Science Current Events | Science News | Brightsurf.com
 

Breakthrough for new diabetes treatment

September 28, 2012
An international team of scientists, led from Karolinska Institutet in Sweden, have discovered an entirely new approach to the treatment of type II diabetes. The therapy involves the blockade of signalling by a protein known as VEGF-B and this prevents fat from accumulating in the 'wrong' places, such as in muscles and in the heart. As a result the cells within these tissues are once again able to respond to insulin.

In experiments on mice and rats, the scientists have managed to both prevent the development of type II diabetes and reverse the progression of established disease. The study is published in the prestigious scientific journal Nature, where it is described as a breakthrough in diabetes research. The findings are the result of a joint effort by Karolinska Institutet, the Ludwig Institute for Cancer Research and the Australian biopharmaceutical company CSL Limited, amongst others.

"It's a great feeling to present these results," says Professor Ulf Eriksson of the Department of Medical Biochemistry and Biophysics at Karolinska Institutet. "We discovered VEGF-B back in 1995, and since then the VEGF-B project has been a lengthy sojourn in the wilderness, but now we're making one important discovery after the other. In this present study we've shown that VEGF-B inhibition can be used to prevent and treat type II diabetes, and that this can be done with a drug candidate."

Type II diabetes is normally preceded by insulin resistance caused by obesity. When this happens, the cells no longer respond sufficiently to insulin, which leads to elevated levels of blood sugar. Insulin resistance is related to the storage of fat in the 'wrong' places, such as the muscles, blood vessels and heart, although exactly how this relationship works is not fully known.

What scientists do know, however, is that the VEGF-B protein affects the transport and storage of fat in body tissue. This was discovered by Professor Ulf Eriksson's research group in a study published in Nature in 2010. These theories have now been developed for a new study in which VEGF-B signalling was blocked in a group of diabetic mice and rats.

A total of four related studies are reported in the Nature paper. In one case, mice bred to spontaneously develop diabetes were given a drug candidate called 2H10, which is an antibody that blocks the effect of VEGF-B. The mice subsequently developed neither insulin resistance, nor diabetes. The team also crossed the diabetes strain of mice with one that lacked the ability to produce VEGF-B, and found that the offspring were protected from developing the disease.

In another two studies, the scientists took normal mice and rats that had not been specially bread to develop type II diabetes, and left them to develop the disease as a result of a fat-rich diet and the resulting obesity. In these cases, progression of the established disease was halted and reversed to varying degrees after treatment with 2H10.

"The results we present in this study represent a major breakthrough and an entirely new principle for the prevention and treatment of type II diabetes," says Professor Ĺke Sjöholm, consultant in diabetology at Stockholm South General Hospital. "Existing treatments can cause many adverse reactions and their effects normally wear off. There is a desperate need for new treatment strategies for type II diabetes."

Current treatments for type II diabetes normally involve initial dietary measures and/or pills designed to boost insulin secretion and sensitivity or to reduce glucose production. After a few years, such treatments eventually prove inadequate for up to 30 per cent of patients, who then require insulin injections. Type II diabetes is reaching epidemic proportions, and according to the World Health Organisation, is expected to afflict over half a billion people by 2030.

The drug candidate used in the study, 2H10, is a monoclonal antibody and is being developed by the biopharmaceutical company CSL Limited. Scientists from CSL contributed to the work and the company co-funded the study. Funding was also supplied by the Ludwig Institute for Cancer Research, the Frans Wilhelm and Waldemar von Frenckell Fund, the Wilhelm and Else Stockmann Foundation, the Novo Nordisk Foundation, the Swedish Cancer Society, the Swedish Research Council, the Torsten and Ragnar Söderberg Foundations, the Research Foundation of the Swedish Diabetes Association (Diabetesfonden), the Peter Wallenberg Foundation for Economics and Technology, and the Swedish Heart-Lung Foundation.

Earlier this year, Professor Eriksson was awarded the Heart-Lung Foundation's grand research grant of SEK 15 million (about 1.7 million / $ 2.3 million) the largest in Sweden in the field of cardiovascular disease. The grant will be used to finance further research into VEGF-B.

Karolinska Institutet


Related Diabetes Current Events and Diabetes News Articles


Research provides strong link between delirium and inflammation in older patients
Delirium is an acute state of confusion that often affects older adults following surgery or serious illness.

Insulin resistance, glucose uptake in the brain in adults at risk for Alzheimer's
An imaging study suggests insulin resistance, a prevalent and increasingly common condition, was associated with lower brain glucose metabolism in a group of late middle-age adults at risk for Alzheimer disease, according to an article published online by JAMA Neurology.

In CRISPR advance, scientists successfully edit human T cells
In a project spearheaded by investigators at UC San Francisco, scientists have devised a new strategy to precisely modify human T cells using the genome-editing system known as CRISPR/Cas9.

