Science Current Events | Science News | Brightsurf.com
 

New HIV-vaccine tested on people

February 14, 2012
Scientists from the Antwerp Institute of Tropical Medicine, Antwerp University Hospital and Antwerp University have tested a new 'therapeutic vaccine' against HIV on volunteers. The participants were so to say vaccinated with their own cells. The researchers filtered certain white blood cells out of the volunteer's blood, 'loaded' them outside the body and then gave them back. The immune system of the testees was better than before in attacking and suppressing the virus, the scientists reported in the top journal AIDS. But they still cannot cure the disease.

Actually, medical science can control an HIV-infection quite well, with a medicine cocktail. 'Seropositive' people (people who are infected with the HIV virus) now can lead a reasonably normal life, but their virus is not exterminated. When they stop the treatment it immediately rebounds.

Science knows what the problem is: the 'special forces' in our blood (the CD8 cells, in medical lingo) get not enough support from the general staff (the dendritic cells, that show the combat units what to attack). Dendritic cells exhibit on their exterior typical parts of the virus to be attacked. But human dendritic cells are not that good in getting the right information on the HIV virus and to transform it into good examples for the CD8 battle cells.

The virologists and HIV-physicians of the Institute of Tropical Medicine and the haematologists of Antwerp University Hospital have cooperated for years on that problem. Together they succeeded to 'load' dendritic cells of seropositive volunteers in the lab with the building instructions (genetic information in the form of so-called messenger RNA) for HIV proteins. They could make the dendritic cells to execute the instructions and to exhibit the resulting typical part of the HIV virus on their surface. Subsequent research in test tubes demonstrated that the 'loaded' dendritic cells were able to activate battle cells.

Time had come to proceed to humans. Flemish, Belgian and French research foundations provided grants. Six seropositive persons who for a long time already used the drug cocktails, were prepared to volunteer. The scientists filtered the dendritic cells from a large volume of their blood, cultivated them in test tubes in the cell-therapy unit of the Antwerp University Hospital and provided them with the genetic instructions of an HIV virus. They then froze the loaded cells.

The volunteers received four times, with four-week intervals, a small quantity of their own reworked dendritic cells. And indeed, after each vaccination the CD8 battle cells in their bodies recognised the virus better and better, while the vaccination had virtually no side effects. The most important result was that the vaccine-activated battle cells became better and better in suppressing the virus, in test tubes for the moment. But HIV remains a disguise artist; it still succeeds in changing its proteins sufficiently fast and often to let at least a few viruses escape the attack.

So it remains impossible to cure AIDS, but the results are encouraging: the vaccine, made of the participant's own dendritic cells, is safe and has some therapeutic effect, be it a limited one. But sufficiently strong for a publication in the most renowned journal for HIV researchers, AIDS. And more than sufficient to enthuse and motivate the Antwerp scientists.

Institute of Tropical Medicine Antwerp


Related HIV Vaccine Current Events and HIV Vaccine News Articles


Study examines long-term adverse health effects of Ebola survivors
Ebola survivors experienced negative health effects that persisted more than two years after the 2007-2008 Bundibugyo ebolavirus (BDBV) outbreak in Uganda that claimed 39 lives.

Happily ever after: Scientists arrange protein-nanoparticle marriage
Fastening protein-based medical treatments to nanoparticles isn't easy.

Six questions about HIV/AIDS that deserve more attention
As HIV investigators work to control and eradicate the virus worldwide, certain myths or misconceptions about the disease have been embraced, whereas other concepts with merit have been left relatively unexplored, argues American HIV/AIDS researcher Jay Levy, MD, in a commentary publishing April 14 in the journal Trends in Molecular Medicine.

In first human study, new antibody therapy shows promise in suppressing HIV infection
In the first results to emerge from HIV patient trials of a new generation of so-called broadly neutralizing antibodies, Rockefeller University researchers have found the experimental therapy can dramatically reduce the amount of virus present in a patient's blood.

Genetically engineered antibody-based molecules show enhanced HIV-fighting abilities
Capitalizing on a new insight into HIV's strategy for evading antibodies--proteins produced by the immune system to identify and wipe out invading objects such as viruses--Caltech researchers have developed antibody-based molecules that are more than 100 times better than our bodies' own defenses at binding to and neutralizing HIV, when tested in vitro.

