Science Current Events | Science News | Brightsurf.com
 

Brain development is delayed in attention-deficit/hyperactivity disorder

July 31, 2012
Is attention-deficit/hyperactivity disorder (ADHD) due to a delay in brain development or the result of complete deviation from typical development? In the current issue of Biological Psychiatry, Dr. Philip Shaw and colleagues present evidence for delay based on a study by the National Institutes of Health.

The cerebral cortex is the folded gray tissue that makes up the outermost portion of the brain, covering the brain's inner structures. This tissue has left and right hemispheres and is divided into lobes. Each lobe performs specific and vitally important functions, including attention, thought, language, and sensory processing.

Two dimensions of this structure are cortical thickness and cortical surface area, both of which mature during childhood as part of the normal developmental process. This group of scientists had previously found that the thickening process is delayed in children diagnosed with ADHD. So in this study, they set out to measure whether surface area development is similarly delayed.

They recruited 234 children with ADHD and 231 typically developing children and scanned each up to 4 times. The first scan was taken at about age 10, and the final scan was around age 17. Using advanced neuroimaging technology, they were able to map the trajectories of surface area development at over 80,000 points across the brain.

They found that the development of the cortical surface is delayed in frontal brain regions in children with ADHD. For example, the typically developing children attained 50% peak area in the right prefrontal cortex at a mean age of 12.7 years, whereas the ADHD children didn't reach this peak until 14.6 years of age.

"As other components of cortical development are also delayed, this suggests there is a global delay in ADHD in brain regions important for the control of action and attention," said Dr. Shaw, a clinician studying ADHD at the National Institute of Mental Health and first author of this study.

"These data highlight the importance of longitudinal approaches to brain structure," commented Dr. John Krystal, Editor of Biological Psychiatry. "Seeing a lag in brain development, we now need to try to understand the causes of this developmental delay in ADHD."

Dr Shaw agrees, adding that this finding "guides us to search for genes that control the timing of brain development in the disorder, opening up new targets for treatment."

Additional work expanding these measures into adulthood will also be important. Such data would help determine whether or when a degree of normalization occurs, or if these delays translate into long-lasting cortical deficits.

Elsevier


Related Brain Development Current Events and Brain Development News Articles


Excessive vitamin intake in pregnant rats impacts food choices in offspring
A research group at the Department of Nutritional Sciences at the University of Toronto, Faculty of Medicine has been using a rat model to see how maternal intake of above-requirement vitamins (A, D, E, and K) impact offspring's brain development and behaviour.

Longer duration of breastfeeding linked with higher adult IQ and earning ability
Longer duration of breastfeeding is linked with increased intelligence in adulthood, longer schooling, and higher adult earnings, a study following a group of almost 3500 newborns for 30 years published in The Lancet Global Health journal has found.

Study reveals previously unknown site of anesthetic action
Anesthetics have been used in surgical procedures for more than 150 years, but the mechanisms by which inhaled anesthesia actually work are poorly understood.

Bioelectricity plays key role in brain development and repair
Research reported today by Tufts University biologists shows for the first time that bioelectrical signals among cells control and instruct embryonic brain development and manipulating these signals can repair genetic defects and induce development of healthy brain tissue in locations where it would not ordinarily grow.

Brain development controlled by epigenetic factor
McGill researchers have discovered, for the first time, the importance of a key epigenetic regulator in the development of the hippocampus, a part of the brain associated with learning, memory and neural stem cells.

Childhood leukemia study reveals disease subtypes, new treatment option
A new study of acute lymphoblastic leukemia (ALL), a blood cancer that primarily affects young children, has revealed that the disease has two distinct subtypes, and provides preliminary evidence that about 13 percent of ALL cases may be successfully treated with targeted drugs that have proved highly effective in the treatment of lymphomas in adults.

Blood-based genetic biomarkers identify young boys with autism
In a study published in the current online issue of JAMA Psychiatry, an international team of scientists, led by researchers at the University of California, San Diego School of Medicine, report finding a highly accurate blood-based measure that could lead to development of a clinical test for autism spectrum disorder (ASD) risk in males as young as one to two years old.

Exposure to endocrine disruptors during pregnancy affects the brain two generations later
Prenatal exposure to low doses of the environmental contaminants polychlorinated biphenyls, or PCBs, change the developing brain in an area involved in metabolism, and some effects are apparent even two generations later, a new study finds.

