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BrightSurf.com Science News Headlines December 2005
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December 30, 2005
'Coaching' in labor makes little difference, UT Southwestern researchers say
Unified physics theory explains animals' running, flying and swimming
New method for examining cost-effectiveness of new drugs for chronic illnesses
Jefferson Scientists Discover Mechanism Tying Obesity to Alzheimer's Disease
Study finds genes that 'fine-tune' muscle development process
Bullying in middle school may lead to increased substance abuse in high school
MDCT angiography for cardiac imaging: Reliable tool, less invasive, fewer complications
New technique points to safer, more efficient vaccination
Vertebroplasty improves back pain, activity level, Mayo Clinic study reports
Ambivalence about migration may contribute to poor mental health in Latino men
Stroke risk returns when children with sickle cell disease stop transfusions
Chandra looks back at the Earth
Positive outcome of Medicare drug benefit
Medicare drug benefit could do harm to poor, elderly, and disabled
December 29, 2005
Tiny pikas seem to be on march toward extinction in Great Basin
Penn study finds hyperbaric oxygen treatments mobilize stem cells
Study suggests way to re-energize immune response to chronic viral infection
Pediatric oncologists should help with difficult decisions
First analysis of FDA's mifepristone adverse event reports
University of Colorado student-built instrument set to launch on Pluto mission
Scientists lift malaria's cloak of invisibility
Bipolar disorder more common than expected in hospitalized adolescents
Researchers discover how a high-fat diet causes type 2 diabetes
Natural compound from 'pond scum' shows potential activity against Alzheimer's
Smithsonian guide to the biodiverse marine environment of Panama's Bocas del Toro
UCSD researchers state vitamin D needed to cut cancer risk
Having sibling with cardiovascular disease associated with higher CVD risk
Dietary intake of antioxidants associated with reduced risk of age-related macular degeneration
Medication reduces risk of heart irregularities after cardiac surgery
Misdosing common for powerful anti-clotting drugs
Sickle cell disease corrected in human models using stem cell-based gene therapy
December 27, 2005
Childhood infections stunt growth, shorten life
NIAID researchers show how promising tuberculosis (TB) drug works
Gene therapy for muscular dystrophy fixes frail muscle cells in animal model, Stanford study finds
Getting an evolutionary handle on life after reproduction
MIT researcher finds neuron growth in adult brain
Fish evolve a longer lifespan by evolving a longer reproductive period, researchers find
After gastric bypass surgery, important to check vitamin B1 deficiency
Stick to wild salmon unless heart disease is a risk factor, risk/benefit analysis of farmed and wild fish shows
Elvis the mystery bird has searchers scouring Arkansas habitats for signs of roosts, nests or stripped bark
Not always having enough to eat can impair reading and math development in children
Treated wood poses long-term threat
New study expands understanding of the role of RNA editing in gene control
Studying the fate of drugs in wastewater
Mechanism for Epstein-Barr virus protein's role in blood cancers discovered
A year on from the Asian tsunami, satellites are aiding regional rebuilding
Rerouting of Major Rivers in Asia Provides Clues to Mountains of the Past
SMART-1 uses new imaging technique in lunar orbit
Evaluation metrics proposed for firefighter thermal imagers
December 23, 2005
Potential pharmaceutical drugs in the field of cancer
DNA self-assembly used to mass-produce patterned nanostructures
Asthma inhalers adopted more slowly for minority patients and children
Effective government/industry collaboration bolsters flu vaccine supply
Researchers develop new method for studying 'mental time travel'
Role of microRNA Identified in Thyroid Cancer
Scientists solve mystery of the 'unicorn' whale
New research in Chesapeake Bay, Pamlico Sound shows hurricanes, runoff tax water quality management efforts
A little telomerase isn't enough
Birth defect gene identified
Bigger brain size matters for intellectual ability
Study finds implantable defibrillators as effective in women as in men
Air pollution, high-fat diet cause atherosclerosis in laboratory mice
Woolly mammoth genome comes to life
Scientists discover 'light echoes' of ancient supernovae
Cluster helps to protect astronauts and satellites against 'killer electrons'
Study Demonstrates Safety of Oral Contraceptives in Women with Lupus
Nervous system's role in fatal heart rhythm studied
MPI researchers have for the first been able to map the activity of the brain by means of electrical microstimulation
Bacterial protein mimics host to cripple defenses
