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SARS antiviral drug discovered: traditional antimalarial drug works against SARS coronavirus infection
September 03, 2004Virologists from the Katholieke Universiteit Leuven (K.U.Leuven) in Belgium report that chloroquine, a widely used antimalarial drug, exhibits antiviral activity against the SARS coronavirus. Chloroquine is an inexpensive and safe drug available worldwide.
SARS (Severe Acute Respiratory Syndrome) is a respiratory illness which was first recognized in the winter of 2002 in China. By the end of June, 2003, the disease had affected over 8096 persons in 30 countries across five continents, causing 774 fatalities. Scientists discovered that SARS was caused by a virus belonging to the coronavirus family.
There is currently no effective and proven antiviral treatment for SARS. Standard antivirals (such as ribavirin) do not appear to alter the ultimate outcome of the disease. Recently, antiviral drugs commonly used to treat AIDS (nelfinavir, lopinavir/ritonavir) were shown to inhibit the SARS virus in the laboratory. However, these drugs are very expensive and have many side effects.
Today, the SARS research team led by Professor Marc Van Ranst of K.U.Leuven's Rega Institute for Medical Research report that chloroquine, a known antimalarial drug, is active against the SARS coronavirus in laboratory experiments. Chloroquine has been prescribed since the 1940s to travellers to malaria-endemic areas for the prevention and treatment of malaria. It is an inexpensive drug with an excellent safety record. A major advantage is that chloroquine is widely available, also in developing countries. When SARS re-emerges, chloroquine could be of great importance as preventive medication for people living in or travelling to SARS-affected areas, and as an antiviral treatment for SARS patients.
Katholieke Universiteit Leuven
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Prioritizing low-cost, simple health measures would save 2.5 million child lives a year
Almost a third of the children under age five who die each year could be saved if governments rebalance health spending to ensure low-cost, simple interventions such as safe water and hygiene, bed nets and basic maternal and newborn care, leading aid agency World Vision said today. Currently, 8.8 million children a year die before age five, most of preventable causes.
Drug industry, nonprofits join forces to fight world's neglected diseases
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U.S. and European Experts Applaud Creation of New Transatlantic Task Force on Global Antibiotic Resistance Threat
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1930s drug slows tumor growth
Drugs sometimes have beneficial side effects. A glaucoma treatment causes luscious eyelashes. A blood pressure drug also aids those with a rare genetic disease.
DNA barcodes: Creative new uses span health, fraud, smuggling, history, more
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PATH Malaria Vaccine Initiative shares strategy for developing 'next-generation' malaria vaccines
Marking its tenth anniversary year, the PATH Malaria Vaccine Initiative (MVI) today unveiled a new strategy that sets the stage for an aggressive push targeting the long-term goal of eliminating and eradicating malaria. Malaria is one of the world's deadliest infectious diseases, killing nearly 900,000 people a year, most of them children in sub-Saharan Africa.
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The Making of a Tropical Disease: A Short History of Malaria (Johns Hopkins Biographies of Disease) by Randall M. Packard (Author) Malaria sickens hundreds of millions of people -- and kills one to three million -- each year. Despite massive efforts to eradicate the disease, it remains a major public health problem in poorer tropical regions. But malaria has not always been concentrated in tropical areas. How did other regions control malaria and why does the disease still flourish in some parts of the globe? From Russia to Bengal to Palm Beach, Randall Packard's far-ranging narrative traces the natural and social forces that help malaria spread and make it deadly. He finds that war, land development, crumbling health systems, and globalization -- coupled with climate change and changes in the distribution and flow of water -- create conditions in which malaria's carrier mosquitoes thrive. The combination of... |
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The Malaria Capers : More Tales of Parasites and People, Research and Reality by Robert S. Desowitz (Author) "Reads like a murder mystery. . . . [Desowitz] writes with uncommon lucidity and verse, leaving the reader with a vivid understanding of malaria and other tropical diseases, and the ways in which culture, climate and politics have affected their spread and containment."—New York Times Why, Robert S. Desowitz asks, has biotechnical research on malaria produced so little when it had promised so much? An expert in tropical diseases, Desowtiz searches for answers in this provocative book. . |
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Humanity's Burden: A Global History of Malaria (Studies in Environment and History) by James L.A. Webb Jr. (Author) Humanity's Burden provides a panoramic overview of the history of malaria. It traces the long arc of malaria out of tropical Africa into Eurasia, its transfer to the Americas during the early years of the Columbian exchange, and its retraction from the middle latitudes into the tropics since the late nineteenth century. Adopting a broadly comparative approach to historical patterns and processes, it synthesizes research findings from the natural and social sciences and weaves these understandings into a narrative that reaches from the earliest evidence of malaria infections in tropical Africa up to the present. Written in a style that is easily accessible to non-specialists, it considers the significance of genetic mutations, diet, lifestyle, migration, warfare, palliative and curative... |
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First Comes Love, Then Comes Malaria: How a Peace Corps Poster Boy Won My Heart and a Third World Adventure Changed My Life by Eve Brown-Waite (Author) In this laugh-out-loud funny memoir, a pampered city girl falls head over little black heels in love with a Peace Corps poster boy and follows him —literally–to the ends of the earth. Eve Brown always thought she would join the Peace Corps someday, although she secretly worried about life without sushi, frothy coffee drinks and air conditioning. But with college diploma in hand, it was time to put up or shut up. So with some ambivalence she arrives at the Peace Corps office–sporting her best safari chic attire –to casually look into the steps one might take if one were to become a global humanitarian, a la Angelina Jolie. But when Eve meets John, her dashing young Peace Corps recruiter, all her ambivalence flies out the window. She absolutely must join the Peace Corps -... |
![GIANTmicrobes: Malaria (Plasmodium Falciparum) [Toy]](http://ecx.images-amazon.com/images/I/21%2BeHMzjARL._SL160_.jpg) |
GIANTmicrobes: Malaria (Plasmodium Falciparum) [Toy] by Giant Microbes GIANTmicrobes are fun and educationala great way to learn about various health topics and the microscopic critters that are found in and around us. Each microbe character is 5-7 in size--over a million times their actual size! Perfect for teachers, parents and budding scientiststhey also make humorous gifts. Each microbe comes with an information tag including scientific name, an image of the actual microbe, and a mini history and science lesson. Not suitable for children under 3 years. Our products are made by top manufacturers who care about toy safety, quality and value. Your order will ship factory fresh directly from our warehouse to your door. We carefully inspect and beautifully package every order before shipment to ensure that you receive high quality products that are... |
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Malaria: Fever Wars Starring: Artist Not Provided |
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Molecular Approaches to Malaria by Irwin W. Sherman (Editor) "Molecular Approaches to Malaria" provides an overview of the rapid and significant developments that have occurred in malaria research, including the 2002 genome sequencing of Plasmodium falciparum and its mosquito vector, Anopheles gambiae. This work: provides a concise source of up-to-date research findings; appeals to a diverse audience, including malaria researchers, teachers, investigators, and public health professionals; offers contributions by recognized malaria researchers with practical experience; and, presents comprehensive coverage of topics including a clearly written introduction to Plasmodium molecular biology. |
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Sea to Summit Personal Mosquito Shelter (Double) by Sea to Summit An indispensible item for traveling or backpacking in bug infested regions. The Sea to Summit Mosquito Net shelters are small, light and compact. Available in a Permetherin treated version. Handy stuff sack for easing packing included. Double version has 22 spreader pole that packs down to 6. |
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