 |
|
Bug factories for drugs: quality control holds key to quantity
August 23, 2004Tiny types of soil bugs already make many of the products we use in washing detergents, foods, and waste treatment, but scientists now hope that similar bacteria will also make the vaccines and drugs of the future, according to new research presented today (Tuesday, 07 September 2004) at the Society for General Microbiology's 155th Meeting at Trinity College Dublin.
Researchers from the Institute of Cell and Molecular Studies at Newcastle University have successfully produced small quantities of a promising new vaccine for anthrax using Bacillus bacteria which have been modified to produce human medicines.
"Many people already use enzymes produced by these bacteria to wash their clothes," says Professor Colin Harwood of Newcastle University. "But the bacteria which make these enzymes, so useful for digesting dirt, have very efficient quality control systems which spot rogue proteins and enzymes and destroy them. This control mechanism stops us using these bacteria to make large quantities of the pure proteins we need for use in vaccines and other medicines."
The scientists have spent the last ten years, working with a Europe-wide group of 11 research laboratories, discovering how bacteria move enzymes and proteins from inside their cells, where they are made, to the outside world, where they are needed.
An important component of the system for moving proteins across the cell membrane turns out to be a quality control mechanism which recognises and breaks down foreign proteins. The bacteria need this checking mechanism to survive in competitive natural environments such as the soil. But this same checking system means that any drug production is disappointingly low if we try to use the bacteria to make useful medicines.
"Bacilli could make authentic versions of some of the important proteins we have identified from the results of the Human Genome Project, at concentrations of 20 grammes per litre - which is commercially acceptable," says Prof Harwood. "These bacteria are wonderfully efficient factories, and using them would reduce purification costs and provide structurally authentic proteins."
"A better understanding of bacteria will allow us to produce human and animal medicines," says Prof Harwood. "However, since the protein secretion apparatus and quality control systems are also essential for the bacteria's survival, they also give us new targets for antibiotic drugs."
Society for General Microbiology
The scientists have spent the last ten years, working with a Europe-wide group of 11 research laboratories, discovering how bacteria move enzymes and proteins from inside their cells, where they are made, to the outside world, where they are needed.
An important component of the system for moving proteins across the cell membrane turns out to be a quality control mechanism which recognises and breaks down foreign proteins. The bacteria need this checking mechanism to survive in competitive natural environments such as the soil. But this same checking system means that any drug production is disappointingly low if we try to use the bacteria to make useful medicines.
"Bacilli could make authentic versions of some of the important proteins we have identified from the results of the Human Genome Project, at concentrations of 20 grammes per litre - which is commercially acceptable," says Prof Harwood. "These bacteria are wonderfully efficient factories, and using them would reduce purification costs and provide structurally authentic proteins."
"A better understanding of bacteria will allow us to produce human and animal medicines," says Prof Harwood. "However, since the protein secretion apparatus and quality control systems are also essential for the bacteria's survival, they also give us new targets for antibiotic drugs."
Society for General Microbiology
Bacteria Current Events and Bacteria News RSSFactors from common human bacteria may trigger multiple sclerosis
Current research suggests that a common oral bacterium may exacerbate autoimmune disease. The related report by Nichols et al, "Unique Lipids from a Common Human Bacterium Represent a New Class of TLR2 Ligands Capable of Enhancing Autoimmunity," appears in the December 2009 issue of The American Journal of Pathology.
Exposure to both traffic, indoor pollutants puts some kids at higher risk for asthma later
New research presents strong evidence that the "synergistic" effect of early-life exposure to both outdoor traffic-related pollution and indoor endotoxin causes more harm to developing lungs than one or the other exposure alone.
New study finds MRSA on the rise in hospital outpatients
The community-associated strain of the deadly superbug MRSA-an infection-causing bacteria resistant to most common antibiotics-poses a far greater health threat than previously known and is making its way into hospitals, according to a study in the December issue of Emerging Infectious Diseases.
Researchers establish common seasonal pattern among bacterial communities in Arctic rivers
New research on bacterial communities throughout six large Arctic river ecosystems reveals predictable temporal patterns, suggesting that scientists could use these communities as markers for monitoring climate change in the polar regions.
Biologists discover bacterial defense mechanism against aggressive oxygen
Bacteria possess an ingenious mechanism for preventing oxygen from harming the building blocks of the cell.
Saving the single cysteine: new antioxidant system found
We've all read studies about the health benefits of having a life partner. The same thing is true at the molecular level, where amino acids known as cysteines are much more vulnerable to damage when single than when paired up with other cysteines.
Beyond sunlight: Explorers census 17,650 ocean species between edge of darkness and black abyss
Census of Marine Life scientists have inventoried an astonishing abundance, diversity and distribution of deep sea species that have never known sunlight - creatures that somehow manage a living in a frigid black world down to 5,000 meters (~3 miles) below the ocean waves.
Surface bacteria maintain skin's healthy balance
On the skin's surface, bacteria are abundant, diverse and constant, but inflammation is undesirable. Research at the University of California, San Diego School of Medicine now shows that the normal bacteria living on the skin surface trigger a pathway that prevents excessive inflammation after injury.
