threat Arises
B. Rehydration
C. Tawa-tawa Leaves
D. Sweet Potato Tops
E. Quail Eggs
F. Pork Liver
G. Papaya Leaves
H. Vitamin C
I. Warnings and Precautions
CHAPTER III. Preventive Measures
A. Clean
B. Wear insect repellent lotions
C. Fumigation

Dengue Fever and Zika: A Traveler's Guide

Dengue Fever and Zika: A Traveler's Guide
by G Roebuck (Author)

Dengue Fever and Zika: A Traveler's Guide is a personal account of what it is like to suffer from this mosquito-borne virus that causes unpleasant symptoms, long-lasting aftereffects and can be fatal. Written in simple layman's terms, Dengue Fever and Zika: A Traveler's Guide offers an in-depth insight into what to expect if you contract dengue fever. It answers many questions that sufferers and their carers may have about the symptoms and treatments to alleviate the fever and rash. The book also covers the unexpected aftereffects such as peeling skin, hair loss, painful joints and vertigo that the author experienced up to 12 weeks after being diagnosed with this tropical disease. As a handbook, Dengue Fever and Zika: A Traveler's Guide gives a detailed day-by-day account of dengue...

Dengue: How To Cure Dengue Fever The Solution And Best Home Remedies Cure For Dengue Fever (Dealing With Dengue,Dengue Cure,Fever,Solution,Home Remedies,)

Dengue: How To Cure Dengue Fever The Solution And Best Home Remedies Cure For Dengue Fever (Dealing With Dengue,Dengue Cure,Fever,Solution,Home Remedies,)

Use These Powerful Secrets To Immediately Cure Your Dengue Fever Fast!

Dengue Fever is caused by the dengue virus that is transmitted from the bite of an effected mosquito. Dengue fever is also known as backbone fever and the virus cannot be directly transmitted from one person to another. There are several mosquitoes in the tropic areas that are carriers of the Dengue Virus and this mosquito can also be infected if it bites any person who has Dengue Virus in his blood. Dengue fever is caused by viruses of the Flavivirida family in genus Flavivirus of the size of 35-45 μm (diameter), carrying a single strand of RNA (ie. Genome). This mosquito borne tropical diseases develops into a life threatening hemorrhagic fever, resulting into a low level of blood platelets,...

Dengue Fever and Other Hemorrhagic Viruses (Deadly Diseases & Epidemics (Hardcover))

Dengue Fever and Other Hemorrhagic Viruses (Deadly Diseases & Epidemics (Hardcover))
by Tirtha Chakraborty (Author), Edward I Alcamo Ph.D. (Editor), David Heymann (Editor)

Dengue fever is an infectious disease that is caused by four types of viruses transmitted by Aedes aegypti mosquitoes. This work explores the biology of the dengue virus and similar viruses such as Ebola and Marburg virus, as well as their symptoms, where they are found, how they are transmitted, and the efforts to treat and eradicate them.

Dealing with Dengue, the Complete Guide: Dengue Disease Prevention and Treatment: A Guide to Healthy Dengue Fever Symptom Treatment and Cures

Dealing with Dengue, the Complete Guide: Dengue Disease Prevention and Treatment: A Guide to Healthy Dengue Fever Symptom Treatment and Cures

The complete Dengue fever guide: informative, authoritative, tightly-written chapters on every aspect of Dengue infection:
What not to Do...
What is Dengue?
Diagnosing Dengue
Folk Remedies
Children & Dengue
Pregnancy & Dengue
Severe Dengue
Painkillers & Your Liver
Recovery & TCM
Doctors & Drugs
Lab Tests
Somebody Stop Me!
Call Me Aedes
99% Prevention
Insecticides & Repellents
Traps, Nets, Coils & More
Case Studies
Vaccines, Bacteria & GMOs
Regular Mosquito Bites
Your Community
Blogs, Links, Downloads
Myths & Rumors
Dengue for MDs

The Dengue mosquito depends on human society (and human laziness), so we CAN...

Travel with Deadly Dengue - Avoiding and Curing Dengue Fever (Natural Health & Wellness Series Book 2)

Travel with Deadly Dengue - Avoiding and Curing Dengue Fever (Natural Health & Wellness Series Book 2)

Your holiday is something you should enjoy and not the time you should fight for your life in the local clinic or hospital. In many tourist destinations around the world this deadly fever is spreading to tourists and locals alike. Thailand who is a popular tourist destination had over 100 000 cases of dengue fever just last year. Brazil the Olympic and the World Cup in Football had over 1 million cases.

This Guide to wellness teaches you how to avoid Dengue and as well as how to avoid getting it in the first place.

Where is safe to Travel?
How to avoid Dengue?
How to cure Dengue?
Treatment for Dengue?

Bonus Inside: Get free Dengue outbreak Warnings!

The Aedes Aegypti, or Yellow Fever Mosquito

The Aedes Aegypti, or Yellow Fever Mosquito

The Aedes aegypti mosquito is one of the most lethal organisms in human history. It is the main vector of several tropical diseases, including yellow fever, dengue fever, chikungunya, and the zika virus. The zika virus, in particular, has attracted attention due to that infection being implicated in an epidemic of babies being born with microcephaly, or unusually small heads in northeastern Brazil. Microcephaly is related to a number of health problems, including developmental delays, intellectual disabilities, and various lifelong health problems.

The A. aegypti mosquito isn’t the only species of mosquito that can spread the zika and other infections to humans. But the fact that this mosquito prefers to feed on people, and breeds near to where people live, has made it an...

A Simple Guide to Dengue Fever, Treatment and Related Diseases (A Simple Guide to Medical Conditions)

A Simple Guide to Dengue Fever, Treatment and Related Diseases (A Simple Guide to Medical Conditions)


Ode to Dengue Fever

Dengue Fever is a serious infectious viral disease
It is a mosquito borne disease which affect all ages
The main symptoms is fever, headache and vomiting
In severe cases there may be anorexia, rashes and bleeding

The disease is transmitted by Aedes mosquito and caused by a flavivirus
The infection quickly spreads to the brain, intestine and bone marrow
With relapse there is damage to the brain, kidney and poor urination
There is blood in the urine and poor liver dysfunction

Diagnosis is based on characteristic fever, and vomiting
Detection of dengue fever antigen and positive (IgM) antibody testing
There is evidence of bleeding and poor coagulation
There are also liver...

© 2016