Science Current Events | Science News | Brightsurf.com
 

Scientists discover enzyme that could slow part of the aging process in astronauts -- and the elderly

May 01, 2012

New research in the FASEB Journal suggests that the 5-lipoxygenase enzyme mediates microgravity-induced lymphocyte programmed cell death and its inhibition could help astronauts and the elderly

New research published online in the FASEB Journal suggests that a specific enzyme, called 5-lipoxygenase, plays a key role in cell death induced by microgravity environments, and that inhibiting this enzyme will likely help prevent or lessen the severity of immune problems in astronauts caused by spaceflight. Additionally, since space conditions initiate health problems that mimic the aging process on Earth, this discovery may also lead to therapeutics that extend lives by bolstering the immune systems of the elderly.

"The outcomes of this space research might be helpful to improve health in the elderly on Earth," said Mauro Maccarrone, Ph.D., a researcher involved in the work from the Department of Biomedical Sciences at the University of Teramo in Teramo, Italy. "In fact, space conditions [cause problems that] resemble the physiological process of aging and drugs able to reduce microgravity-induced immunodepression might be effective therapeutics against loss of immune performance in aging people. 5-lipoxygenase inhibitors, already used to curb human inflammatory diseases, may be such a group of compounds."

Maccarone and colleagues made this discovery by conducting experiments involving two groups of human lymphocytes that were isolated from the blood of two healthy donors. The first group of lymphocytes was exposed to microgravity onboard the International Space Station (ISS). The second group was put in a centrifuge onboard the ISS, to have the same "Space environment" as the other group, but a normal Earth-like force of gravity. When programmed cell death (apoptosis) was measured in both groups, the lymphocytes exposed to microgravity showed an increase above what is considered "normal." The group exposed to the simulated Earth gravity showed no unusual differences. Specifically, the researchers believe that this difference is caused by different levels of the 5-lipoxygenase enzyme.

"It's no surprise that bodies need Earth's gravity to function properly," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal, "because we evolved to survive on this planet. As humanity moves into space and potentially to other planets or asteroids, it's clear that we need know how not only to secure habitable conditions, but also how to secure our health. Fortunately, as we learn how to cope with low gravity environments, we also unlock secrets to longevity back home on Earth."

Federation of American Societies for Experimental Biology


Related 5-lipoxygenase Current Events and 5-lipoxygenase News Articles


Discovery of new signaling intermediates provides clues to novel therapies in pancreatitis
Signaling initiated by pancreatic digestive enzyme-producing (acinar) cells is essential to development of both pain and inflammation in pancreatitis, according to research1 published in the inaugural issue of Cellular and Molecular Gastroenterology and Hepatology, the new basic science journal of the American Gastroenterological Association.

Attack is not always the best defense
It is something like the police force of our body: the immune system.

Drug therapy for allergy moves forward
Researchers have identified several target molecules which are suitable for the development of new allergy drugs. The Journal of Allergy and Clinical Immunology, the most prestigious journal in the field of allergology, has recently published an extensive review article on the prospects of drug therapy for allergy.

Asthma drug could help control or treat Alzheimer's disease
A drug used to treat asthma has been shown to help reduce the formation of amyloid beta, a peptide in the brain that is implicated in the development of Alzheimer's disease, according to researchers at Temple University's School of Medicine.

Modulating a protein in the brain could help control Alzheimer's disease
A protein known to exist in the brain for more than 30 years, called 5-lipoxygenase, has been found to play a regulatory role in the formation of the amyloid beta in the brain, the major component of plaques implicated in the development of Alzheimer's disease, according to researchers at Temple University's School of Medicine.

Potential Lung Disease Biomarkers Yield Clues to COX-2 Inhibitor Side Effects
In searching for a simple way to identify individuals with smoking-related lung injury, scientists at Weill Cornell Medical College have stumbled upon a potential explanation for why the class of pain-relievers known as COX-2 inhibitors increases the risk of heart problems among users.

