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Bug surprise for drug traffickers - Microbiology Today: May 2004 issue
May 17, 2004Bacteria could be the new weapon in the fight against drug trafficking, according to an article published in the May 2004 issue of Microbiology Today, the quarterly magazine for the Society for General Microbiology. Researchers at CNAP, University of York, have found bacteria that grow on heroin and morphine and believe that two special proteins from these bugs could be used to detect heroin.
"This is hugely important", explains Professor Neil Bruce of CNAP, "since the need for a rapid, hand-held detection system for use by Customs officers has never been greater."
The team have also found bacterial proteins that can be used to treat drug overdoses, while other proteins were found to improve the production of morphine-like painkillers.
Microbes have long been associated with drugs and this issue of Microbiology Today takes a look at the close relationship that microbes have with a wide range of drugs - from narcotics to antimicrobials. The introduction of antibacterial agents, chemical disinfectants and antiseptics, had already made significant improvements in public health, long before the famous discovery of penicillin by Alexander Fleming in the 1920's. Later developments brought antiviral and antifungal drugs, and studies of the immune system highlighted the promise offered by host defence peptides. Now genomics is helping in the quest for new drugs.
Other features in the May 2004 issue of Microbiology Today include:
Antimicrobials - where next? (page 55)
Antiviral drugs - a short history of their discovery and development (page 58)
Live and let die (page 62)
New drugs by manipulating Streptomyces genes (page 64)
Host defence peptides (page 70)
Structural pathogenomics (page 74)
Cold rush for drugs? (page 112)
These are just some of the articles that appear, together with all the regular features and reports of Society activities.
Society for General Microbiology
Microbes have long been associated with drugs and this issue of Microbiology Today takes a look at the close relationship that microbes have with a wide range of drugs - from narcotics to antimicrobials. The introduction of antibacterial agents, chemical disinfectants and antiseptics, had already made significant improvements in public health, long before the famous discovery of penicillin by Alexander Fleming in the 1920's. Later developments brought antiviral and antifungal drugs, and studies of the immune system highlighted the promise offered by host defence peptides. Now genomics is helping in the quest for new drugs.
Other features in the May 2004 issue of Microbiology Today include:
Antimicrobials - where next? (page 55)
Antiviral drugs - a short history of their discovery and development (page 58)
Live and let die (page 62)
New drugs by manipulating Streptomyces genes (page 64)
Host defence peptides (page 70)
Structural pathogenomics (page 74)
Cold rush for drugs? (page 112)
These are just some of the articles that appear, together with all the regular features and reports of Society activities.
Society for General Microbiology
Peptides Current Events and Peptides News RSSScientists watch as peptides control crystal growth with 'switches, throttles and brakes'
By producing some of the highest resolution images of peptides attaching to mineral surfaces, scientists have a deeper understanding how biomolecules manipulate the growth crystals. This research may lead to a new treatment for kidney stones using biomolecules.
An atomic-level look at an HIV accomplice
Since the discovery in 2007 that a component of human semen called SEVI boosts infectivity of the virus that causes AIDS, researchers have been trying to learn more about SEVI and how it works, in hopes of thwarting its infection-promoting activity.
Aileron collaborates study in Nature: Stapled peptides inhibit Notch1 transcription factor
This research validates the potential for Stapled Peptides to modulate key intracellular biological targets, such as transcription factors, that have not been addressable with current small molecule or biologic drug modalities.
Researchers 'notch' a victory toward new kind of cancer drug
Scientists have devised an innovative way to disarm a key protein considered to be "undruggable," meaning that all previous efforts to develop a drug against it have failed.
Hybrid molecules show promise for exploring, treating Alzheimer's
One of the many mysteries of Alzheimer's disease is how protein-like snippets called amyloid-beta peptides, which clump together to form plaques in the brain, may cause cell death, leading to the disease's devastating symptoms of memory loss and other mental difficulties.
Study reveals a 'missing link' in immune response to disease
The immune system's T cells have the unique responsibilities of being both jury and executioner. They examine other cells for signs of disease, including cancers or infections, and, if such evidence is found, rid them from the body. Precisely how T cells shift so swiftly from one role to another, however, has been a mystery.
UM Scientists Create Fruit Fly Model to Help Unravel Genetics of Human Diabetes
As rates of obesity, diabetes, and related disorders have reached epidemic proportions in the US in recent years, scientists are working from many angles to pinpoint the causes and contributing factors involved in this public health crisis.
Penn team uses self-assembly to make molecule-sized particles with patches of charge
Physicists, chemists and engineers at the University of Pennsylvania have demonstrated a novel method for the controlled formation of patchy particles, using charged, self-assembling molecules that may one day serve as drug-delivery vehicles to combat disease and perhaps be used in small batteries that store and release charge.
Aggressive microdermabrasion induces wound-healing response in aging skin
Microdermabrasion using a coarse diamond-studded instrument appears to induce molecular changes in the skin of older adults that mimic the way skin is remodeled during the wound healing process.
'Spaghetti' scaffolding could help grow skin in labs
Scientists are developing new scaffolding technology which could be used to grow tissues such as skin, nerves and cartilage using 3D spaghetti-like structures.
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