Science Current Events | Science News | Brightsurf.com
 

Vitamin K2: New hope for Parkinson's patients?

May 14, 2012
Neuroscientist Patrik Verstreken, associated with VIB and KU Leuven, succeeded in undoing the effect of one of the genetic defects that leads to Parkinson's using vitamin K2. His discovery gives hope to Parkinson's patients. This research was done in collaboration with colleagues from Northern Illinois University (US) and will be published this evening on the website of the authorative journal Science.

"It appears from our research that administering vitamin K2 could possibly help patients with Parkinson's. However, more work needs to be done to understand this better," says Patrik Verstreken.

Malfunctioning power plants are at the basis of Parkinson's.

If we looked at cells as small factories, then mitochondria would be the power plants responsible for supplying the energy for their operation. They generate this energy by transporting electrons. In Parkinson's patients, the activity of mitochondria and the transport of electrons have been disrupted, resulting in the mitochondria no longer producing sufficient energy for the cell. This has major consequences as the cells in certain parts of the brain will start dying off, disrupting communication between neurons. The results are the typical symptoms of Parkinson's: lack of movement (akinesia), tremors and muscle stiffness.

The exact cause of this neurodegenerative disease is not known. In recent years, however, scientists have been able to describe several genetic defects (mutations) found in Parkinson's patients, including the so-called PINK1 and Parkin mutations, which both lead to reduced mitochondrial activity. By studying these mutations, scientists hope to unravel the mechanisms underlying the disease process.

Paralyzed fruit flies

Fruit flies (Drosophila) are frequently used in lab experiments because of their short life spans and breeding cycles, among other things. Within two weeks of her emergence, every female is able to produce hundreds of offspring. By genetically modifying fruitflies, scientists can study the function of certain genes and proteins. Patrik Verstreken and his team used fruitflies with a genetic defect in PINK1 or Parkin that is similar to the one associated with Parkinson's. They found that the flies with a PINK1 or Parkin mutation lost their ability to fly.

Upon closer examination, they discovered that the mitochondria in these flies were defective, just as in Parkinson's patients. Because of this they generated less intracellular energy - energy the insects needed to fly. When the flies were given vitamin K2, the energy production in their mitochondria was restored and the insects' ability to fly improved. The researchers were also able to determine that the energy production was restored because the vitamin K2 had improved electron transport in the mitochondria. This in turn led to improved energy production.

Conclusion

Vitamin K2 plays a role in the energy production of defective mitochondria. Because defective mitochondria are also found in Parkinson's patients with a PINK1 or Parkin mutation, vitamin K2 potentially offers hope for a new treatment for Parkinson's.

VIB (the Flanders Institute for Biotechnology)



More Vitamin K2 Current Events and Vitamin K2 News Articles

Vitamin K2 and the Calcium Paradox: How a Little-Known Vitamin Could Save Your Life

Vitamin K2 and the Calcium Paradox: How a Little-Known Vitamin Could Save Your Life
by Kate Rheaume-Bleue (Author)


The secret to avoiding calcium-related osteoporosis and atherosclerosisWhile millions of people take calcium and Vitamin D supplements thinking they're helping their bones, the truth is, without the addition of Vitamin K2, such a health regimen could prove dangerous. Without Vitamin K2, the body cannot direct calcium to the bones where it's needed; instead, the calcium resides in soft tissue (like the arteries)—leading to a combination of osteoporosis and atherosclerosis, or the dreaded "calcium paradox." This is the first book to reveal how universal a Vitamin K2 deficiency is, and the risk (in the form of cancer and diabetes, among other ailments) the absence of Vitamin K2 poses.Written by Dr. Kate Rheaume-Bleue, a popular health expert on Canadian television and radio, Vitamin K2 and...

Vitamin K2: Understanding How a Little Known Vitamin Impacts Your Health

Vitamin K2: Understanding How a Little Known Vitamin Impacts Your Health


With so much focus on vitamin D, it’s surprising you don’t hear more about vitamin K2. A number of studies show a link between vitamin K2, bone health and heart health. Is vitamin K2 a nutrient you need more of in your diet? As physicians, we feel everyone needs to be aware of the role this vitamin plays in health and wellness. This concise ebook explores the link between vitamin K2 and how it may protect against some of the most common diseases you’re at risk for as you age. Here are some of the questions this book will answer:

The Role of Vitamin K in Your Body
How Vitamin K2 Differs from Vitamin K1 and Why Most People Don’t Get Enough of It
The Various Isoforms of Vitamin K2 and Which Ones Are Most Important for Health
The Role Vitamin K2 Plays in...

A (Patented) Heart Disease Cure That Works!: What Your Doctor May Not Know. What Big Pharma Hopes You Don't Find Out.

A (Patented) Heart Disease Cure That Works!: What Your Doctor May Not Know. What Big Pharma Hopes You Don't Find Out.
by David H Leake (Author)


How to Reverse, Cure and Prevent Coronary Artery Disease. No Rx Required! Six months before his death 18 years ago, a 93-year-old genius gave mankind an incredible gift -- a simple, low-cost way to reverse, even cure, heart disease. To keep it in the public domain, he and an associate registered U.S. Patent #5278189 so that pharmaceutical companies could not control it. Instead, he was made out to be an old fool. A desperate heart patient -- allergic to all statin drugs -- decided three years ago he had nothing to lose, and opted to try it. I am that patient, and after an invasive angiogram procedure conducted July 27, 2011, an expert cardiologist reported my heart to be "free of obstructive disease." As you read this book you will learn: • Coronary Artery Disease can be reversed, cured...

