Science Current Events | Science News | Brightsurf.com
 

Higher risk of birth defects from assisted reproduction

May 07, 2012

A University of Adelaide study has identified the risk of major birth defects associated with different types of assisted reproductive technology.

In the most comprehensive study of its kind in the world, researchers from the University's Robinson Institute have compared the risk of major birth defects for each of the reproductive therapies commonly available internationally, such as: IVF (in vitro fertilization), ICSI (intracytoplasmic sperm injection) and ovulation induction. They also compared the risk of birth defects after fresh and frozen embryo transfer.

The results are being published today in the prestigious New England Journal of Medicine, and presented in Barcelona, Spain at the World Congress on Building Consensus in Gynecology, Infertility and Perinatology.

"While assisted reproductive technologies are associated with an increased risk of major birth defects overall, we found significant differences in risk between available treatments," says the lead author of the study, Associate Professor Michael Davies from the University of Adelaide's Robinson Institute and School of Paediatrics and Reproductive Health.

Researchers linked a census of more than 6100 assisted reproductive technology births in South Australia to a registry of more than 300,000 births and 18,000 birth defects. They compared risks of birth defects across all infertility treatments to pregnancies in women with no record of infertility. They also compared successive pregnancies for women.

Previous studies have identified an increased risk of birth defects associated with infertility treatment, but this is the first study to compare all forms of available treatment. This is also the first study to compare pregnancies within women by the treatments received.

"The unadjusted risk of any birth defect in pregnancies involving assisted conception was 8.3% (513 defects), compared with 5.8% for pregnancies not involving assisted conception (17,546 defects)," Associate Professor Davies says.

"The risk of birth defects for IVF was 7.2% (165 birth defects); and the rate for ICSI was higher at 9.9% (139 defects).

"A history of infertility, either with or without assisted conception, was also significantly associated with birth defects. While factors associated with the causes of infertility explained the excess risk associated with IVF, the increased risk for a number of other treatments could not readily be explained by patient factors. ICSI, for instance, had a 57% increase in the odds of major defect, although the absolute size of the risk remained relatively small," he says.

Associate Professor Davies says cryopreservation (freezing) of embryos was associated with a substantially reduced risk of birth defects, particularly for ICSI. "This may be due to developmentally compromised embryos failing to survive the freeze/thaw process," he says.

Also of concern was the tripling of risk in women using clomiphene citrate to stimulate ovulation outside of a closely supervised clinical setting.

"While confined to a small group in our study, this is of particular concern as clomiphene citrate is now very widely available at low cost, and may easily be used contrary to manufacturers' very specific instructions to avoid use if pregnant, as it may cause fetal malformations. This aspect of the study will need additional confirmation from future research," Associate Professor Davies says.

He says the study now needs to be expanded to include more recent years of treatment, as the reproductive technologies have undergone continual innovation which may influence the associated risks of treatment.

University of Adelaide


Related Birth Defects Current Events and Birth Defects News Articles


Researchers solve the structure of the Zika virus helicase
A team led by researchers from Tianjin University (P.R. China) has solved the structure of the Zika virus helicase, which is a key target for antiviral development. The research is published in Springer's journal Protein & Cell.

Less decline than expected in brain, spine defects after folic acid fortification program
Fortifying the U.S. food supply with folic acid was not associated with a decline in certain birth defects that researchers expected to see in California, according to a new study from the Stanford University School of Medicine.

Drug used for pain, anxiety may be linked to birth defects
A drug commonly used to treat pain, epilepsy, anxiety and other brain health disorders may be associated with an increased risk of major birth defects, according to a study published in the May 18, 2016, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Review finds fathers' age, lifestyle associated with birth defects
A growing body of research is revealing associations between birth defects and a father's age, alcohol use and environmental factors, say researchers at Georgetown University Medical Center. They say these defects result from epigenetic alterations that can potentially affect multiple generations.

Brazilian Zika virus strain causes birth defects in experimental models
Researchers at University of California San Diego School of Medicine, with colleagues in Brazil and Senegal, have described the first "direct experimental proof" that the Brazilian strain of Zika virus can actually cause severe birth defects.

