Science Current Events | Science News | Brightsurf.com
 

Vitamin D: A double-edged sword in the fight against osteoporosis

April 24, 2012

Vitamin D is renowned for its role in creating strong bones and is a key regulator of serum calcium levels. Calcium is primarily obtained through diet and absorbed through the intestine and into the blood stream. In addition to building bone, calcium is required for a variety of important physiological processes. Vitamin D, which is detected by receptors in bone and intestinal cells, regulates the level of calcium in the blood stream and determines how much should be stored in the skeleton. Several recent clinical trials have examined the effects of vitamin D supplements on the prevention of bone fractures in the elderly; however, the results of these trials have not offered a consensus on the efficacy of these supplements.

In this month's issue of JCI, Dr. Geert Carmeliet and colleagues at the University of Leuven in Leuven, Belgium, investigated how vitamin D affects the skeleton when serum calcium levels are depleted. Using mice that lack the intestinal vitamin D receptor, the researchers showed that the mice still had normal serum calcium levels even when given a low-calcium diet. Additional experiments demonstrated that vitamin D stimulated bone cells to produce factors that removed calcium from bone in a process known as bone resorption in order to maintain normal serum calcium levels. Thus, while vitamin D is important for maintaining serum calcium levels, it can also promote bone density loss.

In an accompanying article, Dr. Cathleen Colón-Emeric and Dr. Kenneth Lyles of Duke University Medical Center in Durham, North Carolina, discuss the clinical implications of this investigation as well as how these findings may explain clinical trial results where vitamin D supplements failed to prevent fractures in elderly patients and, in some cases, were correlated with increased fracture rates.

Journal of Clinical Investigation


Related Osteoporosis Current Events and Osteoporosis News Articles


Premature babies may grow up to have weaker bones
Among the many important processes that happen during a woman's last few weeks of pregnancy is the transfer of calcium to the growing foetus to boost bone development. But what happens if this transfer is interrupted when a baby is born prematurely?

Survey: 71 percent of hip fracture patients not told they have osteoporosis
More than 7 in 10 older adults who suffer hip fractures aren't told they have the bone-weakening disease osteoporosis - despite the fact that hip fractures nearly always signify the presence of this potentially debilitating condition, according to revealing new research by Northwell Health physicians.

Physical activity is 'magic bullet' for pandemics of obesity and cardiovascular disease
In an editorial published in the current issue of Cardiology, professors from the Charles E. Schmidt College of Medicine at Florida Atlantic University have evaluated the totality of evidence and conclude that regular physical activity bears the closest resemblance to a "magic bullet" to combat the worldwide epidemic of obesity and cardiovascular disease.

Risks of heart attack, stroke may outweigh benefits of calcium supplement
With the highest reported risk of hip fractures in the word, Norway has good reason to consider the benefits and risks of calcium supplements.

Placenta size and offspring bone development linked
Researchers at the Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, studied 518 children in the Avon Longitudinal Study of Parents and Children (ALSPAC) who underwent bone scans at nine, 15 and 17 years old.

Sarcopenia, which affects up to 20 percent of European seniors, may increase 63 percent by 2045
Today, at the World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases. researchers from the University of Liîge, Belgium presented a study that reveals the enormous and growing burden of sarcopenia in Europe.

UK study supports cardiovascular safety of calcium and vitamin D supplementation
UK researchers have presented a new study that supports the cardiovascular safety of calcium and vitamin D supplementation.

To treat a leading cause of osteoporosis, surgery is better than widely used medications
While most cases of osteoporosis are caused by normal aging, another leading cause of the bone-loss disease is a condition called hyperparathyroidism, in which the parathyroid glands release an excessive amount of a hormone that regulates the body's calcium levels.

Abaloparatide may help prevent fractures in postmenopausal women with osteoporosis
The investigational drug abaloparatide-SC (subcutaneous) may help increase bone mineral density in postmenopausal women with osteoporosis and reduce their risk of vertebral and nonvertebral fractures, new industry-sponsored research suggests.