Yale researchers map 'switches' that shaped the evolution of the human brain
Thousands of genetic "dimmer" switches, regions of DNA known as regulatory elements, were turned up high during human evolution in the developing cerebral cortex, according to new research from the Yale School of Medicine.

Drug to control appetite could also fight anxiety: Ottawa study
Did you know that our body produces its own marijuana-like compound to protect us against anxiety?
More Brain Development Current Events and Brain Development News Articles

The Whole-Brain Child: 12 Revolutionary Strategies to Nurture Your Child's Developing Mind

The Whole-Brain Child: 12 Revolutionary Strategies to Nurture Your Child's Developing Mind
by Daniel J. Siegel (Author), Tina Payne Bryson (Author)


NEW YORK TIMES BESTSELLER

“Simple, smart, and effective solutions to your child’s struggles.”—Harvey Karp, M.D.
 
“Daniel Siegel and Tina Payne Bryson have created a masterly, reader-friendly guide to helping children grow their emotional intelligence. This brilliant method transforms everyday interactions into valuable brain-shaping moments. Anyone who cares for children—or who loves a child—should read The Whole-Brain Child.”—Daniel Goleman, author of Emotional Intelligence
 
In this pioneering, practical book, Daniel J. Siegel, neuropsychiatrist and author of the bestselling Mindsight, and parenting expert Tina Payne Bryson offer a revolutionary approach to child rearing with twelve key strategies that foster healthy brain development, leading...

The Brain Book: Development, Function, Disorder, Health

The Brain Book: Development, Function, Disorder, Health
by Dr. Ken Ashwell (Editor), Richard Restak (Editor)


The brain (and mental health) is the most important medical issue of our time. Just two handfuls in size and made of billions of nerve and ganglial cells, the living brain controls our thoughts, movements, behavior and emotions. It is the seat of our consciousness, yet scientists are still discovering how the living brain actually works. The Brain Book combines the latest image technology with easy-to-understand authoritative text. Written by an international team of medical experts on brain science, it covers all aspects of brain function, from development and disorders, to the nature of consciousness, through to the aging brain and brain diseases. Topics include brain chemistry, memory, the teenage brain, illusions and hallucinations, music and the brain, sleep and...

Brain Structure and Its Origins: in Development and in Evolution of Behavior and the Mind

Brain Structure and Its Origins: in Development and in Evolution of Behavior and the Mind
by Gerald E. Schneider (Author)


This introduction to the structure of the central nervous system demonstrates that the best way to learn how the brain is put together is to understand something about why. It explains why the brain is put together as it is by describing basic functions and key aspects of its evolution and development. This approach makes the structure of the brain and spinal cord more comprehensible as well as more interesting and memorable. The book offers a detailed outline of the neuroanatomy of vertebrates, especially mammals, that equips students for further explorations of the field. Gaining familiarity with neuroanatomy requires multiple exposures to the material with...

The Teenage Brain: A Neuroscientist's Survival Guide to Raising Adolescents and Young Adults

The Teenage Brain: A Neuroscientist's Survival Guide to Raising Adolescents and Young Adults
by Frances E. Jensen (Author), Amy Ellis Nutt (Author)


Drawing on her research knowledge and clinical experience, internationally respected neurologist—and mother of two boys—Frances E. Jensen, M.D., offers a revolutionary look at the science of the adolescent brain, providing remarkable insights that translate into practical advice for both parents and teenagers.Driven by the assumption that brain growth was pretty much complete by the time a child began kindergarten, scientists believed for years that the adolescent brain was essentially an adult one—only with fewer miles on it. Over the last decade, however, the scientific community has learned that the teen years encompass vitally important stages of brain development.Motivated by her personal experience of parenting two teenage boys, renowned neurologist Dr. Frances E. Jensen...

Your Child's Growing Mind: Brain Development and Learning From Birth to Adolescence

Your Child's Growing Mind: Brain Development and Learning From Birth to Adolescence
by Jane Healy (Author)


The classic guide to understanding children’s mental development is now updated and better than ever!

Hailed by parents and educators, Your Child’s Growing Mind is a window into the fascinating process of brain development and learning. It looks at the roots of emotion, intelligence, and creativity, translating the most current scientific research into practical suggestions for parents and teachers.

