Science Current Events | Science News | Brightsurf.com
 

OHSU researchers develop new animal model for 1 of the least understood medical issues: ADHD

May 10, 2012
The number of attention deficit hyperactivity disorder (ADHD) cases in the United States are exploding. According to a 2011 statement by the Centers for Disease Control and Prevention, nearly one in 10 American children is diagnosed with the disorder. To better understand the cause of ADHD and to identify methods to prevent and treat it, researchers at Oregon Health & Science University (OHSU) and OHSU's Oregon National Primate Research Center have developed a new form of specially bred mouse that mimics the condition. The research is published in the current edition of the PLoS ONE, a journal of the Public Library of Science.

The research, led by OHSU and ONPRC scientists Jacob Raber, Ph.D., and Sergio Ojeda, D.V.M., found that mice carrying a certain mutated form of gene displayed the human-like symptoms of ADHD. The scientists believe that mice bred with this unique genome can greatly assist in research to combat ADHD.

The specific gene that was studied in this research is called SynCAM1, which is found in glial cells - a type of cell in the central nervous system involved in cellular communication. The researchers found that mice carrying a dominant/negative form of the gene were hyperactive. The mice displayed enhanced and more frequent activity during rest periods. In addition, the mice exhibited reduced anxiety, similar to children diagnosed with ADHD. The mutated gene caused these conditions because it blocks the actions of the normal gene.

"While some animal models for ADHD exist, they are far from perfect," explained Raber, a professor of behavioral neuroscience and neurology in the OHSU School of Medicine and an affiliate scientist at ONPRC "For instance, a rat model of this condition displays high blood pressure also known as spontaneous hypertensive rats or SHR, which is not observed in humans with ADHD. When hypertension is eliminated by crossing SHR rats to another commonly studied rat breed, the resulting rat has normal blood pressure but no longer responds to the methylphenidate in a way that humans with ADHD do."

"We believe that this animal model may more closely mimic ADHD and shed new light on this condition," added Ojeda, a senior scientist at ONPRC.

###

The ONPRC, National Institutes of Health and the National Alliance for Research on Schizophrenia and Depression funded this research.

Oregon Health & Science University


Related ADHD Current Events and ADHD News Articles


Antipsychotic drug use among ADHD-diagnosed foster care youth is increasing
Antipsychotic medications are often used for unlabeled indications, such as treatment of children and adolescents with attention-deficit hyperactivity disorder (ADHD).

Integrating mental health services in pediatric practices feasible, effective, Pitt finds
Brief behavioral and mental health programs for children can be effectively provided within pediatric practices as an alternative to being referred to a community specialist, University of Pittsburgh Schools of the Health Sciences researchers found in a National Institutes of Health-funded randomized trial.

Stimulants Used to Treat ADHD Influence BMI Growth Patterns Through Childhood With a BMI Rebound in Late Adolescence
A new study from researchers at Johns Hopkins Bloomberg School of Public Health found that children treated with stimulants for attention deficit hyperactivity disorder (ADHD) experienced slower body mass index (BMI) growth than their undiagnosed or untreated peers, followed by a rapid rebound of BMI that exceeded that of children with no history of ADHD or stimulant use and that could continue to obesity.

Wishing to be another gender: links to ADHD and autism spectrum disorders
Children and teenagers with an autism spectrum disorder or those who have attention deficit and hyperactivity problems are much more likely to wish to be another gender.

Study finds increased gender variance in children with autism and ADHD
John F. Strang, PsyD, a pediatric neuropsychologist at Children's National Health System, and colleagues, found that children with autism spectrum disorders (ASD) or attention deficit hyperactivity disorder (ADHD) were more likely to exhibit gender variance, the wish to be the other gender, than children with no neurodevelopmental disorder, or a medical neurodevelopmental disorder such as epilepsy or neurofibromatosis.

Ever-so-slight delay improves decision-making accuracy
Columbia University Medical Center (CUMC) researchers have found that decision-making accuracy can be improved by postponing the onset of a decision by a mere fraction of a second.

