Science Current Events | Science News | Brightsurf.com
 

Moffitt Cancer Center Researchers Find Cancer Therapies Affect Cognitive Functioning among Breast Cancer Survivors

April 20, 2012
Researchers at Moffitt Cancer Center and colleagues at the University of South Florida and University of Kentucky have found that breast cancer survivors who have had chemotherapy, radiation or both do not perform as well on some cognitive tests as women who have not had cancer.

They published their study in the April 1 issue of CANCER.

"Survivors of breast cancer are living longer, so there is a need to better understand the long-term effects of cancer therapies, such as chemotherapy and radiation," said study lead author Paul B. Jacobsen, Ph.D., associate center director for Population Sciences.

To carry out their study, the researchers recruited 313 women being treated by either chemotherapy or radiotherapy for early stage breast cancer at Moffitt Cancer Center and the University of Kentucky Chandler Medical Center. Those who had undergone treatment for cancer were tested six months after treatment and then tested again 36 months after having completed treatment.

They also recruited a control group of women who did not have cancer. These participants were also tested at six months and 36 months.

Participants in all groups were within five years of age, and breast cancer patients were matched with noncancer patients who lived in their same ZIP codes. Participants were tested cognitively with respect to processing speed (quick task completion under pressure), executive functioning (ability to shift cognitive sets and solve novel problems), the two domains expected to be most affected by chemotherapy. They were also tested with regard to verbal abilities.

"Our findings were partially consistent with prior research," explained Jacobsen. "We found that chemotherapy-treated patients performed worse than noncancer controls in processing speed, executive functioning and verbal ability. These domains may be the domains most affected by chemotherapy."

The also found test results for the radiotherapy group to be similar to the results of those in the chemotherapy group. Additionally, they discovered that the noncancer group improved in these cognitive abilities over time while the chemotherapy and radiotherapy groups did not. There were no differences in performance between the radiotherapy and chemotherapy groups, noted the researchers.

The researchers commented that they were fortunate for having included the radiotherapy groups because their results were so similar to the chemotherapy group. Had that group not been included, conclusions could have been drawn to suggest that the cognitive differences between the noncancer group and the chemotherapy group were specific to chemotherapy.

"Since patients report cognitive problems that interfere with their daily activities, early workups should include tests to determine cognitive functioning prior to treatment," concluded Jacobsen. "Future research also needs to investigate factors that may affect both chemotherapy patients and those receiving radiotherapy. Providers may wish to communicate that such effects can accompany chemotherapy and radiation therapy."

Moffitt Cancer Center


Related Chemotherapy Current Events and Chemotherapy News Articles


Long-term antibiotic treatment for Q fever causes weight gain
Scientists have unearthed still more evidence that antibiotics can contribute to obesity. Research published ahead of print in the journal Antimicrobial Agents and Chemotherapy suggests that patients on long-term antibiotic treatment gained weight and had significant changes in their gut microbiota.

Shared decision making during radiation therapy improves patient satisfaction
Playing an active role in their radiation treatment decisions leaves cancer patients feeling more satisfied with their care, and may even relieve psychological distress around the experience, researchers from the Perelman School of Medicine at the University of Pennsylvania report in the journal Cancer.

Blood test spots recurrent breast cancers and monitors response to treatment
Johns Hopkins Kimmel Cancer Center investigators report they have designed a blood test that accurately detects the presence of advanced breast cancer and also holds promise for precisely monitoring response to cancer treatment.

Chemotherapy before or after surgery for high-risk bladder cancer improves survival, but is not routinely administered
Contrary to treatment guidelines for high-risk bladder cancer, chemotherapy before or after surgery is not commonly used in routine clinical practice.

Unexpected results in cancer drug trial
Research from the University of Southampton has shown a drug, used in combination with chemotherapy to treat advanced colorectal cancer, is not effective in some settings, and indeed may result in more rapid cancer progression.

Blocking DNA repair mechanisms could improve radiation therapy for brain cancer
UT Southwestern Medical Center researchers have demonstrated in both cancer cell lines and in mice that blocking critical DNA repair mechanisms could improve the effectiveness of radiation therapy for highly fatal brain tumors called glioblastomas.

Deep, integrated genomic analysis re-classifies lower-grade brain tumors
Comprehensive genomic analysis of low-grade brain tumors sorts them into three categories, one of which has the molecular hallmarks and shortened survival of glioblastoma multiforme, the most lethal of brain tumors, researchers reported at the American Association for Cancer Research Annual Meeting 2014.

