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Grape-seed extract kills laboratory leukemia cells, proving value of natural compounds
An extract from grape seeds forces laboratory leukemia cells to commit cell suicide, according to researchers from the University of Kentucky. They found that within 24 hours, 76 percent of leukemia cells had died after being exposed to the extract.   view more (2009-01-05)

A new light on the anti-tumor mechanisms of Scutellaria barbata
Medicinal plants have been used as traditional remedies for hundreds of years. Among them, S. barbata has been traditionally used in treatment of hepatitis, inflammation, osteomyelitis and gynecological diseases in China.   view more (2009-01-05)

How to enhance non-thermal effects of ultrasound
In recent years HIFU has been widely used for the treatment of solid tumors, such as liver tumor, bone tumor, and breast cancer. The mechanism for therapeutic actions of HIFU includes thermal effects and non-thermal effects with the latter dominated by cavitational effects.   view more (2008-12-29)

Cold Spring Harbor Protocols features tissue culture methods for immune cells and neurons
The complexity of vital organ systems makes them difficult to study in living organisms. Tissue culture methods for specific cell types allow researchers to break these systems down into component parts that can be readily manipulated and observed.   view more (2008-12-03)

Could vitamin D save us from radiation?
Radiological health expert Daniel Hayes, Ph.D., of the New York City Department of Health and Mental Hygiene suggests that a form of vitamin D could be one of our body's main protections against damage from low levels of radiation.   view more (2008-11-10)

3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions
Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), disrupt the quality of life for patients, put a tremendous burden on family caregivers, and cost society billions of dollars annually.   view more (2008-10-29)

What is the function of NOD2 in colonic epithelial cells?
NOD2 is a cytosolic pattern recognition receptor similar in structure and function to Toll like receptors (TLRs). It can recognize and respond to a component found in the cell wall of bacteria, muramyl dipeptide (MDP), and has been shown to play an important role in the innate immune response of... view more (2008-10-23)

Genes that control cell death fingered in age-related hearing loss
Several genes that play a role in how our body's cells normally auto-destruct may play a role in age-related hearing loss, according to research published online in the journal Apoptosis - a journal devoted to the topic of cell suicide, or programmed cell death.   view more (2008-10-17)

Keeping herpes infection in check: Pitt researchers describe immune system strategies
Herpes simplex virus type I can cause bouts of cold sores, blindness and potentially lethal encephalitis when it reawakens from a quiescent state in the nerve cells it infects.   view more (2008-10-10)

Hodgkin lymphoma -- new characteristics discovered
Researchers are still discovering new characteristics of Hodgkin lymphoma, a common form of cancer of the lymphatic system. The malignant cells are derived from white blood cells (B cells), but have lost a considerable part of the B cell-specific gene expression pattern.    view more (2008-10-09)

What is the pathogenesis of liver damage induced by ethanol?
They investigated the effects of ethanol on the IGF-I system with the involvement of JNK1/2 activity and ADH by using each chemical inhibitor in primary cultured rat hepatocytes. The results indicate that ethanol inducedp-JNK1/2 activation is associated with the IGF-I system and cell viability in... view more (2008-10-08)

Burnham Researchers Turn Cancer Friend into Cancer Foe
Burnham Institute for Medical Research today announced that scientists have created a peptide that binds to Bcl-2, a protein that protects cancer cells from programmed cell death, and converts it into a cancer cell killer.   view more (2008-10-08)

A new therapeutic option for human hepatocyte cancer
p53-impaired tumors may be particularly suitable to parvovirus H-1-induced therapy. Although the p53 deficiency in tumors may induce resistance to chemotherapeutic agents, this will not affect the tumor cell susceptibility to H-1 PV-induced oncolytic infections.   view more (2008-09-24)

Is Bcl-2 protein a major obstacle in treating colorectal carcinoma?
Apoptosis resistance has been shown to contribute to the development of different cancer entities, such as colorectal carcinoma (CRC).   view more (2008-09-24)

How do the choline compounds change when apoptosis occurs?
Apoptosis is a programmed, active, highly selective mechanism of cell death. Abnormal regulation of apoptosis can lead to disorders such as cancer. The field of apoptosis research has undergone an explosion of new knowledge over the past decade.   view more (2008-09-24)

Photonic crystal biosensors detect protein-DNA interactions
Scientists at the University of Illinois have developed a new class of disposable, microplate-based optical biosensors capable of detecting protein-DNA interactions. Based on the properties of photonic crystals, the biosensors are suitable for the rapid identification of inhibitors of... view more (2008-09-24)

A potential approach to treatment of hepatitis B virus infection
Eukaryotic cells employ multiple strategies of checkpoint signaling and DNA repair mechanisms to monitor and repair damaged DNA.   view more (2008-09-10)

Cardiac cell transplant studies show promise in cardiac tissue repair
Two studies published in the current issue of CELL TRANSPLANTATION (17:6) examine the efficacy of transplanting bone marrow cells (BMCs) for the repair of heart tissue.    view more (2008-09-04)

Yale undergrads' Amazon trip yields a treasure trove of diversity
A group of Yale undergraduates have discovered dozens of potentially beneficial bioactive microorganisms within plants they collected in the Amazon rain forest, including several so genetically distinct that they may be the first members of new taxonomical genera.   view more (2008-08-25)

By amplifying cell death signals, scientists make precancerous cells self-destruct
When a cell begins to multiply in a dangerously abnormal way, a series of death signals trigger it to self-destruct before it turns cancerous. Now, in research to appear in the August 15 issue of Genes & Development, Rockefeller University scientists have figured out a way in mice to amplify... view more (2008-08-18)

NYU researchers demonstrate activity of mebendazole in metastatic melanoma
Researchers at the NYU Cancer Institute and the Ronald O. Perelman Department of Dermatology have identified mebendazole, a drug used globally to treat parasitic infections, as a novel investigational agent for the treatment of chemotherapy-resistant malignant melanoma.   view more (2008-08-07)

Novel structure proteins could play a role in apoptosis
Isoforms from Novel Structure Proteins (NSP), a new family of genes discovered by researchers in the Sbarro Institute for Cancer Research and Molecular Medicine in Temple University's College of Science and Technology, could be involved in apoptosis or programmed cell death.   view more (2008-07-25)

Blue light used to harden tooth fillings stunts tumor growth
A blue curing light used to harden dental fillings also may stunt tumor growth, Medical College of Georgia researchers say.   view more (2008-06-25)

Nerve cells derived from stem cells and transplanted into mice may lead to improved brain treatments
Scientists at the Burnham Institute for Medical Research have, for the first time, genetically programmed embryonic stem (ES) cells to become nerve cells when transplanted into the brain, according to a study published today in The Journal of Neuroscience.   view more (2008-06-25)

Refusal of suicide order: Why tumor cells become resistant
Cells with irreparable DNA damage normally induce programmed cell death, or apoptosis. However, this mechanism often fails in tumor cells so that transformed cells are able to multiply and spread throughout the body.   view more (2008-06-24)

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