Dr. Healy also addresses academic learning, offering countless suggestions for how parents can help without pushing. She explains the building blocks of reading, writing, spelling, and mathematics and shows how to help youngsters of all ages develop motivation, attention, critical thinking, and problem-solving skills.

Using the science of childhood development, she...

The Learning Brain: Memory and Brain Development in Children

The Learning Brain: Memory and Brain Development in Children
by Torkel Klingberg (Author)


Despite all our highly publicized efforts to improve our schools, the United States is still falling behind. We recently ranked 15th in the world in reading, math, and science. Clearly, more needs to be done. In The Learning Brain, Torkel Klingberg urges us to use the insights of neuroscience to improve the education of our children.

The key to improving education lies in understanding how the brain works: that is where learning takes place, after all. The book focuses in particular on "working memory"--our ability to concentrate and to keep relevant information in our head while ignoring distractions (a topic the author covered in The Overflowing Brain). Research shows enormous variation in working memory among children, with some ten-year-olds performing at the level of a...

What's Going on in There? : How the Brain and Mind Develop in the First Five Years of Life

What's Going on in There? : How the Brain and Mind Develop in the First Five Years of Life
by Lise Eliot (Author)


As a research neuroscientist, Lise Eliot has made the study of the human brain her life's work. But it wasn't until she was pregnant with her first child that she became intrigued with the study of brain development. She wanted to know precisely how the baby's brain is formed, and when and how each sense, skill, and cognitive ability is developed. And just as important, she was interested in finding out how her role as a nurturer can affect this complex process. How much of her baby's development is genetically ordained--and how much is determined by environment? Is there anything parents can do to make their babies' brains work better--to help them become smarter, happier people? Drawing upon the exploding research in this field as well as the stories of real children, What's Going On in...

Brain Rules for Baby (Updated and Expanded): How to Raise a Smart and Happy Child from Zero to Five

Brain Rules for Baby (Updated and Expanded): How to Raise a Smart and Happy Child from Zero to Five
by John Medina (Author)


What’s the single most important thing you can do during pregnancy? What does watching TV do to a child’s brain? What’s the best way to handle temper tantrums? Scientists know.

In his New York Times bestseller Brain Rules, Dr. John Medina showed us how our brains really work—and why we ought to redesign our workplaces and schools. Now, in Brain Rules for Baby, he shares what the latest science says about how to raise smart and happy children from zero to five. This book is destined to revolutionize parenting. Just one of the surprises: The best way to get your children into the college of their choice? Teach them impulse control.

Brain Rules for Baby bridges the gap between what scientists know and what parents practice. Through fascinating and funny stories, Medina,...

Welcome to Your Child's Brain: How the Mind Grows from Conception to College

Welcome to Your Child's Brain: How the Mind Grows from Conception to College
by Sandra Aamodt (Author), Sam Wang (Author)


How children think is one of the most enduring mysteries-and difficulties-encountered by parents. In an effort to raise our children smarter, happier, stronger, and better, parents will try almost anything, from vitamins to toys to DVDs. But how can we tell marketing from real science? And what really goes through your kid's growing mind-as an infant, in school, and during adolescence? Neuroscientists Sandra Aamodt and Sam Wang (who is also a parent) explain the facets and functions of the developing brain, discussing salient subjects such as sleep problems, language learning, gender differences, and autism. They dispel common myths about important subjects such as the value of educational videos for babies, the meaning of ADHD in the classroom, and the best predictor of...

Cognitive Development: The Learning Brain

Cognitive Development: The Learning Brain
by Usha Claire Goswami (Author)


Cognitive Development: The Learning Brain is a thoroughly revised and updated edition of the bestselling Cognition in Children. This full-color textbook has been re-written from the perspective of brain science and shows how new discoveries in cognitive neuroscience force us to reconsider traditional theories of cognitive development. Goswami considers the established base of cognitive developmental psychology and demonstrates how new data from brain science require a new theoretical framework based on learning. This book presents a new paradigm for teaching cognitive development, going beyond Piaget to learning and the brain. Conceptualizing cognitive development around three core domains of human knowledge – naïve physics, naïve biology and naïve psychology – the book considers...

© 2015 BrightSurf.com