Rutgers Study: Vitamin E in Diet Protects Against Many CancersApril 24, 2012
While the question of whether vitamin E prevents or promotes cancer has been widely debated in scientific journals and in the news media, scientists at the Center for Cancer Prevention Research, at Rutgers Ernest Mario School of Pharmacy, and the Cancer Institute of New Jersey, believe that two forms of vitamin E - gamma and delta-tocopherols - found in soybean, canola and corn oils as well as nuts do prevent colon, lung, breast and prostate cancers.
"There are studies suggesting that vitamin E actually increases the risk of cancer and decreases bone density," says Chung S. Yang, director of the center. "Our message is that the vitamin E form of gamma-tocopherols, the most abundant form of vitamin E in the American diet, and delta-tocopherols, also found in vegetable oils, are beneficial in preventing cancers while the form of vitamin E, alpha- tocopherol, the most commonly used in vitamin E supplements, has no such benefit."
Yang and colleagues, Nanjoo Suh and Ah-Ng Tony Kong, summarized their findings recently in Cancer Prevention Research, a journal of the American Association for Cancer Research. In a Commentary, "Does Vitamin E Prevent or Promote Cancer?" the Rutgers scientists discuss animal studies done at Rutgers as well as human epidemiological studies that have examined the connection between vitamin E and cancer.
Yang says Rutgers scientists conducting animal studies for colon, lung, breast and prostate cancer found that the forms of vitamin E in vegetable oils, gamma and delta-tocopherols, prevent cancer formation and growth in animal models.
"When animals are exposed to cancer-causing substances, the group that was fed these tocopherols in their diet had fewer and smaller tumors," Yang says. "When cancer cells were injected into mice these tocopherols also slowed down the development of tumors."
In researching colon cancer, Yang pointed to another recently published paper in Cancer Prevention Research indicating that the delta-tocopherol form of vitamin E was more effective than other forms of vitamin E in suppressing the development of colon cancer in rats.
This is good news for cancer research. Recently, in one of the largest prostate cancer clinical trials in the United States and Canada, scientists found that the most commonly used form of vitamin E supplements, alpha-tocopherol, not only did not prevent prostate cancer, but its use significantly increased the risk of this disease among healthy men.
This is why, Yang says, it is important to distinguish between the different forms of vitamin E and conduct more research on its cancer preventive and other biological effects.
"For people who think that they need to take vitamin E supplements," Yang says, "taking a mixture of vitamin E that resembles what is in our diet would be the most prudent supplement to take."
Rutgers, The State University of New Jersey
Related Vitamin E Current Events and Vitamin E News Articles
High cholesterol, triglycerides can keep vitamin E from reaching body tissues
In the continuing debate over how much vitamin E is enough, a new study has found that high levels of blood lipids such as cholesterol and triglycerides can keep this essential micronutrient tied up in the blood stream, and prevent vitamin E from reaching the tissues that need it.
Feast-and-famine diet could extend life, study shows
Think of it as interval training for the dinner table. University of Florida Health researchers have found that putting people on a feast-or-famine diet may mimic some of the benefits of fasting, and that adding antioxidant supplements may counteract those benefits.
Extra vitamin E protected older mice from getting common type of pneumonia
Extra vitamin E protected older mice from a bacterial infection that commonly causes pneumonia. Microbiologists and nutrition researchers from Tufts University report that the extra vitamin E helped regulate the mice's immune system.
Vitamin E deficiency linked to greater risk of miscarriage among poor women
Pregnant women in Bangladesh with low levels of the most common form of vitamin E are nearly twice as likely to have a miscarriage than those with adequate levels of the vitamin in their blood, according to new research led by the Johns Hopkins Bloomberg School of Public Health.
Drug-food interactions in mountaineering
UPV/EHU-University of the Basque Country researchers have studied the nutritional and health situations existing at high altitudes as well as the routinely used nutritional ergogenic and pharmacological aids.
Vitamin E, selenium supplements unlikely to effect age-related cataracts in men
Taking daily supplements of selenium and/or vitamin E appears to have no significant effect on the development of age-related cataracts in men, writes Author William G. Christen, Sc.D., of Brigham & Women's Hospital and Harvard Medical School, Boston, and colleagues.
Vitamin E intake critical during 'the first 1,000 days'
Amid conflicting reports about the need for vitamin E and how much is enough, a new analysis published today suggests that adequate levels of this essential micronutrient are especially critical for the very young, the elderly, and women who are or may become pregnant.
Genetic variations may modify cardiovascular benefit of aspirin
Aspirin is the gold standard for antiplatelet therapy and a daily low-dose aspirin is widely prescribed for the prevention of cardiovascular disease.
New theory of diabetic complications' origin suggests need for new therapeutic approach
Use of anti-oxidants may be ineffective or even contribute to kidney disease and other complications of diabetes, rather than helping to treat such health problems.
Nutrition experts: Debate over value of vitamin, mineral supplements is far from over
Researchers from the Linus Pauling Institute at Oregon State University and three other institutions have taken issue with recent claims that "the case is closed" on whether or not a multivitamin/mineral supplement should be taken by most people to help obtain needed micronutrients.
More Vitamin E Current Events and Vitamin E News Articles