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University of Helsinki to coordinate two large EU research projects
August 24, 2004The European Union has granted nearly 25 MEUR to two large-scale interdisciplinary research projects coordinated by the University of Helsinki. The project leaders are professor Raimo Tuominen from the UH's Faculty of Pharmacy and Academy professor Kari Alitalo from UH's Molecular and Cancer Biology Laboratory. Both projects are part of the European Commission's Sixth Framework Programme for Life Sciences, Genomics, and Biotechnology for Health.
Protein kinases are promising drug targets
The integrated research project lead by Professor Tuominen carrying out basic research into Protein kinases (PKs) was granted over 15 MEUR. The project is the largest in the 6th framework programme (FP6's) for Life sciences, genomics and biotechnology for health.
Protein kinases belong to the largest single family of enzymes, accounting for almost 2% of the proteins encoded by the human genome. Recent success in drug discovery demonstrates that PKs are excellent drug targets. The objectives of the research project are to do basic research on protein kinases and to develop PK inhibitors and activators by designing and screening natural compounds from the European biosphere and compounds from chemical libraries.
The research consortium combines European expertise on basic research on PKs and rational drug discovery, in order to develop new drug candidates for major diseases like cancer, autoimmune disorders, vascular diseases and degenerative brain diseases. The consortium consists of 23 partners from 11 countries.
Lymphatic vasculature has an essential role in metastasis of cancer
The biomedical research project lead by Academy Professor Alitalo was granted 9 MEUR. The project aims at a better understanding of the growth and function of the lymphatic vasculature, with a strong emphasis on the discovery of novel regulatory agents.
The lymphatic vasculature is essential for the maintenance of tissue fluid balance and has an essential role in various pathological conditions such as metastasis of cancer. Recent results suggest that inhibition of lymphatic vessel growth in tumors can block metastasis. Novel discoveries in the field can also be applied to the development of new pharmaceuticals for inflammatory and heart diseases.
The project encompasses European specialists on genetics, genome research, cancer research, developmental biology, cardiovascular research, pathology and biotechnology and combines 11 academic research institutes and two companies from eight European countries.
The 6th framework programme (FP6) is the frame for the EU activities in the field of science, research and innovation. With a budget of 17.5 billion euros for the years 2002 - 2006 it represents about 4 to 5 percent of the overall expenditure on RTD in EU Member States.
Helsingin yliopisto (University of Helsinki)
The research consortium combines European expertise on basic research on PKs and rational drug discovery, in order to develop new drug candidates for major diseases like cancer, autoimmune disorders, vascular diseases and degenerative brain diseases. The consortium consists of 23 partners from 11 countries.
Lymphatic vasculature has an essential role in metastasis of cancer
The biomedical research project lead by Academy Professor Alitalo was granted 9 MEUR. The project aims at a better understanding of the growth and function of the lymphatic vasculature, with a strong emphasis on the discovery of novel regulatory agents.
The lymphatic vasculature is essential for the maintenance of tissue fluid balance and has an essential role in various pathological conditions such as metastasis of cancer. Recent results suggest that inhibition of lymphatic vessel growth in tumors can block metastasis. Novel discoveries in the field can also be applied to the development of new pharmaceuticals for inflammatory and heart diseases.
The project encompasses European specialists on genetics, genome research, cancer research, developmental biology, cardiovascular research, pathology and biotechnology and combines 11 academic research institutes and two companies from eight European countries.
The 6th framework programme (FP6) is the frame for the EU activities in the field of science, research and innovation. With a budget of 17.5 billion euros for the years 2002 - 2006 it represents about 4 to 5 percent of the overall expenditure on RTD in EU Member States.
Helsingin yliopisto (University of Helsinki)
Cancer Current Events and Cancer News RSSDeaths from lung cancer could be reduced by better policies to control indoor radon
About 1100 people each year die in the UK from lung cancer related to indoor radon, but current government protection policies focus mainly on the small number of homes with high radon levels and neglect the 95% of radon related deaths caused by lower levels of radon, according to a study published on bmj.com today.
Protein's essential role in repairing damaged cells revealed
University of Michigan researchers have discovered that a key protein in cells plays a critical role in not one, but two processes affecting the development of cancer.
Interpretation Time for Screening Digital Mammograms: Is it Efficient?
Digital mammograms take longer to interpret than film-screen mammograms, according to a study performed at The University of Texas M.D. Anderson Cancer Center in Houston, Texas.
Scientists can now differentiate between healthy cells and cancer cells
One of the current handicaps of cancer treatments is the difficulty of aiming these treatments at destroying malignant cells without killing healthy cells in the process.
Team finds breast cancer gene linked to disease spread
A team of researchers at Princeton University and The Cancer Institute of New Jersey has identified a long-sought gene that is fatefully switched on in 30 to 40 percent of all breast cancer patients, spreading the disease, resisting traditional chemotherapies and eventually leading to death.
New hope for cancer comes straight from the heart
Digitalis-based drugs like digoxin have been used for centuries to treat patients with irregular heart rhythms and heart failure and are still in use today. In the Dec. 16 issue of the Proceedings of the National Academy of Sciences, researchers at the Johns Hopkins University School of Medicine now report that this same class of drugs may hold new promise as a treatment for cancer.
Cell Biologists Identify New Tumor Suppressor for Lung Cancer
Cancer and cell biology experts at the University of Cincinnati (UC) have identified a new tumor suppressor that may help scientists develop more targeted drug therapies to combat lung cancer.
Errors involving medications common in outpatient cancer treatment
Seven percent of adults and 19 percent of children taking chemotherapy drugs in outpatient clinics or at home were given the wrong dose or experienced other mistakes involving their medications.
Grape-seed extract kills laboratory leukemia cells, proving value of natural compounds
An extract from grape seeds forces laboratory leukemia cells to commit cell suicide, according to researchers from the University of Kentucky. They found that within 24 hours, 76 percent of leukemia cells had died after being exposed to the extract.
In lung cancer, silencing one crucial gene disrupts normal functioning of genome
While examining patterns of DNA modification in lung cancer, a team of international researchers has discovered what they say is a surprising new mechanism.
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