Science Current Events | Science News | Brightsurf.com
 

The concept of 'overactive bladder' serves better commercial rather than patient interests

January 16, 2012
"The overactive bladder syndrome has become an accepted way to simplify a complex array of symptoms and leads people to believe that an overactive bladder is an independent disease in itself. However, the truth is not as simple as this, as there are usually several factors at work explaining the symptoms. This is also one of the reasons why so called overactive bladder medications often do not bring the hoped result," says Kari Tikkinen, MD, PhD, from the HUCS Department of Urology.

The article on overactive bladder syndrome, which was co-written by Tikkinen, who currently holds a senior researcher post at the McMaster University in Canada, and Anssi Auvinen, Professor of Epidemiology from the University of Tampere, was recently published in the European Urology journal. For the article, the researchers systematically reviewed the studies on overactive bladder and the channels through which these studies have been funded.

The authors argue that the symptoms of an 'overactive bladder' ought to be studied individually and not as an ambiguous constellation of symptoms. This way the underlying causes of the symptoms can be better understood and more effective treatments can be developed.

The expression 'overactive bladder' was coined at an industry-sponsored symposium held in 1997. The following year, the FDA approved the first drug for the treatment of 'symptoms of overactive bladder', after which the pharmaceutical industry launched high-profile, worldwide promotional campaigns for drugs aimed at treatment of the syndrome.

According to the current definition, overactive bladder (OAB) syndrome is defined as the presence of urinary urgency with or without urgency incontinence, usually with increased daytime frequency and nocturia in the absence of infection or other obvious pathology.

"The definition is vague and ambiguous because it includes unspecific terms, such as 'usually' and 'with or without', and the unclear expression 'other obvious pathology'," Tikkinen says and continues, "For the pharmaceutical industry this definition is probably quite useful, as it is partly the reason why one medicine can be prescribed to a large number of patients."

Research into overactive bladder has increased significantly over the past ten years and the pharmaceutical industry has invested heavily in it. "It has previously been shown that research funded by commercial actors often ends up unpublished if the results don't serve the interests of the company," Tikkinen points out.

Tikkinen and Auvinen also bring to the fore that in many studies on prevalence of overactive bladder, very mild symptoms have been classified as abnormal.

"More independent, non-commercially funded research on the subject is needed. There are, in the end, a huge number of people who suffer from urinary urgency and increased urinary frequency, and current treatments are not bringing sufficient relief," Tikkinen says.

University of Helsinki


Related Overactive Bladder Current Events and Overactive Bladder News Articles


Study debunks common misconception that urine is sterile
Bacteria have been discovered in the bladders of healthy women, discrediting the common belief that normal urine is sterile.

Myelin-maker: How an FDA-approved drug boosts myelin synthesis
Damage to myelin, the fatty insulator that enables communication between nerve cells, characterizes multiple sclerosis (MS) and other devastating neurological diseases.

Afferent's P2X3 inhibitor shows 75 percent reduction in chronic cough frequency
Afferent Pharmaceuticals today announced publication of results from a Phase 2 clinical trial demonstrating that the company's novel drug candidate, AF-219, reduced daytime cough frequency by 75% compared to placebo in patients with treatment-refractory chronic cough.

Clock gene dysregulation may explain overactive bladder
If you think sleep problems and bladder problems are a fact of life in old age, you may be right. A new report appearing in the November 2014 issue of The FASEB Journal, shows that our sleep-wake cycles are genetically connected to our bladder, and disruptions to one may cause problems with the other.

Transplanted stem cells help prevent bladder fibrosis after spinal cord injury
A team of researchers from Korea and Canada have found that transplantation of B10 cells (a stable immortalized human bone marrow derived -mesenchymal stem cell line; B10 hMSC) directly into the bladder wall of mice modeled with spinal cord injury (SCI) helped inhibit the development of bladder fibrosis and improved bladder function by promoting the growth of smooth muscle cells in the bladder.

Mirabegron for overactive bladder: added benefit not proven
Mirabegron (trade name: Betmiga) has been approved since December 2012 for the treatment of adults with overactive bladder.

Study debunks common myth that urine is sterile
Bacteria live in the bladders of healthy women, discrediting the common belief that normal urine is sterile. This finding was presented today by researchers from Loyola University Chicago at the 114th General Meeting of the American Society for Microbiology in Boston.

Bacteria in urine could contribute to overactive bladder
Contrary to popular belief, urine is not sterile and the bacteria in it may be associated with overactive bladder (OAB) in some women, according to research presented today at the annual meeting of the American Society for Microbiology.

Beaumont study: Nerve stimulation helps with overactive bladder
Beaumont Health System research finds that symptoms of overactive bladder, or OAB, were reduced in those who received tibial nerve stimulation.

