Science Current Events | Science News | Brightsurf.com
 

Moffitt Cancer Center Researchers Find Cancer Therapies Affect Cognitive Functioning among Breast Cancer Survivors

April 20, 2012
Researchers at Moffitt Cancer Center and colleagues at the University of South Florida and University of Kentucky have found that breast cancer survivors who have had chemotherapy, radiation or both do not perform as well on some cognitive tests as women who have not had cancer.

They published their study in the April 1 issue of CANCER.

"Survivors of breast cancer are living longer, so there is a need to better understand the long-term effects of cancer therapies, such as chemotherapy and radiation," said study lead author Paul B. Jacobsen, Ph.D., associate center director for Population Sciences.

To carry out their study, the researchers recruited 313 women being treated by either chemotherapy or radiotherapy for early stage breast cancer at Moffitt Cancer Center and the University of Kentucky Chandler Medical Center. Those who had undergone treatment for cancer were tested six months after treatment and then tested again 36 months after having completed treatment.

They also recruited a control group of women who did not have cancer. These participants were also tested at six months and 36 months.

Participants in all groups were within five years of age, and breast cancer patients were matched with noncancer patients who lived in their same ZIP codes. Participants were tested cognitively with respect to processing speed (quick task completion under pressure), executive functioning (ability to shift cognitive sets and solve novel problems), the two domains expected to be most affected by chemotherapy. They were also tested with regard to verbal abilities.

"Our findings were partially consistent with prior research," explained Jacobsen. "We found that chemotherapy-treated patients performed worse than noncancer controls in processing speed, executive functioning and verbal ability. These domains may be the domains most affected by chemotherapy."

The also found test results for the radiotherapy group to be similar to the results of those in the chemotherapy group. Additionally, they discovered that the noncancer group improved in these cognitive abilities over time while the chemotherapy and radiotherapy groups did not. There were no differences in performance between the radiotherapy and chemotherapy groups, noted the researchers.

The researchers commented that they were fortunate for having included the radiotherapy groups because their results were so similar to the chemotherapy group. Had that group not been included, conclusions could have been drawn to suggest that the cognitive differences between the noncancer group and the chemotherapy group were specific to chemotherapy.

"Since patients report cognitive problems that interfere with their daily activities, early workups should include tests to determine cognitive functioning prior to treatment," concluded Jacobsen. "Future research also needs to investigate factors that may affect both chemotherapy patients and those receiving radiotherapy. Providers may wish to communicate that such effects can accompany chemotherapy and radiation therapy."

Moffitt Cancer Center


Related Chemotherapy Current Events and Chemotherapy News Articles


Many older people have mutations linked to leukemia, lymphoma in their blood cells
At least 2 percent of people over age 40 and 5 percent of people over 70 have mutations linked to leukemia and lymphoma in their blood cells, according to new research at Washington University School of Medicine in St. Louis.

Biomarkers uPA/PAI-1 in breast cancer: benefit and harm of the test unclear
To make a decision for or against adjuvant chemotherapy, a test to measure the concentrations of the biomarkers uPA and PAI-1 in the tumour tissue is available for breast cancer patients.

Researchers develop personalized ovarian cancer vaccines
Researchers at the University of Connecticut have found a new way to identify protein mutations in cancer cells. The novel method is being used to develop personalized vaccines to treat patients with ovarian cancer.

Tuning light to kill deep cancer tumors
An international group of scientists led by Gang Han, PhD, at the University of Massachusetts Medical School, has combined a new type of nanoparticle with an FDA-approved photodynamic therapy to effectively kill deep-set cancer cells in vivo with minimal damage to surrounding tissue and fewer side effects than chemotherapy.

New Treatment Designed to Save More Eyes from Cancer
Doctors at Cincinnati Children's Hospital Medical Center have developed a new technique for treating the eye cancer retinoblastoma to improve the odds for preventing eye loss, blindness or death in children with advanced forms of the disease.

Sonic Hedgehog protein causes DNA damage and the development child brain tumors
Scientists at the IRCM and the University of Montreal discovered a mechanism that promotes the progression of medulloblastoma, the most common brain tumour found in children.

Discovery may lead to lower doses of chemotherapy
No matter what type of chemotherapy you attack a tumor with, many cancer cells resort to the same survival tactic: They start eating themselves.

