Science Current Events | Science News | Brightsurf.com
 

Bee research sheds light on human sweet perception, metabolic disorders

July 02, 2012
Scientists at Arizona State University have discovered that honey bees may teach us about basic connections between taste perception and metabolic disorders in humans.

By experimenting with honey bee genetics, researchers have identified connections between sugar sensitivity, diabetic physiology and carbohydrate metabolism. Bees and humans may partially share these connections.

In a study published in the open-access journal PLoS Genetics (Public Library of Science), Gro Amdam, an associate professor, and Ying Wang, a research scientist, in the School of Life Sciences in ASU's College of Liberal Arts and Sciences, explain how for the first time, they've successfully inactivated two genes in the bees' "master regulator" module that controls food-related behaviors. By doing so, researchers discovered a possible molecular link between sweet taste perception and the state of internal energy.

"A bee's sensitivity to sugar reveals her attitude towards food, how old the bee is when she starts searching for nectar and pollen, and which kind of food she prefers to collect," said Wang, the lead author of the paper. "By suppressing these two 'master' genes, we discovered that bees can become more sensitive to sweet taste. But interestingly, those bees also had very high blood sugar levels, and low levels of insulin, much like people who have Type 1 diabetes."

In Amdam's honey bee lab at ASU, scientists suppressed two genes including vitellogenin, which is similar to a human gene called apolipoprotein B, and ultraspiracle, which partners with an insect hormone that has some functions in common with the human thyroid hormone. The team is the first in the world to accomplish this double gene-suppressing technique. Researchers used this method to understand how the master regulator works.

"Now, if one can use the bees to understand how taste perception and metabolic syndromes are connected, it's a very useful tool," said Amdam, who also has a honey bee laboratory at the Norwegian University of Life Sciences. "Most of what we know about deficits in human perceptions is from people who are very sick or have had a brain trauma. We know shockingly little about people in this area."

The researchers are now considering how, exactly, the bees' sweet taste was enhanced by the experiment. The most metabolically active tissue of the bee, called the fat body, may hold the key. The fat body is similar to the liver and abdominal fat in humans, in that it helps store nutrients and create energy.

Amdam explains that taste perception evolved as a survival mechanism, for bees as well as for people. For example, bitter foods may be poisonous or sweet taste may signal foods rich in calories for energy. For all animals, taste perception must communicate properly with one's internal energetic state to control food intake and maintain normal life functions. Without this, poorly functioning taste perception can contribute to unhealthy eating behaviors and metabolic diseases, such as diabetes and obesity.

"From this study, we realized we can take advantage of honey bees in understanding how food-related behaviors interact with internal metabolism, as well as how to manipulate these food-related behaviors in order to control metabolic disorders," added Amdam.

In addition to Amdam and Wang, the team included former ASU research partners Colin Brent, a research entomologist with the USDA, and Erin Fennern, now with Oregon Health Science University.

Arizona State University


Related Metabolic Disorders Current Events and Metabolic Disorders News Articles


Intrauterine exposure to maternal gestational diabetes linked with risk of autism
Among a group of more than 320,000 children, intrauterine exposure to gestational diabetes mellitus diagnosed by 26 weeks' gestation was associated with risk of autism spectrum disorders (ASDs).

Male offspring get the most benefit from pregnant mother's exercise
Male offspring appear to benefit more than females from the positive effects of exercise during pregnancy, an animal study by UNSW medical researchers has found.

Night owls face greater risk of developing diabetes than early risers
Night owls are more likely to develop diabetes, metabolic syndrome and sarcopenia than early risers, even when they get the same amount of sleep, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

BPA exposure during pregnancy linked to mothers' future diabetes risk
Exposure to the endocrine-disrupting chemical bisphenol A during pregnancy may raise a mother's susceptibility to weight gain and diabetes later in life, according to a new animal study published in the Endocrine Society's journal Endocrinology.

Newly discovered protein has link to gestational diabetes
For at least 40 years, scientists who study how the body metabolizes sugar have accepted one point: there are four enzymes that kick-start the body's process of getting energy from food.

