Science Current Events | Science News | Brightsurf.com
 

Tripping the switches on brain growth to treat depression

August 15, 2012

Depression takes a substantial toll on brain health. Brain imaging and post-mortem studies provide evidence that the wealth of connections in the brain are reduced in individuals with depression, with the result of impaired functional connections between key brain centers involved in mood regulation. Glial cells are one of the cell types that appear to be particularly reduced when analyzing post-mortem brain tissue from people who had depression. Glial cells support the growth and function of nerve cells and their connections.

Over the past several years, it has become increasingly recognized that antidepressants produce positive effects on brain structure that complement their effects on symptoms of depression. These structural effects of antidepressants appear to depend, in large part, on their ability to raise the levels of growth factors in the brain.

In a new study, Elsayed and colleagues from the Yale University School of Medicine report their findings on a relatively novel growth factor named fibroblast growth factor-2 or FGF2. They found that FGF2 can increase the number of glial cells and block the decrease caused by chronic stress exposure by promoting the generation of new glial cells.

Senior author Dr. Ronald Duman said, "Our study uncovers a new pathway that can be targeted for treating depression. Our research shows that we can increase the production and maintenance of glial cells that are important for supporting neurons, providing an enriched environment for proper neuronal function."

To study whether FGF2 can treat depression, the researchers used rodent models where animals are subjected to various natural stressors, which can trigger behaviors that are similar to those expressed by depressed humans, such as despair and loss of pleasure. FGF2 infusions restored the deficit in glial cell number caused by chronic stress. An underlying molecular mechanism was also identified when the data showed that antidepressants increase glial generation and function via increasing FGF2 signaling.

"Although more research is warranted to explore the contribution of glial cells to the antidepressant effects of FGF2, the results of this study present a fundamental new mechanism that merits attention in the quest to find more efficacious and faster-acting antidepressant drugs," concluded Duman.

"The deeper that science digs into the biology underlying antidepressant action, the more complex it becomes. Yet understanding this complexity increases the power of the science, suggesting reasons for the limitations of antidepressant treatment and pointing to novel approaches to the treatment of depression," commented Dr. John Krystal, Editor of Biological Psychiatry and Chairman of the Department of Psychiatry at the Yale University School of Medicine.

Elsevier


Related Depression Current Events and Depression News Articles


Mapping neural networks to strengthen circadian rhythms
If you've ever felt groggy the morning after traversing time zones, you can thank the temporary mismatch between your body's 24-hour circadian rhythm and your new local time.

Maternal inflammation boosts serotonin and impairs fetal brain development in mice
Fighting the flu during pregnancy sickens a pregnant woman, but it may also put the fetus at a slightly increased risk for neurodevelopmental disorders like autism later in life.

Ever-changing moods may be toxic to the brain of bipolar patients
Bipolar disorder (BD) is a severe and complex mental illness with a strong genetic component that affects 2% of the world population. The disorder is characterized by episodes of mania and depression that may alternate throughout life and usually first occur in the early 20s.

Study shows patients require less painkilling medication after breast-cancer surgery if they have opiate-free anesthesia
New research presented at Euroanaesthesia 2016 (London 27-30 May) shows that patients undergoing breast cancer surgery need less painkilling medication post-surgery if they have anaesthesia that is free of opioid drugs.

Increased marrying, and mating, by education level not affecting genetic make-up
While the latter half of the 20th century showed a widening gap between the more and less educated with respect to marriage and fertility, this trend has not significantly altered the genetic makeup of subsequent generations, a team of researchers has found.

Brain structure that tracks negative events backfires in depression
A region of the brain that responds to bad experiences has the opposite reaction to expectations of aversive events in people with depression compared to healthy adults, finds a new UCL study funded by the Medical Research Council.

New findings linking abnormalities in circadian rhythms to neurochemical to changes in specific neurotransmitters
Results of the first study of its kind to link abnormalities in circadian rhythms to changes in specific neurotransmitters in people with bipolar disorder will be published this week in the journal Biological Psychiatry.

Researchers find new signs of stress damage in the brain, plus hope for prevention
Chronic stress can make us worn-out, anxious, depressed--in fact, it can change the architecture of the brain. New research at The Rockefeller University shows that when mice experience prolonged stress, structural changes occur within a little-studied region of their amygdala, a part of the brain that regulates basic emotions, such as fear and anxiety.

