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Early signs that statins could help in treatment of rheumatoid arthritis (pp 2011, 2015)
June 16, 2004Results of a UK study in this week's issue of THE LANCET suggest that the anti-inflammatory effect of statins (a class of cholesterol-lowering drugs) could be effective in relieving symptoms of rheumatoid arthritis.
The inflammatory nature of rheumatoid arthritis puts sufferers at an increased risk of cardiovascular disease. Statins are well known for reducing vascular risk; Iain McInnes, Naveed Sattar, and colleagues from the Glasgow Royal Infirmary, University of Glasgow, UK, investigated whether statins would reduce inflammatory factors in patients with rheumatoid arthritis.
116 patients were randomly allocated either daily 40 mg atorvastatin or placebo in addition to therapy for rheumatoid arthritis. All patients were assessed after 6 months. Among patients given atorvastatin there was a small but statistically significant improvement in arthritis symptoms compared with those given placebo (assessment was done using a composite score for disease severity which included scores for swollen joints and pain scores).
The clinical implications of the study findings are discussed by Lars Klareskog and Anders Hamsten from the Karolinska Institute, Sweden, in an accompanying Commentary (p 2011). Dr Klareskog concludes: "Although of limited size and short-term, their findings support the use of atorvastatin, and presumably of other statins, to prevent cardiovascular disease in patients with rheumatoid arthritis. Needless to say, more work is needed to define the long-term effects on inflammatory diseases and cardiovascular co-morbidities, and to expand the basic understanding of how various statins affect the immune system."
Lancet
Arthritis Current Events and Arthritis News RSSStatins may prevent miscarriages
Hospital for Special Surgery researchers have found that statins may be able to prevent miscarriages in women who are suffering from pregnancy complications caused by antiphospholipid syndrome (APS), according to a study in mice.
Hodgkin lymphoma -- new characteristics discovered
Researchers are still discovering new characteristics of Hodgkin lymphoma, a common form of cancer of the lymphatic system. The malignant cells are derived from white blood cells (B cells), but have lost a considerable part of the B cell-specific gene expression pattern.
Incorporating Education in Exercise Programs Increases Benefits for Arthritis Patients, MU Researchers Find
Arthritis is the nation's most common cause of disability. The number of adults with doctor-diagnosed arthritis is projected to increase to 67 million by 2030, and a large proportion of U.S. adults will limit their activity as a result.
Discovery of natural compounds that could slow blood vessel growth
Using computer models and live cell experiments, biomedical engineers at the Johns Hopkins University School of Medicine have discovered more than 100 human protein fragments that can slow or stop the growth of cells that make up new blood vessels.
UCR researchers propose minocycline as a promising drug for patients with Fragile X syndrome
A UC Riverside-led team of biomedical scientists has found that a readily available drug called minocycline, used widely to treat acne and skin infections, can be used to treat Fragile X syndrome, the most common inherited cause of mental impairment and the most common cause of autism.
New study proves that pain is not a symptom of arthritis, pain causes arthritis
Pain is more than a symptom of osteoarthritis, it is an inherent and damaging part of the disease itself, according to a study published today in journal Arthritis and Rheumatism.
Supplements no better than placebo in slowing cartilage loss in knees of osteoarthritis patients
In a two-year multicenter study led by University of Utah doctors, the dietary supplements glucosamine and chondroitin sulfate performed no better than placebo in slowing the rate of cartilage loss in the knees of osteoarthritis patients.
Occupational therapy gets people with osteoarthritis moving
Physical activity is the cornerstone of any healthy lifestyle - and especially for people with osteoarthritis as exercise helps maintain good joint health, manage their symptoms, and prevent functional decline. Osteoarthritis, however, often makes physical activity, such as exercise, and even performing daily activities, a challenge.
Working environment is 1 cause of rheumatoid arthritis
It has long been known that environmental factors play a part in the development of rheumatoid arthritis; smoking and drinking alcohol, along with heredity, are particularly instrumental in increasing the risk of the disease.
Sinusitis patients have pain similar to the elderly and people with arthritis
A new analysis led by researchers at Georgetown University Medical Center suggests many patients with sinusitis have aches and pains similar in severity to people in their 80s and those with arthritis or depression.
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