Bone density lower with use of ADHD stimulant medicine
Children and teenagers who take stimulant drugs to treat attention-deficit hyperactivity disorder (ADHD) may have lower bone density than their peers who do not take these medications, a new study finds.
More Osteoporosis Current Events and Osteoporosis News Articles

Dr. Lani's No-Nonsense Bone Health Guide: The Truth About Density Testing, Osteoporosis Drugs, and Building Bone Quality at Any Age

Dr. Lani's No-Nonsense Bone Health Guide: The Truth About Density Testing, Osteoporosis Drugs, and Building Bone Quality at Any Age
by Lani Simpson (Author), Claude Arnaud (Foreword)


Part whistle-blower book, part bone health bible, Dr. Lani’s No-Nonsense Bone Health Guide is the first consumer book to expose the shocking difficulty of getting an accurate bone density reading and the serious risks of long-term use of osteoporosis medications, which are often prescribed based on inaccurate readings. In addition to this vital information about bone density testing, Dr. Lani Simpson cuts through the confusion and inaccuracies surrounding osteoporosis and explains what readers can do now to build and maintain healthy bones for life. Dr. Simpson shares her well-rounded, whole-body approach to bone health, including discussions of digestive health, diet, supplements, exercise, and how aging affects the bones. Readers learn surprising facts about what foods and medicines...

The Osteoporosis Diet: The Complete Guide To Osteoporosis Nutrition, Supplements, & Exercise To Reverse Bone Loss Without Drugs

The Osteoporosis Diet: The Complete Guide To Osteoporosis Nutrition, Supplements, & Exercise To Reverse Bone Loss Without Drugs


Are you looking for a natural approach to osteoporosis treatment?

The Osteoporosis Diet was written for those who are looking for a non-drug approach to prevent and treat osteoporosis or osteopenia.

If you're looking for a way to enjoy osteoporosis protection for life, without the need to resort to potentially toxic drugs such as: Fosamax, Boniva, Reclast, and other newer and equally toxic drugs, then The Osteoporosis Diet is the solution.

In the book you'll learn:

1. The form of calcium you will NEVER want to take. Hint: Odds are you take it right now and your doctor probably recommended it! Choose the right calcium, get strong bones. Choose the wrong calcium, lose your skeleton.

2. What it takes to make major increases in your...

Exercise for Better Bones: The Complete Guide to Safe and Effective Exercises for Osteoporosis

Exercise for Better Bones: The Complete Guide to Safe and Effective Exercises for Osteoporosis
by Margaret Martin (Author)


Exercise for Better Bones is the most comprehensive and current exercise program for people with osteoporosis, osteopenia and low bone density. Written by Physical Therapist Margaret Martin, Exercise for Better Bones has been used by thousands of individuals around the world to improve their bone health and reduce their risk of a fall and fracture. Exercise for Better Bones is designed for any individual with osteoporosis and in need of a safe and effective osteoporosis exercise program. The book offers four program levels: Beginner, Active, Athletic and Elite.

Lies My Doctor Told Me: Osteoporosis: How the Latest Medical Research on Bone Drugs and Calcium Could Save Your Bones, Your Heart, and Your Life (Volume 1)

Lies My Doctor Told Me: Osteoporosis: How the Latest Medical Research on Bone Drugs and Calcium Could Save Your Bones, Your Heart, and Your Life (Volume 1)
by Harmony Clearwater Grace (Author)


You just got your bone density test back.
Your doctor wants you to take Actonel, Fosamax, Boniva, or Prolia.
You don't understand why those calcium chews didn't work for you.
You don't know why this is happening.
You did what your doctor told you to do.
You don’t know what you did wrong.
There’s a better way.
This is your answer. In her new book – based on proven facts and over 200 clinical studies – Harmony reveals the special strategies for keeping your bones as strong and healthy as possible. Would a powerful bone-building supplement used by thousands in Japan get your attention? You can start using this radically different unconventional approach TODAY to strengthen your bones. Worried that your bones are getting thin and brittle? Get the bone...

The Whole-Body Approach to Osteoporosis: How to Improve Bone Strength and Reduce Your Fracture Risk (The New Harbinger Whole-Body Healing Series)

The Whole-Body Approach to Osteoporosis: How to Improve Bone Strength and Reduce Your Fracture Risk (The New Harbinger Whole-Body Healing Series)
by R. Keith McCormick (Author)


No pill will cure you of osteoporosis. While medication can sometimes help, it won't fully address the underlying causes of your osteoporosis or osteopenia. To restore bone health, you'll need a targeted program combining the best bone-building strategies from traditional and holistic medicine. The Whole-Body Approach to Osteoporosis distills these complex strategies into a whole-body plan you can begin today to dramatically improve your bone strength and overall vitality.This comprehensive guide includes information on: What to eat for stronger bones Choosing bone-building supplements and osteoporosis medications Foods and medications that may be contributing to bone loss Signs and symptoms that can help you monitor your bone health How lab tests can help you...