The Magnesium Miracle (Revised and Updated Edition)

The Magnesium Miracle (Revised and Updated Edition)
by Carolyn Dean (Author)


REVISED AND UPDATED 2014 EDITION
 
Magnesium is an essential nutrient, indispensable to your health and well-being. By adding this mineral to your diet, you are guarding against—and helping to alleviate—such threats as heart disease, stroke, osteoporosis, diabetes, depression, arthritis, and asthma. But despite magnesium’s numerous benefits, many Americans remain dangerously deficient. Updated and revised throughout with the latest research, featuring an all-new Introduction, this amazing guide explains the vital role that magnesium plays in your body and life. Inside you will discover
 
• newly available magnesium supplements that the body absorbs more efficiently
• how calcium can increase the risk of heart disease—and how magnesium can lower it
...

Health Benefits of Vitamin K2: A Revolutionary Natural Treatment for Heart Disease And Bone Loss

Health Benefits of Vitamin K2: A Revolutionary Natural Treatment for Heart Disease And Bone Loss
by Larry M. Howard (Author), Anthony G. Payne (Author)


Though largely unknown, vitamin K is essential to good health. It is needed for the normal clotting of blood and for the formation and maintenance of healthy bones. Although our bodies produce some vitamin K2, we store it in very limited amounts. A lack of this vitamin-which can be caused by a poor diet and the regular use of certain drugs such as antibiotics-is not uncommon. Fortunately, a new supplemental form of vitamin K2, menaquinone-7 (MK-7), is becoming more widely available. Vitamin K2, specifically MK-7, is showing great promise as a natural treatment for heart diseae and bone loss. Available in soy products and as a nutritional supplement, MK-7 is clinically proven to be safe and effective. It may also be helpful for lowering cholesterol, preventing Alzheimer's disease, and...

The Paleo Manifesto: Ancient Wisdom for Lifelong Health

The Paleo Manifesto: Ancient Wisdom for Lifelong Health
by John Durant (Author)


In The Paleo Manifesto: Ancient Wisdom for Lifelong Health, John Durant argues for an evolutionary – and revolutionary – approach to health. All animals, human or otherwise, thrive when they mimic key elements of life in their natural habitat. From diet to movement to sleep, this evolutionary perspective sheds light on some of our most pressing health concerns. What is causing the rise of chronic conditions, such as obesity, diabetes, and depression? Is eating red meat going to kill you? Is avoiding the sun actually the best way to avoid skin cancer?
 
Durant takes readers on a thrilling ride to the Paleolithic and beyond, unlocking the health secrets of our ancient ancestors. What do obese gorillas teach us about weight loss? How can Paleolithic skulls contain beautiful sets...

The Miraculous Results Of  Extremely High Doses Of  The Sunshine Hormone Vitamin D3  My Experiment With Huge Doses Of D3 From 25,000 To 50,000 To 100,000 Iu A Day Over A 1 Year Period

The Miraculous Results Of Extremely High Doses Of The Sunshine Hormone Vitamin D3 My Experiment With Huge Doses Of D3 From 25,000 To 50,000 To 100,000 Iu A Day Over A 1 Year Period
by Jeff T Bowles (Author)


This updated edition has a fascinating new look at diabetes as an evolved defense to freezing damage in winter gone out of control- Don't miss it!

144+ Pages of
Fact-Packed Science Based Information-But FUN to read-

Upon realizing that taking 4,000 IU of Vitamin D3 a day was not enough for me, I decided to embark on a "dangerous" experiment that directly contradicted everything MD's had told me for years:

“DON'T TAKE TOO MUCH VITAMIN D IT IS DANGEROUS!”

I started taking 20,000 IU a day-50X times the recommended dose of 400 IU a day.

After about 4 months upped the dose to 50,000 IU a day or 150X the old recommended “safe” dose I then boosted it to 100,000 IU a day or 300 x TIMES the old maximum safe dose!

What happened over these...

Vitamin K: The Ultimate Guide to What It Is, Where to Find It, Core Benefits, and Why You Need It

Vitamin K: The Ultimate Guide to What It Is, Where to Find It, Core Benefits, and Why You Need It


Learn everything you need to know about Vitamin K!
Read on your PC, Mac, smartphone, tablet or Kindle device!
In Vitamin K: The Ultimate Guide to What It Is, Where to Find It, Core Benefits, and Why You Need It, you'll learn the various health benefits and powers of Vitamin K. Have you ever wondered why your mother always told you leafy green vegetables were healthy? Well one of the reasons is because of the power of Vitamin K in your every day life. Read on to learn about this fat soluble vitamin that can improve your overall health.
Here is a preview of what is inside this book:

How is Vitamin K Absorbed
How Much Vitamin K Do We Need?
Benefits of Vitamin K
Research Studies on Vitamin K
What are the Consequences of Vitamin K...

The 5-Second Cure: Your Surprisingly Simple Solution to Avoid Getting Sick and Beat Disease Naturally

The 5-Second Cure: Your Surprisingly Simple Solution to Avoid Getting Sick and Beat Disease Naturally


This brief guide is going to show you a simple, uniquely effective way to avoid getting sick. It will help you substantially reduce the number of common colds and cases of the flu you get for the rest of your life.

In short, if you hate getting sick, you should read these suggestions.

The bonus of this guide, for the curious reader, is that it can also show you how to treat and cure more serious health problems in an easier way. The essence of this material contains deeper implications than just learning how to treat the common cold.

© 2014 BrightSurf.com