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Allergy - cancer link
November 03, 2004Some allergic conditions could increase your risk of suffering from blood cancer as an adult, according to a new study published this week in BMC Public Health. This is important news for the increasingly large numbers of allergy sufferers worldwide.
"In our study, people with hives showed an increased risk of leukaemia," said Dr. Karin Söderberg, who carried out the research with her colleagues from the Karolinska Institutet, Sweden. "We also found an increased risk of non-Hodgkin's lymphoma among individuals who had eczema during childhood."
However, other allergic conditions such as hay fever, did not appear to increase the risk of suffering from cancer.
The researchers followed 16,539 twins for 31 years and recorded whether they were diagnosed with a blood cancer during that time. These individuals had all answered a questionnaire sent out by the Swedish Twin Registry in 1967, which included questions about allergies.
"An important strength of our study is that the information about allergic conditions was collected prior to the individuals being diagnosed with cancer," said Dr. Söderberg. This prevents the bias that may arise if people, who have already been diagnosed with cancer, are asked to remember whether or not they have ever suffered from an allergy.
The researchers believe that the chronic stimulation of the immune system caused by allergic conditions, which leads to the formation of increased numbers of white blood cells, increases the risk that cancer-causing mutations occur within the white-blood cell population.
"Findings from our study do not support the 'immune surveillance' hypothesis, which stipulates that allergic conditions protect against malignancies by enhancing the ability of the immune system to detect and eliminate malignant cells," they write.
Although childhood eczema appeared to increase the risk that individuals will suffer from non-Hodgkin's lymphoma by around twofold, it is important to realise that the likelihood of any individual suffering from this condition is still remote. Non-Hodgkin's lymphoma only affects 0.03% of people in the USA.
BioMed Central Limited
The researchers followed 16,539 twins for 31 years and recorded whether they were diagnosed with a blood cancer during that time. These individuals had all answered a questionnaire sent out by the Swedish Twin Registry in 1967, which included questions about allergies.
"An important strength of our study is that the information about allergic conditions was collected prior to the individuals being diagnosed with cancer," said Dr. Söderberg. This prevents the bias that may arise if people, who have already been diagnosed with cancer, are asked to remember whether or not they have ever suffered from an allergy.
The researchers believe that the chronic stimulation of the immune system caused by allergic conditions, which leads to the formation of increased numbers of white blood cells, increases the risk that cancer-causing mutations occur within the white-blood cell population.
"Findings from our study do not support the 'immune surveillance' hypothesis, which stipulates that allergic conditions protect against malignancies by enhancing the ability of the immune system to detect and eliminate malignant cells," they write.
Although childhood eczema appeared to increase the risk that individuals will suffer from non-Hodgkin's lymphoma by around twofold, it is important to realise that the likelihood of any individual suffering from this condition is still remote. Non-Hodgkin's lymphoma only affects 0.03% of people in the USA.
BioMed Central Limited
Lymphoma Current Events and Lymphoma News RSSNew cancer target for non-Hodgkin's lymphoma
Physician-scientists from Weill Cornell Medical College have discovered a molecular mechanism that may prove to be a powerful target for the treatment of non-Hodgkin's lymphoma, a type of cancer that affects lymphocytes, or white blood cells.
Drugs to treat anemia in cancer patients linked to thromboembolism
Medications frequently given to cancer patients to reduce their risk of anemia are associated with an increased risk of deep vein thrombosis or pulmonary embolism, according to new research led by Dawn Hershman, M.D, M.S., co-director of the breast cancer program at the Herbert Irving Comprehensive Cancer Center at NewYork-Presbyterian Hospital/Columbia University Medical Center.
Researchers find new way to attack inflammation in Graves' eye disease
A small group of patients with severe Graves' eye disease experienced rapid improvement of their symptoms - and improved vision - following treatment with the drug rituximab.
Approved lymphoma drug shows promise in early tests against bone cancer
A drug already approved for the treatment of lymphoma may also slow the growth of the most deadly bone cancer in children and teens, according to an early-stage study published online today in the International Journal of Cancer.
Immunotherapy demonstrates long-term success in treating lymphoma
Targeted immunotherapy has been an attractive new therapeutic area for a number of cancers because it has the potential to destroy tumor cells without damaging surrounding normal tissue. New study results demonstrate high success rates using specialized white blood cells to prevent or treat lymphoma associated with the Epstein-Barr virus (EBV-lymphoma) in patients who have received a hematopoietic stem cell transplant (HSCT).
Exercise is good medicine for lymphoma patients
A healthy dose of exercise is good medicine, even for lymphoma patients receiving chemotherapy, University of Alberta researchers have found.
Childhood cancer survivors experience suicidal thoughts decades after diagnosis
Adult survivors of childhood cancer have an increased risk for suicidal thoughts, even decades after their cancer treatments ended, according to a study led by Dana-Farber Cancer Institute scientists.
New therapy for vasculitis will help patients avoid infertility and cancer
Researchers have identified that Rituxan, a drug previously approved for the treatment of non-Hodgkin's B cell lymphoma and rheumatoid arthritis, can treat severe ANCA-associated vasculitis as effectively as cyclophosphamide, the current standard therapy.
Studying cancer in pet dogs to find new treatments for human patients
A team of scientists at the National Cancer Institute (NCI) in Bethesda, USA, says that studying pet dogs with cancer could yield valuable information on how to diagnose and treat human cancers.
Scientists identify genetic cause of previously undefined primary immune deficiency disease
Researchers at the National Institutes of Health have identified a genetic mutation that accounts for a perplexing condition found in people with an inherited immunodeficiency.
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