Blocking previously unrecognized links between inflammatory systems could make COX-2 inhibitors safe
Didgeridoo playing improves your sleep
Shape of glass influences how much alcohol is poured - and how much you will drink
Stanford evolution research cited by Science as a 2005 breakthrough
One third of patients who stop treatment for schizophrenia early do so due to poor response
MicroRNA gene that regulates lifespan found by Yale scientists
Ultracold test produces long-sought quantum mix
Storing carbon to combat global warming may cause other environmental problems, study suggests
Researchers know what you were about to say; fMRI used to detect memory storage and retrieval
December 22, 2005
Polymorphism and antibodies associated with highly increased risk of rheumatoid arthritis
Genome discovery will help combat disease and lead to new drugs
Light-sensing cells in retina develop before vision
Chromosome regions containing genes related to alcohol addiction affect drinking behavior in smokers
Astronomers detect echoes from ancient supernovae
SLU Researchers Uncover Direct Evidence on How HIV Invades Healthy Cells
ASU geologists suggest Mars features are result of meteorite strikes, not of evaporated lakes
Research clarifies how brain replenishes memory-making molecules
Rapid emotional recovery of breast-cancer survivors surprises researchers
New study examines how sense of smell affects mating and aggression in mice
Mayo Clinic finds kidney cancer patients are unlikely to respond to potential treatment drug
Illuminating Alzheimer's: Research sheds light on creatine's presence in brain
Rutgers researchers scientifically link dancing ability to mate quality
Feeling the holiday blues? Then you must have children
Study finds significant independent association between air pollution and cardiovascular risk
New Study Says Two Million Americans Harbor Drug-Resistant Superbug
New view of cancer: 'Epigenetic' changes come before mutations
Possible evidence found for Beagle 2 location
Successful first test for Vega's Zefiro 9 engine
Humans do not understand mirror reflections, say researchers
December 21, 2005
Ancient trans-Atlantic swarm brought locusts to the new world
Membrane research opens window to benefits for plants, humans
Mission to Mars via Antarctica
Antibody therapy promising for pediatric neuroblastoma
Scientists Unlock the Mystery of Liquid Crystal Alignment
New synthetic compounds appear to prevent brain cell death
Aquaporin and obesity
Astronomers use laser to take clearest images of the center of the Milky Way
Benefits of flu vaccine substantially overestimated says study
Researchers demonstrate single molecule absorption spectroscopy
Adults with lazy eye can improve
New NASA satellites shipped to launch site
Blocking the nerve receptor EP1 in mouse models reduces brain damage caused by stroke
Researchers provide study of early heart development and underlying cause of congenital heart defects
Successful treatment for acute heart failure remains elusive
Clinical trial to test stem cell approach for children with brain injury
DMSO raises a stink at sewage treatment plants
Adults also suffer from cyclical vomiting syndrome
MSG-2 will advance long-term monitoring of Earth's energy balance
Researchers show how air pollution can cause heart disease
New approach for genetic screening for syndrome linked to cardiac irregularities and sudden death
Men with erectile dysfunction have increased risk for cardiovascular events
Poor fitness common in teens and adults, with associated rise in cardiovascular disease risk factors
Melanoma risk only partially associated vith exposure to UVB from sunlight
File compression can expand mammography's power
Ultraviolet B light exposure associated with increased risk of skin cancer
Screening chest x-ray detects early-stage lung cancers at high rates, study results show
Patient outcomes linked to biomarker levels by quantitative technology
Tooth Loss and Heart Disease Linked, Even Among Nonsmokers
Novel enzyme offers new look at gene regulation
Brandeis researchers propose model of neural circuit underlying working memory
December 20, 2005
Depression is not good for your heart
Genetic Analysis of Asian Elephants in India Reveals Some Surprises
Genetic analysis of cavefish reveals more about evolution
Ancient Chinese remedy shows potential in preventing breast cancer
Pular antidepressants boost brain growth, Hopkins scientists report
Polio Vaccination Strategies Assessed as Eradication Nears
UCF, NIH study: Effective, safe anthrax vaccine can be grown in tobacco plants
Most of Arctic's Near-Surface Permafrost May Thaw by 2100
New UNC experiments show very weak chlorine solutions can kill noroviruses
Artificial light at night stimulates breast cancer growth in laboratory mice
Drug-eluting stents may cause allergic reactions