New mouse model to aid testing of Zika vaccine, therapeutics
A research team at Washington University School of Medicine in St. Louis has established a mouse model for testing of vaccines and therapeutics to battle Zika virus.

SSRI antidepressants promote bone loss during lactation
Antidepressant use with selective serotonin reuptake inhibitors (SSRIs) during pregnancy and breast-feeding causes decreased bone density in mothers that may put them at higher risk of broken bones later in life, a new study suggests.

Researchers use mouse model to study craniofacial disorders
Researchers from the laboratory of Paul Trainor, Ph.D., at the Stowers Institute of Medical Research have developed an effective and reliable technique for studying high-arched palate using a mouse model.

Nasoalveolar molding use for cleft lip and palate reduces number of surgeries, cost of care
Patients with complete unilateral and bilateral cleft lip and palate (U/BCLP) who were treated with nasoalveolar molding (NAM) required fewer surgeries and a reduction in overall healthcare costs compared to similar patients who did not have NAM treatment, according to a study in The Journal of Craniofacial Surgery, authored by Parit A. Patel, MD.

Breaking through insect shells at a molecular level
With their chitinous shells, insects seem almost invulnerable - but like Achilles' heel in Greek mythology, their impressive armor can still be attacked.
More Birth Defects Current Events and Birth Defects News Articles

Before We Are Born: Essentials of Embryology and Birth Defects, 9e

Before We Are Born: Essentials of Embryology and Birth Defects, 9e
by Keith L. Moore BA MSc PhD DSc FIAC FRSM FAAA (Author), T. V. N. Persaud MD PhD DSc FRCPath (Lond.) FAAA (Author), Mark G. Torchia MSc PhD (Author)


As the study of embryology continues to be integrated with a range of disciplines, Before We Are Born remains the ideal solution for students who need to quickly learn the basics. Fully updated by the world’s foremost embryologists, this medical reference book provides concise guidance on human embryology at every stage of development, utilizing rich illustrations and photographs designed to further explain content.Understand all of the latest advances in embryology, including normal and abnormal embryogenesis, causes of birth defects, and the role of genes in human development. See how discoveries in molecular biology have affected clinical practice, including the development of sophisticated new techniques such as recumbent DNA technology and stem cell manipulation. Prepare for the...

Before We Are Born: Essentials of Embryology and Birth Defects, 8 Edition

Before We Are Born: Essentials of Embryology and Birth Defects, 8 Edition
by Keith L. Moore (Author), T. V. N. Persaud (Author), Mark G. Torchia (Author)


Before We Are Born: Essentials of Embryology and Birth Defects, by Drs. Keith L. Moore, T.V.N. Persaud, and Mark G. Torchia, allows you to efficiently and quickly assimilate the most important concepts related to this subject. Concise and richly illustrated, this popular book delivers the embryology knowledge you need in a highly efficient, reader-friendly manner. You can also access the complete contents online at www.studentconsult.com, along with 17 remarkable animations, downloadable illustrations, additional review questions and answers, and more.Access the full contents of the book online at www.studentconsult.com - as well as 17 remarkable animations that bring normal and abnormal embryological development to life, and hundreds of additional review questions and answers to test...

Before We Are Born: Essentials of Embryology and Birth Defects With STUDENT CONSULT Online Access, 7e (Before We Are Born: Essentials of Embryology & Birth Defects)

Before We Are Born: Essentials of Embryology and Birth Defects With STUDENT CONSULT Online Access, 7e (Before We Are Born: Essentials of Embryology & Birth Defects)
by Keith L. Moore BA MSc PhD DSc FIAC FRSM FAAA (Author), T. V. N. Persaud MD PhD DSc FRCPath (Lond.) FAAA (Author)


Zero in on the most essential concepts in human embryology and development! Concise and richly illustrated, this popular book delivers the embryology knowledge you need in a highly efficient, reader-friendly format. The comprehensively updated 7th edition comes with access to the complete contents online via Student Consult, plus 18 phenomenal embryology animations, additional review questions and answers, and moreEditor Keith L. Moore, BA, MSc, PhD, FIAC, FRSM is the recipient of the first (2007) "Henry Gray/Elsevier Distinguished Educator Award"―the American Association of Anatomists' highest award for excellence in human anatomy education at the medical/dental, graduate, and undergraduate level of teaching―a testament to his masterful teaching abilities, which help make this book...

