UK study shows substantial reduction in stroke over past 20 years (pp 1920, 1925)June 09, 2004Results of a study in this week's issue of THE LANCET highlight how improved treatment and management of risk factors have reduced the incidence of stroke by 40% in a region of the UK over the past 20 years. Stroke is the second largest cause of death worldwide, the largest cause of long-term neurological disability, and the single most costly condition for the UK National Health Service and social services. The rise in the elderly population would be expected to increase the incidence of age-related illness and disability, including stroke. However, improvements in medical and surgical stroke prevention could off-set this anticipated increase in stroke. Peter Rothwell from the Radcliffe Infirmary, Oxford, UK and colleagues assessed the changes in stroke and transient ischaemic attack rates in two studies in Oxfordshire, the Oxford Community Stroke Project (OCSP), 1981-84, and the Oxford Vascular Study (OXVASC), 2002-04. The population aged 75 years or older increased by a third over the 20 years between the two studies. However, age-adjusted occurrence of first stroke was reduced by around 30% in the OXVASC study compared with the expected incidence based on data from the OCSP study. For major disabling or fatal stroke the reduction was 40%. This reduction was associated with increased use of blood-pressure lowering and cholesterol-lowering drugs, and associated substantial reductions in blood pressure, cholesterol, and other risk factors. Dr Rothwell comments: "Although we cannot prove conclusively that the major fall in stroke incidence is a direct result of the measured increase in use of preventive medication, a causal link is highly likely. There remains significant under-treatment of individuals at risk of stroke in the community and so further major reductions in stroke incidence should be possible." (Quote by e-mail, does not appear in published paper). In an accompanying Commentary (p 1920), Valery Feigin and Stephen Vander Hoorn (University of Auckland, New Zealand) conclude ' Rothwell and colleagues' state-of-the-art study makes an important contribution to knowledge about stroke epidemiology.' | |||||||||||||||||||||
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Related Stroke Current Events and Stroke News Articles Study Helps Explain Connection Between Sleep Apnea, Stroke And Death Obstructive sleep apnea decreases blood flow to the brain, elevates blood pressure within the brain and eventually harms the brain's ability to modulate these changes and prevent damage to itself, according to a new study published by The American Physiological Society. Smokers with stroke in the family 6 times more likely to have stroke too A new study shows that people who are smokers and have a family history of brain aneurysm appear to be significantly more likely to suffer a stroke from a brain aneurysm themselves. Arousal frequency in heart failure found to be a unique sleep problem A study in the Jan. 1 issue of the journal Sleep demonstrates that the frequent arousals from sleep that occur in heart failure patients with central sleep apnea (CSA) may reflect the presence of another underlying arousal disorder rather than being a defensive mechanism to terminate apneas. University of Maryland researchers identify common gene variant linked to high blood pressure Researchers at the University of Maryland School of Medicine have identified a common gene variant that appears to influence people's risk of developing high blood pressure, according to the results of a study being published online Dec. 29, 2008 in the Proceedings of the National Academy of Sciences (PNAS). Matrix fragments trigger fatal excitement Shredded extracellular matrix (ECM) is toxic to neurons. Chen et al. reveal a new mechanism for how ECM demolition causes brain damage. The study will appear in the December 29, 2008 issue of The Journal of Cell Biology (www.jcb.org). Researchers at Columbia University Medical Center link blood sugar to normal cognitive aging Maintaining blood sugar levels, even in the absence of disease, may be an important strategy for preserving cognitive health, suggests a study published by researchers at Columbia University Medical Center (CUMC). The study appeared in the December issue of Annals of Neurology. Brain starvation as we age appears to trigger Alzheimer's A slow, chronic starvation of the brain as we age appears to be one of the major triggers of a biochemical process that causes some forms of Alzheimer's disease. Rice psychologist identifies area of brain key to choosing words New research by a Rice University psychologist clearly identifies the parts of the brain involved in the process of choosing appropriate words during speech. Study examines impact of managed care on stroke prevention surgery Policymakers and economists often promote managed-care plans based on the assumption that they prevent the overuse of unnecessary surgical procedures or help steer patients to high-quality providers, compared to traditional fee-for-service insurance plans. Study shows optimal dose management of warfarin improves anticoagulation control Researchers from Boston University School of Medicine (BUSM) have determined the optimal dose-management strategy to derive maximal benefit from warfarin therapy and improve patient outcomes. Results of the study appear online in the December 2008 issue of the Journal of Thrombosis and Haemostasis. More Stroke Current Events and Stroke News Articles |
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