Science Current Events | Science News | Brightsurf.com
 

Moffitt Cancer Center Researchers Find Cancer Therapies Affect Cognitive Functioning among Breast Cancer Survivors

April 20, 2012
Researchers at Moffitt Cancer Center and colleagues at the University of South Florida and University of Kentucky have found that breast cancer survivors who have had chemotherapy, radiation or both do not perform as well on some cognitive tests as women who have not had cancer.

They published their study in the April 1 issue of CANCER.

"Survivors of breast cancer are living longer, so there is a need to better understand the long-term effects of cancer therapies, such as chemotherapy and radiation," said study lead author Paul B. Jacobsen, Ph.D., associate center director for Population Sciences.

To carry out their study, the researchers recruited 313 women being treated by either chemotherapy or radiotherapy for early stage breast cancer at Moffitt Cancer Center and the University of Kentucky Chandler Medical Center. Those who had undergone treatment for cancer were tested six months after treatment and then tested again 36 months after having completed treatment.

They also recruited a control group of women who did not have cancer. These participants were also tested at six months and 36 months.

Participants in all groups were within five years of age, and breast cancer patients were matched with noncancer patients who lived in their same ZIP codes. Participants were tested cognitively with respect to processing speed (quick task completion under pressure), executive functioning (ability to shift cognitive sets and solve novel problems), the two domains expected to be most affected by chemotherapy. They were also tested with regard to verbal abilities.

"Our findings were partially consistent with prior research," explained Jacobsen. "We found that chemotherapy-treated patients performed worse than noncancer controls in processing speed, executive functioning and verbal ability. These domains may be the domains most affected by chemotherapy."

The also found test results for the radiotherapy group to be similar to the results of those in the chemotherapy group. Additionally, they discovered that the noncancer group improved in these cognitive abilities over time while the chemotherapy and radiotherapy groups did not. There were no differences in performance between the radiotherapy and chemotherapy groups, noted the researchers.

The researchers commented that they were fortunate for having included the radiotherapy groups because their results were so similar to the chemotherapy group. Had that group not been included, conclusions could have been drawn to suggest that the cognitive differences between the noncancer group and the chemotherapy group were specific to chemotherapy.

"Since patients report cognitive problems that interfere with their daily activities, early workups should include tests to determine cognitive functioning prior to treatment," concluded Jacobsen. "Future research also needs to investigate factors that may affect both chemotherapy patients and those receiving radiotherapy. Providers may wish to communicate that such effects can accompany chemotherapy and radiation therapy."

Moffitt Cancer Center


Related Chemotherapy Current Events and Chemotherapy News Articles


Novel approach helps prevent early menopause in breast cancer patients, study finds
Early menopause can be prevented and fertility may be preserved in young women with early stage breast cancer, according to a study published today in The New England Journal of Medicine.

Hormone-blocking drug prevents ovarian failure and improves fertility in breast cancer patients
Breast cancer patients who are given the hormone-blocking drug goserelin during chemotherapy are less likely to experience ovarian failure and more likely to have successful pregnancies.

An alternative to medical marijuana for pain?
Medical marijuana is proliferating across the country due to the ability of cannabis ingestion to treat important clinical problems such as chronic pain.

ILROG issues treatment guidelines for pediatric Hodgkin lymphoma
The International Lymphoma Radiation Oncology Group (ILROG) has issued a guideline that outlines the use of 3-D computed tomography (CT)-based radiation therapy planning and volumetric image guidance to more effectively treat pediatric Hodgkin lymphoma and to reduce the radiation dose to normal tissue, thus decreasing the risk of late side effects.

UC Davis scientists describe novel drug mechanism that fights brain cancer
Researchers at UC Davis have developed and characterized a molecule that interferes with the internal regulation of cancer cells, causing them to self-destruct.

Preventing the spread of cancer with copper molecules
Chemists at Bielefeld University have developed a molecule containing copper that binds specifically with DNA and prevents the spread of cancer.

Researchers propose novel new treatment of stroke and other neurological diseases
Medicine should reconsider how it treats stroke and other neurological disorders, focusing on the intrinsic abilities of the brain and nervous system to heal themselves rather than the "modest" benefits of clot-busting drugs and other neuroprotective treatments.

Restoring ability to halt cell division may protect lung cells from cancer
Researchers led by a team at the University of Illinois at Chicago, have identified a novel role for a signaling mechanism in lung cells that permanently places them into a state of suspended animation called senescence.