Increased protein turnover contributes to the development of pulmonary fibrosis
Idiopathic pulmonary fibrosis is a very aggressive form of pulmonary fibrosis and has a particularly poor prognosis.

Exercise mimic molecule may help treat diabetes and obesity
Scientists from the University of Southampton have developed a molecule that acts as an exercise mimic, which could potentially help treat type 2 diabetes and obesity.

Weight loss for a healthy liver
Weight loss through both lifestyle modification and bariatric surgery can significantly reduce features of nonalcoholic steatohepatitis (NASH), a disease characterized by fat in the liver, according to two new studies published in Gastroenterology, the official journal of the American Gastroenterological Association.

Specific cardiovascular risk factors may predict Alzheimer's disease
Specific cardiovascular risk factors, such as alcohol consumption, smoking, obesity and diabetes, are associated with smaller regional brain volumes that may be early indicators of Alzheimer's disease and dementia according to a study published online in the journal Radiology.

Preventing knee pain in at-risk adults with diabetes
Knee pain in older adults, often caused by osteoarthritis, usually means more visits to the doctor and also can be a harbinger of disability.

Spines of boys and girls differ at birth
Looking at measurements of the vertebrae - the series of small bones that make up the spinal column - in newborn children, investigators at Children's Hospital Los Angeles found that differences between the sexes are present at birth.

Low-dose lithium reduces side effects from most common treatment for Parkinson's disease
Low-dose lithium reduced involuntary motor movements - the troubling side effect of the medication most commonly used to treat Parkinson's disease (PD) - in a mouse model of the condition that is diagnosed in about 60,000 Americans each year.
More Diabetes Current Events and Diabetes News Articles

The End of Diabetes: The Eat to Live Plan to Prevent and Reverse Diabetes

The End of Diabetes: The Eat to Live Plan to Prevent and Reverse Diabetes
by Joel Fuhrman (Author)


The New York Times bestselling author of Eat to Live and Super Immunity and one of the country’s leading experts on preventive medicine offers a scientifically proven, practical program to prevent and reverse diabetes—without drugs.At last, a breakthrough program to combat the rising diabetes epidemic and help millions of diabetics, as well as those suffering with high blood pressure and heart disease. Joel Fuhrman, M.D. Research director of the Nutritional Research Foundation, shows you how to live a long, healthy, and happy life—disease free. He offers a complete health transformation, starting with a diet with a high nutrient-per-calorie ratio that can be adapted for individual needs.Dr. Fuhrman makes clear that we don’t have to “control” diabetes. Patients can choose to...

Mayo Clinic The Essential Diabetes Book

Mayo Clinic The Essential Diabetes Book
by Mayo Clinic (Author)


More people than ever before have diabetes. The disease affects an estimated 21 million adults and children in the US and many people with the disease don't have it under control. Unlike years ago, you have a good chance of living an active and healthy life with diabetes - provided you work with your health-care team to take the necessary steps to control your blood sugar. This title covers: the pre-diabetes stage - taking charge to prevent diabetes; types of diabetes; symptoms and risk factors; treatments and strategies for managing your blood sugar; avoiding serious complications; advances in insulin delivery and new medications; and, recipes

The Official Pocket Guide to Diabetic Exchanges: Choose Your Foods

The Official Pocket Guide to Diabetic Exchanges: Choose Your Foods
by American Diabetes Association (Author)


Completely updated to match the newest edition of Choose Your Foods: Exchange Lists for Diabetes Meal Planning, this pocket-sized bestseller is now better and more complete than ever.

Every day and at every meal, millions of people use the exchange list system to help them plan their meal, choose the healthiest foods, and estimate the right portions. By grouping similar foods into exchangeable portion sizes, people with diabetes can instantly create entire meals, specifically designed to help them control their blood glucose and lose weight. This proven system is the most popular approach to diabetes meal planning and has been used by dietitians, diabetes educators, and millions of people with diabetes for over 40 years.

This portable, pocket-sized version of the Choose Your...

Diabetes For Dummies

Diabetes For Dummies
by Alan L. Rubin (Author)


The straight facts on treating diabetes successfully With diabetes now considered pandemic throughout the world, there have been an enormous advances in the field since the last edition of Diabetes For Dummies. Now significantly revised and updated, it includes the latest information on medications and monitoring equipment, updated diet and exercise plans, new findings about treating diabetes in the young and elderly, new ways to diagnose and treat long- and short-term complications, and more. Want to know how to manage diabetes? Trusted diabetes expert Dr. Alan Rubin gives you reassuring, authoritative guidance on putting together a state-of-the-art treatment program to treat diabetes successfully and live a full life. You'll learn about all the advances in monitoring glucose, the...

