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New safety concern related to antipsychotic treatment
Overall, antipsychotic medications are reasonably effective, and fairly well tolerated treatments for mood and psychotic disorders. view more (2009-12-02)
Delirium in hospitalized adults: Situation critical, no relief available
Every year as many as seven million adults in the United States experience delirium during hospitalization. view more (2009-07-07)
Antipsychotic drugs double risk of death among Alzheimer's patients
New research into the effects of antipsychotic drugs commonly prescribed to Alzheimer's patients concludes that the medication nearly doubles risk of death over three years. view more (2009-01-09)
Newer antipsychotics no better than older drug in treating child and adolescent schizophrenia
Two newer atypical antipsychotic medications were no more effective than an older conventional antipsychotic in treating child and adolescent schizophrenia and may lead to more metabolic side effects, according to a new study funded by the National Institutes of Health's National Institute of Mental Health (NIMH). view more (2008-09-15)
Risks and benefits of antipsychotics in children and adolescents
Many of the psychiatric disorders observed in adults have their onset in childhood or adolescence. In fact some studies show that at least 20% of children and adolescents will fulfil a diagnostic criterion for a mental disorder before reaching adulthood. view more (2008-09-02)
Looking beyond the drug receptor for clues to drug effectiveness
Antipsychotic drugs that are widely used to treat schizophrenia and other problems may not work as scientists have assumed, according to findings from Duke University Medical Center researchers that could lead to changes in how these drugs are developed and prescribed. view more (2008-08-26)
Violence declines with medication use in some with schizophrenia
Some schizophrenia patients become less prone to violence when taking medication, but those with a history of childhood conduct problems continue to pose a higher risk even with treatment, according to a new study by researchers at Duke University Medical Center. view more (2008-07-01)
Short-term use of antipsychotics in older adults with dementia linked to serious adverse events
Older adults with dementia who receive short-term courses of antipsychotic medications are more likely to be hospitalized or die than those who do not take the drugs, according to a report in the May 26 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. view more (2008-05-27)
Treatment With An Antipsychotic Drug Found To Cause Changes In Metabolism Earlier Than Expected
Schizophrenia is a complex type of psychotic mental illness characterized by thoughts that are uncoupled from reality. view more (2008-04-08)
New treatment mechanisms for schizophrenia
The field of schizophrenia research has come alive with many exciting new potential approaches to treatment. From the introduction of chlorpromazine to the current day, all treatments approved by the U.S. Food and Drug Administration have had, at their core, a single treatment mechanism, the blockade of the dopamine D2 receptor. view more (2008-01-09)
Antidepressant shows early promise in treating agitation and psychotic symptoms of dementia
Researchers have found surprising evidence that an antidepressant (citalopram) may perform as well as a commonly-prescribed antipsychotic (risperidone) in the alleviation of severe agitation and psychotic symptoms of dementia. Researchers also found that the antidepressant was associated with "significantly lower" adverse side effects. view more (2007-09-10)
Study documents rapid increase in youth bipolar disorder diagnoses
The estimated number of youth with office visits with a diagnosis of bipolar disorder substantially increased between 1994 and 2003, while adult visits with a bipolar disorder diagnoses appeared to almost double. view more (2007-09-04)
Chemical maps hint at drug's effects on schizophrenia
Antipsychotic drugs do most of their work in the brain, but they also leave behind in the bloodstream a trail of hundreds of chemicals that may be used in the future to direct better treatment for schizophrenia and other psychiatric conditions, say Duke University Medical Center researchers. view more (2007-05-15)
Delayed treatment of childhood-onset bipolar disorder results in negative outcome in adults
In bipolar disorder, also called manic-depressive disorder, a person experiences mood changes that fluctuate between periods of abnormally high energy and extreme depression. view more (2007-05-01)
Cost control measures limit patient and physician choice in psychotropic medications
A new Brandeis University study published online in Clinical Therapeutics suggests that private health plans increasingly rely on escalating copayments to manage drug costs, as opposed to administrative controls. view more (2007-03-02)
Severely mentally ill have increased risk of death from cardiovascular disease
A large British study indicates that individuals with severe mental illnesses are significantly more likely to die from coronary heart disease and stroke, but not cancer, than those without mental illnesses. view more (2007-02-06)
Older medication may be more cost-effective for some patients with schizophrenia
A new study analyzing the economic implications of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) concludes that the older (first generation) antipsychotic medication perphenazine was less expensive and no less effective than the newer (second generation) medications used in the trial during initial treatment, suggesting... view more... (2006-12-01)
Studies look at how genes affect antipsychotic drug response
Researchers at the University of Illinois at Chicago College of Pharmacy are attempting to discover how genes determine how well an antipsychotic medication works in adults and children and the side effects it will cause. view more (2006-11-10)
Second-generation antipsychotic medications appear to offer little advantage over older drugs
Among patients with schizophrenia whose medication is changed because of ineffectiveness or harmful side effects, second-generation antipsychotic drugs do not appear to offer significant benefits compared to first-generation antipsychotic drugs. view more (2006-10-03)
NIMH study to guide treatment choices for schizophrenia
A large study funded by NIH's National Institute of Mental Health (NIMH) provides, for the first time, detailed information comparing the effectiveness and side effects of five medications - both new and older medications - that are currently used to treat people with schizophrenia. view more (2005-09-20)
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