Science Current Events | Science News |

Brain radiation after lung cancer treatment reduces risk of cancer spreading

September 07, 2012
Stage III non-small cell lung cancer (NSCLC) patients treated with surgery and/or radiation therapy have a significantly reduced risk of developing brain metastases if they also receive prophylactic cranial irradiation (PCI); however, this study did not show an improvement in overall survival with PCI, according to research presented at the 2012 Chicago Multidisciplinary Symposium in Thoracic Oncology. This symposium is sponsored by the American Society of Clinical Oncology (ASCO), the American Society for Radiation Oncology (ASTRO), the International Association for the Study of Lung Cancer (IASLC) and The University of Chicago.

Patients with non-small cell lung cancer that has not spread outside the chest have a high incidence of brain metastases after receiving treatment for their primary cancer. Radiation to the brain has been proven to decrease the chance of cancer spreading to the brain and to improve overall survival in small cell lung cancer, but its benefits to NSCLC patients are unproven.

Researchers in this study examined 340 stage III NSCLC patients who had received surgery and/or radiation therapy with or without chemotherapy. Patients were randomly assigned to receive PCI or to not receive the additional treatment (observational arm). After a median follow-up time of 24.2 months for all patients and 58.6 months for living patients, the rates of overall survival for the PCI arm versus the observational arm were 26.1 percent versus 24.6 percent, respectively. However, the rate of brain metastases for the PCI arm was much lower at 17.3 percent versus 26.8 percent for the observational arm.

"This is important confirmatory information regarding the effectiveness of brain radiation in decreasing the rate of brain failures. Unfortunately this study was very difficult to enroll patients on and ultimately did not accrue enough patients to answer the primary question-Does PCI improve overall survival in patients with locally advanced NSCLC?," said Elizabeth Gore, MD, lead author of the study and a professor of radiation oncology at the Medical College of Wisconsin in Milwaukee. "I'd like to emphasize the need for participation in clinical trials. This is particularly important in lung cancer, which is understudied despite being the leading cause of cancer death in the United States."

The abstract, "Phase III Comparison of Prophylactic Cranial Irradiation Versus Observation in Patients with Locally Advanced Non-small-cell Lung Cancer: Updated Analysis of RTOG 0214," will be presented during the Plenary Session at 12:30 p.m., Central time on September 7, 2012.

American Society for Radiation Oncology (ASTRO)

Related Lung Cancer Current Events and Lung Cancer News Articles

Lung cancer screening programs do not increase rates of unnecessary surgeries
Lung cancer screening programs that utilize standardized reporting and include cardiothoracic surgeons as part of a multidisciplinary team can successfully be adopted into clinical practice without an increase in surgical intervention for non-cancerous disease, according to an article in the October 2015 issue of The Annals of Thoracic Surgery.

Doctors often overtreat with radiation in late-stage lung cancer
Almost half of patients with advanced lung cancer receive more than the recommended number of radiation treatments to reduce their pain, according to a new study published in the Journal of the National Cancer Institute.

First 'targeted' treatment for small cell lung cancer shows promise
Small cell lung cancer (SCLC) is an aggressive disease that is difficult to treat and is frequently only diagnosed when it has spread to other parts of the body (metastasised).

Word 'breakthrough' dramatically affects perceptions of a new drug's effectiveness
When it comes to our perception of a new drug's benefits and effectiveness, "breakthrough" just may be the "magic" word.

Breakthrough study demonstrates survival advantage with immune checkpoint inhibitor for advanced kidney cancer patients
For the first time, an immune checkpoint inhibitor has been proven to increase survival among patients with advanced renal cell carcinoma (RCC), a patient population for whom treatment options are currently limited.

COPD heightens deadly lung cancer risk in smokers
Smokers who have chronic obstructive pulmonary disorder (COPD) may face nearly twice the risk of getting small cell lung cancer (SCLC)--the deadliest form of lung cancer--than smokers who don't have COPD, according to a large worldwide study led by researchers at the Harvard T.H. Chan School of Public Health.

Lung cancer survival rates improve with CT scan follow-up
Patients with recurrent lung cancer have better post-surgery survival rates if their management includes a follow-up programme based on computer tomography (CT) of the chest, according to new findings.

Differences found between smokers and non-smokers who develop lung cancer
Tobacco smoke is known to be the main risk factor for non-small cell lung cancer (NSCLC), although non-smokers can get it too.

