Science Current Events | Science News | Brightsurf.com
 

Scientists can now block heroin, morphine addiction

August 15, 2012

Clinical trials possible within 18 months

In a major breakthrough, an international team of scientists has proven that addiction to morphine and heroin can be blocked, while at the same time increasing pain relief.

The team from the University of Adelaide and University of Colorado has discovered the key mechanism in the body's immune system that amplifies addiction to opioid drugs.

Laboratory studies have shown that the drug (+)-naloxone (pronounced: PLUS nal-OX-own) will selectively block the immune-addiction response.

The results - which could eventually lead to new co-formulated drugs that assist patients with severe pain, as well as helping heroin users to kick the habit - will be published tomorrow in the Journal of Neuroscience.

"Our studies have shown conclusively that we can block addiction via the immune system of the brain, without targeting the brain's wiring," says the lead author of the study, Dr Mark Hutchinson, ARC Research Fellow in the University of Adelaide's School of Medical Sciences.

"Both the central nervous system and the immune system play important roles in creating addiction, but our studies have shown we only need to block the immune response in the brain to prevent cravings for opioid drugs."

The team has focused its research efforts on the immune receptor known as Toll-Like receptor 4 (TLR4).

"Opioid drugs such as morphine and heroin bind to TLR4 in a similar way to the normal immune response to bacteria. The problem is that TLR4 then acts as an amplifier for addiction," Dr Hutchinson says.

"The drug (+)-naloxone automatically shuts down the addiction. It shuts down the need to take opioids, it cuts out behaviours associated with addiction, and the neurochemistry in the brain changes - dopamine, which is the chemical important for providing that sense of 'reward' from the drug, is no longer produced."

Senior author Professor Linda Watkins, from the Center for Neuroscience at the University of Colorado Boulder, says: "This work fundamentally changes what we understand about opioids, reward and addiction. We've suspected for some years that TLR4 may be the key to blocking opioid addiction, but now we have the proof.

"The drug that we've used to block addiction, (+)-naloxone, is a non-opioid mirror image drug that was created by Dr Kenner Rice in the 1970s. We believe this will prove extremely useful as a co-formulated drug with morphine, so that patients who require relief for severe pain will not become addicted but still receive pain relief . This has the potential to lead to major advances in patient and palliative care," Professor Watkins says.

The researchers say clinical trials may be possible within the next 18 months.

University of Adelaide


Related Morphine Addiction Current Events and Morphine Addiction News Articles


Scientists identify key morphine regulator that may reduce risk of pain-killer abuse
Once used in the 18th century as currency to reverse the trade imbalance between China and Britain, morphine and its pain-killing qualities have been misunderstood (and misused) almost continually ever since.

In animal study, 'cold turkey' withdrawal from drugs triggers mental decline
Can quitting drugs without treatment trigger a decline in mental health? That appears to be the case in an animal model of morphine addiction.

Mount Sinai researchers find mechanism of opiate addiction is completely different from other drugs
Chronic morphine exposure has the opposite effect on the brain compared to cocaine in mice, providing new insight into the basis of opiate addiction, according to Mount Sinai School of Medicine researchers.

A link is found between morphine addiction and the tendency to explore
A team of researchers from the UAB has found experimental evidence in rats showing a link between addiction to morphine and the tendency to explore perseveringly.
More Morphine Addiction Current Events and Morphine Addiction News Articles

Opiate Addiction - How to detox from Opiates (How to Get Off Opiates): SHORT READS - Signs of opiate addiction, Symptoms of opiate use, Signs of opiate ... prescription drugs abuse, heroin addiction)

Opiate Addiction - How to detox from Opiates (How to Get Off Opiates): SHORT READS - Signs of opiate addiction, Symptoms of opiate use, Signs of opiate ... prescription drugs abuse, heroin addiction)


Kick Opiates, Recover From Addiction and Make it Through the Detox Withdrawals (How to detox from opiates, Signs of opiate use, Symptoms of opiate use, How to get off opiates)
***Read this book for FREE on Kindle Unlimited - Download Now!***
Opiate Pain Relievers are now the most commonly prescribed medications in the United States. Prescriptions have climbed up to three hundred percent in the past decade. If used properly opiates can help ease pain from surgery or pain from illnesses like cancer. Such opioid medicines include, but are not limited to Vicodin, Norco, Hydrocodone, Oxycodone, Xanax, Methadone and Percocet. These pain medications do knock out the pain but they can have some serious negative side effects that show as signs and symptoms of opiate use. Addiction is...

