Science Current Events | Science News | Brightsurf.com
 

Study: An Apple a Day Lowers Level of Blood Chemical Linked to Hardening of the Arteries

October 03, 2012
COLUMBUS, Ohio - Eating an apple a day might in fact help keep the cardiologist away, new research suggests.

In a study of healthy, middle-aged adults, consumption of one apple a day for four weeks lowered by 40 percent blood levels of a substance linked to hardening of the arteries.

Taking capsules containing polyphenols, a type of antioxidant found in apples, had a similar, but not as large, effect.

The study, funded by an apple industry group, found that the apples lowered blood levels of oxidized LDL -- low-density lipoprotein, the "bad" cholesterol. When LDL cholesterol interacts with free radicals to become oxidized, the cholesterol is more likely to promote inflammation and can cause tissue damage.

"When LDL becomes oxidized, it takes on a form that begins atherosclerosis, or hardening of the arteries," said lead researcher Robert DiSilvestro, professor of human nutrition at Ohio State University and a researcher at the university's Ohio Agricultural Research and Development Center. "We got a tremendous effect against LDL being oxidized with just one apple a day for four weeks."

The difference was similar to that found between people with normal coronary arteries versus those with coronary artery disease, he said.

The study is published online in the Journal of Functional Foods and will appear in a future print edition.

DiSilvestro described daily apple consumption as significantly more effective at lowering oxidized LDL than other antioxidants he has studied, including the spice-based compound curcumin, green tea and tomato extract.

"Not all antioxidants are created equal when it comes to this particular effect," he said.

DiSilvestro first became interested in studying the health effects of eating an apple a day after reading a Turkish study that found such a regimen increased the amount of a specific antioxidant enzyme in the body.

In the end, his team didn't find the same effect on the enzyme, but was surprised at the considerable influence the apples had on oxidized LDL.

For the study, the researchers recruited nonsmoking healthy adults between the ages of 40 and 60 who had a history of eating apples less than twice a month and who didn't take supplements containing polyphenols or other plant-based concentrates.

In all, 16 participants ate a large Red or Golden Delicious apple purchased at a Columbus-area grocery store daily for four weeks; 17 took capsules containing 194 milligrams of polyphenols a day for four weeks; and 18 took a placebo containing no polyphenols. The researchers found no effect on oxidized LDLs in those taking the placebo.

"We think the polyphenols account for a lot of the effect from apples, but we did try to isolate just the polyphenols, using about what you'd get from an apple a day," DiSilvestro said. "We found the polyphenol extract did register a measurable effect, but not as strong as the straight apple. That could either be because there are other things in the apple that could contribute to the effect, or, in some cases, these bioactive compounds seem to get absorbed better when they're consumed in foods."

Still, DiSilvestro said polyphenol extracts could be useful in some situations, "perhaps in higher doses than we used in the study, or for people who just never eat apples."

The study also found eating apples had some effects on antioxidants in saliva, which has implications for dental health, DiSilvestro said. He hopes to follow up on that finding in a future study.

The study was conducted as a Master's thesis by graduate student Shi Zhao, and was funded by a grant from the U.S. Apple Association/Apple Product Research and Education Council and a donation from Futureceuticals Inc. of Momence, Ill.

Also involved in the study were associate professor Joshua Bomser and research associate Elizabeth Joseph, both in the Department of Human Nutrition, which is housed in the university's College of Education and Human Ecology.

The Ohio State University


Related Polyphenols Current Events and Polyphenols News Articles


Powdered cranberry combats colon cancer in mice
Cranberries are often touted as a way to protect against urinary tract infections, but that may be just the beginning.

Resveratrol, quercetin could provide new options for cancer therapy
Resveratrol and quercetin, two polyphenols that have been widely studied for their health properties, may soon become the basis of an important new advance in cancer treatment, primarily by improving the efficacy and potential use of an existing chemotherapeutic cancer drug.

Cranberry juice may help protect against heart disease and diabetes risk factors
A new study reveals that drinking low-calorie cranberry juice cocktail may help lower the risk of chronic diseases that rank among the leading causes of death worldwide, including heart disease, diabetes and stroke.

WSU scientists turn white fat into obesity-fighting beige fat
Washington State University scientists have shown that berries, grapes and other fruits convert excess white fat into calorie-burning "beige" fat, providing new strategies for the prevention and treatment of obesity.

New evidence for how green tea and apples could protect health
Scientists from the Institute of Food Research have found evidence for a mechanism by which certain food compounds could help protect our health.