Nature Genetics: LMP researchers offer hope for children with previously incurable brain cancer
Imagine the anguish of a parent whose child is diagnosed with an incurable form of childhood brain cancer.

Trastuzumab emtansine: indication of major added benefit in metastatic breast cancer with previous anthracycline therapy
The antibody-drug conjugate trastuzumab emtansine (trade name: Kadcyla) has been approved since November 2013 for the treatment of patients with unresectable, locally advanced or metastatic breast cancer that is HER2-positive, i.e. that overexpresses the human epidermal growth factor receptor 2.

New breast cancer results illustrate promise and potential of I-SPY 2 trial
In an innovative clinical trial led by UC San Francisco, the experimental drug neratinib along with standard chemotherapy was found to be a beneficial treatment for some women with newly diagnosed, high-risk breast cancer.
More Chemotherapy Current Events and Chemotherapy News Articles

Chemo: Secrets to Thriving: From someone who's been there.

Chemo: Secrets to Thriving: From someone who's been there.
by Roxanne Brown (Author), Barbara Mastej (Contributor), John S. Link M.D. (Contributor)


The thought of chemotherapy can be overwhelming, but getting through it doesn’t have to be. Chemo: Secrets to Thriving helps lighten the load. In chronological order, step-by- step, you learn what might occur, why it happens, what you can do (with your doc’s approval), and who to contact for help. Chemo: Secrets to Thriving will be your friend, companion, and guide, giving you the resources to handle possible side effects and better manage your life during chemotherapy. Once you know the secrets in this book you may find yourself still able to enjoy life—and even thrive—while going through chemotherapy. Our endorsements aren’t from the usual celebrities, but from our celebrities: medical teams, fellow chemo travelers, and the people and places that support them.

The Chemotherapy Survival Guide: Everything You Need to Know to Get Through Treatment

The Chemotherapy Survival Guide: Everything You Need to Know to Get Through Treatment
by Judith McKay (Author), Tammy Schacher RN OCN MSN (Author)


When you're facing cancer treatment, it's easy to feel overwhelmed and alone. Between the hospital or clinic environment and the medical terminology used by doctors and health care professionals, you may feel as though you've entered a foreign country.Written by two experienced oncology nurses, this compassionate and comprehensive guide explains in plain English everything you need to know about your treatment, including what you can expect at each stage of chemotherapy and what you can do to prevent or minimize side effects. Packed with practical suggestions, nutritional advice, relaxation skills, and other techniques to help strengthen your body and calm your mind, The Chemotherapy Survival Guide is a must-have resource for anyone navigating this difficult...

Physicians' Cancer Chemotherapy Drug Manual 2014 (Jones and Bartlett Series in Oncology(Physician's Cancer Chemotherapy Drug Manual))

Physicians' Cancer Chemotherapy Drug Manual 2014 (Jones and Bartlett Series in Oncology(Physician's Cancer Chemotherapy Drug Manual))
by Edward Chu (Author), Vincent T. DeVita Jr. (Author)


Completely revised and updated for 2014, the Physicians’ Cancer Chemotherapy Drug Manual 2014 is an up-to-date guide to the latest information on standard therapy and recent advances in the field. Written by world-class experts in clinical cancer therapeutics, this essential reference provides a complete, easy-to-use catalog of over 100 drugs and commonly used drug regimens—both on- and off-label—for the treatment of all the major cancers. Special features: • Revised to reflect rapid advances in the field • A specific chapter focused on profiling antiemetic drug and antiemetic treatment regimens. • Diagrams of drug structures and pathways for many of the agents. • Offers a comprehensive discussion of clinical pharmacology, special considerations, indications, and dosages....

Chemotherapy and Radiation For Dummies

Chemotherapy and Radiation For Dummies
by Alan P. Lyss MD (Author), Humberto Fagundes MD (Author), Patricia Corrigan (Author)


An informative, compassionate guide for cancer patients and their loved onesEach year, more than 1 million people get treated for cancer, and most of these will undergo chemotherapy, radiation therapy, or both. This reassuring, optimistic guide helps people get a handle on treatment options and explains in plain English how chemotherapy and radiation therapy really work. It offers detailed advice on how to alleviate and cope with side effects-which range from hair loss to nausea to anemia-and describes how good nutrition, meditation, support groups, and other techniques and resources can help in the recovery process.

