Science Current Events | Science News | Brightsurf.com
 

The concept of 'overactive bladder' serves better commercial rather than patient interests

January 16, 2012
"The overactive bladder syndrome has become an accepted way to simplify a complex array of symptoms and leads people to believe that an overactive bladder is an independent disease in itself. However, the truth is not as simple as this, as there are usually several factors at work explaining the symptoms. This is also one of the reasons why so called overactive bladder medications often do not bring the hoped result," says Kari Tikkinen, MD, PhD, from the HUCS Department of Urology.

The article on overactive bladder syndrome, which was co-written by Tikkinen, who currently holds a senior researcher post at the McMaster University in Canada, and Anssi Auvinen, Professor of Epidemiology from the University of Tampere, was recently published in the European Urology journal. For the article, the researchers systematically reviewed the studies on overactive bladder and the channels through which these studies have been funded.

The authors argue that the symptoms of an 'overactive bladder' ought to be studied individually and not as an ambiguous constellation of symptoms. This way the underlying causes of the symptoms can be better understood and more effective treatments can be developed.

The expression 'overactive bladder' was coined at an industry-sponsored symposium held in 1997. The following year, the FDA approved the first drug for the treatment of 'symptoms of overactive bladder', after which the pharmaceutical industry launched high-profile, worldwide promotional campaigns for drugs aimed at treatment of the syndrome.

According to the current definition, overactive bladder (OAB) syndrome is defined as the presence of urinary urgency with or without urgency incontinence, usually with increased daytime frequency and nocturia in the absence of infection or other obvious pathology.

"The definition is vague and ambiguous because it includes unspecific terms, such as 'usually' and 'with or without', and the unclear expression 'other obvious pathology'," Tikkinen says and continues, "For the pharmaceutical industry this definition is probably quite useful, as it is partly the reason why one medicine can be prescribed to a large number of patients."

Research into overactive bladder has increased significantly over the past ten years and the pharmaceutical industry has invested heavily in it. "It has previously been shown that research funded by commercial actors often ends up unpublished if the results don't serve the interests of the company," Tikkinen points out.

Tikkinen and Auvinen also bring to the fore that in many studies on prevalence of overactive bladder, very mild symptoms have been classified as abnormal.

"More independent, non-commercially funded research on the subject is needed. There are, in the end, a huge number of people who suffer from urinary urgency and increased urinary frequency, and current treatments are not bringing sufficient relief," Tikkinen says.

University of Helsinki


Related Overactive Bladder Current Events and Overactive Bladder News Articles


Study debunks common myth that urine is sterile
Bacteria live in the bladders of healthy women, discrediting the common belief that normal urine is sterile. This finding was presented today by researchers from Loyola University Chicago at the 114th General Meeting of the American Society for Microbiology in Boston.

Bacteria in urine could contribute to overactive bladder
Contrary to popular belief, urine is not sterile and the bacteria in it may be associated with overactive bladder (OAB) in some women, according to research presented today at the annual meeting of the American Society for Microbiology.

Beaumont study: Nerve stimulation helps with overactive bladder
Beaumont Health System research finds that symptoms of overactive bladder, or OAB, were reduced in those who received tibial nerve stimulation.

Study uncovers new cells in the urethra which may detect hazardous substances
A recent study conducted by a group of German scientists revealed the presence of a previously unknown cell in the urethra of mice.

Study shows mirabegron effective and well tolerated for overactive bladder
In a new phase III trial mirabegron, a β3-adrenoceptor agonist, given once daily for 12 weeks, reduced the frequency of incontinence episodes and number of daily urinations, and improved urgency and nocturia in adults with overactive bladder (OAB) compared to those in a placebo group.

Got to go? Harvard scientists figure out how you know
If you have an overactive bladder or incontinence, help could be on the way. A new research report published online in the FASEB Journal, shows that the epithelium, a thin layer of cells which line the surface of the bladder, is able to sense how full the bladder is through the action of a family of proteins called integrins.

Study shows benefits, drawbacks, for women's incontinence treatments
Oral medication for treating a type of incontinence in women is roughly as effective as Botox injections to the bladder, reported researchers who conducted a National Institutes of Health clinical trials network study, with each form of treatment having benefits and limitations.