NIH-led scientists discover HIV antibody that binds to novel target on virus
An NIH-led team of scientists has discovered a new vulnerability in the armor of HIV that a vaccine, other preventive regimen or treatment could exploit.

New research offers hope for HIV vaccine development
In a scientific discovery that has significant implications for HIV vaccine development, collaborators at the Boston University School of Medicine (BUSM) and Duke University School of Medicine have uncovered novel properties of special HIV antibodies.

Biomarker discovery may lead to new HIV treatment
Further analysis of a Phase II study of therapeutic HIV vaccine candidate Vacc-4x revealed a potential biomarker associated with participants who experienced a more profound viral load reduction after receiving the vaccine.

UNL team awarded $1.9M to develop new approach to HIV vaccine
Using a genetically modified form of the HIV virus, a team of University of Nebraska-Lincoln scientists has developed a promising new approach that could someday lead to a more effective HIV vaccine.

NIH grantees sharpen understanding of antibodies that may cut risk of HIV infection
What immune response should a vaccine elicit to prevent HIV infection?
More HIV Vaccine Current Events and HIV Vaccine News Articles

Immunology and the Quest for an HIV Vaccine: A New Perspective

Immunology and the Quest for an HIV Vaccine: A New Perspective
by AuthorHouse


"How many human immune systems are there? How old are they? Why is there no AIDS vaccine? Is a new approach needed? Why is public opinion growing skeptical of the scientific community after three decades of public awareness about HIV/AIDS?

Consider answers to these puzzling questions. Learn from the decades of experience of two senior scholars: Dr. Omar Bagasra (an eminent molecular biologist, immunologist, and retrovirologist) and Dr. Donald Gene Pace (a highly published writer who examines public health policy). Explore intriguing new possibilities about human immunity, and the development of an effective AIDS vaccine.

Read Immunology and the Quest for an HIV Vaccine. Benefit from an informed synthesis backed by a wealth of peer-reviewed scientific references....

Novel Targets for HIV Vaccines: Finding the Achilles Heel

Novel Targets for HIV Vaccines: Finding the Achilles Heel
by SRIDHAR NADAMUNI


‘Novel targets for HIV vaccines: Finding the Achilles Heel’ comprises five presentations delivered at the AIDS Conference 2014 (July 20-25, 2014, Melbourne, Australia) outlining alternative approaches to preventative and therapeutic vaccine design. This eBook is a succinct report of these presentations. The presentations include the following topics:
1. Preclinical evaluation of a novel HIV vaccine: targeting sequences surrounding protease cleavage sites protects cynomolgus monkeys against pathogenic SIVmac239: Pre-clinical, proof-of-concept evaluation of a novel vaccine immunogen comprising 12 different 20-amino acid peptides was presented by Dr. Ma Luo of National Microbiology Laboratory, Winnipeg, Canada. The strategy elicited immune responses against protease cleavage sites...

HIV Essentials 2014

HIV Essentials 2014
by Paul E. Sax (Author), Calvin J. Cohen (Author), Daniel R. Kuritzkes (Author)


The world's leading experts provide all the 'essentials' needed to manage HIV patients in the office, on the ward, and in the ICU. Completely revised and updated, HIV Essentials 2014 incorporates the latest clinical guidelines into a step-by-step guide to the diagnosis, evaluation, management, and prevention of HIV infection and its complications. Topics include: opportunistic infections and other HIV complications, treatment of HIV and pregnancy, antiretroviral drug summaries, post-exposure prophylaxis, as well as commercially available dosage forms for all ARVs.

The River : A Journey to the Source of HIV and AIDS

The River : A Journey to the Source of HIV and AIDS
by Edward Hooper (Author)


While science has devoted much of its efforts to finding a cure for AIDS, the sources of this deadly epidemic remain largely unexamined. Distinguished science journalist Edward Hooper presents the meticulously researched -- and highly readable -- history of HIV and its possible origins. Pursuing leads across the U.S., the Caribbean, Europe, and Africa, Hooper pieces together the tantalizing clues offered by long-archived blood samples, early AIDS-like cases (such as the "Manchester sailor" case of 1959), immunodeficiency viruses (SIVs), and the medical interventions in Africa and elsewhere that may have played a role in SIVs' crossover into humans.Hooper examines over two dozen theories of origin, and eventually discards most of them. What remains is a remarkable and well-supported theory...