Multiple personality disorder may be rooted in traumatic experiences
A new King's College London study supports the notion that multiple personality disorder is rooted in traumatic experiences such as neglect or abuse in childhood, rather than being related to suggestibility or proneness to fantasy.

Workaholism tied to psychiatric disorders
Researchers at the University of Bergen in Norway have examined the associations between workaholism and psychiatric disorders among 16,426 working adults.
More Depression Current Events and Depression News Articles

The Depression Cure: The 6-Step Program to Beat Depression without Drugs

The Depression Cure: The 6-Step Program to Beat Depression without Drugs
by Stephen S. Ilardi (Author)


In the past decade, depression rates have skyrocketed, and one in four Americans will suffer from major depression at some point in their lives. Where have we gone wrong? Dr. Stephen Ilardi sheds light on our current predicament and reminds us that our bodies were never designed for the sleep-deprived, poorly nourished, frenzied pace of twenty-first century life.Inspired by the extraordinary resilience of aboriginal groups like the Kaluli of Papua New Guinea, Dr. Ilardi prescribes an easy-to-follow, clinically proven program that harks back to what our bodies were originally made for and what they continue to need. The Depression Cure program has already delivered dramatic results, helping even those who have failed to respond to traditional medications.

Depression & Other Magic Tricks

Depression & Other Magic Tricks
by Sabrina Benaim (Author)


Depression & Other Magic Tricks is the debut book by Sabrina Benaim, one of the most-viewed performance poets of all time, whose poem "Explaining My Depression to My Mother" has become a cultural phenomenon with over 5,000,000 views. Depression & Other Magic Tricks explores themes of mental health, love, and family. It is a documentation of struggle and triumph, a celebration of daily life and of living. Benaim's wit, empathy, and gift for language produce a work of endless wonder.

Hardcore Self Help: F**k Depression (Volume 2)

Hardcore Self Help: F**k Depression (Volume 2)
by Robert Duff Ph.D. (Author)


Hardcore Self Help: F**k Depression is the follow up to the best-selling F**K Anxiety. In this book I take the information, tips, and insights that I have gained as a psychologist and translate them into language that doesn’t suck. This is the self-help book for people that don’t usually like self-help books. In Hardcore Self Help: F**K Depression, I talk to you like a friend. That means I speak directly to you without psychobabble. Instead I tell you why your brain is such a troll. I explain why you have literally no energy or motivation. I tell you why people are so terrible at offering help. Best of all, I tell you how to take realistic steps toward solving these and many other issues caused by depression.

The Mindful Way Through Depression: Freeing Yourself from Chronic Unhappiness (Book & CD)

The Mindful Way Through Depression: Freeing Yourself from Chronic Unhappiness (Book & CD)
by Mark Williams (Author), John Teasdale (Author), Zindel Segal (Author), Jon Kabat-Zinn (Author)


If you’ve ever struggled with depression, take heart. Mindfulness, a simple yet powerful way of paying attention to your most difficult emotions and life experiences, can help you break the cycle of chronic unhappiness once and for all.

In The Mindful Way through Depression, four uniquely qualified experts explain why our usual attempts to “think” our way out of a bad mood or just “snap out of it” lead us deeper into the downward spiral. Through insightful lessons drawn from both Eastern meditative traditions and cognitive therapy, they demonstrate how to sidestep the mental habits that lead to despair, including rumination and self-blame, so you can face life’s challenges with greater resilience. Jon Kabat-Zinn gently and encouragingly narrates the accompanying...

The Upward Spiral: Using Neuroscience to Reverse the Course of Depression, One Small Change at a Time

The Upward Spiral: Using Neuroscience to Reverse the Course of Depression, One Small Change at a Time
by Alex Korb PhD (Author), Daniel J. Siegel MD (Foreword)


Depression can feel like a downward spiral, pulling you into a vortex of sadness, fatigue, and apathy. In The Upward Spiral, neuroscientist Alex Korb demystifies the intricate brain processes that cause depression and offers a practical and effective approach to getting better. Based on the latest research in neuroscience, this book provides dozens of straightforward tips you can do every day to rewire your brain and create an upward spiral towards a happier, healthier life.
 
Whether you suffer from depression or just want a better understanding of the brain, this book offers an engaging and informative look at the neuroscience behind our emotions, thoughts, and actions. The truth is that there isn’t one big solution to depression, but there are numerous simple steps you can...

