Science Current Events | Science News | Brightsurf.com
 

Measuring progesterone receptor expression to improve hormone-receptor-positive cancer management

May 03, 2012
Presentations at the 4th IMPAKT Breast Cancer Conference

American and Spanish researchers have found potential ways for doctors to improve the treatment of hormone receptor-positive breast cancer even if they lack access to costly multi-gene tests, as they report at the 4th IMPAKT Breast Cancer Conference.

Because breast cancer is a biologically and clinically varied disease, doctors aim to choose appropriate treatments based on the characteristics of each patient's individual tumor. In the past, this has been done using pathology-based biomarkers; however these do not capture the full diversity of cancers.

"In this context, tests based on multi-gene expression have been shown to provide valuable information beyond the pathology-based biomarkers," says Dr Aleix Prat from the University of North Carolina, Chapel Hill. "However, multi-gene tests are not readily available in most of the world due to cost, assay turnaround times and other logistic issues."

Dr Prat and colleagues addressed this problem by trying to improve the current pathology-based biomarkers to better represent data coming from a particular multi-gene test known as the PAM50 breast cancer intrinsic classifier.

"The PAM50 breast cancer intrinsic classifier identifies two major groups of hormonal receptor-positive breast cancer known as the Luminal A and Luminal B subtypes. These two molecular entities have different risks of relapse and responses to chemotherapy," Dr Prat said.

Alongside the development of this multi-gene assay, clinicians have devised pathology-based surrogate assays for the identification of both the Luminal A and Luminal B subtypes. "In the absence of multi-gene assays, the pathology-based assays are clinically valuable," Dr Prat explained. "However, we observed that the current pathology-based definitions of the Luminal A and Luminal B subtypes still show a 30-40% discordance rate compared to multi-gene tests such as the PAM50 breast cancer intrinsic classifier."

The researchers examined differences in gene expression patterns between Luminal A and Luminal B tumors using the PAM50 test. They also collected clinical-pathological features from 2,950 primary tumors across four independent studies. Using statistical methods, they tested the independent prognostic significance of those features.

They found that the expression of progesterone receptor was one of the most discriminatory molecules. "Addition of quantitative scoring of the progesterone receptor into the current pathology-based Luminal A definition appears to better identify the subgroup of patients that have an outstanding survival when treated with endocrine therapy alone, and therefore do not need systemic chemotherapy," Dr Prat said. "This subpopulation of patients is likely to represent around 30% of the patients with low-risk pathology-defined Luminal A tumors."

"Current pathology-based definitions of the Luminal A and Luminal B subtypes are valuable, but can be improved for the management of hormonal receptor-positive breast cancer," the researcher concluded. "We believe that we have an improvement based upon the progesterone receptor, and given that progesterone receptor is widely used, our improvement could be widely and quickly adopted, if further validated."

According to Dr Di Leo, Hospital of Prato, Italy, former IMPAKT Chair, this is an important study with practical implications, because it tells us that the evaluation of the progesterone receptor along with the evaluation of other biomarkers, such as the estrogen receptor, proliferation markers and c-erbB2, may be relevant to better define the biological profile of the tumor. "This is a critical step towards a personalized medicine approach in breast cancer. It will be important to test the progesterone receptors according to a standardized approach across the pathology departments. One potential concern, in fact, could be the use of different techniques for the progesterone receptors evaluation, which might lead to discordant results between different pathology labs."

European Society for Medical Oncology


Related Breast Cancer Current Events and Breast Cancer News Articles


Latest evidence on using hormone replacement therapy for treating menopausal symptoms
Hormone replacement therapy (HRT) is the most effective treatment for menopausal symptoms, in particular for younger women at the onset of the menopause, suggests a new review published today (19 December) in The Obstetrician & Gynaecologist (TOG).

Orphan receptor proteins deliver 2 knock-out punches to glioblastoma cells
Two related proteins exert a lethal double whammy effect against glioblastoma cells when activated with a small molecule, say researchers at Georgetown Lombardi Comprehensive Cancer Center.

Study shows how breast cancer cells break free to spread in the body
More than 90 percent of cancer-related deaths are caused by the spread of cancer cells from their primary tumor site to other areas of the body. A new study has identified how one important gene helps cancer cells break free from the primary tumor.

Researchers identify new approach to diagnose blood clots in lungs of patients over 50
Researchers from Intermountain Medical Center in Salt Lake City have identified a new "sliding scale" model used to rule out potentially deadly blood clots in the lungs, known as pulmonary embolisms, that is more accurate than current diagnostic methods.

Too much, too little, just right
Scientists have long known the p53 protein suppresses tumors. However, a recent animal study by UC Davis researchers has uncovered a complicated relationship between p53 and another protein, Rbm38, highlighting how the body calibrates protein levels.

Proteins drive cancer cells to change states
A new study from MIT implicates a family of RNA-binding proteins in the regulation of cancer, particularly in a subtype of breast cancer. These proteins, known as Musashi proteins, can force cells into a state associated with increased proliferation.