Dr. Neal Barnard's Program for Reversing Diabetes: The Scientifically Proven System for Reversing Diabetes without Drugs

Dr. Neal Barnard's Program for Reversing Diabetes: The Scientifically Proven System for Reversing Diabetes without Drugs
by Neal D. Barnard (Author)


Until Dr. Barnard’s scientific breakthrough, most health professionals believed that once you developed diabetes, you were stuck with it—and could anticipate one complication after another, from worsening eyesight and nerve symptoms to heart and kidney problems. But as this groundbreaking work reveals, this simply is not true. In a series of studies—the most recent funded by the National Institutes of Health—Dr. Barnard has shown that it is possible to repair insulin function and reverse type 2 diabetes. By following his scientifically proven, life-changing program, diabetics can control blood sugar three times more effectively than with the standard diet; and cut back on and in some cases eliminate medications while reducing the risk of diabetes complications. "The long overdue...

What Do I Eat Now?: A Step-by-Step Guide to Eating Right with Type 2 Diabetes

What Do I Eat Now?: A Step-by-Step Guide to Eating Right with Type 2 Diabetes
by Patti Geil (Author), Tami A. Ross (Author)


The DIY approach to a diabetes diet!
What Do I Eat Now? is the single best resource for people with diabetes to learn how to eat right and eat healthy with diabetes. Each chapter explains a vital concept of diabetes nutrition in easy-to-understand language. “Tell Me What to Eat” meal plans and recipes at the end of each chapter get readers started on a lifetime of healthy eating. Don’t waste time trying to figure everything out from scratch when What Do I Eat Now? gives readers a step-by-step plan for understanding how to eat right. Learn as you go by cooking healthy, nutritious, and flavorful diabetic meals!

The First Year: Type 2 Diabetes: An Essential Guide for the Newly Diagnosed

The First Year: Type 2 Diabetes: An Essential Guide for the Newly Diagnosed
by Gretchen Becker (Author), Allison B. Goldfine (Foreword)


After Gretchen Becker was diagnosed with type 2 diabetes in 1996, she educated herself on every aspect of this chronic condition — by reading medical and scientific books and journals, talking with doctors and listening to her own body. In 2001, she marshaled everything she had learned as a "patient-expert" into the first edition of this book, which she has now completely updated and revised. The First Year®—Type 2 Diabetes uniquely guides you step-by-step through your first year with diabetes, walking you through everything you need to learn and do each day of your first week after diagnosis, each subsequent week of the first month, and each subsequent month of the crucial first year. In clear, concise, accessible language, Becker covers a wide range of practical, medical, and...

DIABETES: Top 20 foods to eat to control your blood sugar and reverse your diabetes

DIABETES: Top 20 foods to eat to control your blood sugar and reverse your diabetes


You may be wondering – Could eating the right foods make a difference in my fight against Diabetes ?
In Diabetes: "Top 20 foods to eat to control your blood sugar and reverse your diabetes" you will get answers to some potentially life and death questions:
What is diabetes?What are some of the symptoms I should watch for? What could happen if I just ignore this?What are some of the complications I should know about?What is retinopathy?What is neuropathy?Can I stop this and if so - HOW?What are some foods I should be eating?Which foods do I need to avoid?Tips on living with diabetes.This book contains proven steps and strategies on how to use certain foods to cope with diabetes

About the author:

Melanie White is first and foremost – a cancer...

Diabetic Living Diabetes Meals by the Plate: 90 Low-Carb Meals to Mix & Match

Diabetic Living Diabetes Meals by the Plate: 90 Low-Carb Meals to Mix & Match
by Diabetic Living Editors (Author)


An easy, graphic guide to planning delicious, diabetes-friendly meals   This innovative, graphic cookbook offers the easiest and most flavorful way to build complete meals that are diabetes-friendly and delicious. Sidestepping complex programs that turn meal-planning into work, the 90 complete meals in Diabetes Meals by the Plate follow the Plate Method—a simple approach to eating the right foods in proper amounts by filling your plate with one half nonstarchy vegetables, one quarter protein, and one quarter starch. A clever photo style showing every meal in its three components makes it easy to enjoy perfectly portioned plates of Balsamic Roasted Chicken and Vegetables with Garlic Toast, or Horseradish BBQ-Topped Mini Meat Loaves with Chopped Romaine Salad. All meals are 500 calories...

The American Diabetes Association Diabetes Comfort Food Cookbook

The American Diabetes Association Diabetes Comfort Food Cookbook
by Robyn Webb (Author)


While fancy and sophisticated foods continue to grow in popularity, ask most people what their favorite foods are and the answer will invariably be classic comfort foods: lasagna, meat loaf, mac and cheese, and cake. Unfortunately, most people think that having diabetes means the days of enjoying these hearty classics are long gone, and that their favorite foods are a thing of the past. Author Robyn Webb shows that healthy eating doesn't have to mean giving up on favorite foods! Diabetes can be overwhelming, but it doesn't mean reinventing the wheel when it comes to cooking. Just a tweak here and there and familiar foods can remain favorites, guilt-free, and enjoyed every day.

The American Diabetes Association Diabetes Comfort Food Cookbook creates a “go-to” collection of...

© 2015 BrightSurf.com