Science Current Events | Science News | Brightsurf.com
 

MRI findings shed light on multiple sclerosis

August 21, 2012
OAK BROOK, Ill. - New magnetic resonance imaging (MRI) research shows that changes in brain blood flow associated with vein abnormalities are not specific for multiple sclerosis (MS) and do not contribute to its severity, despite what some researchers have speculated. Results of the research are published online in the journal Radiology.

"MRI allowed an accurate evaluation of cerebral blood flow that was crucial for our results," said Simone Marziali, M.D., from the Department of Diagnostic Imaging at the University of Rome Tor Vergata in Rome.

MS is a disease of the central nervous system in which the body's immune system attacks the nerves. There are different types of MS, and symptoms and severity vary widely. Recent reports suggest a highly significant association between MS and chronic cerebrospinal venous insufficiency (CCSVI), a condition characterized by compromised blood flow in the veins that drain blood from the brain. This strong correlation has generated substantial attention from the scientific community and the media in recent years, raising the possibility that MS can be treated with endovascular procedures like stent placement. However, the role of brain blood flow alterations on MS patients is still unclear.

To investigate this further, Italian researchers compared brain blood flow in 39 MS patients and 26 healthy control participants. Twenty-five of the MS patients and 14 of the healthy controls were positive for CCSVI, based on Color-Doppler-Ultrasound (CDU) findings. The researchers used dynamic susceptibility contrast-enhanced (DSC) MRI to assess blood flow in the brains of the study groups. DSC MR imaging offers more accurate assessment of brain blood flow than that of CDU. MRI and CDU were used to assess two different anatomical structures.

While CCSVI-positive patients showed decreased cerebral blood flow and volume compared with their CCSVI-negative counterparts, there was no significant interaction between MS and CCSVI for any of the blood flow parameters. Furthermore, the researchers did not find any correlation between the cerebral blood flow and volume in the brain's white matter and the severity of disability in MS patients.

The results suggest that CCSVI is not a pathological condition correlated with MS, according to Dr. Marziali, but probably just an epiphenomenon-an accessory process occurring in the course of a disease that is not necessarily related to the disease. This determination is important because, to date, studies of the prevalence of CCSVI in MS patients have provided inconclusive results.

"This study clearly demonstrates the important role of MRI in defining and understanding the causes of MS," Dr. Marziali said. "I believe that, in the future, it will be necessary to use powerful and advanced diagnostic tools to obtain a better understanding of this and other diseases still under study."

Radiological Society of North America


Related Multiple Sclerosis Current Events and Multiple Sclerosis News Articles


Discovery of a treatment to block the progression of multiple sclerosis
A drug that could halt the progression of multiple sclerosis may soon be developed thanks to a discovery by a team at the CHUM Research Centre and the University of Montreal.

Multiple sclerosis: Scientists ID cause of movement, balance problems
New research into the causes of the excessive inflammation that drives multiple sclerosis has identified a faulty "brake" within immune cells, a brake that should be controlling the inflammation.

Antiviral compound may protect brain from pathogens, West Nile virus study shows
Researchers have found that an antiviral compound may protect the brain from invading pathogens.

Study implicates new gene in multiple sclerosis disease activity
A new study led by investigators at Brigham and Women's Hospital (BWH) reports the discovery of a genetic variant that is associated with a patient's likelihood of responding to interferon-beta, one of the medications used in treating multiple sclerosis (MS).

TSRI scientists identify interferon beta as likely culprit in persistent viral infections
Interferon proteins are normally considered virus-fighters, but scientists at The Scripps Research Institute (TSRI) have found evidence that one of them, interferon beta (IFNβ), has an immune-suppressing effect that can help some viruses establish persistent infections.

Joslin research discovery provides insight into development of autoimmunity
Joslin researchers have uncovered the action of a gene that regulates the education of T cells, providing insight into how and why the immune system begins mistaking the body's own tissues for targets.

Vitamin D levels predict survival chances for sick cats, study finds
Cats may hold vital clues about the health benefits of vitamin D, a study suggests.

Seasonal immunity: Activity of thousands of genes differs from winter to summer
Our immune systems vary with the seasons, according to a study led by the University of Cambridge that could help explain why certain conditions such as heart disease and rheumatoid arthritis are aggravated in winter whilst people tend to be healthier in the summer.