HOPE FOR GENETIC TESTS TO TREAT SCHIZOPHRENIA AND ASTHMA
Scientists are moving a step closer to providing treatment based on a person's genetic profile. Doctors at the Institute of Psychiatry, Kings College, London have found a way to predict the response of an antipsychotic drug called clozapine used for the treatment of schizophrenia.
More 5-lipoxygenase Current Events and 5-lipoxygenase News Articles

Five-Lipoxygenase Products in Asthma: 120 (Lung Biology in Health and Disease)

Five-Lipoxygenase Products in Asthma: 120 (Lung Biology in Health and Disease)
by CRC Press


Five-Lipoxygenase Products in Asthma offers an authoritative examination of the biochemistry, basic pharmacology, and clinical pharmacology of the leukotrienes with special emphasis on their role in asthma.
A critical reference for every asthma researcher and clinician, Five-Lipoxygenase Products in Asthma
highlights agents and products of the 5-LO pathway and its relationship to other pathways
explores the enzymology of the 5-LO pathway with focus on leukotriene transport, degradation, and excretion
details the role of protein identification in the 5-LO pathway
describes human cell types that produce leukotrienes and their activation
outlines pharmacological and binding study evidence for leukotriene receptors
discusses the recovery of leukotrienes in lung...

Lippincott Illustrated Reviews: Pharmacology 6th edition (Lippincott Illustrated Reviews Series)

Lippincott Illustrated Reviews: Pharmacology 6th edition (Lippincott Illustrated Reviews Series)
by Karen Whalen PharmD BCPS (Author)


Lippincott Illustrated Reviews: Pharmacology, Sixth Edition, is the updated, enhanced version of the student-favorite resource for essentials of medical pharmacology. The first-and-best resource, the Lippincott Illustrated Reviews series features clear, effective writing and hundreds of illustrations for ideal rapid review and the assimilation of complex information. Clear, sequential images present mechanisms of action and focus on showing rather than telling students how drugs work. New edition features:
All NEW chapters on Drugs of Abuse, Drugs for Obesity, Antihistamines, Drugs for Urologic Disorders, Drugs for Hematopoietic Disorders, Drugs for Dermatological Disorders, and Drugs for Bone DisordersOver 380 study questions!Nearly 600 annotated, full-color illustrations visually...

Medical Herbalism: The Science Principles and Practices Of Herbal Medicine

Medical Herbalism: The Science Principles and Practices Of Herbal Medicine
by David Hoffmann (Author)


A foundational textbook on the scientific principles of therapeutic herbalism and their application in medicine

• A complete handbook for the medical practitioner

• Includes the most up-to-date information on preparations, dosage, and contraindications

• By the author of The Complete Illustrated Holistic Herbal

Medical Herbalism contains comprehensive information concerning the identification and use of medicinal plants by chemical structure and physiological effect, the art and science of making herbal medicine, the limitations and potential of viewing herbs chemically, and the challenge to current research paradigms posed by complex plant medicines. It also includes information on toxicology and contraindications, the issues involved in determining...

Fat and Cholesterol Don't Cause Heart Attacks and Statins are Not The Solution

Fat and Cholesterol Don't Cause Heart Attacks and Statins are Not The Solution
by Paul J. Rosch MD (Author), Zoë Harcombe PhD (Author), Malcolm Kendrick MD (Author), Uffe Ravnskov MD PhD (Author), Fred A. Kummerow PhD (Author), Harumi Okuyama PhD (Author), Peter H. Langsjoen MD (Author), Alena M. Langsjoen MS (Author), Naoki Ohara PhD (Author), David M. Diamond PhD (Author), Tomohito Hamazaki MD PhD (Author), Stephanie Seneff PhD (Author), Carlos Monteiro (Author), Kilmer S. McCully MD (Author), Luca Mascitelli MD (Author), Mark R. Goldstein MD (Author), Michel de Lorgeril MD (Author), Mikael Rabaeus MD (Author), Duane Graveline MD MPH (Author), Sherif Sultan MD Phd (Author), Edel P. Kavanagh PhD (Author)


This book is dedicated to Uffe Ravnskov, MD, Ph.D. for his seminal and propaedeutic achievements in disputing the dogma that fat and cholesterol cause coronary heart disease, and that statins are safe and cardioprotective for everyone. As will be seen, no studies support the notion that restricting fat reduces coronary morbidity or mortality. More importantly, government recommendations mandating low fat diets are likely the cause of the escalating epidemic of obesity and type 2 diabetes. Several chapters detail the panoply of significant adverse health effects of statins that have been ignored or suppressed in reports of drug company sponsored trials. These include promoting the development of coronary atherosclerosis and congestive failure. In addition, the putative benefits of...