Prenatal nicotine exposure may lead to ADHD in future generations
Prenatal exposure to nicotine could manifest as attention deficit hyperactivity disorder in children born a generation later, according to a new study by Florida State University College of Medicine researchers.

Thirty per cent of adults with attention deficit disorder report childhood physical abuse
Thirty percent of adults with Attention Deficit Disorder or Attention Deficit Hyperactivity Disorder (ADD/ADHD) report they were physically abused before they turned 18.

Suicidal ideation among US soldiers begins before enlistment
Nearly 60% of soldier suicide attempts can be traced to pre-enlistment mental disorders, which are much more common among nondeployed U.S. Army soldiers than demographically similar populations of civilians (25.1% vs. 11.6%), according to a major new study.

Children with ADHD have higher risk of teenage obesity and physical inactivity
Children with attention deficit hyperactivity disorder (ADHD) are more likely to become obese and sedentary teenagers, according to new research.
More ADHD Current Events and ADHD News Articles

Parenting Children with ADHD: 10 Lessons That Medicine Cannot Teach (APA Lifetools)

Parenting Children with ADHD: 10 Lessons That Medicine Cannot Teach (APA Lifetools)
by Vincent J. Monastra (Author)


The author passes on his wisdom about how to help children with ADHD succeed, and includes medical, nutritional, educational, and psychological information in a format usably by parents, K-12 teachers and school adminstrator professionals, and health care professionals.

Your Life Can Be Better, Using strategies for adult ADD/ADHD

Your Life Can Be Better, Using strategies for adult ADD/ADHD
by Douglas A. Puryear (Author)


This book is about using strategies for adult ADD or ADHD to make your life better.  It has more information, too, especially about studying and learning, but it's really about strategies.

It is personal; it tells of how I and my patients and my friends cope, and sometimes fail to cope, with our ADD ADHD.

So it is not particularly scientific, and doesn't go much into the basics, like the history of ADD or how it's diagnosed, or causes, or treatment, though it does have some of that.

But what I'm trying to say is, it is about strategies, what you can do to make your life better.

The ADHD Workbook for Kids: Helping Children Gain Self-Confidence, Social Skills, and Self-Control (Instant Help)

The ADHD Workbook for Kids: Helping Children Gain Self-Confidence, Social Skills, and Self-Control (Instant Help)
by Lawrence Shapiro PhD (Author)


All kids with attention-deficit hyperactivity disorder (ADHD) want to manage their symptoms in order to get along better with others, build confidence, and succeed in school, but most don't have the skills they need to get their impulsive behavior under control. The ADHD Workbook for Kids offers a simple way to help children with ADHD learn these critical skills in just ten minutes a day.This workbook includes more than forty activities for kids developed by child psychologist Lawrence Shapiro that can help your child with ADHD handle everyday tasks, make friends, and build self-esteem while he or she learns to overcome the most challenging aspects of the disorder. Alone or with your help, your child can complete one ten-minute activity each day to learn how to make good decisions and...

ADHD Does Not Exist

ADHD Does Not Exist
by Richard Saul (Author)


In this groundbreaking and controversial book, behavioral neurologist Dr. Richard Saul draws on five decades of experience treating thousands of patients labeled with Attention Deficit and Hyperactivity Disorder—one of the fastest growing and widely diagnosed conditions today—to argue that ADHD is actually a cluster of symptoms stemming from over 20 other conditions and disorders.According to recent data from the Centers for Disease Control and Prevention, an estimated 6.4 million children between the ages of four and seventeen have been diagnosed with attention deficit hyperactivity disorder. While many skeptics believe that ADHD is a fabrication of drug companies and the medical establishment, the symptoms of attention-deficit and hyperactivity are all too real for millions of...

