New findings show Enbrel significantly reduced levels of C-reactive protein
Amgen (NASDAQ: AMGN) and Wyeth Pharmaceuticals, a division of Wyeth (NYSE: WYE), today announced findings from a retrospective analysis, which demonstrated that ENBREL reduced C-reactive protein (CRP), a marker of inflammation, in patients with moderate to severe plaque psoriasis following 12 weeks of treatment. view more (2008-02-04)
TNF-alpha antagonist stops inflammation-induced colon cancer in its tracks
Individuals with the inflammatory bowel disease ulcerative colitis are at increased risk of developing colon cancer. New data generated by Naofumi Mukaida and colleagues at Kanazawa University, Japan, identified a central role for the soluble factor TNF-alpha in the development of colon cancer in mice in which inflammation of the bowel was induced... view more... (2008-01-25)
Popular Arthritis Drug May Disrupt Heart Rhythm, UB Research Finds
Celebrex, a popular arthritis drug that blocks pain by inhibiting an enzyme known as COX-2, has been shown in laboratory studies to induce arrhythmia, or irregular beating of the heart, via a novel pathway unrelated to its COX-2 inhibition. view more (2008-01-25)
Steps toward Stopping Autoimmune Disease
A landmark genetic study has identified multiple genes linked to systemic lupus erythematosus (SLE), or lupus, a debilitating autoimmune disease that affects an estimated 1.4 million Americans. view more (2008-01-21)
A new view of drugs used to treat rheumatoid arthritis
Powerful drugs used to treat patients with rheumatoid arthritis have a profound, previously unrecognized effect on the immune system, breaking up molecular "training camps" for rogue cells that play an increasingly recognized role in autoimmune diseases like rheumatoid arthritis and lupus. view more (2008-01-21)
Study helps explain how allergic reactions are triggered
In demonstrating that a group of calcium ion channels play a crucial role in triggering inflammatory responses, researchers at Beth Israel Deaconess Medical Center (BIDMC) have not only solved a longstanding molecular mystery regarding the onset of asthma and allergy symptoms, but have also provided a fundamental discovery regarding the... view more... (2008-01-15)
Study suggests genetic connection between short stature and arthritis
The new study confirms observations by health professionals of a connection between decreased height and increased risk of osteoarthritis, the most common form of arthritis. Researchers speculate that both extremes of height may be associated with osteoarthritis for different reasons. view more (2008-01-14)
Osteoarthritis risk linked to finger length ratio
People whose index finger is shorter than their ring finger are at higher risk of osteoarthritis, a new University of Nottingham study has found. view more (2008-01-07)
'Electronic switch' opens doors in rheumatoid joints
A breakthrough in understanding the way atoms move across cell membranes in the human body could pave the way for the development of new treatments for inflammatory diseases such as rheumatoid arthritis. view more (2008-01-03)
Protein's New Role Discovered in Autoimmune Disease
Investigators at the University of Alabama at Birmingham (UAB) have identified the previously unknown role of a chemical 'messenger' leading to autoimmune disorders like rheumatoid arthritis and lupus. view more (2008-01-03)
SLU researchers show how to stop muscle weakness caused by myasthenia gravis
Severe muscle weakness caused by myasthenia gravis - a highly debilitating autoimmune disorder - can be prevented or reversed by blocking a key step in the immune response that brings on the disease, researchers at the Saint Louis University School of Medicine have found. view more (2007-12-21)
High-Trauma Fractures in Older Men and Women Linked to Osteoporosis
Researchers at the California Pacific Medical Center (CPMC) Research Institute are challenging a widely held belief that fractures resulting from major trauma, such as automobile accidents, are not related to osteoporosis, the common disease that makes bones weak and prone to fracture. view more (2007-11-29)
New Actemra data shows significant benefit for patients suffering from rheumatoid arthritis
The innovative new rheumatoid arthritis drug Actemra (tocilizumab) has been shown to significantly improve the signs and symptoms of rheumatoid arthritis (RA) in patients who failed to achieve an adequate response to traditional disease modifying agents (DMARDs). view more (2007-11-09)
Mayo Clinic study predicts cardiovascular disease risk for rheumatoid arthritis patients
People with rheumatoid arthritis have a higher risk for developing heart disease than the general population; however, it is difficult to identify which patients are at increased risk. view more (2007-11-08)
Phase 3 data show golimumab improved psoriatic arthritis symptoms
Patients with active psoriatic arthritis receiving monthly subcutaneous (SC) injections of golimumab (CNTO 148) experienced significant and sustained improvements in the joint and skin manifestations of the disease. view more (2007-11-08)
First-Ever Study: Lack of Critical Lubricant Causes Wear in Joints
Mice that don't produce lubricin, a thin film of protein found in the cartilage of joints, showed early wear and higher friction in their joints, a new study led by Brown University researchers shows. view more (2007-11-07)
Manchester researchers identify gene behind rheumatoid arthritis
University of Manchester researchers have identified a genetic variant in a region on chromosome 6 that is associated with rheumatoid arthritis (RA), the most common inflammatory arthritis affecting 387,000 people in the UK. view more (2007-11-05)
Scientists discover how gold eases pain of arthritis
Scientists at Duke University Medical Center may have solved the mystery surrounding the healing properties of gold - a discovery they say may renew interest in gold salts as a treatment for rheumatoid arthritis and other inflammatory diseases. view more (2007-10-23)
What's been causing your knee to ache? Smurfs!
A new clinical trial seeks to predict who is most likely to experience osteoarthritis, and to test whether an experimental treatment can prevent it altogether. Physicians are setting their sights on people who sustain a knee injury, seeking to understand why nearly half of them will later go on to develop osteoarthritis, a debilitating condition... view more... (2007-10-22)
Study reveals 2 genes linked to disabling arthritis
An international team of researchers led by a Fred Hutchinson Cancer Research Center geneticist has discovered two genes linked to a disabling form of arthritis called ankylosing spondylitis, a painful and progressive disease in which some or all of the spine's vertebrae fuse together. view more (2007-10-22)
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