Science Current Events | Science News | Brightsurf.com
 

New HIV-vaccine tested on people

February 14, 2012

Scientists from the Antwerp Institute of Tropical Medicine, Antwerp University Hospital and Antwerp University have tested a new 'therapeutic vaccine' against HIV on volunteers. The participants were so to say vaccinated with their own cells. The researchers filtered certain white blood cells out of the volunteer's blood, 'loaded' them outside the body and then gave them back. The immune system of the testees was better than before in attacking and suppressing the virus, the scientists reported in the top journal AIDS. But they still cannot cure the disease.

Actually, medical science can control an HIV-infection quite well, with a medicine cocktail. 'Seropositive' people (people who are infected with the HIV virus) now can lead a reasonably normal life, but their virus is not exterminated. When they stop the treatment it immediately rebounds.

Science knows what the problem is: the 'special forces' in our blood (the CD8 cells, in medical lingo) get not enough support from the general staff (the dendritic cells, that show the combat units what to attack). Dendritic cells exhibit on their exterior typical parts of the virus to be attacked. But human dendritic cells are not that good in getting the right information on the HIV virus and to transform it into good examples for the CD8 battle cells.

The virologists and HIV-physicians of the Institute of Tropical Medicine and the haematologists of Antwerp University Hospital have cooperated for years on that problem. Together they succeeded to 'load' dendritic cells of seropositive volunteers in the lab with the building instructions (genetic information in the form of so-called messenger RNA) for HIV proteins. They could make the dendritic cells to execute the instructions and to exhibit the resulting typical part of the HIV virus on their surface. Subsequent research in test tubes demonstrated that the 'loaded' dendritic cells were able to activate battle cells.

Time had come to proceed to humans. Flemish, Belgian and French research foundations provided grants. Six seropositive persons who for a long time already used the drug cocktails, were prepared to volunteer. The scientists filtered the dendritic cells from a large volume of their blood, cultivated them in test tubes in the cell-therapy unit of the Antwerp University Hospital and provided them with the genetic instructions of an HIV virus. They then froze the loaded cells.

The volunteers received four times, with four-week intervals, a small quantity of their own reworked dendritic cells. And indeed, after each vaccination the CD8 battle cells in their bodies recognised the virus better and better, while the vaccination had virtually no side effects. The most important result was that the vaccine-activated battle cells became better and better in suppressing the virus, in test tubes for the moment. But HIV remains a disguise artist; it still succeeds in changing its proteins sufficiently fast and often to let at least a few viruses escape the attack.

So it remains impossible to cure AIDS, but the results are encouraging: the vaccine, made of the participant's own dendritic cells, is safe and has some therapeutic effect, be it a limited one. But sufficiently strong for a publication in the most renowned journal for HIV researchers, AIDS. And more than sufficient to enthuse and motivate the Antwerp scientists.

Institute of Tropical Medicine Antwerp


Related HIV Vaccine Current Events and HIV Vaccine News Articles


RNA simulations boost understanding of retroviral diseases
New molecular dynamics research into how RNA folds into hairpin-shaped structures called tetraloops could provide important insights into new treatments for retroviral diseases.

Telephone-based cognitive behavioral therapy significantly improves menopause symptoms
Chatting on the phone with a "sleep coach" and keeping a nightly sleep diary significantly improve sleep quality and reduce insomnia in women through all stages of menopause, according to a new study published today in JAMA Internal Medicine.

HIV vaccine design should adapt as HIV virus mutates
Human immunodeficiency virus is known to be a highly variable virus that adapts to a person's immune response during the lifetime infection, and a new study published in Nature Medicine shows that viral adaptation in HIV can predict a person's current disease status, as well as the degree to which newly transmitted HIV-1 is adapted to their new host.

Precision prevention of colorectal cancer
Precision medicine's public face is that of disease -- and better treatments for that disease through targeted therapies.

Findings in humans provide encouraging foundation for upcoming AIDS vaccine clinical trial
Some people infected with HIV naturally produce antibodies that effectively neutralize many strains of the rapidly mutating virus, and scientists are working to develop a vaccine capable of inducing such "broadly neutralizing" antibodies that can prevent HIV infection.

Progress toward an HIV cure highlighted in special issue of AIDS Research and Human Retroviruses
A cure for HIV/AIDS is the ultimate goal of rapidly advancing research involving diverse and innovative approaches.