Immunology and the Quest for an HIV Vaccine: A New Perspective

Immunology and the Quest for an HIV Vaccine: A New Perspective
by Dr. Omar Bagasra (Author)


How many human immune systems are there? How old are they? Why is there no AIDS vaccine? Is a new approach needed? Why is public opinion growing skeptical of the scientific community after three decades of public awareness about HIV/AIDS? Consider answers to these puzzling questions. Learn from the decades of experience of two senior scholars: Dr. Omar Bagasra (an eminent molecular biologist, immunologist, and retrovirologist) and Dr. Donald Gene Pace (a highly published writer who examines public health policy). Explore intriguing new possibilities about human immunity, and the development of an effective AIDS vaccine. Read Immunology and the Quest for an HIV Vaccine. Benefit from an informed synthesis backed by a wealth of peer-reviewed scientific references. Review basic concepts of...

Vaccine Nation: America's Changing Relationship with Immunization

Vaccine Nation: America's Changing Relationship with Immunization
by Elena Conis (Author)


With employers offering free flu shots and pharmacies expanding into one-stop shops to prevent everything from shingles to tetanus, vaccines are ubiquitous in contemporary life. The past fifty years have witnessed an enormous upsurge in vaccines and immunization in the United States: American children now receive more vaccines than any previous generation, and laws requiring their immunization against a litany of diseases are standard. Yet, while vaccination rates have soared and cases of preventable infections have plummeted, an increasingly vocal cross section of Americans have questioned the safety and necessity of vaccines. In Vaccine Nation, Elena Conis explores this complicated history and its consequences for personal and public health.

Vaccine Nation opens in the 1960s,...

Vaccine Nation

Vaccine Nation
by David Lender (Author)


Dani North is a filmmaker who just won at the Tribeca Film Festival for her documentary, The Drugging of Our Children, a film critical of the pharmaceutical industry. When she is handed "whistleblower" evidence about the U.S. vaccination program, she has to keep herself alive long enough to expose it before a megalomaniacal pharmaceutical company CEO can have her killed.

Excerpts from Trojan Horse, The Gravy Train and Bull Street, David Lender's other thrillers, follow the text of Vaccine Nation.

HIV Protocols: Second Edition (Methods in Molecular Biology)

HIV Protocols: Second Edition (Methods in Molecular Biology)
by Vinayaka R. Prasad (Editor), Ganjam Kalpana (Editor)


Despite major advances in HIV treatment, many areas require more study, in order to create efficacious, potent antiretrovirals that can suppress viral load completely and durably without toxic side effects, to define unknown drug targets and fine-tune known targets, and to better understand the interplay between viral and host factors. In "HIV Protocols, Second Edition", expert researchers provide clear, state-of-the-art methods for the study of HIV. Directed toward three specific goals, this text aims to document up-to-date protocols for select aspects of HIV biology, to bring together both virological and immunological approaches in a single, convenient volume, and to present a comprehensive account of a range of techniques not available in any existing HIV protocol book. As a volume in...

HIV and AIDS: Symptoms, Testing, Treatment, Risk Factors, Preventions, Nutrition, Marriage, Having Children, Legal Issues

HIV and AIDS: Symptoms, Testing, Treatment, Risk Factors, Preventions, Nutrition, Marriage, Having Children, Legal Issues
by James Lee Anderson (Author)


“Although, your health condition may impact your everyday life, do not let it define who you are.” Understanding the cause of AIDS and the ways on how its cause is being transmitted will help a lot in the prevention of the spread of this disease. In case of infection, this book describes in details how HIV affects specific cells in our body (that fights off infections and diseases) and the signs and symptoms that accompany such infection. You will also find ways on how testing and diagnosis (including home test kit) are being done once you see the signs and felt the symptoms. In this way, you will be able to deal with the virus infection early and be able to manage your immune health by suppressing the amount of virus in your body. People infected with HIV can now lead longer and...

HIV and AIDS:: Basic Elements and Priorities

HIV and AIDS:: Basic Elements and Priorities
by S. Kartikeyan (Author), R.N. Bharmal (Author), R.P. Tiwari (Author), P.S. Bisen (Author)


HIV and Aids: Basic Elements and Priorities is a concise collection of all aspects of this disease and a source of readily available knowledge. It examines all currently advocated preventive measures such as health education, condom use, safer sex practices, and treatment of sexually transmitted infections. Coverage details strategies for prevention and control as well as the latest global information about HIV/AIDS.

© 2015 BrightSurf.com