Science Current Events | Science News | Brightsurf.com
 

Breakthrough for new diabetes treatment

September 28, 2012

An international team of scientists, led from Karolinska Institutet in Sweden, have discovered an entirely new approach to the treatment of type II diabetes. The therapy involves the blockade of signalling by a protein known as VEGF-B and this prevents fat from accumulating in the 'wrong' places, such as in muscles and in the heart. As a result the cells within these tissues are once again able to respond to insulin.

In experiments on mice and rats, the scientists have managed to both prevent the development of type II diabetes and reverse the progression of established disease. The study is published in the prestigious scientific journal Nature, where it is described as a breakthrough in diabetes research. The findings are the result of a joint effort by Karolinska Institutet, the Ludwig Institute for Cancer Research and the Australian biopharmaceutical company CSL Limited, amongst others.

"It's a great feeling to present these results," says Professor Ulf Eriksson of the Department of Medical Biochemistry and Biophysics at Karolinska Institutet. "We discovered VEGF-B back in 1995, and since then the VEGF-B project has been a lengthy sojourn in the wilderness, but now we're making one important discovery after the other. In this present study we've shown that VEGF-B inhibition can be used to prevent and treat type II diabetes, and that this can be done with a drug candidate."

Type II diabetes is normally preceded by insulin resistance caused by obesity. When this happens, the cells no longer respond sufficiently to insulin, which leads to elevated levels of blood sugar. Insulin resistance is related to the storage of fat in the 'wrong' places, such as the muscles, blood vessels and heart, although exactly how this relationship works is not fully known.

What scientists do know, however, is that the VEGF-B protein affects the transport and storage of fat in body tissue. This was discovered by Professor Ulf Eriksson's research group in a study published in Nature in 2010. These theories have now been developed for a new study in which VEGF-B signalling was blocked in a group of diabetic mice and rats.

A total of four related studies are reported in the Nature paper. In one case, mice bred to spontaneously develop diabetes were given a drug candidate called 2H10, which is an antibody that blocks the effect of VEGF-B. The mice subsequently developed neither insulin resistance, nor diabetes. The team also crossed the diabetes strain of mice with one that lacked the ability to produce VEGF-B, and found that the offspring were protected from developing the disease.

In another two studies, the scientists took normal mice and rats that had not been specially bread to develop type II diabetes, and left them to develop the disease as a result of a fat-rich diet and the resulting obesity. In these cases, progression of the established disease was halted and reversed to varying degrees after treatment with 2H10.

"The results we present in this study represent a major breakthrough and an entirely new principle for the prevention and treatment of type II diabetes," says Professor Ĺke Sjöholm, consultant in diabetology at Stockholm South General Hospital. "Existing treatments can cause many adverse reactions and their effects normally wear off. There is a desperate need for new treatment strategies for type II diabetes."

Current treatments for type II diabetes normally involve initial dietary measures and/or pills designed to boost insulin secretion and sensitivity or to reduce glucose production. After a few years, such treatments eventually prove inadequate for up to 30 per cent of patients, who then require insulin injections. Type II diabetes is reaching epidemic proportions, and according to the World Health Organisation, is expected to afflict over half a billion people by 2030.

The drug candidate used in the study, 2H10, is a monoclonal antibody and is being developed by the biopharmaceutical company CSL Limited. Scientists from CSL contributed to the work and the company co-funded the study. Funding was also supplied by the Ludwig Institute for Cancer Research, the Frans Wilhelm and Waldemar von Frenckell Fund, the Wilhelm and Else Stockmann Foundation, the Novo Nordisk Foundation, the Swedish Cancer Society, the Swedish Research Council, the Torsten and Ragnar Söderberg Foundations, the Research Foundation of the Swedish Diabetes Association (Diabetesfonden), the Peter Wallenberg Foundation for Economics and Technology, and the Swedish Heart-Lung Foundation.