New nanodevice defeats drug resistance
Chemotherapy often shrinks tumors at first, but as cancer cells become resistant to drug treatment, tumors can grow back.

TSRI scientists find clues to cancer drug failure
Cancer patients fear the possibility that one day their cells might start rendering many different chemotherapy regimens ineffective. This phenomenon, called multidrug resistance, leads to tumors that defy treatment.
More Chemotherapy Current Events and Chemotherapy News Articles

Chemo: Secrets to Thriving: From someone who's been there.

Chemo: Secrets to Thriving: From someone who's been there.
by Roxanne Brown (Author), Barbara Mastej (Contributor), John S. Link M.D. (Contributor)


The thought of chemotherapy can be overwhelming, but getting through it doesn’t have to be. Chemo: Secrets to Thriving helps lighten the load. In chronological order, step-by- step, you learn what might occur, why it happens, what you can do (with your doc’s approval), and who to contact for help. Chemo: Secrets to Thriving will be your friend, companion, and guide, giving you the resources to handle possible side effects and better manage your life during chemotherapy. Once you know the secrets in this book you may find yourself still able to enjoy life—and even thrive—while going through chemotherapy. Our endorsements aren’t from the usual celebrities, but from our celebrities: medical teams, fellow chemo travelers, and the people and places that support them.

Chemotherapy and Biotherapy Guidelines and Recommendations for Practice

Chemotherapy and Biotherapy Guidelines and Recommendations for Practice
by Martha Polovich (Author), MiKeala Olsen (Author), Kris Lefebvre (Author)


Order your copy of the fourth edition of the best-selling resource used by more than 101,000 healthcare professionals since 2009 and keep up-to-date on the latest chemotherapy, biotherapy, and targeted agents. This new edition of the Chemotherapy and Biotherapy Guidelines and Recommendations for Practice has been revised and updated to reflect the current procedures and practices in your specialty. You'll find that this latest edition incorporates a number of significant changes. To help you find the content and information that you need quickly and easily, the text has been reorganized and is now divided into 11 chapters ranging from an overview of cancer and cancer treatment and principles of antineoplastic therapy to post-treatment care and competencies in chemotherapy administration....

The Chemotherapy Survival Guide: Everything You Need to Know to Get Through Treatment

The Chemotherapy Survival Guide: Everything You Need to Know to Get Through Treatment
by Judith McKay (Author), Tammy Schacher RN OCN MSN (Author)


When you're facing cancer treatment, it's easy to feel overwhelmed and alone. Between the hospital or clinic environment and the medical terminology used by doctors and health care professionals, you may feel as though you've entered a foreign country.Written by two experienced oncology nurses, this compassionate and comprehensive guide explains in plain English everything you need to know about your treatment, including what you can expect at each stage of chemotherapy and what you can do to prevent or minimize side effects. Packed with practical suggestions, nutritional advice, relaxation skills, and other techniques to help strengthen your body and calm your mind, The Chemotherapy Survival Guide is a must-have resource for anyone navigating this difficult...

Physicians' Cancer Chemotherapy Drug Manual 2015

Physicians' Cancer Chemotherapy Drug Manual 2015
by Edward Chu (Author), Vincent T. DeVita Jr. (Author)


Completely revised and updated for 2015, the Physicians’ Cancer Chemotherapy Drug Manual is an up-to-date guide to the latest information on standard therapy and recent advances in the field. Written by world-class experts in clinical cancer therapeutics, this essential reference provides a complete, easy-to-use catalogue of over 100 drugs and commonly used drug regimens—both on- and off-label—for the treatment of all the major cancers. SPECIAL FEATURES: • Revised to reflect rapid advances in the field, incorporating treatment strategies and new drugs like afatinib, ceritinib, ibrutinib, idelalisib, obinutuzumab, and ramucirumab. • A specific chapter focused on profiling antiemetic drugs and antiemetic treatment regimens. • Diagrams of drug structures and pathways for many of...

