Science Current Events | Science News | Brightsurf.com
 

New research confirms efficacy of transcranial magnetic stimulation for depression

July 27, 2012
PROVIDENCE, R.I. - In one of the first studies to look at transcranial magnetic stimulation (TMS) in real-world clinical practice settings, researchers at Butler Hospital, along with colleagues across the U.S., confirmed that TMS is an effective treatment for patients with depression who are unable to find symptom relief through antidepressant medications. The study findings are published online in the June 11, 2012 edition of Depression and Anxiety in the Wiley Online Library.

Previous analysis of the efficacy of TMS has been provided through more than 30 published trials, yielding generally consistent results supporting the use of TMS to treat depression when medications aren't sufficient. "Those previous studies were key in laying the groundwork for the FDA to approve the first device for delivery of TMS as a treatment for depression in 2008," said Linda Carpenter, MD, lead author of the report and chief of the Mood Disorders Program and the Neuromodulation Clinic at Butler Hospital. "Naturalistic studies like ours, which provide scrutiny of real-life patient outcomes when TMS therapy is given in actual clinical practice settings, are the next step in further understanding the effectiveness of TMS. They are also important for informing healthcare policy, particularly in an era when difficult decisions must be made about allocation of scarce resources."

Carpenter explains that naturalistic studies differ from controlled clinical trials because they permit the inclusion of subjects with a wider range of symptomatology and comorbidity, whereas controlled clinical trials typically have more rigid criteria for inclusion. "As a multisite study collecting naturalistic outcomes from patients in clinics in various regions in the U.S., we were also able to capture effects that might arise from introducing a novel psychiatric treatment modality like TMS in non-research settings," said Carpenter. In all, the study confirms how well TMS works in diverse settings where TMS is administered to a real-life population of patients with depression that have not found relief through many other available treatments.

The published report summarized data collected from 42 clinical TMS practice sites in the US, and included outcomes from 307 patients with Major Depressive Disorder (MDD) who had persistent symptoms despite the use of antidepressant medication. Change during TMS was assessed using both clinicians' ratings of overall depression severity and scores on patient self-report depression scales, which require the patient to rate the severity of each symptom on the same standardized scale at the end of each 2-week period. Rates for "response" and "remission" to TMS were calculated based on the same cut-off scores and conventions used for other clinical trials of antidepressant treatments. Fifty-eight percent positive response rate to TMS and 37 percent remission rate were observed.

"The patient outcomes we found in this study demonstrated a response rate similar to controlled clinical trial populations," said Dr. Carpenter, explaining that this new data validates TMS efficacy in treating depression for those who have failed to benefit from antidepressant medications. "Continued research and confirmation of the effectiveness of TMS is important for understanding its place in everyday psychiatric care and to support advocacy for insurance coverage of the treatment." Thanks in part to the advocacy efforts of Dr. Carpenter, TMS was recently approved for coverage by Medicare in New England, and it is also now covered by BCBSRI. "Next steps for TMS research involve enhancing our understanding of how to maintain positive response to TMS over time after the course of therapy ends and learning how to customize the treatment for patients using newer technologies, so TMS can help even more patients."

Women & Infants Hospital


Related Depression Current Events and Depression News Articles


Mothers of children with autism benefit from peer-led intervention
Peer-led interventions that target parental well-being can significantly reduce stress, depression and anxiety in mothers of children with disabilities, according to new findings released today in the journal Pediatrics.

Low Strength Brain Stimulation May Be Effective for Depression
Brain stimulation treatments, like electroconvulsive therapy (ECT) and transcranial magnetic stimulation (TMS), are often effective for the treatment of depression. Like antidepressant medications, however, they typically have a delayed onset. For example, a patient may receive several weeks of regular ECT treatments before a full response is achieved.

Experts urge new discipline combining benefits of neuroscience and psychology treatments
When a patient talks with a psychological therapist, what changes occur in the patient's brain that relieve mental disorders?

Performance improvement program helps doctors better manage depression, reports journal of psychiatric practice
A performance improvement initiative for physicians can significantly increase their use of evidence-based practices in screening for and treating depression, in the July Journal of Psychiatric Practice.

Tea Party support linked to educational segregation, new study shows
In January of 2009, Barack Obama assumed the U.S. presidency in the midst of the most severe recession since the great depression of the 1930s.

Feinstein Institute researchers identify brain network
Investigators at The Feinstein Institute for Medical Research have utilized a new image-based strategy to identify and measure placebo effects in randomized clinical trials for brain disorders.

