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New Model Helps Diabetes Research
August 17, 2004Scientists at the Babraham Institute are developing new methods to aid research into the causes of diabetes, a condition suffered by around 2.5 million people in the UK. A new study, published in The Journal of Clinical Investigation, describes an effective model of a rare form of the disease called transient neonatal diabetes mellitus (TNDM), which affects approximately 1 in 600,000 newborn babies. Babies born with TNDM initially cannot produce insulin, but symptoms disappear after about 3 months. However two-thirds of those affected will develop diabetes later in life, usually in their teens.
The mouse model, developed by the research group headed by Dr Gavin Kelsey, shows disappearing and reappearing diabetes similar to that seen in TDNM, and makes the examination of the faulty insulin-producing cells of the pancreas much more straightforward. A reduction in the levels of several key chemicals involved in the development of the pancreas has already been shown.
Dr Kelsey comments "Although a rare form of diabetes, TNDM is important to our understanding of diabetes because the defective gene has been identified. A model for TNDM, such as the one produced at Babraham, will allow us to study in detail the problems that arise in the insulin-producing cells when this defective gene is expressed."
Further information
The Babraham Institute, located just south of Cambridge, UK, is an educational charity focussed on delivering science of the highest quality that will add significantly to knowledge and find applications in the biomedical, biotechnological and pharmaceutical sectors. The work described was funded by the Biotechnology and Biological Sciences Research Council, The Wellcome Trust, the Medical Research Council, Diabetes UK and the Juvenile Diabetes Research Fund International, and was carried out in conjunction with scientists at the Bristol Royal Hospital for Children, the University of Bristol and the Rangueil Hospital in Toulouse, France.
Babraham Institute, The
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