 |
|
Cell Migration And Inflammation
February 23, 2005Chronic inflammation comprises a vast array of diseases that affect millions of people worldwide. Chronic inflammatory diseases include asthma, arthritis, atherosclerosis, Alzheimer's disease, autoimmune diseases and allergies, to name but a few.
A common theme to all of the above diseases is that the inflammatory response, originally aimed at recognizing and eliminating foreign "pathogens" or damaging agents, overreacts to them and causes tissue damage that can be detrimental to the patient.
How to limit such overreaction without compromising the efficiency of the inflammatory response is a phenomenal challenge faced by scientists and clinicians working in this field. Our current therapeutic tools, in particular anti-inflammatory drugs and steroids, fall short of accomplishing such a task as they can decrease the patient's natural defence mechanisms and produce a host of undesirable side effects.
The scientific goal of the MAIN Network of Excellence is to identify and characterize the molecular mechanisms underlying chronic inflammatory responses, with emphasis on a crucial step in such responses, namely the transmigration of leukocytes ("white blood cells") from the bloodstream into inflamed tissues and their local activation by inflammatory substances and pathogens.
To achieve this goal, MAIN has gathered over 150 researchers and graduate students from 13 research institutes and 2 biotechnology companies of five EU member states as well as Switzerland and Israel. MAIN will be co-funded by the EU with a 10 MEUR grant over a four year period.
The international dimension of MAIN is further emphasized by the strong connection existing between MAIN scientists and the US Cell Migration Consortium (CMC), whose goal is to explore the complex mechanisms underlying cell migration in embryonic development, wound healing and cancer. MAIN and CMC will share information and technology platforms and will develop a coordinated agenda of scientific events in order to communicate their scientific achievements to a wider scientific audience as well as to the general public.
MAIN - Network of Excellence
The scientific goal of the MAIN Network of Excellence is to identify and characterize the molecular mechanisms underlying chronic inflammatory responses, with emphasis on a crucial step in such responses, namely the transmigration of leukocytes ("white blood cells") from the bloodstream into inflamed tissues and their local activation by inflammatory substances and pathogens.
To achieve this goal, MAIN has gathered over 150 researchers and graduate students from 13 research institutes and 2 biotechnology companies of five EU member states as well as Switzerland and Israel. MAIN will be co-funded by the EU with a 10 MEUR grant over a four year period.
The international dimension of MAIN is further emphasized by the strong connection existing between MAIN scientists and the US Cell Migration Consortium (CMC), whose goal is to explore the complex mechanisms underlying cell migration in embryonic development, wound healing and cancer. MAIN and CMC will share information and technology platforms and will develop a coordinated agenda of scientific events in order to communicate their scientific achievements to a wider scientific audience as well as to the general public.
MAIN - Network of Excellence
Atherosclerosis Current Events and Atherosclerosis News RSSEstrogen therapy could be dangerous for women with existing heart risk
Hormone therapy could accentuate certain pre-existing heart disease risk factors and a heart health evaluation should become the norm when considering estrogen replacement, new research suggests.
Researchers identify how binge drinking may drive heart disease
As the holidays arrive, a group of researchers has identified the precise mechanisms by which binge drinking contributes to clogs in arteries that lead to heart attack and stroke, according to a study published today in the journal Atherosclerosis.
A scientific breakthrough on the control of the bad cholesterol
A study performed by the team of Dr. Nabil G. Seidah, Director of the Biochemical Neuroendocrinology Research Unit at the IRCM, shows for the very first time that the degradation by PCSK9 of the LDLR receptor
Bad cholesterol inhibits the breakdown of peripheral fat
he so called bad cholesterol (LDL) inhibits the breakdown of fat in cells of peripheral deposits, according to a study from the Swedish medical university Karolinska Institutet. The discovery reveals a novel function of LDL as a regulator of fat turnover besides its well-established detrimental effects in promoting atherosclerosis.
Vitamin C lowers levels of heart disease biomarker, finds study, adds to debate of health benefits
A new study led by researchers at the University of California, Berkeley, adds to the evidence that vitamin C supplements can lower concentrations of C-reactive protein (CRP), a central biomarker of inflammation that has been shown to be a powerful predictor of heart disease and diabetes.
Genetics for personalized coronary heart disease treatment
Identifying a single, common variation in a person's genetic information improves prediction of his or her risk of a heart attack or other heart disease events and thus, choice of the best treatment accordingly, said researchers at Baylor College of Medicine in Houston.
Low risk for heart attack? Could an ultrasound hold the answer?
By adding the results of an imaging technique to the traditional risk factors for coronary heart disease, doctors at Baylor College of Medicine in Houston found they were able to improve prediction of heart attacks in people previously considered low risk.