Obesity and weight gain in HIV-infected adults on antiretroviral therapy: What's the harm?
The percentage of HIV-infected adults who were obese-body mass index >30 kg/m2-when they began antiretroviral therapy (ART) doubled over a 12-year period.

Fred Hutch endorses HPV vaccination for cancer prevention
In response to low national vaccination rates for the human papillomavirus, or HPV, Fred Hutchinson Cancer Research Center has joined with the 68 other U.S. National Cancer Institute-designated cancer centers in issuing a statement urging for increased vaccination in adolescent girls and boys for the prevention of many types of HPV-related cancers in adulthood.

In pursuit of HIV vaccine, TSRI scientists shed light on antibody origins
From Peter Parker's fateful spider bite to Arthur pulling the sword from the stone at the beginning of his reign--everyone likes to know a hero's origin story.

Have sex workers revealed a connection between semen exposure and HIV resistance?
More than half of all people infected by the HIV-1 virus worldwide are women. Commercial sex workers, who are at increased risk of contracting HIV because of repeated exposure to the virus, have long been studied to test preventive behavioral and vaccine approaches aimed at decreasing the number of infections.
More HIV Vaccine Current Events and HIV Vaccine News Articles

Immunology and the Quest for an HIV Vaccine: A New Perspective

Immunology and the Quest for an HIV Vaccine: A New Perspective
by Dr. Omar Bagasra (Author)


How many human immune systems are there? How old are they? Why is there no AIDS vaccine? Is a new approach needed? Why is public opinion growing skeptical of the scientific community after three decades of public awareness about HIV/AIDS? Consider answers to these puzzling questions. Learn from the decades of experience of two senior scholars: Dr. Omar Bagasra (an eminent molecular biologist, immunologist, and retrovirologist) and Dr. Donald Gene Pace (a highly published writer who examines public health policy). Explore intriguing new possibilities about human immunity, and the development of an effective AIDS vaccine. Read Immunology and the Quest for an HIV Vaccine. Benefit from an informed synthesis backed by a wealth of peer-reviewed scientific references. Review basic concepts of...

Shots in the Dark: The Wayward Search for an AIDS Vaccine

Shots in the Dark: The Wayward Search for an AIDS Vaccine
by Jon Cohen (Author)


"[A]n important book not only for the now but for the future of this epidemic and those to come."―Dr. Robert Gallo When scientists proved in 1984 that HIV causes AIDS, a vaccine race spun into action. But the sprint to develop an AIDS vaccine now more closely resembles a crawl. Jon Cohen elucidates the forces that have hindered the search: unforeseen scientific obstacles, clashing personalities, the uncertain marketplace, haphazard political organization, and serious ethical dilemmas. Beyond a powerful critique, Cohen also offers specific recommendations for accelerating the effort. 6 pages of b/w photographs.

Roitt's Essential Immunology (Essentials)

Roitt's Essential Immunology (Essentials)
by Peter J. Delves (Author), Seamus J. Martin (Author), Dennis R. Burton (Author), Ivan M. Roitt (Author)


Roitt's Essential Immunology - the textbook of choice for students and instructors of immunology worldwide  Roitt’s Essential Immunology clearly explains the key principles needed by medical and health sciences students, from the basis of immunity to clinical applications.  A brand new introduction sets the scene to section 1, Fundamentals of Immunology, introducing the microbial world and the strategies the body employs to defend itself. Each chapter then guides the reader through a different part of the immune system, and explains the role of each cell or molecule individually, and then as a whole.  Section 2, Applied Immunology, discusses what happens when things go wrong, and the role the immune system plays alongside the damaging effects of a disease, including cancer,...

The River : A Journey to the Source of HIV and AIDS

The River : A Journey to the Source of HIV and AIDS
by Edward Hooper (Author)


While science has devoted much of its efforts to finding a cure for AIDS, the sources of this deadly epidemic remain largely unexamined. Distinguished science journalist Edward Hooper presents the meticulously researched -- and highly readable -- history of HIV and its possible origins. Pursuing leads across the U.S., the Caribbean, Europe, and Africa, Hooper pieces together the tantalizing clues offered by long-archived blood samples, early AIDS-like cases (such as the "Manchester sailor" case of 1959), immunodeficiency viruses (SIVs), and the medical interventions in Africa and elsewhere that may have played a role in SIVs' crossover into humans.Hooper examines over two dozen theories of origin, and eventually discards most of them. What remains is a remarkable and well-supported theory...