Breast Cancer Specialist Presents Positive Results for Triple-Negative Breast Cancer Presurgery Chemotherapy Benefits
A breast cancer specialist and clinical researcher at Women & Infants Hospital of Rhode Island presented research yesterday at the 2014 San Antonio Breast Cancer Symposium showing that adding either the chemotherapy drug carboplatin or the blood vessel-targeting drug bevacizumab to the standard treatment of chemotherapy before surgery helped women who have the basal-like subtype of triple-negative breast cancer.

Herceptin found to improve long-term survival of HER2-positive breast cancer patients
VCU Massey Cancer Center physician-researcher Charles E. Geyer, Jr., M.D., was the National Protocol Officer for one component of a large national study involving two National Cancer Institute (NCI)-supported clinical trials that demonstrated that trastuzumab significantly improves the long-term survival of HER-2 positive breast cancer patients.

Migraine was not associated with BC in a pooled analysis of prospective cohort studies
Migraine was not associated with breast cancer risk or differences in the endogenous sex hormones that have been proposed to be associated with migraines, according to a new study published December 12 in the JNCI: Journal of the National Cancer Institute.

Male and female breast cancers are not identical
Results of the EORTC10085/TBCRC/BIG/NABCG International Male Breast Cancer Program conducted in both Europe and in the United States and presented at the 2014 San Antonio Breast Cancer Symposium found significant improvement in survival for men with breast cancer, but this improvement was not as good as that observed for women.
More Breast Cancer Current Events and Breast Cancer News Articles

Let Me Get This Off My Chest: A Breast Cancer Survivor Over-Shares

Let Me Get This Off My Chest: A Breast Cancer Survivor Over-Shares
by Margaret Lesh (Author)


Tamoxifen hot flashes, mastectomy, reconstruction, breast cancer etiquette, Frankenboobs, bras with special attachments—Margaret Lesh shares all in her funny, heartfelt collection of essays, anecdotes, and life lessons from the perspective of a two-time breast cancer survivor. She’ll tell you when it’s okay to play the cancer card, what you should take to the hospital, and gives suggestions on how to cope in those dark moments of the soul. With practical tips sprinkled throughout, LET ME GET THIS OFF MY CHEST explores how breast cancer changed her outlook on life, offering honest insights, humor, and sensitivity as she looks for the silver lining in a not-so-great situation. Whether you are a woman diagnosed with breast cancer or whether you know someone with breast cancer, this...

The Breast Cancer Survival Manual, Fifth Edition: A Step-by-Step Guide for Women with Newly Diagnosed Breast Cancer

The Breast Cancer Survival Manual, Fifth Edition: A Step-by-Step Guide for Women with Newly Diagnosed Breast Cancer
by John Link (Author)


The updated edition of the essential resource for the 250,000 women diagnosed with breast cancer each yearBreast cancer is the leading cause of death in women from thirty-five to fifty-four years of age, and few things are as terrifying and confusing as a diagnosis of this disease. The fifth edition of The Breast Cancer Survival Manual is a concise, information-packed guide that is newly revised to contain all of the latest findings to help the woman facing treatment feel informed and empowered. John Link, M.D., a pioneer developer of Breastlink Medical Group in Southern California includes the most current medical advice on     • Tamoxifen, Herceptin, and other chemotherapy options      • The growing importance of HER2 oncogene testing      • Clinical research trials...

The Whole-Food Guide for Breast Cancer Survivors: A Nutritional Approach to Preventing Recurrence (The New Harbinger Whole-Body Healing Series)

The Whole-Food Guide for Breast Cancer Survivors: A Nutritional Approach to Preventing Recurrence (The New Harbinger Whole-Body Healing Series)
by Edward Bauman MEd PhD (Author), Helayne Waldman MS EdD (Author), Donald I. Abrams MD (Foreword)


If you’re a breast cancer survivor, chances are you have renewed your commitment to maintaining your good health and taking care of your body. As one of the best preventative measures known to doctors and nutritionists today, a robust, cancer-fighting diet is vital to your personal plan for breast cancer prevention.The Whole-Food Guide for Breast Cancer Survivors is an essential guide for every woman seeking to understand the effect of nutritional deficiencies and environmental factors on her overall health and wellness. Based on Edward Bauman’s groundbreaking Eating for Health model, this highly comprehensive, practical approach can help you reduce the chance of breast cancer recurrence; rebuild your immune system; and enjoy a stronger, healthier body.Reduce the chance of breast...