Study shows complex link between abuse and eating disorders
Euclid returns to maths lessons
Motorcycles emit 'disproportionately high' amounts of air pollutants
Scientists close in on genes responsible for Parkinson's disease
Two New UCLA Studies Show Benefits of Newborn Screening for 'Bubble Boy Disease'
Overfishing may drive endangered seabird to rely upon lower quality food
Scientists sequence DNA of woolly mammoth
Ninety-six percent of minimally invasive knee replacement patients leave same day, no complication
Scientists narrow the time limits for the human and chimpanzee split
A few squares of dark chocolate a day may stave off artery hardening in smokers
Passive smoking almost doubles risk of degenerative eye disease
Smoking associated with severity of psoriasis
Dramatic increase in annual rate of laparoscopic bariatric surgeries
Adherence to pneumonia treatment guidelines results in better outcomes
Bare metal stents deliver gene therapy to heart vessels with less inflammation in animal studies
December 19, 2005
Whooping cough persistence traced to key toxin
Carbon monoxide soothes inflammatory bowel disease
Software might revolutionize glucose monitoring in critically ill patients
Penicillin, amoxicillin: Step aside for strep throat treatment
Cancer support cells may evolve, fuel tumor growth, study shows
Japan reports first coring operations of CHIKYU
WWF peeks into mysterious life of Borneo's pygmy elephants
Toward the future of cancer prevention
Conditions for slavery: New study sheds light on the development of early social hierarchies
Sea slug mixes chemical defense before firing at predators
An obstacle to cancer cells
Switching to new anti-bacterial targets: Riboswitches
Some good news for the world's poor
Gene variation affects tamoxifen's benefit for breast cancer
Rules to Target RNA Are Focus of Research
Boys more likely when pregnancy takes longer
December 16, 2005
Gladstone researchers hone in on differentiation of heart stem cells
Traditional risk-factor scoring misses one-third of women vulnerable to coronary heart disease
Earliest evidence for large scale organized warfare in the Mesopotamian world
Stretchable silicon could be next wave in electronics
Bats Use Touch Receptors on Wings to Fly, Catch Prey, Study Finds
New methods offer insight into regulatory DNA
Prepregnancy Weight Increasing, Bringing More Risk
DOE Atmospheric Radiation Measurement program mobile facility moves to Niger
New small RNAs found
Columbia University Medical Center researchers discover potential mechanism for tumor growth
Why Nanolayers Buckle when Microbeams Bend
Fishing for the Origins of Genome Complexity
Household cleaners effectively remove lead-laden dust
Nearly a quarter of children are especially susceptible to respiratory illness if they are exposed to second-hand smoke
Fish oil prevents potentially deadly decline in heart rate variability
New microchip technology for medical imaging biomarkers of disease
Unexpected finding: Some dinosaurs grew slower in hard times
Surprising Killer of Southeastern Salt Marshes: Common Sea Snails
A Theoretical Breakthrough Inspired by Experiment-Calculating Electron Correlations in the Hydrogen Molecule
Food additive inhibits longevity enzyme in yeast, increases cell toxicity, new study finds
Standing up to paraplegia with gene therapy
December 15, 2005
Bio-archaeologists pinpoint oldest Northern European human activity
Ability to capture large prey may be origin of army ants' cooperative behavior
New Study Identifies Louse-Borne Diseases That Ravaged Napoleon's Army
Second-hand smoke hits genetically susceptible kids harder
Breast cancer drugs may slow growth of lung cancer
Engineered stem cells show promise for sneaking drugs into the brain
Cancer scientists call for a large-scale human epigenome project
Gladstone study links Alzheimer's with toxic protein fragments
Key brain antioxidant linked to Alzheimer's and Parkinson's
Another world-record achievement for National High Magnetic Field Laboratory
Microbes under Greenland Ice may be preview of what scientists find under Mars' surface
Blood test can accurately diagnose heart failure in patients with kidney dysfunction
One small step means giant leap for spinal cord research
New discovery may improve treatment of neurodegenerative diseases and type 2 diabetes
OHSU discovery sheds light into how stem cells become brain cells
'Armored' bubbles can exist in stable non-spherical shapes
USC researchers track down the stem cells that create feathers
Ancient glaciers still affect the shape of North America, say scientists
New technique helps researchers determine amino-acid charge
Researchers identify key protein involved in neuropathic pain
Genetic clues to Sodalis deepens knowledge of bacterial diseases
Astronomers link old stars and mysterious cosmic explosions
December 14, 2005