Researchers uncover more clues to how drug reverses obesity, diabetes, fatty liver disease
Researchers at the University of Michigan have identified how a promising drug in clinical trials for the treatment of obesity and related metabolic disorders improves the metabolism of sugar by generating a new signal between fat cells and the liver.

Is stem cell therapy less effective in older patients with chronic diseases?
A promising new therapeutic approach to treat a variety of diseases involves taking a patient's own cells, turning them into stem cells, and then deriving targeted cell types such as muscle or nerve cells to return to the patient to repair damaged tissues and organs.

Exposure to cold reveals the 'switch' that controls the formation of brown and white fat
The roles that white fat and brown fat play in metabolism is well documented, but new research published in the January 2015 issue of the FASEB Journal presents a new wrinkle: each type of fat may change into the other, depending on the temperature.

Receptor may be key to treating nonalcoholic fatty liver disease
Inhibiting a nuclear receptor in the gut could lead to a treatment for a liver disorder that affects almost 30 percent of the Western world's adult population, according to an international team of researchers.

Plant used in traditonal Chinese medicine may treat metabolic diseases and obesity
New research published in the December 2014 issue of the Journal of Leukocyte Biology, shows that a component found in in the plant, Glycyrrhiza uralensis, may inhibit the development of metabolic disorders by stopping the activation of NLRP3, a protein involved in the disease process.
More Metabolic Disorders Current Events and Metabolic Disorders News Articles

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
by Clifford J. Rosen (Editor), Roger Bouillon (Editor), Juliet E. Compston (Editor), Vicki Rosen (Editor)


Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 8th Edition is the comprehensive revision of the field-leading reference on bone and mineral health. The eighth edition has been fully revised by the leading researchers and clinicians in the field to provide concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism. Chapters look to explain basic biological factors of healthy development and disease states and make it easily translatable to clinical interventions.

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism is the definitive, one-stop reference for anyone working in the field of bone health and disease.

Visit the companion site to access supplementary...

Nutrition Management of Patients With Inherited Metabolic Disorders

Nutrition Management of Patients With Inherited Metabolic Disorders
by Phyllis B. Acosta (Author)


5 Stars! Doody's Book Review Written by the foremost nutritionists in the United States, each of whom has more than 15 years of clinical experience providing nutrition management of patients with an inherited metabolic disorder (IMD), Nutrition Management of Patients with Inherited Metabolic Disorders supplies information to enhance the knowledge and skills needed by nutritionists/dietitians and other health care professionals who provide services to patients with IMDs. Many disorders that are disastrous to patients have been diagnosed and managed by diet, improving neurological and physical outcomes. However, nutrition problems still occur, whether due to the quality of the medical foods, inadequate prescription by health care providers or poor diet adherence by the patient. This book...

Atlas of the Newborn: Thorax, Abdomen, Blood, Endocrine, and Metabolic Disorders (Atlas of the Newborn)

Atlas of the Newborn: Thorax, Abdomen, Blood, Endocrine, and Metabolic Disorders (Atlas of the Newborn)
by Arnold J. Rudolph M.D. (Author), Arnold J. Rudolph MD (Author)


This is part of a spectacular 5-volume set representing the life work of the most meticulous photographic archivist in neonatology. Over the course of 40 years, Dr. Rudolph collected photographs of virtually every disease, disorder, and condition affecting the newborn. Collectively they act as a uniquely powerful diagnostic tool.

Metabolic Disorders in Poultry

Metabolic Disorders in Poultry
by J D Summer (Author), Clifford A. Adams (Author), S Leeson (Author)


Modern poultry production now has the ability to control most infectious diseases and it is evident that the economically significant issues relating to poultry health and welfare world-wide are non-infectious, most commonly referred to as metabolic disorders. General mortality of both meat birds and laying hens seem to affect birds with the greatest growth rate or the highest egg output, and is now most commonly due to disorders of various biological systems. Metabolic disorders such as those impacting skeletal development have also now become important animal welfare issues in many countries. This book addresses the problems of all the significant metabolic disorders such as ascites, sudden death syndrome, liver and kidney problems and skeletal disorders. In some instances we have...