The Chemotherapy Diet: 5 Steps to Staying Healthy During Cancer Treatment

The Chemotherapy Diet: 5 Steps to Staying Healthy During Cancer Treatment
by Mike Herbert ND (Author), Joseph Dispenza (Contributor)


During cancer treatment, it is vitally important to stay healthy. The best way of doing that is to work with the body's own natural healing abilities. And that means, in the first place to eat right.

The Chemotherapy Diet is a practical guide to feeling good during chemo... and beyond with 100+ simple recipes, menu planning guide, and more, presented in a simple 5-step program:

Change your thinking and develop an attitude focused on healing. Detoxify with therapeutic baths to promote healing from the inside out. Eat the best foods to create a healing chemistry in your body. Supplement your diet to support the healing momentum. Exercise and rest to speed the healing process.

Handbook of Cancer Chemotherapy (Lippincott Williams & Wilkins Handbook Series)

Handbook of Cancer Chemotherapy (Lippincott Williams & Wilkins Handbook Series)
by Roland T. Skeel (Author), Samir N. Khlief (Author)


Skeel's Handbook of Cancer Chemotherapy combines in one place the most current rationale and specific details necessary to safely administer chemotherapy for most adult cancers. The handbook is a practical, diseased-focused pocket reference that emphasizes the best current medical practice as it relates to the delivery of chemotherapeutic drugs. By focusing on specific plans for treatment, the book is an invaluable resource for the daily care of cancer patients.

Chemotherapy and Biotherapy Guidelines and Recommendations for Practice

Chemotherapy and Biotherapy Guidelines and Recommendations for Practice
by Julie M. Whitford (Editor), Mikaela M. Olsen (Editor), Martha Polovich (Editor)


This is the most recent edition of this book. It contains the most recent evidence-based recommendations for the administration of chemotherapy and biotherapy. It also contains information on the most recently approved agents (from when the guidelines were published.)

  Chemotherapy and Biotherapy Guidelines and Recommendations for Practice
by Martha Polovich (Author), MiKeala Olsen (Author), Kris Lefebvre (Author)


Order your copy of the fourth edition of the best-selling resource used by more than 101,000 healthcare professionals since 2009 and keep up-to-date on the latest chemotherapy, biotherapy, and targeted agents. This new edition of the Chemotherapy and Biotherapy Guidelines and Recommendations for Practice has been revised and updated to reflect the current procedures and practices in your specialty. You'll find that this latest edition incorporates a number of significant changes. To help you find the content and information that you need quickly and easily, the text has been reorganized and is now divided into 11 chapters ranging from an overview of cancer and cancer treatment and principles of antineoplastic therapy to post-treatment care and competencies in chemotherapy administration....

Pocket Guide To Chemotherapy Protocols

Pocket Guide To Chemotherapy Protocols
by Edward Chu (Author)


Newly updated for 2012, the Pocket Guide to Chemotherapy Protocols, Seventh Edition, is a spiral-bound quick-reference guide arranged alphabetically by cancer type. This handy, practical pocket guide contains combination, as well as selected single-agent regimens for solid tumor and hematologic malignancies. In each case, the regimens selected are based on published literature and are used in clinical practice in the medical oncology community. The Seventh Edition of the bestselling pocket guide is completely revised and updated and continues the success of previous editions by offering cancer care professionals complete, authoritative information in a convenient format. Pocket Guide to Chemotherapy Protocols is a must-have quick reference guide for physicians, nurses, and other health...

Healthy Eating During Chemotherapy

Healthy Eating During Chemotherapy
by Jose van Mil (Author), Christina Mackenzie-Archer (Author)


People undergoing chemotherapy often experience changes in appetite and taste. Similar problems frequently arise during radiotherapy, Another common side effect is a sore mouth, making it painful to eat. At the same time, it is vital for their recovery that patients keep their body weight up. This unique cookbook is the first of its kind, offering nutritional advice and delicious recipes to help cancer patients keep on enjoying food while fighting to get better. Devised by a chef and based on medical research, the first section of the book discusses which foods are good to eat and which are not. The second part of the book contains over 160 recipes that have been created to soothe the palate. With chapter titles like Smooth, Crispy, and Soft with a Bite, the recipes focus on the...

© 2014 BrightSurf.com