Earlier this year, Professor Eriksson was awarded the Heart-Lung Foundation's grand research grant of SEK 15 million (about 1.7 million / $ 2.3 million) the largest in Sweden in the field of cardiovascular disease. The grant will be used to finance further research into VEGF-B.

Karolinska Institutet


Related Diabetes Current Events and Diabetes News Articles


Leaky blood-brain barrier linked to Alzheimer's disease
Researchers using contrast-enhanced MRI have identified leakages in the blood-brain barrier (BBB) of people with early Alzheimer's disease (AD), according to a new study published online in the journal Radiology.

Researchers suggest whole-person perspective is needed to assess obesity
Authors from the Cleveland Clinic's Bariatric and Metabolic Institute recommend physicians use obesity staging models to recognize and manage weight-related health issues that may not be captured by traditional diagnosis criteria.

Autism care improved, diagnosis time shortened by new MU program
Wait lists for a specialist to confirm an autism diagnosis can be agonizing and last months. As the prevalence of autism and autism spectrum disorders increase, so does the demand for a health care system that is fully equipped to respond to the complex needs associated with autism.

Novel type 2 diabetes risk model more accurately assesses disease trajectory
An innovative model for determining a person's risk of developing type 2 diabetes (T2D) overcomes many of the challenges associated with estimating the onset of a chronic condition based on the usual sequence of comorbid conditions that lead up to a diagnosis of T2D.

Newly discovered gene regulates hyperglycemia-induced beta cell death in type 2 diabetes
It's no secret that over time, elevated levels of blood glucose (hyperglycemia) can induce the death of the pancreatic beta cells.

Study show female heart patients less likely to get blood thinning therapy
Female atrial fibrillation patients are less likely than their male counterparts to receive blood thinning therapies to prevent stroke, say University of Cincinnati College of Medicine researchers.

Ancient anti-inflammatory drug salicylic acid has cancer-fighting properties
Scientists from the Gladstone Institutes have identified a new pathway by which salicylic acid--a key compound in the nonsteroidal anti-inflammatory drugs aspirin and diflunisal--stops inflammation and cancer.

New study uncovers mechanisms underlying how diabetes damages the heart
Cardiac complications are the number one cause of death among diabetics. Now a team of scientists has uncovered a molecular mechanism involved in a common form of heart damage found in people with diabetes.

PNNL helps lead national microbiome initiative
Scientists at the U.S. Department of Energy's Pacific Northwest National Laboratory are playing a central role as the nation devotes more than $500 million to understand communities of microorganisms and their role in climate science, food production and human health.

Study finds one third of children have higher levels of cardiometabolic risk factors due to family history
A new study published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]) shows that children with a strong family history of cardiovascular disease (CVD) and/or type 2 diabetes were found to have cholesterol levels significantly higher than children with no family history of those conditions.
More Diabetes Current Events and Diabetes News Articles

The End of Diabetes: The Eat to Live Plan to Prevent and Reverse Diabetes

The End of Diabetes: The Eat to Live Plan to Prevent and Reverse Diabetes
by Joel Fuhrman (Author)


The New York Times bestselling author of Eat to Live and Super Immunity and one of the country’s leading experts on preventive medicine offers a scientifically proven, practical program to prevent and reverse diabetes—without drugs.At last, a breakthrough program to combat the rising diabetes epidemic and help millions of diabetics, as well as those suffering with high blood pressure and heart disease. Joel Fuhrman, M.D. Research director of the Nutritional Research Foundation, shows you how to live a long, healthy, and happy life—disease free. He offers a complete health transformation, starting with a diet with a high nutrient-per-calorie ratio that can be adapted for individual needs.Dr. Fuhrman makes clear that we don’t have to “control” diabetes. Patients can choose to...