Neuromuscular Disorders of Infancy, Childhood, and Adolescence, Second Edition: A Clinician's Approach

Neuromuscular Disorders of Infancy, Childhood, and Adolescence, Second Edition: A Clinician's Approach
by Basil T. Darras (Editor), H. Royden Jones Jr. Jr. (Editor), Monique M. Ryan (Editor), Darryl C. De Vivo (Editor)


Neuromuscular disorders are diagnosed across the lifespan and create many challenges especially with infants, children and adolescents. This new edition of the definitive reference, edited by the established world renowned authorities on the science, diagnosis and treatment of neuromuscular disorders in childhood is a timely and needed resource for all clinicians and researchers studying neuromuscular disorders, especially in childhood. The Second Edition is completely revised to remain current with advances in the field and to insure this remains the standard reference for clinical neurologists and clinical research neurologists. The Second Edition retains comprehensive coverage while shortening the total chapter count to be an even more manageable and effective reference. Carefully...

Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer

Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer
by Thomas Seyfried (Author)


The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism.  However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited.  This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention.  Support for this position is derived from critical assessment of current cancer theories.  Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due...

Scientific Publications by Walter Kempner, MD. Volume II - Radical Dietart Treatment of Vascular and Metabolic Disorders

Scientific Publications by Walter Kempner, MD. Volume II - Radical Dietart Treatment of Vascular and Metabolic Disorders
by Walter Kempner MD (Author)




Diet Recovery: Restoring Hormonal Health, Metabolism, Mood, and Your Relationship with Food (Diet Recovery Series Book 1)

Diet Recovery: Restoring Hormonal Health, Metabolism, Mood, and Your Relationship with Food (Diet Recovery Series Book 1)
by Archangel Ink


Have you noticed since starting all this “healthy” eating, dieting, perfect Paleo diets, wholesome Vegan escapades, and all that glorious exercise that you did in the name of better health and a better appearance…
THAT YOU LOOK AND FEEL WORSE?
Eating pretty much any overly restricted diet will do these things to you. Throw some “healthy” exercise in there with it and you’ve got a recipe for shutting down your entire system. It’s all caused by a drop in metabolic rate. Diet Recovery is your guide to bringing your metabolism back up to its ideal level.

When you’ve had enough and you are ready to stop dieting forever, get your health back on track, stop obsessing over your body fat percentage, be happy, and join the rest of society by eating somewhat...

Renal and Metabolic Disorders (Pittsburgh Critical Care Medicine)

Renal and Metabolic Disorders (Pittsburgh Critical Care Medicine)
by John A. Kellum (Author), Jorge Cerda (Author)


Metabolic and electrolyte disorders can pose special challenges to physicians caring for the critically ill patients. Constrained by time and circumstances, clinicians require rapid access to information to help assess and manage these often life-threatening conditions. In this book, a readily useable road map is presented, emphasizing the interactions among problems and suggesting clear lines of action. Keeping the physiopathological mechanisms to the essential, and maintaining an uncluttered format, each chapter provides guidelines to understanding "how did we get here" and "what should we do now", as quickly and safely as possible. Chapters describe clinical presentation and management of the most common renal, electrolyte, acid-base, metabolic and endocrine disorders, complicating the...

Small Animal Abdominal & Metabolic Disorders: Self-Assessment Color Review (Veterinary Self-Assessment Color Review Series)

Small Animal Abdominal & Metabolic Disorders: Self-Assessment Color Review (Veterinary Self-Assessment Color Review Series)
by Bryn Tennant (Author)


Veterinary medicine continues to evolve and progress, as concepts change, new disorders are recognised and novel diagnostic approaches are reported. This book brings together a wide variety of cases and clinical situations which are related to disorders and diseases affecting organs of the abdominal cavity and the endocrine/metabolic system.

Each case is presented in a different way reflecting the experience of each specialist author who has contributed to the text. This book is of interest to all veterinary surgeons and students, as it provides a rich mix of material ranging from relatively simple straightforward cases to complex and controversial subjects. It is designed not only to test the ability of the reader but also to educate and inform.

© 2015 BrightSurf.com