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Reduced mitochondrial function important mechanism in aging
May 27, 2004Scientists at the Karolinska Institute have found that changes in the "powerhouse" of cells, the mitochondria, play a key role in aging. The findings are being published in this week's issue of the journal Nature.
Mitochondria, which provide energy to cells, have their own set of DNA. Mutations of mitochondrial DNA increase with age, but until now no one knew whether this is a result of aging or a cause of aging. New research findings now indicate that the latter is the case.
Mice with a deficient capacity to correct mutations in mitochondrial DNA acquired an increased number of mutations and proved to age considerably earlier than normal. They lived an average of 10 to 12 months compared with the normal 2 or 3 years. These mice also developed several typical signs of premature aging, such as osteoporosis, weight loss, hair loss, anemia, reduced fertility, and heart muscle disorders.
The findings reveal fundamental biological mechanisms that lie behind the aging process. This knowledge paves the way for the possibility of slowing down aging and treating pathological changes that arise in connection with aging by protecting mitochondrial DNA from damage.
Vetenskapsrådet (The Swedish Research Council)
DNA Current Events and DNA News RSSScientists at UA, collaborating institutions decode maize genome
Scientists from the University of Arizona led by Arizona Genomics Institute director Rod A. Wing and from collaborating institutions have deciphered the complete genetic code of the maize plant for the first time.
Ancestry attracts, but love is blind
People preferentially marry those with similar ancestry, but their decisions are not necessarily based on hair, eye or skin colour.
Scientists unlock clues for tailoring corn plant for food, energy needs
Scientists have long known that the offspring of two inbred strains tend to be superior to both their parents. Now, a team of researchers including a University of Florida geneticist has discovered clues to why that might be the case for one of the most important crops in the world: corn.
Cigarettes Harbor Many Bacteria Harmful to Human Health
Cigarettes are "widely contaminated" with bacteria, including some known to cause disease in people, concludes a new international study conducted by a University of Maryland environmental health researcher and microbial ecologists at the Ecole Centrale de Lyon in France.
Technique finds gene regulatory sites without knowledge of regulators
A new statistical technique developed by researchers at the University of Illinois allows scientists to scan a genome for specific gene-regulatory regions without requiring prior knowledge of the relevant transcription factors.
Unknowlingly consuming endangered tuna
While most of us would never willingly consume a highly endangered species, doing so might be as easy as plucking sushi from a bento box.
New research into the mechanisms of gene regulation
A team led by Penn State's Ross Hardison, T. Ming Chu Professor of Biochemistry and Molecular Biology, has taken a large step toward unraveling how regulatory proteins control the production of gene products during development and growth.
New Maize Map to Aid Plant Breeding Efforts
In a massive survey of genetic diversity in maize, also known as corn, researchers across the United States, have developed a gene map that should pave the way to significant improvements in a plant that is a major source of food, fuel, animal feed and fiber around the world.
UAB Researchers Discover Antibody Receptor Identity, Propose Renaming Immune-System Gene
Researchers at the University of Alabama at Birmingham (UAB) have uncovered the genetic identity of a cellular receptor for the immune system's first-response antibody, a discovery that sheds new light on infection control and immune disorders.
GEN reports on enhancing the applications of qPCR
Quantitative polymerase chain reaction (qPCR) technology is experiencing a surge of interest and rapid expansion as a result of advances such as instrumentation that pushes capacity to 1,536 wells and optimization-free multiplexing.