The 'Cyberwar' Against Cancer Gets a Boost from Intelligent
Two years ago, Prof. Eshel Ben-Jacob of Tel Aviv University's School of Physics and Astronomy and Rice University's Center for Theoretical Biological Physics made the startling discovery that cancer, like an enemy hacker in cyberspace, targets the body's communication network to inflict widespread damage on the entire system.

Researchers identify 'Achilles heel' in metabolic pathway that could lead to new cancer treatment
Researchers at UT Southwestern Medical Center have found an "Achilles heel" in a metabolic pathway crucial to stopping the growth of lung cancer cells.

Drug regimen enough to control immune disease after some bone marrow transplants
Johns Hopkins and other cancer researchers report that a very short course of a chemotherapy drug, called cyclophosphamide, not only can prevent a life-threatening immune response in some bone marrow transplant recipients, but also can eliminate such patients' need for the usual six months of immune suppression medicines commonly prescribed to prevent severe forms of this immune response.
More Chemotherapy Current Events and Chemotherapy News Articles

Chemo: Secrets to Thriving: From someone who's been there.

Chemo: Secrets to Thriving: From someone who's been there.
by Roxanne Brown (Author), Barbara Mastej (Contributor), John S. Link M.D. (Contributor)


The thought of chemotherapy can be overwhelming, but getting through it doesn’t have to be. Chemo: Secrets to Thriving helps lighten the load. In chronological order, step-by- step, you learn what might occur, why it happens, what you can do (with your doc’s approval), and who to contact for help. Chemo: Secrets to Thriving will be your friend, companion, and guide, giving you the resources to handle possible side effects and better manage your life during chemotherapy. Once you know the secrets in this book you may find yourself still able to enjoy life—and even thrive—while going through chemotherapy. Our endorsements aren’t from the usual celebrities, but from our celebrities: medical teams, fellow chemo travelers, and the people and places that support them.

Chemotherapy and Biotherapy Guidelines and Recommendations for Practice

Chemotherapy and Biotherapy Guidelines and Recommendations for Practice
by Martha Polovich (Author), MiKeala Olsen (Author), Kris Lefebvre (Author)


Order your copy of the fourth edition of the best-selling resource used by more than 101,000 healthcare professionals since 2009 and keep up-to-date on the latest chemotherapy, biotherapy, and targeted agents. This new edition of the Chemotherapy and Biotherapy Guidelines and Recommendations for Practice has been revised and updated to reflect the current procedures and practices in your specialty. You'll find that this latest edition incorporates a number of significant changes. To help you find the content and information that you need quickly and easily, the text has been reorganized and is now divided into 11 chapters ranging from an overview of cancer and cancer treatment and principles of antineoplastic therapy to post-treatment care and competencies in chemotherapy administration....

The Chemotherapy Survival Guide: Everything You Need to Know to Get Through Treatment

The Chemotherapy Survival Guide: Everything You Need to Know to Get Through Treatment
by Judith McKay (Author), Tammy Schacher RN OCN MSN (Author)


When you're facing cancer treatment, it's easy to feel overwhelmed and alone. Between the hospital or clinic environment and the medical terminology used by doctors and health care professionals, you may feel as though you've entered a foreign country.Written by two experienced oncology nurses, this compassionate and comprehensive guide explains in plain English everything you need to know about your treatment, including what you can expect at each stage of chemotherapy and what you can do to prevent or minimize side effects. Packed with practical suggestions, nutritional advice, relaxation skills, and other techniques to help strengthen your body and calm your mind, The Chemotherapy Survival Guide is a must-have resource for anyone navigating this difficult...

Physicians' Cancer Chemotherapy Drug Manual 2014 (Jones and Bartlett Series in Oncology(Physician's Cancer Chemotherapy Drug Manual))

Physicians' Cancer Chemotherapy Drug Manual 2014 (Jones and Bartlett Series in Oncology(Physician's Cancer Chemotherapy Drug Manual))
by Edward Chu (Author), Vincent T. DeVita Jr. (Author)


Completely revised and updated for 2014, the Physicians’ Cancer Chemotherapy Drug Manual 2014 is an up-to-date guide to the latest information on standard therapy and recent advances in the field. Written by world-class experts in clinical cancer therapeutics, this essential reference provides a complete, easy-to-use catalog of over 100 drugs and commonly used drug regimens—both on- and off-label—for the treatment of all the major cancers. Special features: • Revised to reflect rapid advances in the field • A specific chapter focused on profiling antiemetic drug and antiemetic treatment regimens. • Diagrams of drug structures and pathways for many of the agents. • Offers a comprehensive discussion of clinical pharmacology, special considerations, indications, and dosages....