Danish DNA could be key to happiness
Genetics could be the key to explaining nation's levels of happiness, according to research from the University of Warwick.

Weight Management Program Also Reduces Depression Among Black Women
An intervention program aimed at helping obese women maintain their weight without adding pounds also significantly reduced depression in nearly half the participants, according to a new study from Duke University.

NYU Researchers Expand Efforts to Seek Out Persons with HIV/AIDS Who Are Not Taking Medication and Not Engaged in Care
Regular attendance at HIV primary care visits and high adherence to antiretroviral therapy (ART) are vital for people living with HIV/AIDS (PLHA), as these health behaviors lead to lowered rates of morbidity and mortality, increased quality of life, and reducing the risk of HIV transmission to others.

Chinese researchers describe impaired self-face recognition in those with major depressive disorder
Neuropsychological impairment has long been established as a fundamental characteristic of depression, but a specific pattern of impairment that is widely recognized has not been summarized.
More Depression Current Events and Depression News Articles

The Depression Cure: The 6-Step Program to Beat Depression without Drugs

The Depression Cure: The 6-Step Program to Beat Depression without Drugs
by Stephen S. Ilardi (Author)


In the past decade, depression rates have skyrocketed, and one in four Americans will suffer from major depression at some point in their lives. Where have we gone wrong? Dr. Stephen Ilardi sheds light on our current predicament and reminds us that our bodies were never designed for the sleep-deprived, poorly nourished, frenzied pace of twenty-first century life.Inspired by the extraordinary resilience of aboriginal groups like the Kaluli of Papua New Guinea, Dr. Ilardi prescribes an easy-to-follow, clinically proven program that harks back to what our bodies were originally made for and what they continue to need. The Depression Cure program has already delivered dramatic results, helping even those who have failed to respond to traditional medications.

The Mindful Way Through Depression: Freeing Yourself from Chronic Unhappiness (Book & CD)

The Mindful Way Through Depression: Freeing Yourself from Chronic Unhappiness (Book & CD)
by Mark Williams (Author), John Teasdale (Author), Zindel Segal (Author), Jon Kabat-Zinn (Author)


If you’ve ever struggled with depression, take heart. Mindfulness, a simple yet powerful way of paying attention to your most difficult emotions and life experiences, can help you break the cycle of chronic unhappiness once and for all.

In The Mindful Way through Depression, four uniquely qualified experts explain why our usual attempts to “think” our way out of a bad mood or just “snap out of it” lead us deeper into the downward spiral. Through insightful lessons drawn from both Eastern meditative traditions and cognitive therapy, they demonstrate how to sidestep the mental habits that lead to despair, including rumination and self-blame, so you can face life’s challenges with greater resilience. Jon Kabat-Zinn gently and encouragingly narrates the accompanying...

Feeling Good: The New Mood Therapy

Feeling Good: The New Mood Therapy
by David D., M.D. Burns (Author)


The good news is that anxiety, guilt, pessimism, procrastination, low self-esteem, and other "black holes" of depression can be cured without drugs. In Feeling Good, eminent psychiatrist, David D. Burns, M.D., outlines the remarkable, scientifically proven techniques that will immediately lift your spirits and help you develop a positive outlook on life. Now, in this updated edition, Dr. Burns adds an All-New Consumer′s Guide To Anti-depressant Drugs as well as a new introduction to help answer your questions about the many options available for treating depression.

- Recognise what causes your mood swings
- Nip negative feelings in the bud
- Deal with guilt
- Handle hostility and criticism
- Overcome addiction to love and approval
- Build self-esteem
-...

Love Yourself Like Your Life Depends On It

Love Yourself Like Your Life Depends On It
by Kamal Ravikant (Author)


In December of 2011, I gave a talk to an audience of scientists, Pentagon officials, politicians, and CEOs on the secret of life and how I'd figured it out the previous summer. Afterwards, people came up individually and told me how much what I'd shared meant to them. This book is based on the truth I spoke about. It's something I learned from within myself, something I believed saved me. And more than that, the way I set about to do it. This is a collection of thoughts on what I learned, what worked, what didn't. Where I succeed and importantly, where I fail daily. The truth is to love yourself with the same intensity you would use to pull yourself up if you were hanging off a cliff with your fingers. As if your life depended upon it. Once you get going, it's not hard to do. Just takes...