Healthy Eating During Chemotherapy

Healthy Eating During Chemotherapy
by Jose van Mil (Author), Christina Mackenzie-Archer (Author)


People undergoing chemotherapy often experience changes in appetite and taste. Similar problems frequently arise during radiotherapy, Another common side effect is a sore mouth, making it painful to eat. At the same time, it is vital for their recovery that patients keep their body weight up. This unique cookbook is the first of its kind, offering nutritional advice and delicious recipes to help cancer patients keep on enjoying food while fighting to get better. Devised by a chef and based on medical research, the first section of the book discusses which foods are good to eat and which are not. The second part of the book contains over 160 recipes that have been created to soothe the palate. With chapter titles like Smooth, Crispy, and Soft with a Bite, the recipes focus on the...

The Chemotherapy Diet: 5 Steps to Staying Healthy During Cancer Treatment

The Chemotherapy Diet: 5 Steps to Staying Healthy During Cancer Treatment
by Mike Herbert ND (Author), Joseph Dispenza (Contributor)


During cancer treatment, it is vitally important to stay healthy. The best way of doing that is to work with the body's own natural healing abilities. And that means, in the first place to eat right.

The Chemotherapy Diet is a practical guide to feeling good during chemo... and beyond with 100+ simple recipes, menu planning guide, and more, presented in a simple 5-step program:

Change your thinking and develop an attitude focused on healing. Detoxify with therapeutic baths to promote healing from the inside out. Eat the best foods to create a healing chemistry in your body. Supplement your diet to support the healing momentum. Exercise and rest to speed the healing process.

An Inconvenient Year

An Inconvenient Year
by Original Writing


It is a book that deals with the social side of cancer, as a parent, a lover and a friend. It is a story of coping with uncertainty, the reactions of others and living with them too. It documents the total shock and utter fear that a diagnosis brings and the hopelessness of surrendering to a treatment that brings its own baggage yet ultimately insures life. It talks about confronting hair loss along with discovering the more covert assault on all things feminine. Yet at the very root of the book, ahead of the fear and anger, there is humour and laughter. Though the story of cancer has been told before, it has not been told like this"

Physicians' Cancer Chemotherapy Drug Manual 2014 (Jones and Bartlett Series in Oncology(Physician's Cancer Chemotherapy Drug Manual))

Physicians' Cancer Chemotherapy Drug Manual 2014 (Jones and Bartlett Series in Oncology(Physician's Cancer Chemotherapy Drug Manual))
by Edward Chu (Author), Vincent T. DeVita Jr. (Author)


Completely revised and updated for 2014, the Physicians’ Cancer Chemotherapy Drug Manual 2014 is an up-to-date guide to the latest information on standard therapy and recent advances in the field. Written by world-class experts in clinical cancer therapeutics, this essential reference provides a complete, easy-to-use catalog of over 100 drugs and commonly used drug regimens—both on- and off-label—for the treatment of all the major cancers. Special features: • Revised to reflect rapid advances in the field • A specific chapter focused on profiling antiemetic drug and antiemetic treatment regimens. • Diagrams of drug structures and pathways for many of the agents. • Offers a comprehensive discussion of clinical pharmacology, special considerations, indications, and dosages....

Chemotherapy and Biotherapy Guidelines and Recommendations for Practice

Chemotherapy and Biotherapy Guidelines and Recommendations for Practice
by Julie M. Whitford (Editor), Mikaela M. Olsen (Editor), Martha Polovich (Editor)


Edited by Martha Polovich, Julie M. Whitford, and MiKaela Olsen, this new edition has been revised and updated to reflect the current procedures and practices in your specialty. Featured are sections detailing principles of antineoplastic therapy, cancer therapy goals and response, fundamentals of administration, pre-treatment, treatment and post-treatment care, side effects of cancer therapy, immediate complications of cytotoxic therapy, and more. Also included are treatment schedules, including dose category and determination, as well as nursing and chemotherapy flow charts, information on safe management of chemotherapy in the home, clinical practicum and evaluations, and much, much more.

Handbook of Cancer Chemotherapy (Lippincott Williams & Wilkins Handbook Series)

Handbook of Cancer Chemotherapy (Lippincott Williams & Wilkins Handbook Series)
by Roland T. Skeel (Author), Samir N. Khlief (Author)


Skeel's Handbook of Cancer Chemotherapy combines in one place the most current rationale and specific details necessary to administer chemotherapy for most adult cancers. The handbook is a practical, diseased-focused pocket reference that emphasizes the best current medical practice as it relates to the delivery of chemotherapeutic drugs. By focusing on specific plans for treatment, the book is an invaluable resource for the daily care of cancer patients.

© 2015 BrightSurf.com