Low-dose aspirin does not appear to reduce risk of CV events in patients with diabetes
Low-dose aspirin as primary prevention did not appear to significantly reduce the risk of a combined end point of coronary, cerebrovascular and peripheral vascular events in patients with type 2 diabetes, according to a new study in JAMA.
Friend or foe? How the body's clot-busting system speeds up atherosclerosis
Sometimes it's hard to tell friends from foes, biologically speaking. Naturally produced in the body, urokinase plasminogen activator and plasminogen interact to break up blood clots and recruit clean-up cells to clear away debris related to inflammation. In fact, urokinase manufactured as a drug effectively clears clogged arteries by generating clot-busting plasmin from blood-derived plasminogen.
Mounting evidence shows health benefits of grape polyphenols
A growing body of research data suggests that consuming foods rich in polyphenols from grapes, including red wine, helps reduce the risk of heart disease, according to a review article in the November issue of Nutrition Research.
More Atherosclerosis Current Events and Atherosclerosis News Articles
 | Unclog Your Arteries : How I Beat Atherosclerosis by Gene McDougall Heart attack or bypass surgery? - or even if not- if you are overweight, have high blood pressure, high blood sugar, diabetes, high cholesterol, heart disease, or a family history of any, read this and then keep it for... |
 | Molecular Mechanisms of Atherosclerosis Atherosclerosis is the most common cardiovascular disorder in western societies and is rapidly becoming similarly prevalent in the underdeveloped world. Written by notable authorities and providing text rich in illustrative figures, Molecular Mechanisms in Atherosclerosis addresses the fundamental mechanisms underlying atherothrombosis and delineates current views of the molecular and cellular... |
 | Atherosclerosis and Heart Disease Exploring the entire range of recent advances, Atherosclerosis and Heart Disease covers all aspects of atherosclerotic disease, including chronic manifestations, bypass surgery, stroke prevention and methods to lower blood pressure. Prof. Tonkin brings together a team of internationally-recognized experts to discuss sound clinical practices, based on scientific research and publications. They... |
 | Biochemistry of Atherosclerosis (Advances in Biochemistry in Health and Disease) At its present rate of growth, atherosclerosis will be the major cause of death from disease by the year 2020. Atherosclerosis is an extremely complex, biochemical, multifactorial process. This book will cover many aspects of atherogenesis, with particular emphasis on lipid and lipoprotein metabolism. We will cover all aspects of the regulation of cholesterol homeostasis and the importance of... |
 | Atlas of Atherosclerosis Progression and Regression, Second Edition (The Encyclopedia of Visual Medicine Series) by Herbert C. Stary Completely revised and updated, the Second Edition of the Atlas of Atherosclerosis Progression and Regression contains new material and new illustrations from Dr. Stary's groundbreaking work in the field of atherosclerosis diagnosis, prevention, and treatment. Over 100 photographs show arterial and lesion structure and individual components in unprecedented detail. These images allow you to... |
 | The Nutritional Bypass : Reverse Atherosclerosis Without Surgery by David W. Rowland Did you know that there is a time tested, safe, non-surgical method of removing arterial blockages-without side effects? Severe arterial blockages do not have to lead to coronary bypass surgery or heart attacks. Inside this book is a complete program for successfully reversing and preventing hardening of the arteries. You may be surprised to know that cholesterol is not the cause of heart... |
 | Focus On Atherosclerosis Research Atherosclerosis is a degenerative condition in which arteries build up deposits called plaques (atheromas) which consist of lipids (mainly cholesterol), connective tissue and smooth muscle cells originating from the arterial wall. Plaques develop quietly over a period of years and are unnoticeable until there is an interruption in the normal flow of blood. Plaques may partially or totally block... |
 | Atherosclerosis: Experimental Methods and Protocols (Methods in Molecular Medicine) (Methods in Molecular Medicine) Children's Hospital Research Foundation, Cincinnati, OH. Enables biomedical researchers to select those optimized techniques that may be used to study the development, progression, and treatment of atherosclerotic lesions. Outline... |
 | Atlas of Atherosclerosis : Risk Factors and Treatment by Scott M. Grundy (Editor) This new edition is an intergral source of information covering topics such as newer coronary risk factors, high- density lipoprotein metabolism, lipid-lowering drugs, endothelium and thrombosis in atherogenesis, and contributing risk factors. With over 500 exceptional photographs, diagrams, and charts, each chapter illustrates an improtant facet of diagnosing and treating this common and often... |
 | Non-Invasive Imaging of Atherosclerosis (Developments in Cardiovascular Medicine) Non-Invasive Imaging of Atherosclerosis is a primer, reference and review of some of the key features of current activities in the field of atherosclerosis. The Editors' goal is to provide material and stimulating ideas to basic scientists and clinical researchers in order to extend the application of vascular imaging and to further develop methods suitable for investigation of the arterial ... |
| © 2008 BrightSurf.com |