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Early signs that statins could help in treatment of rheumatoid arthritis (pp 2011, 2015)
June 16, 2004Results of a UK study in this week's issue of THE LANCET suggest that the anti-inflammatory effect of statins (a class of cholesterol-lowering drugs) could be effective in relieving symptoms of rheumatoid arthritis.
The inflammatory nature of rheumatoid arthritis puts sufferers at an increased risk of cardiovascular disease. Statins are well known for reducing vascular risk; Iain McInnes, Naveed Sattar, and colleagues from the Glasgow Royal Infirmary, University of Glasgow, UK, investigated whether statins would reduce inflammatory factors in patients with rheumatoid arthritis.
116 patients were randomly allocated either daily 40 mg atorvastatin or placebo in addition to therapy for rheumatoid arthritis. All patients were assessed after 6 months. Among patients given atorvastatin there was a small but statistically significant improvement in arthritis symptoms compared with those given placebo (assessment was done using a composite score for disease severity which included scores for swollen joints and pain scores).
The clinical implications of the study findings are discussed by Lars Klareskog and Anders Hamsten from the Karolinska Institute, Sweden, in an accompanying Commentary (p 2011). Dr Klareskog concludes: "Although of limited size and short-term, their findings support the use of atorvastatin, and presumably of other statins, to prevent cardiovascular disease in patients with rheumatoid arthritis. Needless to say, more work is needed to define the long-term effects on inflammatory diseases and cardiovascular co-morbidities, and to expand the basic understanding of how various statins affect the immune system."
Lancet
The clinical implications of the study findings are discussed by Lars Klareskog and Anders Hamsten from the Karolinska Institute, Sweden, in an accompanying Commentary (p 2011). Dr Klareskog concludes: "Although of limited size and short-term, their findings support the use of atorvastatin, and presumably of other statins, to prevent cardiovascular disease in patients with rheumatoid arthritis. Needless to say, more work is needed to define the long-term effects on inflammatory diseases and cardiovascular co-morbidities, and to expand the basic understanding of how various statins affect the immune system."
Lancet
Arthritis Current Events and Arthritis News RSSCommon Pain Relievers May Dilute Power of Flu Shots
With flu vaccination season in full swing, research from the University of Rochester Medical Center cautions that use of many common pain killers - Advil, Tylenol, aspirin - at the time of injection may blunt the effect of the shot and have a negative effect on the immune system.
Mending meniscals in children, improving diagnosis and recovery
The meniscus is a rubber-like, crescent moon-shaped cartilage cushion that sits between the leg and thigh bone. Each knee has two menisci: one on the inside of the knee joint and one on the outside.
Study finds link between childhood physical abuse and arthritis
Adults who had experienced physical abuse as children have 56 per cent higher odds of osteoarthritis compared to those who have not been abused, according to a new study by University of Toronto researchers.
Pain thresholds linked to inflammation and sleep problems in arthritis patients
Despite recent advances in anti-inflammatory therapy, many rheumatoid arthritis (RA) patients continue to suffer from pain.
URI research couple's method targets cancerous tumors
Two University of Rhode Island associate professors, biophysicists Yana Reshetnyak and Oleg Andreev, have discovered a technology that can detect cancerous tumors and deliver treatment to them without the harming the healthy cells surrounding them, thereby significantly reducing side effects.
Changing behavior helps patients take medication as prescribed
Taking medication as the doctor prescribes is crucial to improving health. However, 26 to 59 percent of older adults do not adhere to instructions, according to a 2003 study published in Drugs and Aging.
Extra care for outwardly healthy workers costs companies millions annually
Someone healthy enough to work could still cost an employer more than $4,000 annually in unnecessary health care costs.
New therapy for vasculitis will help patients avoid infertility and cancer
Researchers have identified that Rituxan, a drug previously approved for the treatment of non-Hodgkin's B cell lymphoma and rheumatoid arthritis, can treat severe ANCA-associated vasculitis as effectively as cyclophosphamide, the current standard therapy.
Stanford study identifies cellular mechanism that causes lupuslike symptoms in mice
Macrophages, the scavenger cells of the body's immune system, are responsible for disposing of dying cells. Stanford University School of Medicine researchers have identified one pathway in this important process in mice that, if disrupted, causes a lupuslike autoimmune disease.
Trial raises doubts over alternative pain therapy for arthritis
Copper bracelets and magnetic wrist straps are ineffective in relieving arthritis pain, according to a new study led by a University of York academic.
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