What Do I Eat Now?: A Step-by-Step Guide to Eating Right with Type 2 Diabetes

What Do I Eat Now?: A Step-by-Step Guide to Eating Right with Type 2 Diabetes
by Patti B. Geil R.D. (Author), Tami A. Ross R.D. (Author)


Any person diagnosed with diabetes has one simple question: What do I eat now? When diagnosed with type 2 diabetes, doctors typically tell their patients to start eating healthy. But what does that mean? If figuring out what to eat seems like taking a test, here’s the solution, the American Diabetes Association book, What Do I Eat Now?. Written in clear, concise, and down-to-earth language that takes the mystery out of confusing nutrition recommendations, this indispensable guide can help readers make lasting changes in as little as a month. In only 4 weeks, readers can eat better, improve their diabetes management, and live a healthier lifestyle. With What Do I Eat Now?, readers will be able to:

Start off fast – quickly turn their diet around
Do It Right – learn what to eat...

Diabetes:: Reverse Your Diabetes With a Clear and Concise Step by Step Guide (Diabetes - Diabetes Diet - Diabetes free - Diabetes Cure - Reversing Diabetes)

Diabetes:: Reverse Your Diabetes With a Clear and Concise Step by Step Guide (Diabetes - Diabetes Diet - Diabetes free - Diabetes Cure - Reversing Diabetes)
by David Corr (Author)


Clear and Concise Guide to Reverse your Diabetes Starting Today

Excessive thirst, frequent urination, blurry vision, tiredness, tingling sensation in your extremities, wounds that take too long to heal – you notice these symptoms, visit your doctor, are advised some blood work ……..and then …….a sad reality dawns on you! You! Of all the people….you have been impacted by diabetes!

You are scared because you have heard that diabetes is irreversible. You know about friends and family who are struggling with diabetes and trying to live a normal life.

Well, if you or any of your family members are struggling with diabetes, then you understand these symptoms very well. You would have also heard that diabetes is irreversible.

Now, here is the...

Mayo Clinic The Essential Diabetes Book

Mayo Clinic The Essential Diabetes Book
by Mayo Clinic (Author)


More people than ever before have diabetes. The disease affects an estimated 21 million adults and children in the US and many people with the disease don't have it under control. Unlike years ago, you have a good chance of living an active and healthy life with diabetes - provided you work with your health-care team to take the necessary steps to control your blood sugar. This title covers: the pre-diabetes stage - taking charge to prevent diabetes; types of diabetes; symptoms and risk factors; treatments and strategies for managing your blood sugar; avoiding serious complications; advances in insulin delivery and new medications; and, recipes

Diabetes: The Ultimate Step-By-Step Guide to Reverse Diabetes Forever and Have Long-Lasting Success (Includes a 3-Week Diabetes Countdown Program and 25 Delicious Superfoods Recipes)

Diabetes: The Ultimate Step-By-Step Guide to Reverse Diabetes Forever and Have Long-Lasting Success (Includes a 3-Week Diabetes Countdown Program and 25 Delicious Superfoods Recipes)


This is an in depth beginners guide on how to tackle diabetes head on and take control of your life. This book will take you on the journey through how and why diabetes rears its ugly head, and then shows you how to reverse it. With clear and relevant tips on how to change your life and your health, this guide will arm you with the tools and knowledge to become healthier, stronger, happier and diabetes free. It will take you step by step through the changes that you can make, offering a planner, a 3-week eating plan strategy and 25 fantastic diabetes beating meal recipes to choose the best way forward for you. Written with a clear approach, this book will help you build the foundations to living a diabetes free life.