Finding should enhance treatments that stop immune system attack
Scientists at The University of Manchester have made an important discovery about an immune cell which is already being used in immunotherapy to treat diseases such as type I diabetes.

Researchers discover how cocaine, amphetamines disrupt the brain's normal functioning
In a major advance in the field of neuropsychiatry, researchers in the Vollum Institute at Oregon Health & Science University have illuminated how cocaine and amphetamines disrupt the normal functioning of the dopamine transporter in the brain.
More Multiple Sclerosis Current Events and Multiple Sclerosis News Articles

Multiple Sclerosis: A Comprehensive Review

Multiple Sclerosis: A Comprehensive Review
by CME Resource/NetCE


The purpose of this course is to provide a comprehensive review of current knowledge regarding multiple sclerosis, emphasizing new developments with respect to detection and treatment options, in order to improve patient care. In addition, members of the public may use this course to enhance their personal knowledge of the subject matter presented.

Upon completion of this course, you should be able to:

1. Describe the risk factors for multiple sclerosis (MS).
2. Define the etiology and pathophysiology of MS.
3. Identify common signs and symptoms of MS.
4. Compare and contrast early-onset and late-onset MS.
5. Distinguish between the various MS disease courses, including relapsing-remitting, primary progressive, and secondary progressive...

Multiple Sclerosis: How to Heal Your Chronic Autoimmune Condition through Diet, Exercise & Lifestyle Changes (Multiple Sclerosis, Multiple Sclerosis Diet, ... Autoimmune Diet, Autoimmune Disease)

Multiple Sclerosis: How to Heal Your Chronic Autoimmune Condition through Diet, Exercise & Lifestyle Changes (Multiple Sclerosis, Multiple Sclerosis Diet, ... Autoimmune Diet, Autoimmune Disease)


Learn How to Reverse Your Multiple Sclerosis Symptoms Naturally
Today only, get this Amazon bestseller for just $0.99. Regularly priced
at $4.99. Read on your PC, Mac, smart phone, tablet or Kindle device.

You’re about to discover how to use diet, exercise, and lifestyle changes to reverse you multiple sclerosis. Millions of people around the world suffer from the debilitating affects of MS. Many see multiple doctors and are placed on immunosuppressant medications in order to stop their symptoms. Unfortunately, this approach does not address the underlying cause and promote the bodies ability to heal.

The truth is MS can be a very serious and limiting disease. In this book, we provide a step-by-step guide at how to make simple lifestyle changes in...

Multiple Sclerosis For Dummies

Multiple Sclerosis For Dummies
by Rosalind Kalb (Author), Barbara Giesser (Author), Kathleen Costello (Author)


Your trusted, compassionate guide to living with MS Being diagnosed with multiple sclerosis (MS) doesn't mean your life is over. Everyone's MS is different and no one can predict exactly what yours will be like. The fact is, lots of people live their lives with MS without making a full-time job of it. Multiple Sclerosis For Dummies gives you accessible, easy-to-understand information about what happens with MS—what kinds of symptoms it can cause, how it can affect your life at home and at work, what you can do to feel and function better, and how you can protect yourself and your family against the long-term unpredictability of the disease. You'll learn how to make treatment and lifestyle choices that work for you, what qualities to look for in a neurologist and the rest of your...

Healing Multiple Sclerosis: Diet, Detox & Nutritional Makeover for Total Recovery, New Revised Edition

Healing Multiple Sclerosis: Diet, Detox & Nutritional Makeover for Total Recovery, New Revised Edition
by Ann Boroch (Author)


This new, expanded edition (revised in 2014) gives a breakthrough treatment protocol that can restore health to those with multiple sclerosis. Even though MS is widely believed to be unbeatable, Ann Boroch, certified nutritional consultant and naturopath, has developed a breakthrough treatment protocol that is having dramatic results.
 
This landmark work describes how she cured herself of MS using complementary medicine, the real causes of MS, case histories of those who have triumphed over multiple sclerosis, and a comprehensive how-to section that will show you how to develop your own treatment plan.

Healing Multiple Sclerosis contains everything you need to know to bring about recovery, including:

A detailed and effective self-help treatment plan Delicious...

