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New Discovery in Preventing Diabetic Complications
August 23, 2004A new study sheds light on the response to infection in people with type 2 diabetes. These individuals develop diabetes associated with obesity. Findings from this study revealed that controlling a specific protein produced by the body, known as a cytokine, reduces the expression of other molecules and helps control inflammation. This is significant because many complications associated with diabetes trigger an inflammatory response. Right now, type 2 diabetes affects over 17 million people in the United States and impacts the health industry significantly on economic and individual levels [1].
Tumor necrosis factor (TNF), a type of cytokine, can cause inflammation and damage [2] in soft tissue infections, bite wounds and in periodontal disease. In a recent study published in the Journal of Investigative Dermatology, two groups of lab mice, one normal, the other diabetic, were injected with anaerobic bacteria, a germ present in "approximately one-third of bite wounds and associated with the formation of abscesses and with relatively serious infections," [3,4] to determine how type 2 diabetes affects the inflammatory response in surrounding tissue. Results from the tests demonstrated that the presence of diabetes prolongs inflammation. Following infection, the normal mice were able to rapidly resolve the ensuing inflammation within three days whereas the diabetic mice could not.
"It may be particularly important in diabetics to consider the impact that prolonged inflammation might have on the course of events," states contributing author Dr. Dana T. Graves. According to the study, diabetics are particularly susceptible to the detrimental effects of infection associated with inflammatory cytokines. Further, inflammation can often be a precursor to complications such as cardiovascular disease and poor wound healing. Dr. Graves concludes, "If excess TNF in diabetics is inhibited, the tendency for prolonged inflammation is reduced."
1 American Diabetes Association, All About Diabetes, 2004
2 Gorman JD, et al: Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor a. New England Journal of Medicine, 346(18): 1349-1356, 2002
3 Edelman S: Importance of glucose control. Med Clin North Am 82:665-687, 1998
4 Zimmet P, Alberti K, Shaw J: Global and societal implications of the diabetes epidemic. Nature 414: 782-787, 2001
Blackwell Publishing Ltd
1 American Diabetes Association, All About Diabetes, 2004
2 Gorman JD, et al: Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor a. New England Journal of Medicine, 346(18): 1349-1356, 2002
3 Edelman S: Importance of glucose control. Med Clin North Am 82:665-687, 1998
4 Zimmet P, Alberti K, Shaw J: Global and societal implications of the diabetes epidemic. Nature 414: 782-787, 2001
Blackwell Publishing Ltd
Diabetes Current Events and Diabetes News RSSFlaxseed oil and osteoporosis
Animal studies suggest that adding flaxseed oil to the diet could reduce the risk of osteoporosis in post-menopausal women and women with diabetes, according to a report to be published in the International Journal of Food Safety, Nutrition and Public Health.
Diabetes surgery summit consensus lays foundation for new field of medicine
A first-of-its-kind consensus statement on diabetes surgery is published online today in the Annals of Surgery.
ESC to give talks on Diabetes in three cities in China
As a result of successful events organised last year, a second Joint Scientific Forum, organised by the European Society of Cardiology (ESC) and the European Association for the Study of Diabetes (EASD), two of the most respected professional medical organisations in Europe, will be held from 27-29 November at three venues across China - Beijing, Shanghai and Guangzhou.
New research shows versatility of amniotic fluid stem cells
For the first time, scientists have demonstrated that stem cells found in amniotic fluid meet an important test of potential to become specialized cell types, which suggests they may be useful for treating a wider array of diseases and conditions than scientists originally thought.
First reconstitution of an epidermis from human embryonic stem cells
Stem cell research is making great strides. This is yet again illustrated by a study carried out by the I-STEM* Institute (I-STEM/ Inserm UEVE U861/AFM), published in the Lancet on 21 November 2009. The I-STEM team, directed by Marc Peschanski has just succeeded in recreating a whole epidermis from human embryonic stem cells.
An atomic-level look at an HIV accomplice
Since the discovery in 2007 that a component of human semen called SEVI boosts infectivity of the virus that causes AIDS, researchers have been trying to learn more about SEVI and how it works, in hopes of thwarting its infection-promoting activity.
Scripps research scientists find new link between insulin and core body temperature
A team led by scientists at The Scripps Research Institute have discovered a direct link between insulin-a hormone long associated with metabolism and metabolic disorders such as diabetes-and core body temperature.
Scientists find molecular trigger that helps prevent aging and disease
Researchers at Mount Sinai School of Medicine set out to address a question that has been challenging scientists for years: How do dietary restriction-and the reverse, overconsumption-produce protective effects against aging and disease?
Pivotal study for PSD502 -- the first potential treatment for premature ejaculation
At the annual meeting of the Sexual Medicine Society of North America (SMSNA), Inc. in San Diego, Sciele Pharma, Inc., a Shionogi Company and Plethora Solutions Limited, a wholly owned subsidiary of Plethora Solutions Holdings PLC ("Plethora" - AIM:PLE)., today presented data from its second positive pivotal study of PSD502 for the treatment of premature ejaculation (PE).
Night Beat, Overtime and a Disrupted Sleep Pattern Can Harm Officers' Health
A police officer who works the night shift, typically from 8 p.m. to 4 a.m., already is at a disadvantage when it comes to getting a good "night's" sleep.
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