Physicists find evidence for highest energy photons ever detected from Milky Way's equator
National study improves outcome for pediatric AML
New antidepressant drug increases 'brain's own cannabis'
Growth factor protects brain against damage from stroke
Bacteria that cause tooth decay able to survive without important biochemical pathway
Flatworm genes may provide insights into human diseases, researchers say
Mayo clinic reports some chronic leukemia patients may improve by taking an extract of green tea
Researchers discover trees in Amazon much older than assumed, raising questions on global climate impact of region
New study finds common herbal supplement helps to reduce cocaine cravings
New study identifies key gene in development of connections between brain and spinal cord
New study finds anabolic steroids may be addictive
Ancient humans brought bottle gourds to the Americas from Asia
Marine Biology Mystery Solved: Function of "Unicorn" Whale's 8-foot Tooth Discovered
Enhancement in the precision of high-speed milling of complex parts
200 proteins which detect diseases of the liver
South African Geraniums Effective in Treatment of Adults with Acute Bronchitis
Univ. of Chicago scientists find potential cause of breathing problems in Rett Syndrome children
UC Santa Barbara researcher tapped by Europeans for design of instrument to test soil on Mars
Parents of children with cancer suffer post-traumatic stress symptoms, both immediate and lingering
A crucial role for TGFbeta signaling in congenital eye disorders
Insulin levels and resistance linked to risk of pancreatic cancer
Progress slow in improving hospitals' patient safety systems
High intake of dietary fiber not associated with reduced risk of colorectal cancer
Zeroing in on progeria: How mutant lamins cause premature aging
December 13, 2005
ESA accelerates towards a new space thruster
Silicon-germanium microchips may herald new applications from radar to space exploration
Evidence links cocaine abuse and Parkinson's disease
Astronomers use Hubble to 'weigh' Dog Star's companion
Scythe balances life and death during development
Tiny self-assembling cubes could carry medicine, cell therapy
Hundreds of auroras detected on Mars
Magnetic transistor could 'dial in' quantum effects
Good for the heart - and the wallet: African-American heart failure drug is cost-effective
New study pinpoints epicenters of Earth's imminent extinctions
UNICEF report shows disabled children at serious risk
Chronic disability in older Americans greatly overestimated
Relationship between incarceration and race disparities in US HIV rates explored
New evidence supports century-old theory of cancer spread
Hopkins study describes potentially fatal heart condition among young athletes
Key brain regulatory gene shows evolution in humans
Consumers need carrots, not sticks, to make 'green' choices
Pretreating rogue cancer cells with aspirin cripples their resistance to targeted therapy
New research examines genetics of successful aging
New study finds that older Americans may improve memory by exercising their brains and bodies
Depression and anxiety improve after epilepsy surgery
New study shows successful aging a question of 'mind over matter'
REVLIMID improves overall survival and delays disease progression in multiple myeloma patients
Infections are a major cause of childhood cancer, study suggests
New UW study offers strategy for treatment of fatal nervous system disorder
Rein for pain lays mainly in the brain, Stanford researchers find
Testosterone therapy may help elderly men with mild Alzheimer's disease
Drinking tea associated with lower risk of ovarian cancer
December 12, 2005
New studies identify advances in treatment of chronic myeloid leukemia
Hearing loss from chemotherapy underestimated
New study shows palliative care programs surging trend in US hospitals
Gene increases risk of tuberculosis
Mental distress due to abortion lasts for years
AMN107 has potent activity in leukemia resistant to Gleevec
Study shows combination of immune substances to be safe
Southern Research Station-USDA Forest Service
How the Neuron Sprouts Its Branches
Glacial pace of erosion was not so slow, new technique shows
Eisai announces Phase II data on E7389, a potential new therapy for the treatment of breast cancer
Mayo Clinic Cancer Center reports advancements and solutions for quality of life assessments
JHU-STScI team maps dark matter in startling detail
Magnet lab researcher exploring science behind commercial applications of liquid helium
Pramipexole delivered sustained efficacy in clinical trial of patients with Restless Legs Syndrome
Cell phones, driving don't mix
New Models of Weather Pattern
Movement of Earth's North Magnetic Pole Accelerating Rapidly
Mayo Clinic researchers find hole in heart does not make stroke inevitable
Prelude to an Earthquake?
