Science Current Events | Science News | Brightsurf.com
 

New tumor tracking technique may improve outcomes for lung cancer patients

November 20, 2012
Real-time approach tracks and radiates moving tumors and spares healthy tissue

PHILADELPHIA- Medical physicists at Thomas Jefferson University and Jefferson's Kimmel Cancer Center are one step closer to bringing a new tumor-tracking technique into the clinic that delivers higher levels of radiation to moving tumors, while sparing healthy tissue in lung cancer patients.

Evidence has shown a survival advantage for lung cancer patients treated with higher doses of radiation. Therefore, there is an increased interest to find novel ways to better track tumors-which are in constant motion because of breathing-in order to up the dosage during radiation therapy without increasing harmful side effects

After proving its success in simulations, researchers have now shown that their real-time tracking technique can achieve such tasks. Not only can it better predict and track tumor motion and deliver higher levels of radiation to lung cancer patients and others with moving tumor targets, it can also successfully be implemented into existing clinical equipment (i.e., Elekta Precise Table).

The results of the study, led by Ivan Buzurovic, Ph.D., a medical physics resident and researcher in the Department of Radiation Oncology at Thomas Jefferson University, and Yan Yu, Ph.D., Professor, Vice Chair and Director of Medical Physics at Thomas Jefferson University, were published in the November issue of Medical Physics.

"We've shown here that our system can better predict and continuously track moving tumors during radiotherapy, preventing unnecessary amounts of radiation from being administered to unnecessary areas," said Dr. Buzurovic. "Just as important, we've successfully modified existing technology to integrate with the system to perform the tracking and delivery, meaning no additional robotic systems is needed."

Respiratory and cardiac motions have been found to displace and deform tumors in the lung and other organs. Because of this, radiation oncologists must expand the margin during radiotherapy, and consequently a large volume of healthy tissue is irradiated, and critical organs adjacent to the tumor are sometimes difficult to spare.

In an effort to shrink that margin, Jefferson researchers developed a new, robotic technique that better tracks tumor motion to deliver more precise radiation.

Here, the researchers applied a new control system (software and hardware) and robotic technology to existing treatment couches used for radiation therapy to determine the tracking technology's feasibility in a clinical setting.

They found the technology can be integrated onto treatment couches and validated the tumor tracking system capabilities to follow desired trajectories. When the active tracking system was applied, irradiated planning target volume (the area set for treatment) was 20 to 30 percent less for medium size tumors and more than 50 percent for small size tumors.

"The use of tumor tracking technology during radiotherapy treatment for lung cancer would result in significant reduction in dose to critical organs and tissue, potentially decreasing the probability or severity of side effects, and thus improving cancer treatments," Dr. Yu said.

Based on these results, it can be hypothesized that clinical implementation of real-time tracking is feasible for achieving potentially improved patient outcome.

"With this new technique, it shrinks the margin, and radiation oncologists would be able to administer more radiation and faster to the tumor than conventional methods," said Adam P. Dicker, M.D, Ph.D., Professor and Chairman of the Department of Radiation Oncology at Thomas Jefferson University. "And a higher, more targeted dose means a better cure in lung cancer."

Thomas Jefferson University


Related Lung Cancer Current Events and Lung Cancer News Articles


Blood samples as surrogates for tumor biopsies in patients with lung cancer
A study examined the feasibility of using circulating free DNA (cfDNA) from blood samples of patients with advanced non-small-cell lung cancer as a surrogate for tumor biopsies to determine tumor-causing epidermal growth factor receptor (EGFR) mutations and then correlate that with expected patient outcomes, according to a study published online by JAMA Oncology.

Online education tool helps bridge gaps in therapeutic decision-making for advanced NSCLC
A new interactive online tool helps educate practicing oncologists worldwide with therapeutic decision-making for advanced non-small cell lung cancer (NSCLC) based on a patient's molecular and clinical characteristics by providing feedback from an expert panel.

Breakthrough in understanding how cancer cells metastasize
A protein commonly found in human cells could be an important switch that activates cancer cell metastasis, according to a new study by researchers at the Montreal Neurological Institute and Hospital - The Neuro at McGill University and the MUHC.

Study suggests need for more sensitive lung cancer screening criteria
An analysis of lung cancer incidence and screening found a decline in the proportion of patients with lung cancer meeting high-risk screening criteria, suggesting that an increasing number of patients with lung cancer would not have been candidates for screening.

Decline in smoking rates may increase lung cancer mortality
A decline in smoking rates may mean that many people who could have benefited from early detection of lung cancer are dying because they don't qualify for low-dose CT scans.