Study uncovers new cells in the urethra which may detect hazardous substances
A recent study conducted by a group of German scientists revealed the presence of a previously unknown cell in the urethra of mice.
More Overactive Bladder Current Events and Overactive Bladder News Articles

Overcoming Overactive Bladder: Your Complete Self-Care Guide

Overcoming Overactive Bladder: Your Complete Self-Care Guide
by Diane K. Newman (Author), Alan Wein (Author)


Learn exactly what OAB is, how it is diagnoses, who is most at risk, and what other common probelms tend to occur in conjunction with it. You'll find out when you should seek a doctor's help, what to ask and what medications are available. This is the most comprehensive guide on this subject.

The Bathroom Key

The Bathroom Key
by Kathryn Kassai PT CES (Author), Kim Perelli (Author)


Urinary incontinence is an underdiagnosed and underreported condition with major economic and psychosocial effects on society. Women are more likely to experience it due to issues with the pelvic floor brought on by pregnancy and menopause. The Bathroom Key is a treatment plan for women to cure their own incontinence issues. It also allows women to identify with other women through the anecdotal stories that echo their feelings of isolation and embarrassment. Written in easy-to-understand language, the book is a genuine teaching tool, guiding the reader to a better understanding of her body and effective remedies. Whereas in recent years some mention of the Kegel muscles and exercises have become common knowledge, this book is much more than just Kegels. By incorporating key elements of...

Overactive Bladder: Practical Management

Overactive Bladder: Practical Management
by Jacques Corcos (Editor), Scott MacDiarmid (Editor), John Heesakkers (Editor)


Overactive Bladder: Practical Management provides urologists, gynecologists and other health practitioners with a comprehensive clinical guide to this very common problem, resulting in a perfect resource to consult time and time again. Beginning with an introductory section covering the definition and pathophysiolgy of OAB, it then moves on to cover evaluation, first-line management, second-line management and finally surgery. Well-illustrated throughout, each chapter begins with a key points box outlining the most important take-home messages. Also included are clear management algorithms to aid decision-making, 'Do's and Don't' boxes to help avoid errors made, key references to the top journal articles, and the very latest guidelines from the EAU, AUA and other major urology societies....

A  Simple  Guide  To  Overactive Bladder,  Diagnosis,  Treatment  And  Related Conditions (A Simple Guide to Medical Conditions)

A Simple Guide To Overactive Bladder, Diagnosis, Treatment And Related Conditions (A Simple Guide to Medical Conditions)


Chapter 1

Overactive Bladder

What is the Overactive Bladder?

The Overactive Bladder is defined as urgency to pass urine with or without urge incontinence and usually with frequency and nocturia.

Overactive bladder is a medical disorder in which the bladder squeezes urine out at the wrong time.

An overactive bladder is present if you have two or more of the following symptoms:

1. Urinate eight or more times a day or two or more times at night
2. Have the sudden, strong urge to urinate immediately
3. Leak urine during a sudden, strong urination urge
4. Have incontinence which is the loss of bladder control.

OAB maybe categorized into 2 forms:

1. OAB wet is OAB with...

Healthy Diet, Happy Bladder: How Diet Affects Bladder Behavior (Your Perfect Pelvis)

Healthy Diet, Happy Bladder: How Diet Affects Bladder Behavior (Your Perfect Pelvis)
by Elizabeth E Houser MD (Author)


This new book by board certified urologist Elizabeth E. Houser, M.D. examines the constituents in our modern day diet that may contribute to urinary problems such as frequency, urgency, and incontinence. Co-author of "A Woman's Guide to Pelvic Health", Dr. Houser focuses on factors in our daily lives that can affect our health and sense of well being, and outlines the measures that we can take to promote pelvic health. Written for men and women alike, "Healthy Diet, Happy Bladder" describes fluid management, foods, preservatives, and beverages that may have an irritative action on the bladder. The book also offers alternatives to these bladder caustic substances, as well as some tools to combat the effects of these substances when we do indulge. This concisely written book will allow...

New Surgical Techniques and Medical Treatment in Urogynecology: Treatment of Stress Urinary Incontinence, Pelvic Floor Defects, and Overactive Bladder in Women

New Surgical Techniques and Medical Treatment in Urogynecology: Treatment of Stress Urinary Incontinence, Pelvic Floor Defects, and Overactive Bladder in Women
by Maxdorf s.r.o.


The book deals with practical aspects of the treatment of pelvic floor disorders with the accent on novel techniques that entered medical practice during the last decade. It is a handbook both for gynecologists and urologists with detailed description of surgical techniques in a step-by-step style. A special chapters address the use of foreign implant materials in pelvic floor reconstruction surgery as well as the pharmacotherapy of urinary stress incontinence, OAB, and urgency UI in women. * "The book discusses all of the major aspects of pelvic floor disorders, such as their anatomy, physiology, examination and pathophysiology; it summarizes surgical procedures for incontinence and prolapse as well as drug therapy for incontinence and overactive bladder. The chapters describe...