December 09, 2005
'Computer-chemistry' yields new insight into a puzzle of cell division
Moderate exercise may delay congestive heart failure, CU-Boulder study suggests
Mouse study: New muscle-building agent beats all previous ones
New technique puts brain-imaging research on its head
GROWing the next generation of water recycling plants
Data in New England Journal of Medicine show benefits of REMICADE in ulcerative colitis patients
Facial transplants are justified, say experts
Breakthrough in unravelling the causes of sudden cardiac death in young people
Bayer launches Phase III clinical study of Trasylol in elective spinal fusion surgery
Low-dose chemotherapy plus antiangiogenesis drug has activity in advanced breast cancer
NASA satellite eyes atmosphere to improve pollution and climate forecasting
ASU researchers 'wire' DNA to identify mutations
Vitamin supplement could help treatment-resistant asthma
Changes to land cover may enhance global warming in Amazon, reduce it in midlatitudes
Alzheimer's disease prevention may be easier than cure
Trust-building hormone short-circuits fear in humans
Understanding the oceans microbes is key to the Earth's future
December 08, 2005
Performing monkeys in Asia carry viruses that could jump species to humans
Advance in cholera bacteria points to new treatment and vaccine
Breakthrough Chip Delivers Better Digital Pictures For Less Power
Ulcerative colitis survey unmasks challenges for patients beyond devastating symptoms
Mercury in atmosphere could be washed out more easily than earlier believed
Large Himalaya earthquakes may occur sooner than expected
Global warming could halt ocean circulation, with harmful results
Acne, Milk and the Iodine Connection
Sunflower seeds, pistachios among top nuts for lowering cholesterol
Argonne researchers confirm lead as cause of Beethoven's illness
Mountainous plateau creates ozone 'halo' around Tibet
Salty taste preference linked to birth weight
Tufts professor chews on the nutrition-oral health connection
Nutritional genomics identifies a potential weight-loss resistance gene
Scientists push forward understanding of multiple sclerosis
TLR4 gene found to protect against tumor development
Researchers discover a protein responsible for shaping the nervous system
Alaska's Columbia Glacier continues on disintegration course
Similar stem cells in insect and human gut
Dog genome sequence and analysis published in Nature
Physicists demonstrate storage and retrieval of single photons between remote memories
How seizures progress to epilepsy in the young
UF scientists find sugar may have a sour side
December 07, 2005
Getting ready for the 'big one,' researchers make most detailed survey ever of San Adreas Fault
NASA's AURA satellite peers into Earth's ozone hole
Inflammation linked to chronic pain
A 2002 disease threat offers lessons for avian flu preparedness
Minimally invasive surgery may increase options for octogenarians with some lung cancers
UK researchers find way to reduce power consumption of transistors in computer chips
New treatment for pancreatic cancer allows life-saving surgery
Popularity Doesn't Necessarily Make Prozac Best Antidepressant Choice
Groundbreaking Guidelines Promote Early Detection,
NASA's Cassini images reveal spectacular evidence of an active moon
CPR and external defibrillator training may decrease adolescent sports-related deaths
T-rays: New imaging technology spotlighted by American Chemical Society
Temperate Forests Could Worsen Global Warming
UCLA scientists discover immune response to HIV differs, even in identical twins
Modeling of long-term fossil fuel consumption shows 14.5 degree hike in temperature
Researchers say estrogen can kill breast cancer cells once fueled by the hormone
Serious adverse reactions to smallpox vaccine appear to be limited
Wide-spread use of intranasal flu vaccine does not show unexpected serious risks
Unexpected link between gene in liver and iron overload
Autistic children's brains grow larger during first years of development
December 06, 2005
Russian River coho recovery project seeing first hopeful signs of success
Computer simulation shows buckyballs deform DNA
Galaxy collisions dominate the local universe
Threat of avian influenza pandemic grows, but people can take precautions
Warming could free far more carbon from high Arctic soil than earlier thought
Physicists describe strange new fluid-like state of matter
Sooner is better with cochlear implants, Stanford scientist shows
San Andreas Fault Observatory at Depth reveals new insights into the 'earthquake machine'