The First Year: Type 2 Diabetes: An Essential Guide for the Newly Diagnosed (The Complete First Year)

The First Year: Type 2 Diabetes: An Essential Guide for the Newly Diagnosed (The Complete First Year)
by Gretchen Becker (Author), Allison B. Goldfine (Author)


The go-to step-by-step guide that walks you through the first days, weeks, and months of your diagnosis–fully revised and updated

Gretchen Becker was diagnosed with type 2 diabetes in 1996; over the past twenty years, she has educated herself on every aspect of the condition by reading medical texts and journals, talking with doctors, and corresponding with others who have type 2, sharing everything she's learned in a comprehensive, easy-to-use guide. Now in its third edition, The First Year: Type 2 Diabetes takes you through everything you need to learn and do in your first year with diabetes, offering the most up-to-date information on new medications and supplements. In clear and accessible language, Becker covers a wide range of practical, medical, and lifestyle issues,...

Dr. Neal Barnard's Program for Reversing Diabetes: The Scientifically Proven System for Reversing Diabetes without Drugs

Dr. Neal Barnard's Program for Reversing Diabetes: The Scientifically Proven System for Reversing Diabetes without Drugs
by Neal D. Barnard (Author)


Until Dr. Barnard’s scientific breakthrough, most health professionals believed that once you developed diabetes, you were stuck with it—and could anticipate one complication after another, from worsening eyesight and nerve symptoms to heart and kidney problems. But as this groundbreaking work reveals, this simply is not true. In a series of studies—the most recent funded by the National Institutes of Health—Dr. Barnard has shown that it is possible to repair insulin function and reverse type 2 diabetes. By following his scientifically proven, life-changing program, diabetics can control blood sugar three times more effectively than with the standard diet; and cut back on and in some cases eliminate medications while reducing the risk of diabetes complications. "The long overdue...

Diabetic Living Diabetes Meals by the Plate: 90 Low-Carb Meals to Mix & Match

Diabetic Living Diabetes Meals by the Plate: 90 Low-Carb Meals to Mix & Match
by Diabetic Living Editors (Author)


An easy, graphic guide to planning delicious, diabetes-friendly meals This innovative, graphic cookbook offers the easiest and most flavorful way to build complete meals that are diabetes-friendly and delicious. Sidestepping complex programs that turn meal-planning into work, the 90 complete meals in Diabetes Meals by the Plate follow the Plate Method—a simple approach to eating the right foods in proper amounts by filling your plate with one half nonstarchy vegetables, one quarter protein, and one quarter starch. A clever photo style showing every meal in its three components makes it easy to enjoy perfectly portioned plates of Balsamic Roasted Chicken and Vegetables with Garlic Toast, or Horseradish BBQ-Topped Mini Meat Loaves with Chopped Romaine Salad. All meals are 500 calories or...

Diabetes For Dummies

Diabetes For Dummies
by Dr. Alan L. Rubin (Author)


The straight facts on treating diabetes successfully With diabetes now considered pandemic throughout the world, there have been enormous advances in the field. Now significantly revised and updated, this new edition of Diabetes For Dummies includes the latest information on diabetes medications and monitoring equipment, new findings about treating diabetes in the young and elderly, new ways to diagnose and treat long- and short-term complications, updated nutritional guidelines, new tools for measuring blood sugar and delivering insulin to the body, and much more. There's no question that the burden of diabetes is increasing globally: it's estimated that 387 million people worldwide are living with diabetes, and that staggering number is expected to increase an additional 205 million+ by...

The Official Pocket Guide to Diabetic Food Choices

The Official Pocket Guide to Diabetic Food Choices
by American Diabetes Association ADA (Author)


Completely updated to match the newest edition of Choose Your Foods: Food Lists for Diabetes Meal Planning, this pocket-sized guide is now better and more complete than ever.

Every day and at every meal, millions of people use the food list system to plan meals, make healthier choices, and better estimate portions. This proven system is the most popular approach to diabetes meal planning and has been used by dietitians, diabetes educators, and millions of people with diabetes for more than 70 years. This portable version of the Food Lists takes all of the information from the original and repackages it in a format that's perfect for trips to the grocery store or meals on the go. Updates include new foods, revised portions, and updated meal planning tips and techniques.

With...

© 2016 BrightSurf.com