Affirmation | The 100 Most Powerful Affirmations for HIV AIDS - Including 2 Positive & Affirmative Action Bonus Books on Healing & Law of Attraction, Also Included Conscious Visualization

Affirmation | The 100 Most Powerful Affirmations for HIV AIDS - Including 2 Positive & Affirmative Action Bonus Books on Healing & Law of Attraction, Also Included Conscious Visualization
by Jason Thomas (Author)


Audio Version is Now Available with Audible! Exclusive Offer — Today Includes 2 Amazing Bonus Books: The 100 Most Powerful Affirmations for Healing & The 100 Most Powerful Affirmations for Law of Attraction


You will not achieve fulfillment and happiness until YOU become the architect of your own reality. Imagine that with a few moments each day, you could begin the powerful transformation toward complete control of your own life and well being through positive affirmation. Because you can.

You will be able to release all fear and doubt simply because you know that you can. Utilize this simple, proven technique to regain the lost comforts of joy, love, and fulfillment in your life.

You have the ability to unlock your full inner-potential and achieve...

Pandora's Lab: Seven Stories of Science Gone Wrong

Pandora's Lab: Seven Stories of Science Gone Wrong
by Paul A. Offit (Author)


What happens when ideas presented as science lead us in the wrong direction? 

History is filled with brilliant ideas that gave rise to disaster, and this book explores the most fascinating—and significant—missteps: from opium's heyday as the pain reliever of choice to recognition of opioids as a major cause of death in the U.S.; from the rise of trans fats as the golden ingredient for tastier, cheaper food to the heart disease epidemic that followed; and from the cries to ban DDT for the sake of the environment to an epidemic-level rise in world malaria.

These are today's sins of science—as deplorable as mistaken past ideas about advocating racial purity or using lobotomies as a cure for mental illness. These unwitting errors add up to seven lessons both cautionary...

HIV Protocols: Second Edition (Methods in Molecular Biology)

HIV Protocols: Second Edition (Methods in Molecular Biology)
by Vinayaka R. Prasad (Editor), Ganjam V. Kalpana (Editor)


Despite major advances in HIV treatment, many areas require more study, in order to create efficacious, potent antiretrovirals that can suppress viral load completely and durably without toxic side effects, to define unknown drug targets and fine-tune known targets, and to better understand the interplay between viral and host factors. In "HIV Protocols, Second Edition", expert researchers provide clear, state-of-the-art methods for the study of HIV. Directed toward three specific goals, this text aims to document up-to-date protocols for select aspects of HIV biology, to bring together both virological and immunological approaches in a single, convenient volume, and to present a comprehensive account of a range of techniques not available in any existing HIV protocol book. As a volume in...

Prayer | The 100 Most Powerful Prayers for HIV AIDS - Including 2 Bonus Books to Pray for Healing & Law of Attraction - Also Included Conscious Visualization

Prayer | The 100 Most Powerful Prayers for HIV AIDS - Including 2 Bonus Books to Pray for Healing & Law of Attraction - Also Included Conscious Visualization
by Toby Peterson (Author)


Audio Version is Now Available with Audible! Exclusive Offer — Today Includes 2 Amazing Bonus Books: The 100 Most Powerful Prayers for Healing & The 100 Most Powerful Prayers for Law of Attraction


You will not achieve fulfillment and happiness until you allow God to be the architect of your reality. Imagine that with a few moments each day, you could begin the powerful transformation toward complete control of your own life and well being through prayer.

You will be able to release all fear and doubt simply because you know that God gives you the strength. You can utilize this simple, proven technique to regain the lost comforts of joy, love, and fulfillment in your life.

God's gift of life is too short to be exhausted on thousands of everyday...

Big Shot: Passion, Politics, and the Struggle for an AIDS Vaccine

Big Shot: Passion, Politics, and the Struggle for an AIDS Vaccine
by Patricia Thomas (Author)


A veteran journalist dramatizes the controversial search for an AIDS vaccine-the players, the politics, the money-in a vivid, suspenseful story that reveals how science is done, and not done, in America today. . When the human immunodeficiency virus was identified in 1984, the competition to create an AIDS vaccine was fierce. Now Patricia Thomas brings the contenders to life in a fast-paced, dramatic narrative: Two biologists rescue precious virus cultures from destruction by a military biohazard team. Other researchers drive hundreds of miles during a heat wave to work in a safe containment lab. And a heroic figure from Randy Shilts's And The Band Played On just might win the vaccine marathon. Thomas shows how the scientists' youthful optimism is honed into gritty determination as they...

© 2017 BrightSurf.com