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Research suggests aspirin helps combat cataracts
June 03, 2004Ongoing research in the School of Animal and Microbial Sciences (AMS) at the University of Reading has helped to clarify the process of cataract, the largest cause of blindness in the world.
Professor James Crabbe and his team in AMS have targeted the importance of non-steroidal anti-inflammatory drugs - such as aspirin - in helping protect against the development of cataracts.
"Aspirin-like analgesics have a protective effect against retinopathy and cataract," says Professor Crabbe. "We have found that aspirin inhibits the protein cross-linking process responsible for cataract.
"This accords with epidemiological evidence from people suffering from diabetes and rheumatoid arthritis and who take aspirin, and suggests that aspirin could delay the onset of cataract by 43%. Similar studies on paracetamol and ibuprofen suggest that consumption of these analgesics would halve the risk of cataract visually impairing the lens."
Professor Crabbe's work has also led to the development of novel methods of experimental design in drug discovery.
"We have demonstrated that a Bayesian approach (the use of prior knowledge) can produce major gains in terms of the productivity and accuracy of each experiment. By developing the use of the Bayesian approach, it is possible to reduce the necessary amount of experiments and data points measured, but to increase their efficiency and cost-effectiveness.
"This work has clear commercial potential as our novel methods can be directly applied to the study of several important kinetic systems in biology, including enzymes, drug transport, receptor binding, microbial culture and cell transport kinetics."
Professor Crabbe, who is Head of the School of AMS, presented his findings at a recent workshop held by AGEnet, the University's unique network for bringing together researchers, healthcare professionals, charity workers and members of the public interested in ageing, impairment and disability.
The next AGEnet workshop, 'Research for a New Age: New Dimensions of Ageing' takes place on Thursday 24 June and will explore the research and practice being pursued by ageing and health specialists recently appointed to the University, and their approaches to improving the quality of life of older people. Please contact Verity Smith, the AGEnet co-ordinator by e-mail: h.v.smith@reading.ac.uk
Reading, University of
"This accords with epidemiological evidence from people suffering from diabetes and rheumatoid arthritis and who take aspirin, and suggests that aspirin could delay the onset of cataract by 43%. Similar studies on paracetamol and ibuprofen suggest that consumption of these analgesics would halve the risk of cataract visually impairing the lens."
Professor Crabbe's work has also led to the development of novel methods of experimental design in drug discovery.
"We have demonstrated that a Bayesian approach (the use of prior knowledge) can produce major gains in terms of the productivity and accuracy of each experiment. By developing the use of the Bayesian approach, it is possible to reduce the necessary amount of experiments and data points measured, but to increase their efficiency and cost-effectiveness.
"This work has clear commercial potential as our novel methods can be directly applied to the study of several important kinetic systems in biology, including enzymes, drug transport, receptor binding, microbial culture and cell transport kinetics."
Professor Crabbe, who is Head of the School of AMS, presented his findings at a recent workshop held by AGEnet, the University's unique network for bringing together researchers, healthcare professionals, charity workers and members of the public interested in ageing, impairment and disability.
The next AGEnet workshop, 'Research for a New Age: New Dimensions of Ageing' takes place on Thursday 24 June and will explore the research and practice being pursued by ageing and health specialists recently appointed to the University, and their approaches to improving the quality of life of older people. Please contact Verity Smith, the AGEnet co-ordinator by e-mail: h.v.smith@reading.ac.uk
Reading, University of
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Cogent trial shows lack of adverse interaction between clopidogrel and stomach medicine
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Small peptide found to stop lung cancer tumor growth in mice
In new animal research done by investigators at Wake Forest University School of Medicine, scientists have discovered a treatment effective in mice at blocking the growth and shrinking the size of lung cancer tumors, one of the leading causes of cancer death in the world.
Genetic variation associated with poorer response, cardiovascular outcomes with use of clopidogrel
Patients with a certain genetic variation who received the antiplatelet drug clopidogrel had a decreased platelet response to treatment and among those who had percutaneous coronary intervention (procedures such as balloon angioplasty or stent placement used to open narrowed coronary arteries) had an increased risk of having a cardiovascular event in the following year than patients who did not have this variant, according to a study in the August 26 issue of JAMA.
Study reveals mounting evidence of fish oil's heart health benefits
There is mounting evidence that omega-3 fatty acids from fish or fish oil supplements not only help prevent cardiovascular diseases in healthy individuals, but also reduce the incidence of cardiac events and mortality in patients with existing heart disease.
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