Taking Charge of ADHD, Third Edition: The Complete, Authoritative Guide for Parents

Taking Charge of ADHD, Third Edition: The Complete, Authoritative Guide for Parents
by Russell A. Barkley (Author)


From distinguished researcher/clinician Russell A. Barkley, this treasured parent resource gives you the science-based information you need about attention-deficit/hyperactivity disorder (ADHD) and its treatment. It also presents a proven eight-step behavior management plan specifically designed for 6- to 18-year-olds with ADHD. Offering encouragement, guidance, and loads of practical tips, Dr. Barkley helps you:

*Make sense of your child's symptoms.
*Get an accurate diagnosis.
*Work with school and health care professionals to get needed support.
*Learn parenting techniques that promote better behavior.
*Strengthen your child's academic and social skills.
*Use rewards and incentives effectively.
*Restore harmony at home.

Updated throughout with...

ADHD in Children - An Essential Guide for Parents

ADHD in Children - An Essential Guide for Parents


If you suspect that your child has ADHD, you might find this book helpful as it provides some guidelines to see if your child needs to be considered for an ADHD test. This book helps you get a better understanding of ADHD. It covers the comprehensive aspects of ADHD like types, causes, diagnosis and treatments, etc.

If your child has been diagnosed with ADHD, this book provides a list of what to expect as your child grows up and it offers a ton of valuable information that you can use to help your child in coping with the disorder.

You'll learn the things you need to consider in finding the right school for your child. This book provides a list of questions that you need to ask while looking for an ideal set-up for your child's education.

Another...

Learning To Slow Down & Pay Attention: A Book for Kids About ADHD

Learning To Slow Down & Pay Attention: A Book for Kids About ADHD
by Kathleen G. Nadeau (Author), Ellen B. Dixon (Author), Charles Beyl (Illustrator)


Parents, teachers and kids will love the checklists found in this book to help children organize their time and daily tasks. New edition includes more explanations about medication and how it works. Also, increased emphasis is placed on the aspects of ADHD that are troublesome to the children.

Raising Boys with ADHD: Secrets for Parenting Healthy, Happy Sons

Raising Boys with ADHD: Secrets for Parenting Healthy, Happy Sons
by Mary Anne Richey (Author), James W. Forgan (Author)


Written by two professionals who have "been there and done that" with their own sons with ADHD, "Raising Boys With ADHD" empowers parents to help their sons with ADHD find success in school and beyond. The book covers topics not often found in other parenting guides such as the preschool years and early diagnosis and strategies for teens transitioning to work and college. Filled with practical knowledge, resources, and tools needed to help parents address the many strengths and challenges of boys with ADHD, this book provides parents with encouragement and hope for the future.

ADHD: How to Diagnose and Combat ADHD without any Prescription Medicine

ADHD: How to Diagnose and Combat ADHD without any Prescription Medicine


Do you or your child suffer from Attention Deficit Hyperactive Disorder?

Are you looking for the natural cure to ADHD so one does not have to go to the doctor and get addicted to that horrible and expensive medicine?

I am speaking from experience when I say the medicine is expensive and extremely addicting. I was on adderall for years and it is made out of methamphetamine, but a medical grade. Any time I would skip a pill, I would get severe headaches and withdraws. On top of all of that, I would pay $150.00 WITH INSURANCE for a one month supply. Yes, the medicine helped, but at what cost? I have discovered a way to handle my ADHD without having to run to the doctor and rely on some over the counter meth.

What you'll learn inside:

- The...

The ADHD Effect on Marriage: Understand and Rebuild Your Relationship in Six Steps

The ADHD Effect on Marriage: Understand and Rebuild Your Relationship in Six Steps
by Melissa Orlov (Author)


Awarded "Best Psychology Book of 2010" by ForeWord Reviews, this book is an invaluable resource for couples in which one of the partners suffers from Attention Deficit Hyperactivity Disorder (ADHD).  It authoritatively guides couples in troubled marriages towards an understanding and appreciation for the struggles and triumphs of a relationship affected by ADHD, and to look at the disorder in a more positive and less disruptive way. Going beyond traditional marriage counseling which can often discount the influence of ADHD, this straight-forward discussion offers advice from the author's personal experience and years of research and identifies patterns of behavior that can hurt marriages —such as nagging, intimacy problems, sudden anger, and memory issues —through the use of...

© 2014 BrightSurf.com