Nivolumab improves the proportion of lung cancer patients alive after more than a year
Patients with a type of lung cancer called non-squamous non-small cell lung cancer (non-SQ NSCLC) have limited treatment options and a dismal prognosis once their disease has advanced and initial treatment with platinum-based chemotherapy has failed.

Guideline released on minimally invasive procedure, EBUS-TBNA, to diagnose lung diseases
The American College of Chest Physicians announced the release of new clinical guidelines on endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA).
More Lung Cancer Current Events and Lung Cancer News Articles

Non-Small Cell Lung Cancer: Across the Continuum of Care

Non-Small Cell Lung Cancer: Across the Continuum of Care
by Asante Communications, LLC

This Clinical Resource Tool is structured around consensus statements developed by the Non-Small Cell Lung Cancer (NSCLC) Working Group, a panel of oncologists with particular expertise in the multidimensional care of patients with advanced lung cancer. Using a modified Delphi process, the NSCLC Working Group has consolidated published evidence and expert clinical experience on critical issues pertaining to the comprehensive assessment of patients with advanced NSCLC, formulation of appropriate treatment regimens, implementation of maintenance therapy, and therapeutic alliances among pathologists, oncologists, and pulmonologists. The consensus statements and accompanying resources are intended as a practical companion to current guidelines, helping clinicians individualize best-practice...

Lung Cancer: Diagnosis and Management

Lung Cancer: Diagnosis and Management
by NetCE

The purpose of this course is to address the various aspects of diagnosis, treatment, disease management and appropriate patient care for healthcare professionals caring for patients with lung cancer. In addition, members of the public may use this course to enhance their personal knowledge of the subject matter presented.

Upon completion of this course, you should be able to:

1. Discuss the risk factors and incidence of lung cancer.
2. Explain the pathophysiology of lung cancer.
3. Identify the signs and symptoms of lung cancer.
4. Discuss the various tests used to diagnose lung cancer.
5. Describe the lung cancer classification and staging system.
6. Discuss the treatment options available to the patient with lung cancer, including...

Lung Cancer Causes, Symptoms,  Stages & Treatment Guide: Cure Lung Cancer With  A Positive Outlook

Lung Cancer Causes, Symptoms, Stages & Treatment Guide: Cure Lung Cancer With A Positive Outlook
by Danielle Dixon

This book contains proven steps and strategies on how to prevent, treat and fight cancer.

Cancer has long been closely associated with death, low quality of life, and financial difficulties. With all the complications it causes, lives it takes, and people it subjects to suffering, cancer is definitely a difficult disease.

Lung cancer is one of the leading causes of cancer deaths worldwide. Different risk factors have been attributed to its development- with genetics and environmental influences playing a major role. The diversity of its causes makes its treatment all the more difficult, which makes identification of causes essential to its management. The recognition of symptoms and diagnosis early in the course of the disease most frequently leads to good...

Bonnie J. Addario Navigating Lung Cancer 360 Degrees of Hope

Bonnie J. Addario Navigating Lung Cancer 360 Degrees of Hope
by Bonnie J. Addario (Author), MD, PhD, Shane P. Dormady (Author), RN, MSN, CPHQ, Eileen Johnson (Author), RN, MBA, Alicia Sable-Hunt (Author), Danielle Hicks (Editor), MD, Paul Hesketh (Editor), MD, Robert Sinha (Editor), MD, PhD, D. Ross Camidge (Editor), MD, Elizabeth A. David (Editor), MD, Lisa Boohar (Editor), MD, David R. Gandara (Editor), PhD, Guneet Walia (Editor), Inc., Sheila Von Driska?White Space (Editor)

Navigating Lung Cancer 360 Degrees of Hope is the most comprehensive guidebook for surviving lung cancer. Inside each latest edition you will get the most up-to-date navigation tools on the diagnosis process, lung cancer staging, treatment options, clinical trials, living with lung cancer, financing your care, hope for surviving lung cancer, and more. Written by survivor Bonnie J. Addario and the leading experts in lung cancer with one goal: to turn lung cancer into a manageable and survival disease.