Multiple Sclerosis: How I Reversed My Chronic Autoimmune Symptoms By Making Simple Changes To The Way I Eat

Multiple Sclerosis: How I Reversed My Chronic Autoimmune Symptoms By Making Simple Changes To The Way I Eat
by Talent Writers


Can you beat Multiple Sclerosis by changing your eating habits? Yes, you can! Having suffered from this progressive autoimmune disease for many years, I finally beat my symptoms simply by

To help you understand this miracle plan, I start by laying down the basic ground rules for eating right, providing you with a list of foods and other secrets of success that I used to initiate detoxification and support better brain health. I also use this book as a personal diary, chronicling the improvements in my condition day by day, as a progress from being virtually immobile to being able to run - yes, run! - on a treadmill. It’s the real deal that allowed me to improve, reverse and overcome the debilitating symptoms of MS.

Is this diet right for you? Read my personal...

Awkward Bitch: My Life with MS

Awkward Bitch: My Life with MS
by Marlo Donato Parmelee (Author)


Book by Parmelee, Marlo Donato

Multiple Sclerosis

Multiple Sclerosis
by T. Jock Murray MD (Author), Carol Saunders BA BSN MSCN (Author), Nancy Holland RN EdD (Author)


This book has been written for those newly diagnosed with multiple sclerosis. It is a guide to learning about the disease, its potential impact on your life, and the medical treatments now available for managing it successfully. This is a time of great excitement in research and advances in clinical management, such that most people who have multiple sclerosis can lead full and productive lives. This fourth edition is current and updated throughout, and includes a review of the controversy surrounding CCVSI and multiple sclerosis, discussion of the new pill Gelenya and other drugs in development for multiple sclerosis, new information on the drug Tysabri, and discussion of treatments and complementary and alternative medicine in MS. This the place to begin your education about MS.

Optimal Health with Multiple Sclerosis: A Guide to Integrating Lifestyle, Alternative, and Conventional Medicine

Optimal Health with Multiple Sclerosis: A Guide to Integrating Lifestyle, Alternative, and Conventional Medicine
by Allen C. Bowling MD PhD (Author)


For everyone in the MS community, the only source for reliable, evidence-based information on the relevance, safety, and effectiveness of various alternative and lifestyle medicine approaches to MS treatment and the best ways to safely integrate them with conventional medicine In addition to conventional medicine, many people with MS also use some form of alternative medicine and there is growing evidence and interest in the effects of lifestyle factors, such as diet and exercise, on MS. Yet, until now, it has been difficult to obtain unbiased and practical information about the MS-relevant aspects of these non-medication approaches. Written by a renowned specialist in MS and alternative medicine, Optimal Health with Multiple Sclerosis provides the accurate and unbiased information...

Overcoming Multiple Sclerosis: An Evidence-Based Guide to Recovery

Overcoming Multiple Sclerosis: An Evidence-Based Guide to Recovery
by Professor George Jelinek (Author)


A research-based approach to treating the devastating neurological condition multiple sclerosis, based on a combination of drug treatment and lifestyle modifications Multiple sclerosis (MS) is a serious, progressively disabling condition for which current medical treatment is not particularly effective and has many side effects, however, this guide provides a genuine alternative. Through an exhaustive, evidence-based analysis of medical research, the study concludes that MS is a disease largely determined by lifestyle factors. Showing that people with MS who modify their diet, their exercise habits, and other aspects of their lifestyle can stabilize the illness and potentially recover, these recommendations will change the lives of thousands of people with MS and support their loved...

Overcome The BS of MS: A 3-Step Plan For Women Living With Multiple Sclerosis

Overcome The BS of MS: A 3-Step Plan For Women Living With Multiple Sclerosis


Having lived with Multiple Sclerosis (“MS”) herself since 2001, author Lisa Cohen defines the “BS of MS” as an amalgam of the physical changes and losses caused by MS, the life changes and challenges that result, and the psychological and emotional “stuff” that comes along with those changes and challenges. This BS of MS may cause women living with MS to “live small,” feel burdened, and feel defeated on a daily basis. An easy-read reference handbook, “Overcome the BS of MS” provides a 3-Step Plan that is a system of preparation, personal empowerment, and conscious forward action that is designed to help women living with MS to consistently overcome the BS of MS.

“Overcome the BS of MS” is for any woman who wants to truly feel like she is actively...

© 2015 BrightSurf.com