Novel anti-cancer DNA vaccine may fight aging, chronic inflammation and osteoporosis
An international team of scientists including CureLab Oncology, Inc. (Boston), University of Camerino (Italy), and Boston University have serendipitously discovered a DNA vaccine, which systemically alleviates chronic inflammation in the body.

Not all EGFR mutations are the same when it comes to therapy for NSCLC
Certain rare epidermal growth factor receptor (EGFR) mutations are associated with tobacco smoking, worse prognosis and poor response to EGFR tyrosine kinase inhibitor (TKI) therapy compared to the more common "classical" EGFR mutations.

The NELSON lung cancer screening trial results are inferable for the general high-risk
Results of the NELSON lung cancer screening trial using low dose computed tomography (LDCT) can be used to predict the effect of population-based screening on the Dutch population even though there were slight differences in baseline characteristics of participants in the control arm versus eligible non-participants.

Mesothelioma in southern Nevada likely result of asbestos in environment
Malignant mesothelioma has been found at higher than expected levels in women and in individuals younger than 55 years old in the southern Nevada counties of Clark and Nye, likewise in the same region carcinogenic mineral fibers including actinolite asbestos, erionite, winchite, magnesioriebeckite and richterite were discovered.

Cancer's ability to 'hijack' regulatory mechanism increases metastasis
When skyscrapers go up, contractors rely on an infrastructure of steel beams and braces. Some cancers grow the same way, using a biological matrix from which the tumor can thrive and spread.
More Lung Cancer Current Events and Lung Cancer News Articles

Non-Small Cell Lung Cancer: Across the Continuum of Care

Non-Small Cell Lung Cancer: Across the Continuum of Care
by Asante Communications, LLC


This Clinical Resource Tool is structured around consensus statements developed by the Non-Small Cell Lung Cancer (NSCLC) Working Group, a panel of oncologists with particular expertise in the multidimensional care of patients with advanced lung cancer. Using a modified Delphi process, the NSCLC Working Group has consolidated published evidence and expert clinical experience on critical issues pertaining to the comprehensive assessment of patients with advanced NSCLC, formulation of appropriate treatment regimens, implementation of maintenance therapy, and therapeutic alliances among pathologists, oncologists, and pulmonologists. The consensus statements and accompanying resources are intended as a practical companion to current guidelines, helping clinicians individualize best-practice...

Lung Cancer: A Guide to Diagnosis and Treatment

Lung Cancer: A Guide to Diagnosis and Treatment
by Walter J. Scott MD (Author)


What is my prognosis? What are my treatment options? Which therapies would be the most effective for my stage of lung cancer? These and other frequently asked questions are addressed in this crucial reference designed to help patients educate themselves and obtain the best possible treatments. The completely revised second edition has been updated to include a discussion of the movement towards customized chemotherapy; treatment options for early-stage lung cancer including minimally invasive surgery; and the most promising treatments, among them multimodality therapy—a combination of surgery, chemotherapy, and radiation. Dr. Scott also surveys tests for early detection of lung cancer, talks about the importance of cancer staging, examines alternative treatments, and offers advice on...

Lung Cancer

Lung Cancer
by Jack A. Roth (Editor), Waun Ki Hong (Editor), Ritsuko U. Komaki (Editor)


The best and most concise single source for state-of-the-art diagnosis and treatment of lung cancer –newly revised, updated, and expanded.

Lung cancer has long been the number-one cause of death from cancer every year and the third most frequently diagnosed after breast and prostate cancers. In 2010, about 15% of all cancer diagnoses and 30% of all cancer deaths were due to lung cancer. Needless to say, there is a great need for more rapid advancements in diagnosis and treatment of this devastating disease. Here is the comprehensively revised, updated, and expanded edition of the well-established, evidence-based reference book that deals with the most recent advances in lung cancer prevention, screening, diagnosis, research, and treatment for the clinician. Edited and...

Fighting Lung Cancer: Discover How You Can Fight Lung Cancer Symptoms & Live Longer

Fighting Lung Cancer: Discover How You Can Fight Lung Cancer Symptoms & Live Longer


Has someone you know been diagnosed with Lung Cancer?

If so... this book will help prolong their life.

"Fighting Lung Cancer" is your complete guide to understanding what your best options are for prolonging your life once you have been diagnosed with lung cancer.

Within this book you'll discover why there is hope and how with the correct knowledge you can stop lung cancer from destroying your life.

In this easy to read, information packed book, you'll learn:
* the underlying causes of Lung cancer and how to counteract those causes

* You'll learn which supplements have been proven to be the most effective

* How to reduce the size of the cancer cells and stop them from returning.