Five-Lipoxygenase Products in Asthma

Five-Lipoxygenase Products in Asthma
b




Five-Lipoxygenase Products in Asthma (Lung Biology in Health & Disease) (Lung Biology in Health and Disease) 1st edition by Drazen, Jeffrey published by Informa Healthcare Hardcover

Five-Lipoxygenase Products in Asthma (Lung Biology in Health & Disease) (Lung Biology in Health and Disease) 1st edition by Drazen, Jeffrey published by Informa Healthcare Hardcover
by Informa Healthcare (Publisher)




Untersuchungen der 5-Lipoxygenase-Kaskade in Dendritischen Zellen der Maus: Ein Einblick in die Biologie der Langerhans-Zellen (German Edition)

Untersuchungen der 5-Lipoxygenase-Kaskade in Dendritischen Zellen der Maus: Ein Einblick in die Biologie der Langerhans-Zellen (German Edition)
by Sandra Döpping (Author)


5-Lipoxygenase (5-LO) katalysiert die initialen Biosyntheseschritte der Leukotriene, die in verschiedenen Immunreaktionen involviert sind. In dieser Arbeit geht es um genetische Beweise für eine Rolle von endogenen Leukotrienen bei der Funktion von Dendritischen Zellen (DZs) durch die Studie von 5-LO defizienten Mäusen. Obwohl die Anzahl der DZs in der Haut, Milz, und peripheren Lymphknoten sowohl in 5-LO defizienten als auch in Wildtyp Mäusen ähnlich waren, konnte in den 5-LO defizienten Mäusen eine um 75% reduzierte Migration von FITC-markierten DZs nachgewiesen werden. In Wildtyp Mäusen ist die 5-LO in den Langerhans-Zellen der Haut, in einer Subpopulation dermaler Makrophagen und in aus der Haut eingewanderten Langerhans-Zellen in peripheren Lymphknoten nachweisbar. Das Enzym...

Why Do I Still Have Thyroid Symptoms? when My Lab Tests Are Normal: a Revolutionary Breakthrough in Understanding Hashimoto's Disease and Hypothyroidism

Why Do I Still Have Thyroid Symptoms? when My Lab Tests Are Normal: a Revolutionary Breakthrough in Understanding Hashimoto's Disease and Hypothyroidism
by Dr. Datis Kharrazian (Author)


Why Do I Still Have Thyroid Symptoms? was written to address the true causes of hypothyroidism in this country and how to manage them. The vast majority of hypothyroid cases are being treated inappropriately or misdiagnosed by the standard health care model. Through exhaustive research and clinical experience, Dr. Kharrazian has discovered what really causes hypothyroidism and how to manage it.

Biochemistry (Lippincott Illustrated Reviews Series)

Biochemistry (Lippincott Illustrated Reviews Series)
by Richard A. Harvey (Author), Denise R. Ferrier (Author)


Thoroughly updated for its Fifth Edition, Lippincott's Illustrated Reviews: Biochemistry enables students to quickly review and assimilate large amounts of complex information through powerful visual resources essential to mastery of difficult biochemical concepts. Its signature outline format, full-color illustrations, end-of-chapter summaries, and USMLE-style review questions make it one of the most user-friendly books in the field. New features include expanded coverage of molecular biology.A companion website offers fully searchable online text and additional USMLE-style questions for students and an image bank for faculty.

Lyme Brain: The Impact of Lyme Disease on Your Brain, and How To Reclaim Your Smarts

Lyme Brain: The Impact of Lyme Disease on Your Brain, and How To Reclaim Your Smarts
by Dr. Nicola McFadzean Ducharme ND (Author), Dr. Robert C. Bransfield MD (Foreword)


Lyme Brain. Most people with Lyme have experienced it. It's the most intrusive symptom that comes with the disease, and also one of the most difficult to alleviate. The brain is a very delicate organ, and is often the last organ to experience relief from the effects of Borrelia, co-infections, and co-conditions. In this cutting-edge book, Naturopathic Doctor Nicola McFadzean Ducharme opens up her vault of experience, wisdom, and practical tools, to bring you the most comprehensive protocol for Lyme brain that's ever been written. Dr. Nicola’s training in natural medicine makes her the perfect doctor to write this book. While she isn't afraid to use pharmaceuticals when necessary,...

© 2016 BrightSurf.com