The Chemotherapy Diet: 5 Steps to Staying Healthy During Cancer Treatment

The Chemotherapy Diet: 5 Steps to Staying Healthy During Cancer Treatment
by Mike Herbert ND (Author), Joseph Dispenza (Contributor)


During cancer treatment, it is vitally important to stay healthy. The best way of doing that is to work with the body's own natural healing abilities. And that means, in the first place to eat right.

The Chemotherapy Diet is a practical guide to feeling good during chemo... and beyond with 100+ simple recipes, menu planning guide, and more, presented in a simple 5-step program:

Change your thinking and develop an attitude focused on healing. Detoxify with therapeutic baths to promote healing from the inside out. Eat the best foods to create a healing chemistry in your body. Supplement your diet to support the healing momentum. Exercise and rest to speed the healing process.

Chemotherapy and Biotherapy Guidelines and Recommendations for Practice

Chemotherapy and Biotherapy Guidelines and Recommendations for Practice
by Julie M. Whitford (Editor), Mikaela M. Olsen (Editor), Martha Polovich (Editor)


Edited by Martha Polovich, Julie M. Whitford, and MiKaela Olsen, this new edition has been revised and updated to reflect the current procedures and practices in your specialty. Featured are sections detailing principles of antineoplastic therapy, cancer therapy goals and response, fundamentals of administration, pre-treatment, treatment and post-treatment care, side effects of cancer therapy, immediate complications of cytotoxic therapy, and more. Also included are treatment schedules, including dose category and determination, as well as nursing and chemotherapy flow charts, information on safe management of chemotherapy in the home, clinical practicum and evaluations, and much, much more.

Handbook of Cancer Chemotherapy (Lippincott Williams & Wilkins Handbook Series)

Handbook of Cancer Chemotherapy (Lippincott Williams & Wilkins Handbook Series)
by Roland T. Skeel (Author), Samir N. Khlief (Author)


Skeel's Handbook of Cancer Chemotherapy combines in one place the most current rationale and specific details necessary to administer chemotherapy for most adult cancers. The handbook is a practical, diseased-focused pocket reference that emphasizes the best current medical practice as it relates to the delivery of chemotherapeutic drugs. By focusing on specific plans for treatment, the book is an invaluable resource for the daily care of cancer patients.

Chemotherapy and Radiation For Dummies

Chemotherapy and Radiation For Dummies
by Alan P. Lyss MD (Author), Humberto Fagundes MD (Author), Patricia Corrigan (Author)


An informative, compassionate guide for cancer patients and their loved onesEach year, more than 1 million people get treated for cancer, and most of these will undergo chemotherapy, radiation therapy, or both. This reassuring, optimistic guide helps people get a handle on treatment options and explains in plain English how chemotherapy and radiation therapy really work. It offers detailed advice on how to alleviate and cope with side effects-which range from hair loss to nausea to anemia-and describes how good nutrition, meditation, support groups, and other techniques and resources can help in the recovery process.

Meditation To Help You With Chemotherapy (Health Journeys)

Meditation To Help You With Chemotherapy (Health Journeys)
by Belleruth Naparstek (Author)


This imagery was designed to help listeners see their chemotherapy in a positive light; to help reduce aversive side effects, such as fatigue and nausea; to help the body's immune cells fight cancer; to encourage relaxation and a sense of hope, safety, support and peace. With affirmations. (Running time: 41 minutes)

2014 Oncology Nursing Drug Handbook

2014 Oncology Nursing Drug Handbook
by Gail M. Wilkes (Author), Margaret Barton-Burke (Author)


Written especially for nurses caring for patients with cancer, the 2014 Oncology Nursing Drug Handbook uniquely expresses drug therapy in terms of the nursing process: nursing diagnoses, etiologies of toxicities, and key points for nursing assessment, intervention, and evaluation. Updated annually, this essential reference provides valuable information on effective symptom management, patient education, and chemotherapy administration. Completely revised and updated, the 2014 Oncology Nursing Drug Handbook includes: * New chapter on Chemobiotherapy for Noncancer Diseases * Specific drugs described in terms of their mechanism of action, metabolism, drug interactions, laboratory effects/interference, and special considerations * The most important and common drug side effects * Greater...

© 2014 BrightSurf.com