Science Current Events | Science News | Brightsurf.com
 

'Mad Cow' blood test now on the horizon

September 12, 2012
A simple blood test for Creutzfeldt-Jakob Disease and Mad Cow disease is a step closer, following a breakthrough by medical researchers at the University of Melbourne.

Using newly available genetic sequencing scientists discovered cells infected with prions (the infectious agent responsible for these diseases) release particles which contain easily recognized 'signature genes'.

Associate Professor Andrew Hill - from the Department of Biochemistry and Molecular Biology at the Bio21 Institute - said these particles travel in the blood stream, making a diagnostic blood test a possibility.

"This might provide a way to screen people who have spent time in the UK, who currently face restrictions on their ability to donate blood," he said.

"With a simple blood test nurses could deem a prospective donor's blood as healthy, with the potential to significantly boost critical blood stocks."

Mad Cow disease was linked to the deaths of nearly 200 people in Great Britain who consumed meat from infected animals in the late 1980s.

Since 2000, the Australia Red Cross Blood Service has not accepted blood from anybody who lived in the UK for more than six months between 1980 and 1996, or who received a blood transfusion in the UK after 1980.

The research is published in this week's Oxford University Press Nucleic Acids Research journal.

Lead author Dr Shayne Bellingham said the breakthrough might also help detect other human neurodegenerative diseases, such as Alzheimer's and Parkinson's.

"This is an exciting new field where we can test for conditions in the brain and throughout the body, without being invasive," he said.

The researchers' genetic testing focused on a form of cell discharge called exosomes.

If exosomes were infected with prions (the pathogen that causes Creutzfeldt-Jakob Disease and Bovine Spongiform Encephalopathy, commonly known as Mad Cow Disease) they were found to also carry a specific signature of small genes called microRNA's.

The research was undertaken at the University of Melbourne, with assistance from the Mental Health Research Institute of Victoria, the National Health and Medical Research Council and the Australian Research Council.

The University of Melbourne


Related Mad Cow Disease Current Events and Mad Cow Disease News Articles


UTHealth research: Grass plants can transport infectious prions
Grass plants can bind, uptake and transport infectious prions, according to researchers at The University of Texas Health Science Center at Houston (UTHealth). The research was published online in the latest issue of Cell Reports.

Satellite telemetry tracks bearded vultures
The Pyrenees are home to continental Europe's only wild population of bearded vultures, a species classified as endangered in Spain. A study compiled by Spanish researchers reveals - in a level of detail hitherto unseen - the size of the home range of this bird species using satellite tracking technologies.

First successful vaccination against 'mad cow'-like wasting disease in deer
Researchers at NYU Langone Medical Center and elsewhere say that a vaccination they have developed to fight a brain-based, wasting syndrome among deer and other animals may hold promise on two additional fronts: Protecting U.S. livestock from contracting the disease, and preventing similar brain infections in humans.

UTHealth researchers discover infectious prion protein in urine of patients with variant Creutzfeldt-Jakob disease
The misfolded and infectious prion protein that is a marker for variant Creutzfeldt-Jakob disease - linked to the consumption of infected cattle meat - has been detected in the urine of patients with the disease by researchers at The University of Texas Health Science Center at Houston (UTHealth) Medical School.

Prion discovery could help keep deadly brain diseases in check
New research from David Westaway, PhD, of the University of Alberta and Jiri Safar, PhD, Case Western Reserve University School of Medicine has uncovered a quality control mechanism in brain cells that may help keep deadly neurological diseases in check for months or years.

Lasers might be the cure for brain diseases such as Alzheimer's and Parkinson's
Researchers at Chalmers University of Technology in Sweden, together with researchers at the Polish Wroclaw University of Technology, have made a discovery that may lead to the curing of diseases such as Alzheimer's, Parkinson's and Creutzfeldt-Jakob disease (the so called mad cow disease) through photo therapy.

Targeted culling of deer controls disease with little effect on hunting
Chronic wasting disease, the deer-equivalent of mad cow disease, has crept across the U.S. landscape from west to east. It appeared first in captive mule deer in Colorado in the late 1960s.