On the Trail of a Vaccine for Lyme Disease: Yale Researchers Target Tick Saliva
A protein found in the saliva of ticks helps protect mice from developing Lyme disease, Yale researchers have discovered. The findings, published in the November 19 issue of Cell Host & Microbe, may spur development of a new vaccine against infection from Lyme disease, which is spread through tick bites.
Cigarettes Harbor Many Bacteria Harmful to Human Health
Cigarettes are "widely contaminated" with bacteria, including some known to cause disease in people, concludes a new international study conducted by a University of Maryland environmental health researcher and microbial ecologists at the Ecole Centrale de Lyon in France.
More Bacteria Current Events and Bacteria News Articles
 |
A Field Guide to Bacteria (Comstock Book) by Betsey Dexter Dyer (Author) Pocket-guide to observing bacteria without a laboratory or fancy equipment. Presents all the major taxonomic groups of bacteria in a useable, accessible format for amateur naturalists who may or may not have access to a microscope. Includes ideas for planning field trips to explore bacteria in their natural environments. Illustrated, some color. Softcover, hardcover available. |
 |
Ein-O Science BioSigns Bacteria by Tedco The hands on cell and microbiology models provide magnified and cross section details. The set includes Virus, Bacteria, Plant Cell, White Blood Cell, Red Blood Cell and Animal Cell. Ein-O's I Know Guides and storage box are included. Consider using these models with a display of your own making - featuring the intricacies of cell structure, comparing and contrasting differences, investigating functions & interactions, or describing the efforts of modern medicine... a neat Science Fair Project. Virus - This hands-on interactive model provides magnified and cross-sectioned detailing of a Virus. Animal Cell - This hands-on interactive model provides magnified and cross-sectioned detailing of an Animal Cell. White Blood Cell - This hands-on interactive model provides... |
 |
Bacteria (Discovery Channel School Science) by Lynn Brunelle (Author), Barbara Ravage (Author), Lynn Brunelle (Editor), Barbara Ravage (Editor), Gareth Stevens Publishing (Editor) |
 |
Good Germs, Bad Germs: Health and Survival in a Bacterial World by Jessica Snyder Sachs (Author) Making Peace with Microbes Public sanitation and antibiotic drugs have brought about historic increases in the human life span; they have also unintentionally produced new health crises by disrupting the intimate, age-old balance between humans and the microorganisms that inhabit our bodies and our environment. As a result, antibiotic resistance now ranks among the gravest medical problems of modern times. Good Germs, Bad Germs addresses not only this issue but also what has become known as the “hygiene hypothesis”— an argument that links the over-sanitation of modern life to now-epidemic increases in immune and other disorders. In telling the story of what went terribly wrong in our war on germs, Jessica Snyder Sachs explores our emerging understanding of the symbiotic... |
 |
60 Minutes - Superbug (November 11, 2007) Airdate 11/11/07 MRSA is a superbug, a staff infection that has moved out of hospitals and nursing homes and is now infecting healthy people, sometimes killing them. That's because once the MRSA infection gets into the blood stream, it is largely resistant to antibiotics. For now, the best medicine is prevention. What does this mean? Scrubbing down school desks? Hosing down team locker rooms? Sending infected kids home? Lesley Stahl reports. This product is manufactured on demand using DVD-R recordable media. Amazon.com's standard return policy will apply. |
 |
Molecular Genetics of Bacteria (Snyder, Molecular Genetics of Bacteria) by Larry Snyder (Author), Wendy Champness (Author) This landmark volume provides the single most comprehensive and authoritative textbook on bacterial molecular genetics. Perfect for advanced undergraduate and graduate-level courses, the text presents the latest research on the subject in a clearly written and well-illustrated style. It provides descriptive background information, detailed experimental methods, examples of genetic analyses, and advanced material relevant to current applications of molecular genetics. While providing a deep understanding of bacterial molecular genetics, the material is integrated with biochemical, genomic, and structural information to broaden understanding. The approach centers on the most-studied bacteria, Escherichia coli and Bacillus subtilis. In addition, examples from other bacteria with... |
 |
Magic School Bus World of Germs Science Kit by Young Scientist Club The World of Germs- Magic School Bus Science Kit FUN |
 |
Disposable EARLOOP Face MASK, Filters Bacteria 3 Ply - (Box of 50) by EVERREADY FIRST AID Tie-on surgical face mask with high bacterial filtration efficiency (BFE), low breathing resistance, soft, odorless, non-irritating, comfortable superior fit, fiberglass free. |
 |
Essick Air #1970 Quart Bacteria Treatment by ESSICK AIR PRODUCTS QT, Humidifier Bacteria Treatment, Helps Fight Bacteria & Algae Build Up, Keeps Water Smelling Clean, EPA Registered, For Use In All Evaporative Console & Room Size Humidifiers. |
 |
Enzymatic Therapy Acidophilus Pearls (90 Pearls) by Enzymatic This formula provides a combination of Acidophilus and Bididiobacterium species to support the overall health of the intestinal tract. |
| © 2009 BrightSurf.com |