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DNA: The Secret of Life by James D. Watson (Author) James Watson, the co-discoverer of the structure of DNA and author of the international bestseller "The Double Helix" tells the story of the amazing molecule since its discovery fifty years ago, following modern genetics from his own Nobel prize-winning work in the fifties to today's Dolly the sheep, designer babies and GM foods. Professor Watson introduces the science of modern genetics, along with its history and its implications, in this magnificent guide to one of the most triumphant achievements of human science. |
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Thames & Kosmos Genetics and DNA by Thames & Kosmos In depth investigation of genetics and DNA. Isolate the DNA from a tomato, learn about inheritance and how traits are expressed, build a DNA model, breed bacteria to experiment with genetic engineering. The full-color, 48-page manual guides your experiments. |
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DNA Science: A First Course, Second Edition by David Micklos (Author), Greg A. Freyer (Author) This is the second edition of a highly successful textbook (over 50,000 copies sold) in which a highly illustrated, narrative text is combined with easy–to–use thoroughly reliable laboratory protocols. It contains a fully up–to–date collection of 12 rigorously tested and reliable lab experiments in molecular biology, developed at the internationally renowned Dolan DNA Learning Center of Cold Spring Harbor Laboratory, which culminate in the construction and cloning of a recombinant DNA molecule. Proven through more than 10 years’ of teaching at research and nonresearch colleges and universities, junior colleges, community colleges, and advanced biology programs in high school, this book has been successfully integrated into introductory biology, general biology,... |
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Science Wiz DNA Kit by Sciencewiz The central concepts of molecular biology becomes child's play in this set of camp favorites. 40 Page science book and materials with 8 Major Activities. Makes the DNA revolution accessible. Extract DNA from a fruit Probe and spool real DNA Build a double helix Solve a chromosome puzzle Is it a boy or a girl? Play the gene construction game Country of Origin: U.S.A., China & Hong Kong. |
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Genes and DNA (Kingfisher Knowledge) by Richard Walker (Author), Steve Jones (Author) Genes & DNA explores modern genetics, from an investigation of genes and their function, to forensics, therapy, and cloning. |
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K'NEX Educational DNA, Replications and Transcription Set by K'NEX K'Nex kits inspire young minds and satisfy kids' curiosity on how to build simple creations. Each innovative kit keeps young builders busy and intrigued for hours on end. This K'Nex Kit allows one to two kids to work as a team. Models demonstrate the structure and processes of DNA and mRNA molecules. Everything comes in a large compartmentalized storage case with snap-on lid. Curriculum sold separately. |
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NOVA - Cracking the Code of Life Starring: Robert Krulwich Directed By: Betsey Arledge; Elizabeth Arledge Does it amaze you that yeast is your very close relative? That you possess roughly the same number of genes as a mouse? That you are 99.9% genetically identical to every other human? ABC Nightline correspondent Robert Krulwich lends a lighthearted touch to genetic science in this provocative two-hour NOVA special that takes you inside the amazing, complex and contentious race to decode the human genome. The Human Genome Project was born in 1990, when an international consortium of labs set out to sequence all 3 billion letters of our DNA, predicting they’d finish by 2005. Halfway through their schedule, controversial scientist and entrepreneur J. Craig Venter threw the genome world into turmoil, when he announced his for-profit company Celera could finish the job in just two years.... |
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The Stuff of Life: A Graphic Guide to Genetics and DNA by Mark Schultz (Author), Zander Cannon (Illustrator), Kevin Cannon (Illustrator) The Stuff of Life gives readers a complete introduction to the history of genetics that's as easy to understand as it is entertaining to read. |
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DNA on DNA by DNA Previously released on CD by No More Records, now issued on a limited edition 2LP featuring newly-discovered songs exclusive to this LP: "Pompeii," "Shrinking Thing," "Drinking Water," plus two encores from DNA's final performance at CBGB's. Definitive collection of studio and live recordings by New York's seminal no wave band DNA. Surviving two line-ups over a brief period of four years; this highly influential, strikingly original and extremely under-recorded band left a huge void in its wake. Formed in 1978, Brazilian-raised singer/guitarist Arto Lindsay hastily assembled an international trio of non-musicians. Robin Crutchfield played keyboard and Japan's Ikue Mori played drums. DNA played their first gig within weeks and recorded their first 7" shortly afterwards. The ear of Brian... |
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Signature in the Cell: DNA and the Evidence for Intelligent Design by Stephen C. Meyer (Author) One hundred fifty years ago, Charles Darwin revolutionized biology, but did he refute intelligent design (ID)? In Signature in the Cell, Stephen Meyer argues that he did not. Much confusion surrounds the theory of intelligent design. Frequently misrepresented by the media, politicians, and local school boards, intelligent design can be defended on purely scientific grounds in accordance with the same rigorous methods that apply to every proposed origin-of-life theory. Signature in the Cell is the first book to make a comprehensive case for intelligent design based upon DNA. Meyer embarks on an odyssey of discovery as he investigates current evolutionary theories and the evidence that ultimately led him to affirm intelligent design. Clearly defining what ID is and is... |
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