Overactive bladder linked to sleep apnoea in women
Sleep apnoea in women has been linked to overactive bladder syndrome in a new study.

New Therapy Provides Hope for Millions of People Suffering from Bowel Incontinence
A new procedure is now available for the treatment of chronic bowel incontinence, a disorder impacting the lives of more than 18 million Americans.

Genes an important factor in urinary incontinence
Much of the risk of developing incontinence before middle age is determined by our genes.
More Overactive Bladder Current Events and Overactive Bladder News Articles

Overcoming Overactive Bladder: Your Complete Self-Care Guide

Overcoming Overactive Bladder: Your Complete Self-Care Guide
by Diane K. Newman (Author), Alan Wein (Author)


Learn exactly what OAB is, how it is diagnoses, who is most at risk, and what other common probelms tend to occur in conjunction with it. You'll find out when you should seek a doctor's help, what to ask and what medications are available. This is the most comprehensive guide on this subject.

The Bathroom Key

The Bathroom Key
by Kathryn Kassai PT CES (Author), Kim Perelli (Author)


Urinary incontinence is an underdiagnosed and underreported condition with major economic and psychosocial effects on society. Women are more likely to experience it due to issues with the pelvic floor brought on by pregnancy and menopause. The Bathroom Key is a treatment plan for women to cure their own incontinence issues. It also allows women to identify with other women through the anecdotal stories that echo their feelings of isolation and embarrassment. Written in easy-to-understand language, the book is a genuine teaching tool, guiding the reader to a better understanding of her body and effective remedies. Whereas in recent years some mention of the Kegel muscles and exercises have become common knowledge, this book is much more than just Kegels. By incorporating key elements of...

Healthy Diet, Happy Bladder: How Diet Affects Bladder Behavior (Your Perfect Pelvis)

Healthy Diet, Happy Bladder: How Diet Affects Bladder Behavior (Your Perfect Pelvis)
by Elizabeth E Houser MD (Author)


This new book by board certified urologist Elizabeth E. Houser, M.D. examines the constituents in our modern day diet that may contribute to urinary problems such as frequency, urgency, and incontinence. Co-author of "A Woman's Guide to Pelvic Health", Dr. Houser focuses on factors in our daily lives that can affect our health and sense of well being, and outlines the measures that we can take to promote pelvic health. Written for men and women alike, "Healthy Diet, Happy Bladder" describes fluid management, foods, preservatives, and beverages that may have an irritative action on the bladder. The book also offers alternatives to these bladder caustic substances, as well as some tools to combat the effects of these substances when we do indulge. This concisely written book will allow...

Questions & Answers About Overactive Bladder, Second Edition

Questions & Answers About Overactive Bladder, Second Edition
by Pamela Ellsworth (Author), Alan Wein (Author)


Overactive bladder and urinary incontinence affect over 30 million men and women in the United States alone. Despite this high prevalence, incidents are largely undiagnosed and untreated, mainly because patients hold misconceptions or are too embarrassed to talk about it. If you suffer from the discomfort, inconvenience, and embarrassment of overactive bladder or urinary incontinence, or have a friend or relative who does, this book offers help. The only book to provide the doctor’s and patient’s view, Questions & Answers About Overactive Bladder gives you authoritative, practical answers to your questions about treatment options, coping strategies, sources of support, and much more. Written by two prominent urologists, with “insider” advice from actual patients, this book is an...

Overactive Bladder Syndrome and Urinary Incontinence (Oxford Urology Library)

Overactive Bladder Syndrome and Urinary Incontinence (Oxford Urology Library)
by Hashim Hashim (Author), Paul Abrams (Author)


Overactive bladder (OAB) syndrome and urinary incontinence are prevalent conditions that affect millions of people worldwide. As such, it is important that these conditions are understood, diagnosed and treated appropriately. Part of the Oxford Urology Library, this pocketbook provides a practical and easy-to-read reference, covering all clinically relevant aspects of OAB and incontinence.

With chapters covering the epidemiology, diagnosis and treatment of OAB and urinary incontinence, this book will serve as a useful guide for urologists, gynaecologists, geriatricians, trainees, nurses, continence advisors, physiotherapists, medical students and general practitioners all over the world.

