Science Current Events | Science News | Brightsurf.com
 

New research confirms efficacy of transcranial magnetic stimulation for depression

July 27, 2012
PROVIDENCE, R.I. - In one of the first studies to look at transcranial magnetic stimulation (TMS) in real-world clinical practice settings, researchers at Butler Hospital, along with colleagues across the U.S., confirmed that TMS is an effective treatment for patients with depression who are unable to find symptom relief through antidepressant medications. The study findings are published online in the June 11, 2012 edition of Depression and Anxiety in the Wiley Online Library.

Previous analysis of the efficacy of TMS has been provided through more than 30 published trials, yielding generally consistent results supporting the use of TMS to treat depression when medications aren't sufficient. "Those previous studies were key in laying the groundwork for the FDA to approve the first device for delivery of TMS as a treatment for depression in 2008," said Linda Carpenter, MD, lead author of the report and chief of the Mood Disorders Program and the Neuromodulation Clinic at Butler Hospital. "Naturalistic studies like ours, which provide scrutiny of real-life patient outcomes when TMS therapy is given in actual clinical practice settings, are the next step in further understanding the effectiveness of TMS. They are also important for informing healthcare policy, particularly in an era when difficult decisions must be made about allocation of scarce resources."

Carpenter explains that naturalistic studies differ from controlled clinical trials because they permit the inclusion of subjects with a wider range of symptomatology and comorbidity, whereas controlled clinical trials typically have more rigid criteria for inclusion. "As a multisite study collecting naturalistic outcomes from patients in clinics in various regions in the U.S., we were also able to capture effects that might arise from introducing a novel psychiatric treatment modality like TMS in non-research settings," said Carpenter. In all, the study confirms how well TMS works in diverse settings where TMS is administered to a real-life population of patients with depression that have not found relief through many other available treatments.

The published report summarized data collected from 42 clinical TMS practice sites in the US, and included outcomes from 307 patients with Major Depressive Disorder (MDD) who had persistent symptoms despite the use of antidepressant medication. Change during TMS was assessed using both clinicians' ratings of overall depression severity and scores on patient self-report depression scales, which require the patient to rate the severity of each symptom on the same standardized scale at the end of each 2-week period. Rates for "response" and "remission" to TMS were calculated based on the same cut-off scores and conventions used for other clinical trials of antidepressant treatments. Fifty-eight percent positive response rate to TMS and 37 percent remission rate were observed.

"The patient outcomes we found in this study demonstrated a response rate similar to controlled clinical trial populations," said Dr. Carpenter, explaining that this new data validates TMS efficacy in treating depression for those who have failed to benefit from antidepressant medications. "Continued research and confirmation of the effectiveness of TMS is important for understanding its place in everyday psychiatric care and to support advocacy for insurance coverage of the treatment." Thanks in part to the advocacy efforts of Dr. Carpenter, TMS was recently approved for coverage by Medicare in New England, and it is also now covered by BCBSRI. "Next steps for TMS research involve enhancing our understanding of how to maintain positive response to TMS over time after the course of therapy ends and learning how to customize the treatment for patients using newer technologies, so TMS can help even more patients."

Women & Infants Hospital


Related Depression Current Events and Depression News Articles


Antidepressants fine-tune brain reward pathway to lessen neuropathic pain
Commonly used antidepressant drugs change levels of a key signaling protein in the brain region that processes both pain and mood, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published August 24 in the Proceedings of the National Academy of Sciences (PNAS).

Spouses of stroke survivors face lingering health issues
Caregiver spouses of stroke survivors are at an increased risk of mental and physical health issues that may continue for years, according to research in the American Heart Association journal Stroke.

Women warriors at no greater risk for PTSD than men, study finds
While past research on the question has been mixed, a new study by Defense and Veterans Affairs researchers suggests that women in the military are at no greater risk than men for developing posttraumatic stress disorder, given similar experiences--including combat.

Saliva test for stress hormone levels may identify healthy older people with thinking problems
Testing the saliva of healthy older people for the level of the stress hormone cortisol may help identify individuals who should be screened for problems with thinking skills.

Healthy mood spreads through social contact, depression doesn't
But crucially having depressed friends does not make you more likely to become depressed yourself. In other words the results indicate that healthy mood spreads through social networks but depression does not.

Increased risk of depression for mothers undergoing fertility treatment
Women giving birth after undergoing fertility treatment face an increased risk of depression compared to women ending up not having a child following fertility treatment, according to new research from the University of Copenhagen. According to the researchers, this has key implications for fertility treatment in future.

New compounds could reduce alcoholics' impulse to drink
Alcoholism inflicts a heavy physical, emotional and financial toll on individuals and society. Now new discoveries and promising animal studies are offering a glimmer of hope that a new class of drugs could treat the disease without many of the unwanted side effects caused by current therapies.