* You'll also...

Johns Hopkins Patients' Guide To Lung Cancer

Johns Hopkins Patients' Guide To Lung Cancer
by Justin F. Klamerus (Author), Julie R. Brahmer (Author), David S Ettinger (Author)


Johns Hopkins Patients' Guide to Lung Cancer is a concise, easy-to-follow “how to” guide that puts you on the path to wellness by explaining lung cancer treatment from start to finish. It guides you through the overwhelming maze of treatment decisions, simplifies the complicated schedule that lies ahead, and performs the task of putting together your plan of care in layman's terms. Empower yourself with accurate, understandable information that will give you the ability to confidently participate in the decision making about your care and treatment.

How to Survive Lung Cancer - A Practical 12-Step Plan

How to Survive Lung Cancer - A Practical 12-Step Plan
by Michael Lloyd (Author)


Written by a lung cancer survivor who understands what it takes to beat the odds, this book offers unparalleled hope and direction for anyone facing this illness. It is filled with specific exercises and techniques to promote healing and reverse side effects by taking a pro-active approach in helping to restore your mind, body and spirit to an optimum state of health. Endorsed by a Lung Cancer Specialist and Associate Professor at Harvard Medical School, this book combines what the doctors tell you with critical information they don't tell you. Visit www.SurviveLungCancer.com for chapter summaries.

You Can Beat Lung Cancer: Using Alternative/Integrative Interventions

You Can Beat Lung Cancer: Using Alternative/Integrative Interventions
by Carl O. Helvie (Author)


Can you overcome lung cancer without harsh chemicals, surgery and debilitation? Are alternative interventions effective? Why do conventional physicians not use them? Can you prevent cancer recurrences and live into old age without chronic diseases and prescribed medications? This book answers these and other questions. This is one of the most comprehensive books available on alternative treatments for lung cancer. It explains the treatments used successfully by a health professional/cancer survivor of 36 years and by some of the leading medical and health practitioners currently in the field. G. Edward Griffin, Author of World Without Cancer, The Politics of Cancer Therapy, and other books and films. Recipient of the Telly Award for Excellence in Television Production. President of...

Lung Cancer Causes, Symptoms,  Stages & Treatment Guide: Cure Lung Cancer With  A Positive Outlook

Lung Cancer Causes, Symptoms, Stages & Treatment Guide: Cure Lung Cancer With A Positive Outlook
by Danielle Dixon


This book contains proven steps and strategies on how to prevent, treat and fight cancer.

Cancer has long been closely associated with death, low quality of life, and financial difficulties. With all the complications it causes, lives it takes, and people it subjects to suffering, cancer is definitely a difficult disease.

Lung cancer is one of the leading causes of cancer deaths worldwide. Different risk factors have been attributed to its development- with genetics and environmental influences playing a major role. The diversity of its causes makes its treatment all the more difficult, which makes identification of causes essential to its management. The recognition of symptoms and diagnosis early in the course of the disease most frequently leads to good...

Understanding Lung Cancer: An Introduction for Patients and Caregivers

Understanding Lung Cancer: An Introduction for Patients and Caregivers
by Naheed Ali (Author)


Cancer of any kind is scary, but lung cancer is unique in that most people think that only people who smoke can or do get it. The truth is that anyone can get lung cancer, and it can be deadly. In 2008 (the most recent year numbers are available), 208,493 people in the United States were diagnosed with lung cancer, while 158,592 people in the United States died from lung cancer. Here, Dr. Naheed Ali dispels the notion that only smokers develop lung cancer, but also goes over their increased risk for getting the disease, while also considering the risk factors that non-smokers face. He provides background and tips for combating lung cancer, from prevention, to treatment, to coping with the disease should a person fall victim.

In typical fashion, Ali helps readers to understand...

100 Questions  &  Answers About Lung Cancer (100 Questions and Answers)

100 Questions & Answers About Lung Cancer (100 Questions and Answers)
by Joan H. Schiller (Author), Amy Cipau (Author)


EMPOWER YOURSELF! No one with lung cancer needs to be alone in their fight against this disease. 100 Questions & Answers About Lung Cancer, Third Edition, guides patients and their families through diagnosis, treatment and survivorship. Providing both the doctor’s and patient’s point of view, this book is a complete guide to understanding treatment options, post-treatment quality of life, sources of support, and much more. Through 100 Questions & Answers About Lung Cancer, Third Edition, expert authors use their experiences with patients to provide support and hope to the tens of thousands of people coping with lung cancer.

© 2015 BrightSurf.com