Overactive Bladder Syndrome and Urinary Incontinence (Oxford Urology Library)

Overactive Bladder Syndrome and Urinary Incontinence (Oxford Urology Library)
by Hashim Hashim (Author), Paul Abrams (Author)


Overactive bladder (OAB) syndrome and urinary incontinence are prevalent conditions that affect millions of people worldwide. As such, it is important that these conditions are understood, diagnosed and treated appropriately. Part of the Oxford Urology Library, this pocketbook provides a practical and easy-to-read reference, covering all clinically relevant aspects of OAB and incontinence.

With chapters covering the epidemiology, diagnosis and treatment of OAB and urinary incontinence, this book will serve as a useful guide for urologists, gynaecologists, geriatricians, trainees, nurses, continence advisors, physiotherapists, medical students and general practitioners all over the world.

Botox: Treats Blepharospasm, Cervical Dystonia, Chronic Migraine, Overactive Bladder, Severe Underarm Sweating when Antiperspirants Fail, Strabismus, ... the Appearance of Wrinkles on the Face

Botox: Treats Blepharospasm, Cervical Dystonia, Chronic Migraine, Overactive Bladder, Severe Underarm Sweating when Antiperspirants Fail, Strabismus, ... the Appearance of Wrinkles on the Face
by James Lee Anderson (Author)


“Although, your health condition may impact your everyday life, do not let it define who you are.” BOTOX or BOTOX COSMETIC (OnabotulinumtoxinA) injection is used to treat a number of conditions. BOTOX (OnabotulinumtoxinA) injection is used to: (1) relieve the symptoms of cervical dystonia in people 16 years of age and older; (2) relieve the symptoms of strabismus and blepharospasm in people 12 years of age and older; (3) prevent headaches in people older than 18 years of age with chronic migraine who have 15 or more days each month with headaches lasting 4 hours or more; (4) treat overactive bladder in people 18 years of age and older when other medications do not work well enough or cannot be taken; (5) treat incontinence in people 18 years of age and older with overactive bladder...

BOTOX: Treats Blepharospasm, Cervical Dystonia, Chronic Migraine, Overactive Bladder, Severe Underarm Sweating when Antiperspirants Fail, Strabismus, Muscle Stiffness, and Face Wrinkles

BOTOX: Treats Blepharospasm, Cervical Dystonia, Chronic Migraine, Overactive Bladder, Severe Underarm Sweating when Antiperspirants Fail, Strabismus, Muscle Stiffness, and Face Wrinkles


“Although, your health condition may impact your everyday life, do not let it define who you are.”

BOTOX or BOTOX COSMETIC (OnabotulinumtoxinA) injection is used to treat a number of conditions. BOTOX (OnabotulinumtoxinA) injection is used to: (1) relieve the symptoms of cervical dystonia in people 16 years of age and older; (2) relieve the symptoms of strabismus and blepharospasm in people 12 years of age and older; (3) prevent headaches in people older than 18 years of age with chronic migraine who have 15 or more days each month with headaches lasting 4 hours or more; (4) treat overactive bladder in people 18 years of age and older when other medications do not work well enough or cannot be taken; (5) treat incontinence in people 18 years of age and older with...

INCONTINENCE. CONTROL YOUR FEMALE URINE ACCIDENTS AND OVERACTIVE BLADDER DISORDERS. Yes You Can Do It - Really! (Difficult Subjects Made Easy)

INCONTINENCE. CONTROL YOUR FEMALE URINE ACCIDENTS AND OVERACTIVE BLADDER DISORDERS. Yes You Can Do It - Really! (Difficult Subjects Made Easy)
by Heather Latimer (Author), Dr. Jewel Simpson (Editor), Richard Ramsdell (Editor)


Ladies! Help is available! Immediately! There's no need to suffer urine accidents one moment longer. This 6th expanded edition is jam-packed with vital information for controlling bladder incontinence and urine accidents. Booklet 1: A quick, easy, low cost, home remedy, used by European women for over 50 years; Booklet II: Step-by-step instructions in Kegel Basic and Kegel Advanced exercises, and more self help options for staying dry; Booklet III: Should you (wisely) prefer to seek professional help, don't be embarrassed. Here's what you need to tell your primary doctor, questions s/he will ask, plus details of new developments in medications, state-of-the-art tests, modern treatments, and 21st century surgical operations. Covered by most insurances and available right now. Brand new...

© 2015 BrightSurf.com