An Inconvenient Year

An Inconvenient Year
by Original Writing


It is a book that deals with the social side of cancer, as a parent, a lover and a friend. It is a story of coping with uncertainty, the reactions of others and living with them too. It documents the total shock and utter fear that a diagnosis brings and the hopelessness of surrendering to a treatment that brings its own baggage yet ultimately insures life. It talks about confronting hair loss along with discovering the more covert assault on all things feminine. Yet at the very root of the book, ahead of the fear and anger, there is humour and laughter. Though the story of cancer has been told before, it has not been told like this"

Beating Breast Cancer: A survivors guides to beating cancer and changing your life for the better

Beating Breast Cancer: A survivors guides to beating cancer and changing your life for the better


This book contains proven steps and strategies on how to help your body help itself by providing it with essential nutrients and removing those that have negative results. This book will also show you how and why your emotions play a significant part in disease and healing. As well as how taking charge of your life helps your body heal.

Cancer: What I Wish I Had Known When I Was First Diagnosed: Tips and Advice From a Survivor

Cancer: What I Wish I Had Known When I Was First Diagnosed: Tips and Advice From a Survivor
by Michele Ryan (Author)


A cancer diagnosis results, understandably, in fear and uncertainty. Once the initial shock passes, the questions begin. Some are medical in nature: What are your treatment options? Some are intensely personal: How do you tell your children? Will your hair grow back after chemo? How will the disease affect your sex life and relationships? In Cancer: What I Wish I Had Known When I Was First Diagnosed, ten-year breast cancer survivor Michele Ryan answers these questions and more. Michele's common sense advice and practical tips provide a comprehensive road map to help navigate the basic challenges of life with cancer. She covers everything from how to evaluate your health insurance to what to pack for hospital stays, all carefully laid out in an easy-to-navigate format so readers can find...

Fight Now: Eat & Live Proactively Against Breast Cancer

Fight Now: Eat & Live Proactively Against Breast Cancer
by Aaron Tabor, MD


Dr. Tabor’s FIGHT NOW book provides information on lifestyle choices that might improve breast health and overall health. The purpose of Dr. Tabor’s medical research is to empower you to become proactive against breast cancer now with specific food and lifestyle choices. We can make specific food and lifestyle choices to lower the risk of getting breast cancer, risk of recurrence, and risk of dying from breast cancer. The only alternative is to be reactive after you get breast cancer or have a recurrence of breast cancer. The choice is clear

Whether you are currently fighting breast cancer; are a survivor; or, simply trying to lower your risk, Dr. Tabor’s FIGHT NOW book will give you concise, critical information that you can start using today. You don’t have to read...

Breast Cancer (2015): 150 Latest & Illustrated Questions & Answers

Breast Cancer (2015): 150 Latest & Illustrated Questions & Answers


Why this book -- what is so exciting in the field of breast cancer? Take a look:
• Many early breast cancers, with timely and appropriate treatments, are now curable.
• The five-year survival rate of cancers confined to the milk ducts and milk lobules (DCIS & LCIS) has gone up to 100%.The five-year survival of Stage 1 (larger tumor or lymph node-positive tumor) has gone up to almost 90%.
• Combination of 3-D and Digital Mammograms Reduces False Positive Mammograms by 14% & Weeds out Invasive Ductal Carcinoma by 39 %.
• For the first time FDA labels a promising & new breast cancer drug the title of "Breakthrough" drug which doubles Progression Free Survival and extends overall survival (Ch:13).
• Do Aspirin, Ibuprofen, Advil, Aleve...Help Reduce...

The Mayo Clinic Breast Cancer Book

The Mayo Clinic Breast Cancer Book
by the breast-health experts at Mayo Clinic Cancer Center (Author)


From the breast health experts at Mayo Clinic comes a guide to the many aspects of breast cancer—from prevention, to care and coping, to survival, to living with hope.

The Mayo Clinic Breast Cancer Book is the trusted resource for anyone wanting reliable information about this dreaded disease. Mayo Clinic set out to provide comprehensive and up-to-date facts in easy-to-understand language. They've succeeded in this handbook for those who've been diagnosed, or for those who want to give sensitive and helpful support to someone with breast cancer. The Mayo Clinic Breast Cancer Book stands out for its tone of companionship, as well as for the many patient stories that appear throughout the book. 

This straightforward yet approachable resource will empower all who are...

Breast Cancer Husband: How to Help Your Wife (and Yourself) during Diagnosis, Treatment and Beyond

Breast Cancer Husband: How to Help Your Wife (and Yourself) during Diagnosis, Treatment and Beyond
by Marc Silver (Author)


A unique guide, like none other on the market-packed with medical information, practical tips, psychological insight, and coping strategies-to help men help the women they love through this trying time.

When Marc Silver became a breast cancer husband three years ago, he learned firsthand how frightened and helpless the breast cancer husband feels. He searched in vain for a book that would give him the information and advice he so desperately sought. Now this award-winning journalist has compiled just the kind of emotionally supportive and useful resource that he wished he had been able to consult-to give men the tools they need to help their wives, their families, and themselves through this scary, uncertain time.

In his years as a consumer journalist and veteran of the News...

© 2014 BrightSurf.com