NASA & NSF create unprecedented view of upper atmosphere
Chemotherapy after surgery extends survival for patients with advanced endometrial cancer
Rivers on Titan, one of Saturn's moons, resemble those on Earth
Climate models need deeper roots, scientists say
Chemists detect toxic emissions linked to catalytic converters in US
New nanosensor uses quantum dots to detect DNA
Jungle discovery opens new chapter in Maya history
A century after 1906 earthquake, geophysicists revisit 'Big One' and come up with new model
Why the Amazon rainforest is so rich in species
A salty tale: New bacterial genome sequenced from ancient salterns
Titania nanoparticles could lead to improved sensors and solar energy
Team care more cost-effective than usual care for depression
Mayo Clinic researchers: Stroke risk significant in month following heart attack
Molecule links Down syndrome to Alzheimer's
Brain enlargement may be characteristic of autism
December 05, 2005
Satellites capture first-ever gravity map of tides under Antarctic ice
Modern forests suffer from century-old logging legacy
Sydney researchers explain how stress can make you sick
Obesity before pregnancy linked to childhood weight problems
UCLA imaging study of children with autism finds broken mirror neuron system
Drinking small amounts of alcohol regularly reduces risk of obesity
Arsenic discharged from landfills, says Dartmouth research
Heparin antibodies may pose risk in heart surgery patients
Iron particles and MRI could replace biopsies to track stem cell therapy and deploy stents
Scientists directly view immune cells interacting to avert autoimmunity
Tracking the memory trace
New species of diatom discovered
Poison + water = hydrogen. New microbial genome shows how
Study Finds That Nutritionally Enhanced Rice Reduces Iron Deficiency
Earthquake 'pulses' could predict tsunami impact
Tropical Atlantic cooling and African deforestation correlate to drought, report scientists
Huge tsunami spurred progress, revealed needs
December 02, 2005
UCSF study finds nerve regeneration is possible in spinal cord injuries
Johns Hopkins study suggests link between caffeine dependence and family history of alcoholism
Research suggests doctor-assisted suicide wouldn't undermine patient trust
Scientists unlock solid tumor treatment genetic secrets
Gladstone researchers identify new drug target for Alzheimer's disease
Study confirms that stents releasing medication help keep heart bypass vein grafts open
Nano-cages 'fill up' with hydrogen
MicroRNA may have fail-safe role in limb development
Crystal sponges excel at sopping up CO2
Coffee and tea can reduce the risk of chronic liver disease
Fat tissue surrounding thoracic arteries may be beneficial
Childbirth not linked to urinary incontinence, study finds
Needle-free immunizations
Disruption of gene interaction linked to schizophrenia
Hopkins study shows 30-day soft contact lenses pose very small risk of vision loss
Men and women differ in brain use during same tasks
Atherosclerosis studied at the cellular level
No safe ground for life to stand on during world's largest mass extinction
Study demonstrates role of exercise in modifying melatonin levels
First Galileo satellite travels to launch site
December 01, 2005
Overproducing leptin receptors in fat cells may be key to halting weight gain
Endotoxins in house dust pose a significant risk for asthma
Overfishing in inland waters reduces biodiversity and threatens health
Texas A&M anthropologist studies ancient human footprints
Research findings contradict longstanding bias against morphine
Purdue 'metamaterial' could lead to better optics, communications
Optical vortex could look directly at extrasolar planets
Genetic key to growth of new arteries is identified
Yale scientists decipher 'wiring pattern' of cell signaling networks
Interactive 3-D atlas of mouse brain now available on web
Buried craters and underground ice-Mars Express uncovers depths of Mars
Nanotech discovery could have radical implications
Slight increased risk of major birth defects associated with IVF
MUHC and McGill scientists identify gene for debilitating vitamin B12 disease
Young women who smoke higher risk of breask cancer
Survey: Refusal to Evacuate, Complacency Remain Problems During Hurricanes
Skimmed milk reduces the risk of hypertension by 50%
Scientists pool information to boost understanding of drug action
Q-Fever: A global health risk
World first trial to test human implant of HeartPOD‚—¢
UI's Gurnett finds 'lumpy' ionosphere, glimpses of the subsurface of Mars
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