Urology: Overactive Bladder: Diagnosis and Treatment (Audio-Digest Foundation Urology Continuing Medical Education (CME). Book 34)

Urology: Overactive Bladder: Diagnosis and Treatment (Audio-Digest Foundation Urology Continuing Medical Education (CME). Book 34)


Purpose: Audio-Digest Foundation CME/CE activities are designed to provide its learners – physicians and other healthcare professionals – with continuing education that will help identify clinical problems in their practice settings, provide content to help to solve those problems, and increase their application of knowledge to practice.

Audio-Digest Urology is specifically designed to provide the participant with state-of-the-art information, including, but not limited to, the diagnosis and management of:

Benign prostatic hyperplasia
Bladder cancer
Prostate cancer
Renal cancer
Impotence and infertility
Female stress urinary incontinence
Calculus disease
Interstitial cystitis
Pediatric urologic...

Overactive Bladder in Clinical Practice

Overactive Bladder in Clinical Practice
by Alan J. Wein (Author), Christopher R. Chapple (Author)


The book provides a timely and comprehensive update on the overactive bladder (OAB) syndrome. The symptoms of urgency, with or without urge incontinence, usually with frequency or nocturia, now defined as the overactive bladder syndrome, have become a hot topic in urology, gynecology and urogynecology. Epidemiological data show very high disease prevalence (19%), particularly when compared with other chronic conditions such as diabetes (2%) and asthma (7%). OAB symptoms impact severely on patient’s quality of life, causing significant impairment of patient vitality and limiting their physical role, similar to diabetes. The OAB syndrome involves all age groups, both sexes and is frequently found in neurogenic patients. This book will cover all aspects of OAB epidemiology, economics,...

  Don't allow overactive bladder to compromise your quality of life: behavior modifications and/or medications often can reduce symptoms of urinary ... An article from: Women's Health Advisor
by Unavailable (Author)


This digital document is an article from Women's Health Advisor, published by Belvoir Media Group, LLC on August 1, 2014. The length of the article is 776 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser.

Citation Details
Title: Don't allow overactive bladder to compromise your quality of life: behavior modifications and/or medications often can reduce symptoms of urinary urgency and frequency.(UROLOGY)
Author: Unavailable
Publication: Women's Health Advisor (Magazine/Journal)
Date: August 1, 2014
Publisher: Belvoir Media Group, LLC
Volume: 18 Issue: 8 Page: 4(1)

Distributed by Gale, a part of Cengage...

Saunders Comprehensive Review for the NCLEX-RN® Examination, 6e (Saunders Comprehensive Review for Nclex-Rn)

Saunders Comprehensive Review for the NCLEX-RN® Examination, 6e (Saunders Comprehensive Review for Nclex-Rn)
by Linda Anne Silvestri PhD RN (Author)


Often called the 'the best NCLEX® exam review book ever,' Saunders Comprehensive Review for the NCLEX-RN® Examination provides everything you need to prepare for the NCLEX exam - complete content review and over 5,100 NCLEX examination-style questions in the book and online. Don't make the mistake of assuming the quality of the questions is the same in all NCLEX exam review books, because only this book includes the kind of questions that consistently test the critical thinking skills necessary to pass today's NCLEX exam. Even better, all answers include detailed rationales to help you learn from your answer choices, as well as test-taking strategies with tips on how to best approach each question. Written by the most trusted name in NCLEX review, Linda Anne Silvestri, and updated to...

Pathophysiology: The Biologic Basis for Disease in Adults and Children, 7e

Pathophysiology: The Biologic Basis for Disease in Adults and Children, 7e
by Kathryn L. McCance RN PhD (Author), Sue E. Huether RN PhD (Author)


With easy-to-read, in-depth descriptions of disease, disease etiology, and disease processes, Pathophysiology: The Biologic Basis for Disease in Adults and Children, 7th Edition helps you understand the most important and the most complex pathophysiology concepts. More than 1,200 full-color illustrations and photographs make it easier to identify normal anatomy and physiology, as well as alterations of function. This edition includes a NEW Epigenetics and Disease chapter along with additional What's New boxes highlighting the latest advances in pathophysiology. Written by well-known educators Kathryn McCance and Sue Huether, and joined by a team of expert contributors, this resource is the most comprehensive and authoritative pathophysiology text available!Over 1,200 full-color...

© 2014 BrightSurf.com