Researchers estimate 1 in 2,000 people in the UK carry variant CJD proteins
The survey provides the most robust prevalence measure to date - and identifies abnormal prion protein across a wider age group than found previously and in all genotypes.

Recombinant Human Prion Protein Inhibits Prion Propagation
Case Western Reserve University researchers today published findings that point to a promising discovery for the treatment and prevention of prion diseases, rare neurodegenerative disorders that are always fatal. The researchers discovered that recombinant human prion protein stops the propagation of prions, the infectious pathogens that cause the diseases.

Prion-like proteins drive several diseases of aging
Two leading neurology researchers have proposed a theory that could unify scientists' thinking about several neurodegenerative diseases and suggest therapeutic strategies to combat them.
More Mad Cow Disease Current Events and Mad Cow Disease News Articles

The Pathological Protein: Mad Cow, Chronic Wasting, and Other Deadly Prion Diseases

The Pathological Protein: Mad Cow, Chronic Wasting, and Other Deadly Prion Diseases
by Philip Yam (Author)


Prions are an entirely new class of pathogens, and scientists are just beginning to understand them. Although they have plagued humans and animals for 3 centuries, only in the last 2 decades have researchers linked them to diseases like Mad Cow. This book tells the strange story of their discovery, and the medical controversies that swirl around them. The author, Philip Yam, is a well-respected and connected journalist who is now an editor at Scientific American.

How the Cows Turned Mad: Unlocking the Mysteries of Mad Cow Disease

How the Cows Turned Mad: Unlocking the Mysteries of Mad Cow Disease
by Maxime Schwartz (Author), Edward Schneider (Translator), Marion Nestle (Translator)


Fear of mad cow disease, a lethal illness transmitted from infected beef to humans, has spread from Europe to the United States and around the world. Originally published to much acclaim in France, this scientific thriller, available in English for the first time and updated with a new chapter on developments in 2001, tells of the hunt for the cause of an enigmatic class of fatal brain infections, of which mad cow disease is the latest incarnation. In gripping, nontechnical prose, Maxime Schwartz details the deadly manifestations of these diseases throughout history, describes the major players and events that led to discoveries about their true nature, and outlines our current state of knowledge. The book concludes by addressing the question we all want answered: should we be...

Mad Cow Disease (Diseases and Disorders)

Mad Cow Disease (Diseases and Disorders)
by Barbara Sheen (Author)




No More Bull!: The Mad Cowboy Targets America's Worst Enemy: Our Diet

No More Bull!: The Mad Cowboy Targets America's Worst Enemy: Our Diet
by Howard F. Lyman (Author), Glen Merzer (Author), Joanna Samorow-Merzer (Author)


In 1996, when Howard Lyman warned America on The Oprah Winfrey Show that Mad Cow Disease was coming to America, offended cattlemen sued him and Oprah both. Not only were Lyman and Oprah vindicated in court, but events have proved many of Lyman's predictions absolutely right. Mad Cow Disease has come to America, and Lyman argues persuasively in No More Bull! that the problem will only grow more deadly until our government deals with it seriously.
In Mad Cowboy, Lyman, a fourth-generation Montana rancher turned vegetarian then vegan, told the story of his personal transformation after a spinal tumor, which he believes was caused by agricultural chemicals, nearly left him paralyzed. In No More Bull!, Lyman uses his humor, compassion, firsthand experience in agriculture, and command of...

Mad Cow Disease: Webster's Timeline History, 1986 - 2007

Mad Cow Disease: Webster's Timeline History, 1986 - 2007
by Icon Group International (Author)


Webster's bibliographic and event-based timelines are comprehensive in scope, covering virtually all topics, geographic locations and people. They do so from a linguistic point of view, and in the case of this book, the focus is on "Mad Cow Disease," including when used in literature (e.g. all authors that might have Mad Cow Disease in their name). As such, this book represents the largest compilation of timeline events associated with Mad Cow Disease when it is used in proper noun form. Webster's timelines cover bibliographic citations, patented inventions, as well as non-conventional and alternative meanings which capture ambiguities in usage. These furthermore cover all parts of speech (possessive, institutional usage, geographic usage) and contexts, including pop culture, the arts,...

