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Human Brain Connectivity Mapping
September 23, 2004The unique connectivity pattern of a brain region determines the type of information available to it, and hence influences its function. Defining these patterns enhances our knowledge of human brain architecture and function. Non-invasive in vivo definition of brain connectivity patterns complements functional imaging and provides new understanding of disorders associated with developmental or regional alterations of brain connectivity. There are extensions to this approach to clinically important issues. As an example, brain connectivity problems are important in developmental and acquired brain disorders.
Researchers working within the University of Oxford Clinical Neurology Department have developed a technique that is able to provide non-invasive identification of boundaries between major nuclei in a patient undergoing surgery, thereby improving both targeting accuracy and outcomes. The invention relates to mapping the connectivity of the brain's nervous system in a human, and uses imaging data derived from magnetic resonance imaging. New computer methods derive the anatomical connectivity patterns, and analyse the structure of the nervous system.
Testing the hypothesis that changes in fronto-thalamic circuitry i.e. thalamic dysfunction is a factor in schizophrenia becomes a reality using this methodology. Impairments in cortico-cortical connectivity are found in individuals with learning disabilities. The new method allows a quantitative approach to the differences so that actual variations in learning abilities and performance can be determined. At present localisation in stereotactic neurosurgery or deep brain stimulation of specific thalamic nuclei in movement disorders remains difficult. This approach to grey matter segmentation has the potential to improve targeting accuracy and outcomes.
The technology is the subject of a patent application and Isis Innovation Ltd would welcome the opportunity to discuss the commercial applications with interested companies.
Isis Innovation Ltd
The technology is the subject of a patent application and Isis Innovation Ltd would welcome the opportunity to discuss the commercial applications with interested companies.
Isis Innovation Ltd
Aging News and Current Aging Events RSSGene associated with pair-bonding in animals has similar effects in human males
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Experts Establish Baseline for Civic Engagement Among Retirees
The rise of retired people seeking active participation in their communities has led researchers to define this new aspect of American life. As a result, civic engagement can now be considered a distinct retirement role.
Age-related memory loss tied to slip in filtering information quickly
Scientists have identified a way in which the brain's ability to process information diminishes with age, and shown that this break down contributes to the decreased ability to form memories that is associated with normal aging.
Study finds B-vitamin deficiency may cause vascular cognitive impairment
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Clearing the airways in cystic fibrosis
By manipulating the machinery used by our cells for quality control, researchers from the University of Pittsburgh have found a way to restore the function of cystic fibrosis (CF) airway cells.
Why do eyelids sag with age? UCLA study answers mystery
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Hospice and palliative medicine specialty strives to prepare physicians for aging baby boomers
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Research Finds America's Elderly Suffering Abuse
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Researchers discover how rheumatoid arthritis causes bone loss
Researchers have discovered key details of how rheumatoid arthritis (RA) destroys bone, according to a study published in the Aug. 22 edition of the Journal of Biological Chemistry.
Researchers discover scent of skin cancer
According to new research from the Monell Center, odors from skin can be used to identify basal cell carcinoma, the most common form of skin cancer. The findings, presented at the 236th meeting of the American Chemical Society, may open doors to development of new methods to detect basal cell carcinoma and other forms of skin cancer.
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