Scientists discover atomic-resolution details of brain signaling
Scientists have revealed never-before-seen details of how our brain sends rapid-fire messages between its cells.

Imaging study looks at brain effects of early adversity, mental health disorders
Adversity during the first six years of life was associated with higher levels of childhood internalizing symptoms, such as depression and anxiety, in a group of boys, as well as altered brain structure in late adolescence between the ages of 18 and 21, according to an article published online by JAMA Pediatrics.

How traumatic memories hide in the brain, and how to retrieve them
Some stressful experiences - such as chronic childhood abuse - are so overwhelming and traumatic, the memories hide like a shadow in the brain.
More Depression Current Events and Depression News Articles

The Depression Cure: The 6-Step Program to Beat Depression without Drugs

The Depression Cure: The 6-Step Program to Beat Depression without Drugs
by Stephen S. Ilardi (Author)


In the past decade, depression rates have skyrocketed, and one in four Americans will suffer from major depression at some point in their lives. Where have we gone wrong? Dr. Stephen Ilardi sheds light on our current predicament and reminds us that our bodies were never designed for the sleep-deprived, poorly nourished, frenzied pace of twenty-first century life.Inspired by the extraordinary resilience of aboriginal groups like the Kaluli of Papua New Guinea, Dr. Ilardi prescribes an easy-to-follow, clinically proven program that harks back to what our bodies were originally made for and what they continue to need. The Depression Cure program has already delivered dramatic results, helping even those who have failed to respond to traditional medications.

Love Yourself Like Your Life Depends On It

Love Yourself Like Your Life Depends On It
by Kamal Ravikant (Author)


In December of 2011, I gave a talk to an audience of scientists, Pentagon officials, politicians, and CEOs on the secret of life and how I'd figured it out the previous summer. Afterwards, people came up individually and told me how much what I'd shared meant to them. This book is based on the truth I spoke about. It's something I learned from within myself, something I believed saved me. And more than that, the way I set about to do it. This is a collection of thoughts on what I learned, what worked, what didn't. Where I succeed and importantly, where I fail daily. The truth is to love yourself with the same intensity you would use to pull yourself up if you were hanging off a cliff with your fingers. As if your life depended upon it. Once you get going, it's not hard to do. Just...

The Cognitive Behavioral Workbook for Depression: A Step-by-Step Program

The Cognitive Behavioral Workbook for Depression: A Step-by-Step Program
by Dr. William J Knaus EdD (Author), Albert Ellis PhD (Author)


Cognitive behavioral therapy (CBT) is the most widely used treatment for depression for one simple reason: it works. The CBT program in this workbook has helped thousands of readers defeat the depressive thoughts and beliefs that keep them from enjoying life and feeling like themselves. Used alone or in conjunction with therapy, The Cognitive Behavioral Workbook for Depression delivers evidence-based tools you can confidently use to do better, feel better, and prevent depression from coming back.Through a series of worksheets and exercises, you’ll evaluate your depression and learn key skills for overcoming it. Once you have your depression symptoms under control, you will appreciate the additional information on preventing relapse that is special to this new edition. This workbook also...

Feeling Good: The New Mood Therapy

Feeling Good: The New Mood Therapy
by David D. Burns (Author)


The good news is that anxiety, guilt, pessimism, procrastination, low self-esteem, and other "black holes" of depression can be cured without drugs. In Feeling Good, eminent psychiatrist, David D. Burns, M.D., outlines the remarkable, scientifically proven techniques that will immediately lift your spirits and help you develop a positive outlook on life. Now, in this updated edition, Dr. Burns adds an All-New Consumer′s Guide To Anti-depressant Drugs as well as a new introduction to help answer your questions about the many options available for treating depression.

- Recognise what causes your mood swings
- Nip negative feelings in the bud
- Deal with guilt
- Handle hostility and criticism
- Overcome addiction to love and approval
- Build self-esteem
-...

The Mindful Way Through Depression: Freeing Yourself from Chronic Unhappiness (Book & CD)

The Mindful Way Through Depression: Freeing Yourself from Chronic Unhappiness (Book & CD)
by Mark Williams (Author), John Teasdale (Author), Zindel Segal (Author), Jon Kabat-Zinn (Author)


If you’ve ever struggled with depression, take heart. Mindfulness, a simple yet powerful way of paying attention to your most difficult emotions and life experiences, can help you break the cycle of chronic unhappiness once and for all.