Brain Trust: The Hidden Connection Between Mad Cow and Misdiagnosed Alzheimer's Disease

Brain Trust: The Hidden Connection Between Mad Cow and Misdiagnosed Alzheimer's Disease
by Colm A. Kelleher (Author)


On December 23, 2003 authorities announced that the first case of Mad Cow Disease in the United States had been found in a dairy cow in Mabton, Washington. The admission, though downplayed, hides a frightening reality. For thirty years, a covert sampling operation has been conducted on North American cattle to reveal how far the deadly prions that are thought to cause Mad Cow Disease have spread thought the nation's livestock. These efforts may be too late: BRAIN TRUST warns of an impending public health catastrophe as the American food supply, and other countries to which they export, becomes progressively more contaminated. Although statistics argue that only one in a million people become affected with the human version of Mad Cow Disease, research on many postmortem brains of...

When to Rob a Bank: ...And 131 More Warped Suggestions and Well-Intended Rants

When to Rob a Bank: ...And 131 More Warped Suggestions and Well-Intended Rants
by Steven D. Levitt (Author), Stephen J. Dubner (Author)


In celebration of the 10th anniversary of the landmark book Freakonomics comes this curated collection from the most readable economics blog in the universe. It’s the perfect solution for the millions of readers who love all things Freakonomics. Surprising and erudite, eloquent and witty, When to Rob a Bank demonstrates the brilliance that has made the Freakonomics guys an international sensation, with more than 7 million books sold in 40 languages, and 150 million downloads of their Freakonomics Radio podcast.When Freakonomics was first published, the authors started a blog—and they’ve kept it up. The writing is more casual, more personal, even more outlandish than in their books. In When to Rob a Bank, they ask a host of typically off-center questions: Why don’t flight...

And the Good News Is...: Lessons and Advice from the Bright Side

And the Good News Is...: Lessons and Advice from the Bright Side
by Dana Perino (Author)


#1 New York Times Bestseller#1 Wall Street Journal Bestseller

From her years as the presidential press secretary to her debates with colleagues on Fox News' The Five, Dana Perino reveals the lessons she's learned that have guided her through life, kept her level-headed, and led to her success, even in the face of adversity.

Thoughtful, inspiring, and often surprising, AND THE GOOD NEWS IS . . . traces Dana Perino's unlikely journey through politics and television. It's a remarkable American story-made up of equal parts determination and clear-eyed optimism.

From facing professional challenges and confronting personal fears to stepping up to a podium for a President, Dana has come to expect the unexpected and has an uncanny ability to find the good news in any...

Revival: A Novel

Revival: A Novel
by Stephen King (Author)


A dark and electrifying novel about addiction, fanaticism, and what might exist on the other side of life.

In a small New England town, over half a century ago, a shadow falls over a small boy playing with his toy soldiers. Jamie Morton looks up to see a striking man, the new minister. Charles Jacobs, along with his beautiful wife, will transform the local church. The men and boys are all a bit in love with Mrs. Jacobs; the women and girls feel the same about Reverend Jacobs—including Jamie’s mother and beloved sister, Claire. With Jamie, the Reverend shares a deeper bond based on a secret obsession. When tragedy strikes the Jacobs family, this charismatic preacher curses God, mocks all religious belief, and is banished from the shocked town.

Jamie has demons of his...

Grain Brain: The Surprising Truth about Wheat, Carbs,  and Sugar--Your Brain's Silent Killers

Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers
by David Perlmutter (Author), Kristin Loberg (Contributor)


A #1 New York Times bestseller--the devastating truth about the effects of wheat, sugar, and carbs on the brain, with a 4-week plan to achieve optimum health.

Renowned neurologist David Perlmutter, MD, blows the lid off a topic that's been buried in medical literature for far too long: carbs are destroying your brain. And not just unhealthy carbs, but even healthy ones like whole grains can cause dementia, ADHD, anxiety, chronic headaches, depression, and much more. Dr. Perlmutter explains what happens when the brain encounters common ingredients in your daily bread and fruit bowls, why your brain thrives on fat and cholesterol, and how you can spur the growth of new brain cells at any age. He offers an in-depth look at how we can take control of our "smart genes" through specific...

© 2015 BrightSurf.com