Depression: 101 Powerful Ways To Beat Depression, Stress, Anxiety And Be Happy NATURALLY! (Depression and Anxiety, Depression cure, Depression self help)

Depression: 101 Powerful Ways To Beat Depression, Stress, Anxiety And Be Happy NATURALLY! (Depression and Anxiety, Depression cure, Depression self help)


New and Improved - 2nd Edition. Now packed with even more information.
Invite happiness into your life by learning 101 powerful NATURAL techniques which will help you keep away from Depression, Stress and Anxiety forever.

This book contains actionable strategies on how to beat depression and be happy always. The steps mentioned in this book are extremely simple but very powerful and when practiced over a period of time can really make a difference to one’s life and overall personality.

Depression affects millions of people worldwide. In fact, it is as common as ‘common cold’. Recognizing the problem is the first step but unfortunately, many a times, people do not even realize they are going through depression.

This book will educate you on how...

How to Be Happy (Or at Least Less Sad): A Creative Workbook

How to Be Happy (Or at Least Less Sad): A Creative Workbook
by Lee Crutchley (Author), Oliver Burkeman (Foreword)


Author and illustrator Lee Crutchley brings his lively interactive approach to a little-discussed but very common issue: the struggle with depression and anxiety.
 
Through a series of supportive, surprising, and engaging prompts, HOW TO BE HAPPY (OR AT LEAST LESS SAD) helps readers see things in a new light, and rediscover simple pleasures and everyday joy…or at least feel a little less sad. By turns a workbook, trusted friend, creative outlet, security blanket, and secret diary, the pages of this book will offer solace, distraction, engagement, a fresh perspective, and hopeful new beginnings—for readers of all ages and walks of life.

Depression Treatment: Be Happier and Love Your Life

Depression Treatment: Be Happier and Love Your Life


Depression Treatment. Be Happier and Love Your Life
Dear Friends!
Problems. All of us have Problems with the job, with family, maybe with friends. Anything, but problems.
Those problems lead to Depression and everything only makes worse.
What is that? What kind of depression can be? What is the cause?
Understand it! Treat it! Beat it!
Depression treatment – is a cure, is a way to be happy again! And I know few ways how WE can do that. Depression is a real danger. Don’t waste your time, JUST BEAT DEPRESSION!!!
Just few hours with this book gives you the vision of Depression Treatment. Pros and cons to all the methods. The decision is up to you, but I can give you “real weapon” to Beat Depression.

Please, check the methods and other...

Depression-Free, Naturally: 7 Weeks to Eliminating Anxiety, Despair, Fatigue, and Anger from Your Life

Depression-Free, Naturally: 7 Weeks to Eliminating Anxiety, Despair, Fatigue, and Anger from Your Life
by Joan Mathews Larson PhD (Author)


In this groundbreaking book, nutritionist Joan Mathews Larson, Ph.D., founder of Minnesota's esteemed Health Recovery Center, offers her revolutionary formulas for healing your emotions--biochemically. Through proven all-natural formulas, Seven Weeks to Emotional Healing will help you find the emotional well-being you've been missing your entire life. Inside you'll discover how to

- Screen yourself for emotional and behavioral symptoms
- Recognize the mental and physical clues that indicate biochemical imbalances
- Heal your depression and anxiety with the right vitamins and minerals
- Stabilize your mood swings and protect your well-being with essential fatty acids
- Choose the right foods for optimal mental fitness
- Rejuvenate your body with key natural...

Retrain Your Brain: Cognitive Behavioral Therapy in 7 Weeks: A Workbook for Managing Depression and Anxiety

Retrain Your Brain: Cognitive Behavioral Therapy in 7 Weeks: A Workbook for Managing Depression and Anxiety
by Seth J. Gillihan PhD (Author)


Masterfully written with relatable examples, Cognitive Behavioral Therapy in 7 Weeks allows the reader to quickly connect and feel understood, and offers hope for those who are looking to regain control over their life. ―DR. ROBIN ZASIO, Psy. D., LCSW, director of The Anxiety Treatment Center of Sacramento, featured doctor on the A&E series HoardersCognitive Behavioral Therapy (CBT) has proven to be the tipping point through which many people are finally able to make significant changes and break free of anxiety and depression. Cognitive Behavioral Therapy in 7 Weeks is an interactive workbook that outlines a simple, practical plan that occurs over the course of 7 weeks, and offers real, tangible relief from anxiety and depression. This is a cumulative workbook―the work you do each...

© 2017 BrightSurf.com