Opiate Addiction - The Painkiller Addiction Epidemic, Heroin Addiction and the Way Out

Opiate Addiction - The Painkiller Addiction Epidemic, Heroin Addiction and the Way Out
by Taite Adams (Author)


Opiate Addiction - The Painkiller Addiction Epidemic, Heroin Addiction and the Way Out Now in its 3rd Edition - Get this Best Selling book that has helped thousands. Opiate addiction has reached epidemic proportions in the United States and the problem shows no signs of slowing. Overcoming addiction is tough and, with opiates, many find it nearly impossible. Overdose deaths from prescription painkillers have more than tripled over the last decade and this is just a fraction of the problem. In fact, with prescription opiate addiction now shown to be a gateway drug to heroin, the issue is only getting worse. In 2011 alone, nearly 200,000 people in this country tried heroin for the first time, a drug that can be deadly from its first use.

If you or someone you love is...

Morphine The Phantom of Love

Morphine The Phantom of Love
by Rom Amor


What if your beloved woman has gone in the middle of the storm from your honeymoon yacht? How wouldn’t you search for her, there is the only one key - Morphine. It brings her ghost to your gray day, giving the feeling of previous love. Addiction to hearty feelings or simply drug abuse?

Beauteous young girl, mashed on the widower, could break the circle and rescue him. Shall she?

The distinct novel of her first and his last love packed with twists, deepest emotions and unpredictable ending.


From Chocolate to Morphine: Everything You Need to Know About Mind-Altering Drugs

From Chocolate to Morphine: Everything You Need to Know About Mind-Altering Drugs
by Winifred Rosen (Author), Andrew T. Weil M.D. (Author)


From Chocolate to Morphine is the definitive guide to drugs and drug use from one of America’s most respected and best-known doctors. This enormously popular book — the best and most authoritative resource for unbiased information about how drugs affect the mind and the body — covers a wide range of available substances, from coffee to marijuana, antihistamines to psychedelics, steroids to smart drugs, and discusses likely effects, precautions, and alternatives. Now expanded and updated to cover such drugs as oxycontin, Ecstasy, Prozac, and ephedra and to address numerous ongoing issues, including the United States’ war on drugs, marijuana for therapeutic use, the overuse of drugs for children diagnosed with ADHD, and more, From Chocolate to Morphine is an invaluable...

The Anatomy of Addiction: What Science and Research Tell Us About the True Causes, Best Preventive Techniques, and Most Successful Treatments

The Anatomy of Addiction: What Science and Research Tell Us About the True Causes, Best Preventive Techniques, and Most Successful Treatments
by Akikur Mohammad MD (Author)


As compelling as it is informative and authoritative, The Anatomy of Addiction will lead you to a better understanding about the causes, prevention, and treatment of addiction. It explains in layman's terms what constitutes effective, evidence-based addiction medicine and how to find it.  

This book provides actionable, scientific information for addicts and their families and details how to avoid so-called rehab clinics that are at best useless and at worst dangerous and even life threatening.