New findings support the benefits of eating walnuts on overall health
Multiple new research abstracts suggest walnuts may have the potential to positively affect several important health factors. From their impact on colon cancer and certain aspects of cognitive aging, to their positive effect on both gut health and vascular health, the research findings presented at Experimental Biology 2015 (EB) detail our latest understanding of walnuts' inner workings.

Green tea ingredient may target protein to kill oral cancer cells
A compound found in green tea may trigger a cycle that kills oral cancer cells while leaving healthy cells alone, according to Penn State food scientists. The research could lead to treatments for oral cancer, as well as other types of cancer.

Wild blueberries (bilberries) can help tackle the adverse effects of a high-fat diet
Eating bilberries diminishes the adverse effects of a high-fat diet, according to a recent study at the University of Eastern Finland.

Controlling obesity with potato extract
Take a look in your pantry: the miracle ingredient for fighting obesity may already be there. A simple potato extract may limit weight gain from a diet that is high in fat and refined carbohydrates, according to scientists at McGill University.

New scientific review reveals emerging and established health benefits of whole grain oats
According to a new, wide-reaching collection of scientific reviews published in the October 2014 supplement issue of the British Journal of Nutrition, oats may play an important role in improving satiety, diet quality and digestive, cardiovascular and general metabolic health.
More Polyphenols Current Events and Polyphenols News Articles

Polyphenols in Plants: Isolation, Purification and Extract Preparation

Polyphenols in Plants: Isolation, Purification and Extract Preparation
by Ronald Ross Watson (Editor)


Polyphenols in Plants assists plant scientists and dietary supplement producers in assessing polyphenol content and factors affecting their composition. It also aids in selecting sources and regulating environmental conditions affecting yield for more consistent and function dietary supplements. Polyphenols play key roles in the growth, regulation and structure of plants and vary widely within different plants. Stress, growth conditions and plant species modify polyphenol structure and content. This book describes techniques to identify, isolate and characterize polyphenols, taking mammalian toxicology into account as well. Defines conditions of growth affecting the polyphenol levelsDescribes assay and instrumentation techniques critical to identifying and defining polyphenols, critical...

Polyphenols in Human Health and Disease (2 Volumes set)

Polyphenols in Human Health and Disease (2 Volumes set)
by Ronald Ross Watson (Editor), Victor R. Preedy (Editor), Sherma Zibadi (Editor)


Polyphenols in Human Health and Disease documents antioxidant actions of polyphenols in protection of cells and cell organelles, critical for understanding their health-promoting actions to help the dietary supplement industry. The book begins by describing the fundamentals of absorption, metabolism and bioavailability of polyphenols, as well as the effect of microbes on polyphenol structure and function and toxicity. It then examines the role of polyphenols in the treatment of chronic disease, including vascular and cardiac health, obesity and diabetes therapy, cancer treatment and prevention, and more.Explores neuronal protection by polyphenol metabolites and their application to medical careDefines modulation of enzyme actions to help researchers see and study polyphenols’ mechanisms...

Green Tea Polyphenols: Nutraceuticals of Modern Life

Green Tea Polyphenols: Nutraceuticals of Modern Life
by Lekh R. Juneja (Editor), Mahendra P. Kapoor (Editor), Tsutomu Okubo (Editor), Theertham Rao (Editor)


There is a wealth of published research on the health-promoting effects of green tea and its various components including polyphenols. Green Tea Polyphenols: Nutraceuticals of Modern Life presents a collection of global findings on the numerous health benefits of green tea polyphenols, confirming their position as healthy functional ingredients. With chapters contributed by experts in the field of green tea science and the inclusion of extensive references, this book provides an authoritative volume that can be used to guide researchers, scientists, and regulatory bodies.

Each chapter previews a specific theme and highlights recent research and development conducted in the field. The book begins with the history, processing, and features of green tea. It then describes the chemical...

Effects of Dried Plum Polyphenol Extract on Bone Formation and Aging: Osteoporosis Prevention by Nutrition

Effects of Dried Plum Polyphenol Extract on Bone Formation and Aging: Osteoporosis Prevention by Nutrition
by L. Lily Kamkar (Author)


It is shown that dried plums are highly effective in preventing and reversing ovarian hormone deficiency-associated bone loss in a rat model of osteoporosis. Moreover, it is shown that dried plum supplementation significantly increases indices of bone formation in postmenopausal women. The bone protective effect of dried plum, in part, may be due to its polyphenol content. The intent of this study is to investigate the bone formation mechanisms of action of polyphenol extracted from dried plum using a cell culture system. Overall, the finding of the present study suggests that dried plum polyphenol extract enhances bone formation and suppresses the production of inflammatory molecules known to be harmful to bone.