In The Mindful Way through Depression, four uniquely qualified experts explain why our usual attempts to “think” our way out of a bad mood or just “snap out of it” lead us deeper into the downward spiral. Through insightful lessons drawn from both Eastern meditative traditions and cognitive therapy, they demonstrate how to sidestep the mental habits that lead to despair, including rumination and self-blame, so you can face life’s challenges with greater resilience. Jon Kabat-Zinn gently and encouragingly narrates the accompanying...

The Upward Spiral: Using Neuroscience to Reverse the Course of Depression, One Small Change at a Time

The Upward Spiral: Using Neuroscience to Reverse the Course of Depression, One Small Change at a Time
by Alex Korb PhD (Author), Daniel J. Siegel MD (Foreword)


Depression can feel like a downward spiral, pulling you into a vortex of sadness, fatigue, and apathy. In The Upward Spiral, neuroscientist Alex Korb demystifies the intricate brain processes that cause depression and offers a practical and effective approach to getting better. Based on the latest research in neuroscience, this book provides dozens of straightforward tips you can do every day to rewire your brain and create an upward spiral towards a happier, healthier life.
 
Whether you suffer from depression or just want a better understanding of the brain, this book offers an engaging and informative look at the neuroscience behind our emotions, thoughts, and actions. The truth is that there isn’t one big solution to depression, but there are numerous simple steps you can...

Depression: 10 Little Known Ways to Naturally Fight Depression

Depression: 10 Little Known Ways to Naturally Fight Depression
by John Franz (Author)


Depression: 10 Little Known Ways To Naturally Fight Depression

Are you depressed all the time and not sure why?

Do you know EXACTLY why you are depressed but you're not sure what to do about it?

Do you want to find a way to fight the depression without having to make doctors appointment?

If you have answer yes to any of the above questions, “Depression: 10 Little Known Ways To Naturally Fight Depression” is the book for you! This book was created specifically for people suffering from depression who want to find a way to NATURALLY fight it without having to take some type of prescription drug.

What Will I Learn In This Book?

Here are some of the key topics that will be covered in this book.

Understanding the...

F*ck Depression: Breaking Free From Depression And Start Living A Kick-Ass Life! (Cognitive Behavioral Therapy, How To Be Happy, Positive Thinking, Binge Eating, Love Yourself, NLP, Mindfulness)

F*ck Depression: Breaking Free From Depression And Start Living A Kick-Ass Life! (Cognitive Behavioral Therapy, How To Be Happy, Positive Thinking, Binge Eating, Love Yourself, NLP, Mindfulness)


Time For You To Break Through The Chains of Depression!
Are you feeling a lot of sadness when you encounter life’s setbacks, struggles and disappointments?
Are you having trouble sleeping, can’t concentrate well, have countless negative thoughts and seem to always feel hopeless?
Are you sick and tired of having your depression rob you from ultimate life fulfillment?
It’s time to reclaim your life!

Depression is one such psychological imbalance that has adverse effects on our personal, professional and social lives. It is best if we identify the cause and work on becoming happier. Depression is created from many factors: different life experiences, information we obtain, and people we may surround ourselves with. So if depression was created why...

The Noonday Demon: An Atlas of Depression

The Noonday Demon: An Atlas of Depression
by Andrew Solomon (Author)


Andrew Solomon’s National Book Award-winning, bestselling, and transformative masterpiece on depression—“the book for a generation, elegantly written, meticulously researched, empathetic, and enlightening” (Time)—now with a major new chapter covering recently introduced and novel treatments, suicide and anti-depressants, pregnancy and depression, and much more.

The Noonday Demon examines depression in personal, cultural, and scientific terms. Drawing on his own struggles with the illness and interviews with fellow sufferers, doctors and scientists, policy makers and politicians, drug designers, and philosophers, Andrew Solomon reveals the subtle complexities and sheer agony of the disease as well as the reasons for hope. He confronts the challenge of defining the illness...

Uncovering Happiness: Overcoming Depression with Mindfulness and Self-Compassion

Uncovering Happiness: Overcoming Depression with Mindfulness and Self-Compassion
by Elisha Goldstein Ph.D. (Author)


In seven simple steps, Uncovering Happiness uses cutting-edge mindfulness and self-compassion techniques along with innovations in neuroscience to release natural antidepressants in the brain. Dr. Goldstein shows you how to take back control of your mind, your mood, and your life.

Most of us believe when we’re depressed that our situation is hopeless. That’s a mistake, Dr. Elisha Goldstein reassures us in Uncovering Happiness. The secret to overcoming depression and uncovering happiness is in harnessing our brain’s own natural antidepressant power and ultimately creating a more resilient antidepressant brain. Uncovering Happiness is grounded in two key foundations: mindfulness and self-compassion, and backed by recent scientific discoveries. New research shows that...

© 2015 BrightSurf.com