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Spray to Stop Scarring in Development
October 28, 2004A spray that halves the healing time of burns and wounds is being designed for immediate use. Marina Murphy explains how the spray could be the difference between having a disfiguring scar or not in Chemistry & Industry magazine.
Tissue Therapies of Brisbane, Australia are developing an active ingredient that could help avoid the need for skin grafting sheets, significantly reduce scarring in children and help in healing chronic diabetic ulcers.
'Our aim is to reduce healing time in children to 10-14 days', says Zee Upton, the company's consulting chief scientific officer. Scars in children are particularly damaging because the scarred region cannot keep up with the child's natural growth. This causes areas of restriction, which are painful and often require surgery.
Also in Chemistry & Industry:
Down's Syndrome Treatment in the Womb
Scientists are working on a treatment that could be used to treat the retardation associated with Down's Syndrome while the baby is still in the womb, reports Marina Murphy in Chemistry & Industry magazine.
Roger Reeves and his group at Johns Hopkins University in Pennsylvania, USA had earlier shown that there are changes in the cell content of the cerebellum - part of the brain located at the nape of the neck - in individuals with Down's Syndrome.
Reeves' group is now trying to determine when neurons in the cerebellum are generated and when they differentiate. 'The individual neurons may not be defective, but it may be that there are not enough of them and they may not be hooked up correctly,' he said.
Reeves points out that, if a Down's Syndrome-related problem is detected before birth, it makes sense to intervene then. But, because the cerebellum develops mainly after birth, it may also be possible to develop post-natal treatments.
Last year, William Mobley at Stanford University reported that retardation caused by the degeneration of neurons in the basal forebrain of adults with Down's might also be reversed (C&I, 2003, 21, 10-11).
Society of Chemical Industry
Also in Chemistry & Industry:
Down's Syndrome Treatment in the Womb
Scientists are working on a treatment that could be used to treat the retardation associated with Down's Syndrome while the baby is still in the womb, reports Marina Murphy in Chemistry & Industry magazine.
Roger Reeves and his group at Johns Hopkins University in Pennsylvania, USA had earlier shown that there are changes in the cell content of the cerebellum - part of the brain located at the nape of the neck - in individuals with Down's Syndrome.
Reeves' group is now trying to determine when neurons in the cerebellum are generated and when they differentiate. 'The individual neurons may not be defective, but it may be that there are not enough of them and they may not be hooked up correctly,' he said.
Reeves points out that, if a Down's Syndrome-related problem is detected before birth, it makes sense to intervene then. But, because the cerebellum develops mainly after birth, it may also be possible to develop post-natal treatments.
Last year, William Mobley at Stanford University reported that retardation caused by the degeneration of neurons in the basal forebrain of adults with Down's might also be reversed (C&I, 2003, 21, 10-11).
Society of Chemical Industry
Neurons Current Events and Neurons News RSSScripps research scientists find new link between insulin and core body temperature
A team led by scientists at The Scripps Research Institute have discovered a direct link between insulin-a hormone long associated with metabolism and metabolic disorders such as diabetes-and core body temperature.
New Down syndrome treatment suggested by Stanford/Packard study in mice
At birth, children with Down syndrome aren't developmentally delayed. But as they age, these kids fall behind. Memory deficits inherent in Down syndrome hinder learning, making it hard for the brain to collect experiences needed for normal cognitive development.
Cognitive dysfunction reversed in mouse model of Down syndrome
A study by neuroscientist William C. Mobley, MD, PhD, chair of the Department of Neurosciences at the University of California, San Diego School of Medicine, and colleagues at Stanford University Medical School has demonstrated a possible new approach to slowing the inevitable progression of cognitive decline found in Down's syndrome.
Pushing the brain to find new pathways
Until recently, scientists believed that, following a stroke, a patient had about six months to regain any lost function. After that, patients would be forced to compensate for the lost function by focusing on their remaining abilities.
Scientists decipher the formation of lasting memories
Researchers at Karolinska Institutet have discovered a mechanism that controls the brain's ability to create lasting memories. In experiments on genetically manipulated mice, they were able to switch on and off the animals' ability to form lasting memories by adding a substance to their drinking water.
Developmental delay could stem from nicotinic receptor deletion
The loss of a gene through deletion of genetic material on chromosome 15 is associated with significant abnormalities in learning and behavior, said a consortium of researchers led by Baylor College of Medicine (www.bcm.edu) in a report that appears online today in the journal Nature Genetics.
New TMS clinic offers noninvasive treatment for major depression
Rush University Medical Center has opened the Transcranial Magnetic Stimulation (TMS) Clinic to offer patients suffering from major depression a safe, effective, non-drug treatment.
Researchers explore new ways to prevent spinal cord damage using a vitamin B3 precursor
Substances naturally produced by the human body may one day help prevent paralysis following a spinal cord injury, according to researchers at Weill Cornell Medical College. A recent $2.5 million grant from the New York State Spinal Cord Injury Research Board will fund their research investigating this possibility.
Estrogen therapy likely must be given soon after menopause to provide stroke protection
For estrogen replacement to provide stroke protection, it likely must be given soon after levels drop because of menopause or surgical removal of the ovaries, scientists report in the Journal of Neuroscience.
Researchers identify drug candidate for treating spinal muscular atrophy
A chemical cousin of the common antibiotic tetracycline might be useful in treating spinal muscular atrophy (SMA), a currently incurable disease that is the leading genetic cause of death in infants.
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