Morphine (New Directions Pearls)

Morphine (New Directions Pearls)
by Mikhail Afanasevich Bulgakov (Author), Hugh Aplin (Translator)


From the author of The Master and Margarita comes this short and tragic masterpiece about drug addiction Young Dr. Bromgard has come to a small country town to assume a new practice. No sooner has he arrived than he receives word that a colleague, Dr. Polyakov, has fallen gravely ill. Before Bromgard can go to his friend’s aid, Polyakov is brought to his practice in the middle of the night with a self-inflicted gunshot wound, and, barely conscious, gives Bromgard his journal before dying. What Bromgard uncovers in the entries is Polyakov’s uncontrollable and merciless descent into morphine addiction ― his first injection to ease his back pain, the thrill of the drug as it overtakes him, the looming signs of addiction, and the feverish final entries before his...

The Addiction of Mary Todd Lincoln

The Addiction of Mary Todd Lincoln
by Anne E. Beidler (Author), Sabrina S. Beidler (Cover Design)


Mary Todd Lincoln, wife of the president we have immortalized, has always been difficult for us to understand. She could appear poised and brilliant one moment yet rude and ugly the next. Sometimes competent and strong, able to entertain dignitaries from around the world, at other times she appeared dependent and weak. At times she seemed utterly beside herself with sobbing and screaming. Historians have mostly avoided saying very much about Mary Todd Lincoln except in reference to her husband, Abraham. To many it would seem that Mary Todd Lincoln is still an embarrassment in the tragic story of her martyred husband. But Mary Todd Lincoln lived her own tragic story even before Abraham was murdered. She was an addict, addicted to the opiates she needed for her migraine headaches....

Morphine (Understanding Drugs)

Morphine (Understanding Drugs)
by M. Foster Olive (Author), David J. Triggle (Editor)


Morphine is one of the oldest and most powerful pain relievers. Referred to as an opiate, morphine is one of the main chemicals found in opium, a gooey sap-like substance obtained from the opium poppy. Morphine can produce extraordinary relief from many types of pain, but also produces other effects such as sedation, constipation, lowered pulse and blood pressure, and feelings of extreme pleasure. Morphine and other opiate drugs are often called narcotic drugs, since in high doses they can produce heavy sedation and a sleep- or coma-like state called narcosis. Prolonged use of morphine can result in dependence and addiction, even when the pain that necessitated a prescription for the narcotic has disappeared. This use of prescription narcotic pain relievers for reasons other than pain...

Addiction Unplugged : How To Be Free: For all those affected by their own addictions or the addictions of others

Addiction Unplugged : How To Be Free: For all those affected by their own addictions or the addictions of others
by John Flaherty (Author)


Addiction Unplugged : How To Be Free is for all those affected by their own addictions or the addictions of others. It acknowledges that for far too long, we have all been playing out a victim consciousness, convincing ourselves that dependency and powerlessness are absolutely fundamental to the human condition. Nowhere is this belief more deeply ingrained than in the "world" of addiction and in the traditional treatment and recovery programs available to the masses. Drawing on modern day scientific discoveries, ancient spiritual wisdom and real life testimonies. John Flaherty resources readers with the practical means to move beyond the drama of addictive behaviours; leading the way out from victim mentality and into a more compelling, spiritually liberating and empowered way of living....

The Hunger Fix: The Three-Stage Detox and Recovery Plan for Overeating and Food Addiction

The Hunger Fix: The Three-Stage Detox and Recovery Plan for Overeating and Food Addiction
by Pamela Peeke (Author), Mariska van Aalst (Author)


The body's built-in reward system, driven by the chemical dopamine, tells us to do more of the things that give us pleasure: Creative energy, falling in love, entrepreneurship, and even the continued propagation of the human race are driven by this system. Unfortunately, so is the urge to overeat.In The Hunger Fix, Dr. Pam Peeke uses the latest neuroscience to explain how unhealthy food and behavioral "fixes" have gotten us ensnared in a vicious cycle of overeating and addiction. She even shows that dopamine rushes in the body work exactly the same way with food as with cocaine. Luckily, we are all capable of rewiring, and the very same dopamine-driven system can be used to reward us for healthful, exciting, and fulfilling activities.

The Hunger Fix lays out a science-based,...

© 2016 BrightSurf.com