The Cocoa Polyphenols Supplement: Alternative Medicine for a Healthy Body

The Cocoa Polyphenols Supplement: Alternative Medicine for a Healthy Body
by William Wagner M.D. (Author)


Learn how Cocoa Polyphenols can boost your overall health. Learning about ways that you can supplement a healthy diet is a great step in the right direction towards a healthier you!

Chocolate & Red Wine Antioxidants (Polyphenols, Flavonoids & Resveratrol): Facts vs. Falsehoods

Chocolate & Red Wine Antioxidants (Polyphenols, Flavonoids & Resveratrol): Facts vs. Falsehoods


Sadly, profiteers will "Tell you anything, to sell you anything." Profit and deception are the underlying motivations for the false claims regarding chocolate and red wine polyphenols and flavonoids. Hordes of people who have been misled to believe that the polyphenolic antioxidants in chocolate, red wine, tea and berries can have a miraculous effect on overall health and well being. Many books claim chocolate itself or its flavonoid supplements and red wine polyphenols, such as resveratrol, as being "miracles" or "wonder pills." But, such is far from the scientific reality of failed and disappointing studies conducted on these so-called super food products. Nearly fifty percent of Americans take dietary supplements, especially those containing overly hyped antioxidants. These...

Polyphénols d'huile d'olive, trésors santé ! : Etude scientifique

Polyphénols d'huile d'olive, trésors santé ! : Etude scientifique
b




Polyphenol: Webster's Timeline History, 1951 - 2007

Polyphenol: Webster's Timeline History, 1951 - 2007
by Icon Group International (Author)


Webster's bibliographic and event-based timelines are comprehensive in scope, covering virtually all topics, geographic locations and people. They do so from a linguistic point of view, and in the case of this book, the focus is on "Polyphenol," including when used in literature (e.g. all authors that might have Polyphenol in their name). As such, this book represents the largest compilation of timeline events associated with Polyphenol when it is used in proper noun form. Webster's timelines cover bibliographic citations, patented inventions, as well as non-conventional and alternative meanings which capture ambiguities in usage. These furthermore cover all parts of speech (possessive, institutional usage, geographic usage) and contexts, including pop culture, the arts, social sciences...

Chemistry and Biology of Ellagitannins: An Underestimated Class of Bioactive Plant Polyphenois

Chemistry and Biology of Ellagitannins: An Underestimated Class of Bioactive Plant Polyphenois
by Stephane Quideau (Author), Stephane Quideau (Editor)


This book is the first of its kind that focuses on the chemistry and biology of ellagitannins, a special class of naturally occurring polyphenols which have so far not received the attention they deserve. These polyphenolic substances are found in many plants, including numerous food sources. They not only exhibit unique structural features that fascinate most chemists who are aware of their existence, but also express remarkable biological activities that have yet to attract the interest of the pharmaceutical industry. This is surprising because ellagitannins have been identified as active principles in traditional Chinese medicines. The principal aim of this book is to set the record straight. Most, if not all, worldwide experts in each aspect of the chemistry and biology of this...

Natural Antioxidants and Weight Loss: Anti-Obesity and Anti-Inflammatory Effects of Polyphenol Extracts from Fruits and Herbs (Journal of Personalized and Systems Medicine)

Natural Antioxidants and Weight Loss: Anti-Obesity and Anti-Inflammatory Effects of Polyphenol Extracts from Fruits and Herbs (Journal of Personalized and Systems Medicine)
by PharmTao.com


Polyphenols are chemicals found in many plants. Polyphenols are usually antioxidants that can protect cells from oxidative damage caused by free radicals. Polyphenols include tannins, lignins, and flavonoids. Many polyphenols have anti-obesity activities and are beneficial for weight loss. Aging and obesity may lead to inflammatory and oxidative conditions. Inflammation and oxidative stress are also important pathological factors in obesity-related diseases such as diabetes, fatty liver, cardiovascular diseases, and cancer. Polyphenol extracts from fruits and herbs such as apples and green tea can inhibit inflammation, lower blood cholesterol and glucose levels, and reduce risks of heart diseases. These natural antioxidants can be used as dietary supplements without evident adverse...

© 2015 BrightSurf.com