Undoing Depression: What Therapy Doesn't Teach You and Medication Can't Give You

Undoing Depression: What Therapy Doesn't Teach You and Medication Can't Give You
by Richard O'Connor (Author)


Like heart disease, says psychotherapist Richard O'Connor, depression is fueled by complex and interrelated factors: genetic, biochemical, environmental. In this refreshingly sensible book, O'Connor focuses on an additional factor often overlooked: our own habits. Unwittingly we get good at depression. We learn how to hide it, how to work around it. We may even achieve great things, but with constant struggle rather than satisfaction. Relying on these methods to make it through each day, we deprive ourselves of true recovery, of deep joy and healthy emotion.

UNDOING DEPRESSION teaches us how to replace depressive patterns with a new and more effective set of skills. We already know how to "do" depression-and we can learn how to undo it. With a truly holistic approach that...

The Cognitive Behavioral Workbook for Depression: A Step-by-Step Program

The Cognitive Behavioral Workbook for Depression: A Step-by-Step Program
by Dr. William J Knaus EdD (Author), Albert Ellis PhD (Author)


Cognitive behavioral therapy (CBT) is the most widely used treatment for depression for one simple reason: it works. The CBT program in this workbook has helped thousands of readers defeat the depressive thoughts and beliefs that keep them from enjoying life and feeling like themselves. Used alone or in conjunction with therapy, The Cognitive Behavioral Workbook for Depression delivers evidence-based tools you can confidently use to do better, feel better, and prevent depression from coming back.Through a series of worksheets and exercises, you’ll evaluate your depression and learn key skills for overcoming it. Once you have your depression symptoms under control, you will appreciate the additional information on preventing relapse that is special to this new edition. This workbook also...

The Noonday Demon: An Atlas of Depression

The Noonday Demon: An Atlas of Depression
by Andrew Solomon (Author)


The Noonday Demon examines depression in personal, cultural, and scientific terms. Drawing on his own struggles with the illness and interviews with fellow sufferers, doctors and scientists, policy makers and politicians, drug designers and philosophers, Andrew Solomon reveals the subtle complexities and sheer agony of the disease. He confronts the challenge of defining the illness and describes the vast range of available medications, the efficacy of alternative treatments, and the impact the malady has on various demographic populations -- around the world and throughout history. He also explores the thorny patch of moral and ethical questions posed by emerging biological explanations for mental illness. With uncommon humanity, candor, wit, and erudition, award-winning author Solomon...

How to Help Someone with Depression (Updated)

How to Help Someone with Depression (Updated)


Can your loved one ever be happy again?

They need all the support we can get. But what should we say and how can we help to make sure they’re on the right track to living an optimistic life?

With a remarkably honest perspective, the author gives practical tips on how to help a loved one through depression without sabotaging an otherwise healthy relationship. Real life stories bring you into the world of depression to help you understand what they are going through.

Depression is not the end of the world. Your loved one can get better and happier!

"Laura is a struggling mother of three who works two jobs a day and juggles through her miscellaneous payments to make ends meet by the end of a week. Being a single mom has wreaked its toll...

The Mindful Way Workbook: An 8-Week Program to Free Yourself from Depression and Emotional Distress

The Mindful Way Workbook: An 8-Week Program to Free Yourself from Depression and Emotional Distress
by John D. Teasdale PhD (Author), J. Mark G. Williams DPhil (Author), Zindel V. Segal PhD (Author), Jon Kabat-Zinn PhD (Foreword)


Imagine an 8-week program that can help you overcome depression, anxiety, and stress--by simply learning new ways to respond to your own thoughts and feelings. That program is mindfulness-based cognitive therapy (MBCT), and it has been tested and proven effective in clinical trials throughout the world. Now you can get the benefits of MBCT any time, any place, by working through this carefully constructed book. The expert authors introduce specific mindfulness practices to try each week, plus reflection questions, tools for keeping track of progress, and helpful comments from others going through the program. Like a trusted map, this book guides you step by step along the path of change.

Guided meditations are provided on the accompanying MP3 CD and are also available as...

Depression: Looking Up from the Stubborn Darkness

Depression: Looking Up from the Stubborn Darkness
by Edward T. Welch (Author)


Where Is God in the Struggle? Looking away from despair towards hope can feel risky. What if God doesn't come through for you? What if you don't feel instantly better? Instead of offering simple platitudes or unrealistic "cure-all" formulas, Edward T. Welch addresses the complex nature of depression with compassion and insight, applying the rich treasures of the gospel, and giving fresh hope to those who struggle. Originally published as Depression: A Stubborn Darkness Light for the Path, this new edition is updated with added content.

© 2014 BrightSurf.com