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Children's National Researchers Identify a New Trigger for Alternate Reproduction Pathway of HIV-related Cancer Virus

April 18, 2012
Washington, DC-A research team led by Children's National Medical Center has identified a trigger that causes latent Kaposi's sarcoma-associated herpesvirus (KSHV) to rapidly replicate itself. KSHV causes Kaposi's sarcoma, primary effusion lymphoma, and other cancers that commonly affect immunocompromised patients, including those with AIDS. Appearing in the online edition of the Journal of Virology, the study identifies apoptosis, or the programmed death of a virus' host cell, as the trigger for high-level viral replication.

"Finding that the programmed death of a host cell triggered rapid production of Kaposi's sarcoma-associated herpesvirus, means that KSHV has the ability to sense and respond to critical changes in the cells that it grows in, something we didn't know before," stated lead author Alka Prasad, PhD, who is a member of the Center for Cancer and Immunology Research at Children's National Medical Center. "We previously thought that the virus was more of an inanimate entity. This newly discovered pathway is clearly helpful to the virus and clues researchers in on how we might target treatments. If the host cell died quickly, before the virus could reproduce, then the virus could not infect any new cells. Having the ability to sense when the host cell is about to die and reproduce quickly in response gives the virus an evolutionary advantage. In addition, cancers caused by KSHV and other herpesviruses are commonly treated with drugs that kill cells, so the results could have a significant effect on the treatment of KSHV-related cancers, which we will need to explore."

KSHV and the cancers it causes most commonly afflict patients with AIDS and other disorders that impact the immune system. KSHV attaches to white blood cells and either actively replicates through a controlled gene expression program or remains latent. A specific genetic protein in the virus, called an ORF50 gene product, is thought to control the transition from latency to replication. Using a derivative of this specific protein that blocks gene expression and replication, the scientists found that when apoptosis was induced, KSHV replicated itself. They also discovered that whether this derivative was present or not, apoptopsis induced the virus' replication.

"In addition to looking at the clinical implications of these research findings, we now need to focus in on the pathway that links apoptosis to this particular replication pathway and perhaps expand our research from KSHV to include another example of herpesvirus," commented Steven Zeichner, MD, PhD, the senior author on the paper, who is a principal investigator for the Center for Cancer and Immunology Research at Children's National and a professor at the George Washington University School of Medicine. The study was supported in part by the new NIH-funded District of Columbia Center for AIDS Research, of which Children's National is a key member.

Children's National Medical Center


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ATRIPLA: Treats HIV infection and may decrease the chance of developing AIDS and HIV-Related Illnesses such as serious infections or cancer

ATRIPLA: Treats HIV infection and may decrease the chance of developing AIDS and HIV-Related Illnesses such as serious infections or cancer


“Although, your health condition may impact your everyday life, do not let it define who you are.”

ATRIPLA is used along with other medications to treat human immunodeficiency virus (HIV) infection. ATRIPLA is in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). It works by decreasing the amount of HIV in the blood. Although ATRIPLA does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other life-style changes may decrease the risk of transmitting (spreading) the HIV virus to other people.

Thanks and may you have a good understanding about this...

Fitzpatrick's Color Atlas and Synopsis of Clinical Dermatology, Seventh Edition (Color Atlas & Synopsis of Clinical Dermatology (Fitzpatrick))

Fitzpatrick's Color Atlas and Synopsis of Clinical Dermatology, Seventh Edition (Color Atlas & Synopsis of Clinical Dermatology (Fitzpatrick))
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The world's #1 visual atlas of dermatology--updated to keep pace with today's practice"…should serve as a standard against which allfuture atlases will be measured…" -- The New England Journal of Medicine review of an earlier editionThis compact, diagnosis-speeding guide has virtually defined the field of dermatology for thousands of physicians, dermatology residents, and medical students across the globe. Spanning the entire spectrum of skin problems, it combines laser-precise color images of skinlesions with a concise summary outline of dermatologic disorders, along with the cutaneous signs of systemic disease. A color-coded 4-part organization facilitates review at a glance and features helpful icons denoting the incidence and morbidity of disease.Fitzpatrick's Color Atlas and...

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A Simple Guide to Kaposi's Sarcoma, Treatment and Related Diseases (A Simple Guide to Medical Conditions)

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Introduction


Ode To Kaposi Sarcoma

In the past Kaposi Sarcoma is synonymous with HIV disease
KS was very rare isolated to men of Jewish or African of elderly age
In the 1980s the increased number of AIDS was associated with Kaposi Sarcoma
Highly Active AntiRetroviral Therapy (HAART) has now reduced the KS number

Skin lesions may be blotchy, nodular and papular
Lesions may also involve the lymphatics resulting in lymphedema
Full examination includes skin, mucosa and lymph node examination
CXR should be performed to pick up any lung involvement

Definitive diagnosis is based on biopsy features with the presence of spindle cells.
Transfusion of blood after the leukocytes is removed should be...

  Smoking lies behind higher risk of virus-related cancers in people with HIV.(Article 7): An article from: HIV Treatment: ALERTS!
by Unavailable (Author)




  Thalidomide is promising for HIV-related cancers. (Multiple Myeloma).: An article from: Skin & Allergy News
by Mary Ann Moon (Author)


This digital document is an article from Skin & Allergy News, published by International Medical News Group on September 1, 2002. The length of the article is 545 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Thalidomide is promising for HIV-related cancers. (Multiple Myeloma).
Author: Mary Ann Moon
Publication: Skin & Allergy News (Magazine/Journal)
Date: September 1, 2002
Publisher: International Medical News Group
Volume: 33 Issue: 9 Page: 29(1)

Distributed by Thomson...

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