The Healthy Bones Nutrition Plan and Cookbook: How to Prepare and Combine Whole Foods to Prevent and Treat Osteoporosis Naturally

The Healthy Bones Nutrition Plan and Cookbook: How to Prepare and Combine Whole Foods to Prevent and Treat Osteoporosis Naturally
by Dr. Laura Kelly (Author), Helen Bryman Kelly (Author), Dr. Sidney MacDonald Baker (Foreword)


A Medicine Through Food™ Guide Drugs that claim to prevent or redress bone loss can actually cause bones to crumble and break. Calcium supplements, fortified processed food, and pasteurized dairy don't work because the calcium in them doesn't reach our bones. It’s a grim picture, but The Healthy Bones Nutrition Plan and Cookbook can help. Coauthors Dr. Laura Kelly and Helen Bryman Kelly, daughter and mother, have a firm grasp on the disciplines concerned with bone health, including nutrient absorption and bone metabolism. They offer readers a natural, effective, and safe approach to conserving bone mass and building healthy bones by creating a personalized nutrition plan that includes eating the right foods in the right combinations. The authors’ quest for a natural, effective,...

Yoga for Osteoporosis: The Complete Guide

Yoga for Osteoporosis: The Complete Guide
by Loren Fishman MD (Author), Ellen Saltonstall MD (Author)


A comprehensive, user-friendly medical yoga program designed for the management and prevention of osteoporosis, with more than four hundred illustrations. Osteoporosis leads to painful fractures due to loss of bone mass; yoga strengthens bones without endangering joints: it stands to reason that yoga is the perfect therapy for osteoporosis. Forty-four million Americans suffer from low bone mass, and osteoporosis is responsible for more than 1.5 million fractures annually. Drugs and surgeries can alleviate pain, but study after study has shown that exercise is the best treatment, specifically low-impact, bone-strengthening exercises―hence, yoga.

In this comprehensive and thoroughly illustrated guide, Loren Fishman and Ellen Saltonstall, who between them have seven decades of...

Beat Osteoporosis with Exercise: A Low-Impact Program for Building Strength, Increasing Bone Density and Improving Posture

Beat Osteoporosis with Exercise: A Low-Impact Program for Building Strength, Increasing Bone Density and Improving Posture
by Karl Knopf (Author)


PREVENT BONE LOSS AND DECREASE THE RISK OF INJURY WITH THIS FULLY-ILLUSTRATED WORKOUT GUIDE

As you get older, osteoporosis is a big concern. Luckily, there are things you can do to keep it from adversely affecting your life. Featuring more than 100 step-by-step exercises divided into detailed fitness plans, Beat Osteoporosis with Exercise guarantees that, regardless of your current fitness level, you can radically improve all aspects of your health, including:

• Preventing bone loss
• Increasing mobility
• Avoiding fractures
• Building strength
• Lowering risk of injury
• Improving balance
• Fixing posture

As these exercises become a regular habit, you’ll have an improved and sustainable quality of life while engaging in your favorite...

Osteoporosis For Dummies

Osteoporosis For Dummies
by Carolyn Riester O'Connor (Author), Sharon Perkins (Author)


Facts and advice to help people understand and prevent osteoporosis There are an estimated 55 million Americans over the age of 50 who have low bone mass. This easy-to-understand guide helps readers assess their risk and find a practical approach to the diagnosis, treatment, and prevention of osteoporosis. It covers bone density tests and a wide range of treatment options for osteoporosis-from hormone replacement therapy and acupuncture to calcium-rich foods, supplements, and exercise-and offers pointers on preventing broken hips and other common fractures.

Resolving Osteoporosis: The Cure & Guidebook

Resolving Osteoporosis: The Cure & Guidebook
by Dr. Dan Purser (Author)


From the SEVEN TIME #1 Bestselling Medical Author & Educator -- Transform Osteoporosis with a NATURAL Approach to Your Bone Health! Women -- this is about YOUR Osteoporosis. LEARN THIS is NOT a Disease, but a Deficiency State -- Find Out Which Vitamin REALLY INCREASES YOUR BONE DENSITY & HEALTH! Learn About Natural Prevention of Fractures, Bone Loss, Osteoporosis Diet. You just got told by your medical doctor (in your 2 1/2 minutes of allotted time) you have bad osteoporosis. She hands you a prescription with a warning that it has a 75% rate of side effects -- to stop it immediately if you develop chest or jaw pain. Welcome to modern medicine -- you have poor bone health, bone density & mineral density issues, reduced bone mass, and you're just going to die... YOU ARE NOT. Journey now...

© 2016 BrightSurf.com