Shakyehra Baines: How I overcame bullying (The Chronicles of Invisible Birth Defects)

Shakyehra Baines: How I overcame bullying (The Chronicles of Invisible Birth Defects)
by Sahkyehra Baines (Author)


This book is about a high-school senior reflecting on how her peers taunted her over the years about her invisible birth defect and the method she chose to cope with bullying. By creating relationships and surrounding herself with true friends, she could cope with the mean words her peers snarled at her day after day. She hopes her stories will help others deal with this issue in a healthy manner.

Wonder

Wonder
by R. J. Palacio (Author)


SOON TO BE A MAJOR MOTION PICTURE STARRING JULIA ROBERTS, OWEN WILSON, AND JACOB TREMBLAY!

Over 5 million people have read the #1 New York Times bestseller WONDER and have fallen in love with Auggie Pullman, an ordinary boy with an extraordinary face. 

The book that inspired the Choose Kind movement.

I won't describe what I look like. Whatever you're thinking, it's probably worse.

August Pullman was born with a facial difference that, up until now, has prevented him from going to a mainstream school. Starting 5th grade at Beecher Prep, he wants nothing more than to be treated as an ordinary kid—but his new classmates can’t get past Auggie’s extraordinary face. WONDER, now a #1 New York Times bestseller and included on the Texas Bluebonnet Award...

God Heals Birth Defects: First Fruits

God Heals Birth Defects: First Fruits
by Andy Hayner (Author), Margaret Weishuhn (Author)


In this revolutionary book, you will discover solid Biblical truth that demonstrates beyond all doubt that God doesn’t cause birth defects— He HEALS them! You will also read firsthand testimonies written by parents from around the world who are seeing God heal their children from diagnoses such as cerebral palsy, autism, and down syndrome. You will read of: ~ Doctors amazed by disappearing defects ~ Children moved to normal classes because they no longer qualify as "special needs" ~ Organs, bones, facial features, and muscles restored to normal function ~ Families restored to joy and peace by the truth of God's grace. If you are looking for hope and practical Biblical answers that will empower you to minister healing to those afflicted with birth defects, then this is the book is...

Before We Are Born: Essentials of Embryology and Birth Defects, 9e 9th Edition by Moore BA MSc PhD DSc FIAC FRSM FAAA, Keith L., Persaud (2015) Paperback

Before We Are Born: Essentials of Embryology and Birth Defects, 9e 9th Edition by Moore BA MSc PhD DSc FIAC FRSM FAAA, Keith L., Persaud (2015) Paperback
by Saunders (Publisher)




Birth Defects : 10 step preventing your baby to birth defects (Knowledge of Disease Book 5)

Birth Defects : 10 step preventing your baby to birth defects (Knowledge of Disease Book 5)


Major birth defects are conditions that cause structural changes in one or more parts of the body; are present at birth; and have a serious, adverse effect on health, development, or functional ability.
About one in every 33 babies is born with a birth defect.1 Birth defects are a leading cause of infant death, accounting for more than 1 of every 5 infant deaths.2 In addition, babies born with birth defects have a greater chance of illness and long term disability than babies without birth defects.

10 Step for Preventing Birth Defects

Not all birth defects can be prevented. But, a woman can increase her own chances of having a healthy baby. Many birth defects happen very early during pregnancy, sometimes before a woman even knows she is pregnant
Here are...

Drugs and Birth Defects (Drug Abuse Prevention Library)

Drugs and Birth Defects (Drug Abuse Prevention Library)
by Nancy Shniderman (Author), Sue Hurwitz (Author)


Explains the dangers that various drugs can pose to pregnant women and their unborn children, discussing birth defects such as fetal alcohol syndrome and the effects of cocaine and heroin.

Birth Defects and Drugs in Pregnancy: Maternal Drug Exposure and Congenital Malformations

Birth Defects and Drugs in Pregnancy: Maternal Drug Exposure and Congenital Malformations
by O.P. Heinonen (Author), Dennis Slone (Author), Samuel Shapiro (Author)




© 2017 BrightSurf.com