Living with Lung Cancer--My Journey

Living with Lung Cancer--My Journey
by Thomas E. Cappiello (Author)

On October 5 2007, Thomas Cappiello was diagnosed with inoperable Stage IIIA locally-advanced adenocarcinoma (Non-Small Cell Lung Cancer), an incurable disease. This book is the inspirational story of how he beat the odds and survived and thrived in the face of this devastating illness. This book is for patients and caregivers who want to know what life is like after getting a cancer diagnosis. The story is about overcoming the emotional turmoil and devastation of a cancer diagnosis, dealing with the disease, and making choices. Most of all, it's about living a full life each day. Cancer patients suddenly realize that time is a precious gift from God and there is no time to waste. By telling his story Cappiello seeks to inspire cancer patients to fight hard and live, with whatever time...

How to Survive Lung Cancer - A Practical 12-Step Plan

How to Survive Lung Cancer - A Practical 12-Step Plan
by Michael Lloyd (Author)

Written by a lung cancer survivor who understands what it takes to beat the odds, this book offers unparalleled hope and direction for anyone facing this illness. It is filled with specific exercises and techniques to promote healing and reverse side effects by taking a pro-active approach in helping to restore your mind, body and spirit to an optimum state of health. Endorsed by a Lung Cancer Specialist and Associate Professor at Harvard Medical School, this book combines what the doctors tell you with critical information they don't tell you. Visit for chapter summaries.

Johns Hopkins Patients' Guide To Lung Cancer

Johns Hopkins Patients' Guide To Lung Cancer
by Justin F. Klamerus (Author), Julie R. Brahmer (Author), David S Ettinger (Author)

Johns Hopkins Patients' Guide to Lung Cancer is a concise, easy-to-follow “how to” guide that puts you on the path to wellness by explaining lung cancer treatment from start to finish. It guides you through the overwhelming maze of treatment decisions, simplifies the complicated schedule that lies ahead, and performs the task of putting together your plan of care in layman's terms. Empower yourself with accurate, understandable information that will give you the ability to confidently participate in the decision making about your care and treatment.

The Cancer-Fighting Kitchen: Nourishing, Big-Flavor Recipes for Cancer Treatment and Recovery

The Cancer-Fighting Kitchen: Nourishing, Big-Flavor Recipes for Cancer Treatment and Recovery
by Rebecca Katz (Author), Mat Edelson (Author)

A Culinary Pharmacy in Your Pantry

The Cancer-Fighting Kitchen features 150 science-based, nutrient-rich recipes that are easy to prepare and designed to give patients a much-needed boost by stimulating appetite and addressing treatment side effects including fatigue, nausea, dehydration, mouth and throat soreness, tastebud changes, and weight loss. A step-by-step guide helps patients nutritionally prepare for all phases of treatment, and a full nutritional analysis accompanies each recipe. This remarkable resource teaches patients and caregivers how to use readily available powerhouse ingredients to build a symptom- and cancer-fighting culinary toolkit. Blending fantastic taste and meticulous science, these recipes for soups, vegetable dishes, proteins, and sweet and savory snacks...

Fighting Lung Cancer: Discover How You Can Fight Lung Cancer Symptoms & Live Longer

Fighting Lung Cancer: Discover How You Can Fight Lung Cancer Symptoms & Live Longer

Has someone you know been diagnosed with Lung Cancer?

If so... this book will help prolong their life.

"Fighting Lung Cancer" is your complete guide to understanding what your best options are for prolonging your life once you have been diagnosed with lung cancer.

Within this book you'll discover why there is hope and how with the correct knowledge you can stop lung cancer from destroying your life.

In this easy to read, information packed book, you'll learn:
* the underlying causes of Lung cancer and how to counteract those causes

* You'll learn which supplements have been proven to be the most effective

* How to reduce the size of the cancer cells and stop them from returning.

* You'll also...

You Can Beat Lung Cancer: Using Alternative/Integrative Interventions

You Can Beat Lung Cancer: Using Alternative/Integrative Interventions
by Carl O. Helvie (Author)

Can you overcome lung cancer without harsh chemicals, surgery and debilitation? Are alternative interventions effective? Why do conventional physicians not use them? Can you prevent cancer recurrences and live into old age without chronic diseases and prescribed medications? This book answers these and other questions.

This is one of the most comprehensive books available on alternative treatments for lung cancer. It explains the treatments used successfully by a health professional/cancer survivor of 36 years and by some of the leading medical and health practitioners currently in the field. G. Edward Griffin, Author of World Without Cancer, The Politics of Cancer Therapy, and other books and films. Recipient of the Telly Award for Excellence in Television Production. President of...

© 2015