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New scientific knowledge on juvenile diabetes
Finnish scientists have reported a breakthrough in the attempts to understand the development of type 1 diabetes. They discovered disturbances in lipid and amino acid metabolism in children who later progressed to type 1 diabetes, also known as juvenile diabetes.   view more (2008-12-18)

JDRF funded research shows promise for prevention, reversal of type 1 diabetes
Researchers at the University of California, San Francisco have reported that two common cancer drugs have been used to block and reverse type 1 diabetes in mice.   view more (2008-11-19)

Penn Scientists Show How Body Determines Optimal Amount of Germ-Fighting B Cells
Researchers at the University of Pennsylvania School of Medicine can now explain how the body determines whether there are enough mature B-cells in the blood stream at any one time. These are the cells that produce antibodies against germs to fight infections.   view more (2008-11-05)

Accumulated bits of a cell's own DNA can trigger autoimmune disease
A security system wired within every cell to detect the presence of rogue viral DNA can sometimes go awry, triggering an autoimmune response to single-stranded bits of the cell's own DNA, according to a report in the August 22nd issue of the journal Cell, a Cell Press publication.   view more (2008-08-22)

NIH scientists find a novel mechanism that controls the development of autoimmunity
Scientists at the National Institutes of Health (NIH) have found a mechanism in the immune systems of mice that can lead to the development of autoimmune disease when turned off.   view more (2008-08-14)

Finding suggests novel ways to boost vaccination or natural defenses
Our bodies rely on the production of potent, or 'high affinity', antibodies to fight infection. The process is very complex, yet Sydney scientists have discovered that it hinges on a single molecule, a growth factor, without which it cannot function.   view more (2008-07-08)

Cell surface receptors are all 'talk' in T cell stimulation
Understanding the mechanisms that drive healthy immune responses is important when it comes to combating autoimmune diseases, which occur when cells that should attack invading organisms turn on the body instead.   view more (2008-06-13)

Common bacteria activating natural killer T cells may cause autoimmune liver disease
A bacteria commonly found in soil and water triggered autoimmune symptoms in mice similar to those found in an incurable liver disease called Primary Biliary Cirrhosis (PBC).   view more (2008-05-15)

St. Jude study shows how T cell's machinery dials down autoimmunity
A St. Jude Children's Research Hospital study shows that T cells, the body's master immune regulators, do not use simple on/off switches to govern the cellular machinery that regulates their development and function. Rather, they possess sophisticated molecular controls that enable them to adjust... view more (2008-05-13)

Specialized white blood cells coordinate first responders to viral infection
Just as fire engines arrive quickly at the scene to save people and property, the cells that fight viruses have to reach the site of an infection promptly to mount a protective response.   view more (2008-04-25)

Strengthening the tumor-fighting ability of T cells
When faced with cancer, the immune system dispatches cells, called T cells, to kill the tumor. But these killer cells often fail to completely eliminate the tumor because they're deactivated by a distinct population of T cells known as regulatory T cells.   view more (2008-03-25)

Prostate cancer: Watchful wait or vaccinate?
Researchers at the University of Southern California have developed a prostate cancer vaccine that prevented the development of cancer in 90 percent of young mice genetically predestined to develop the disease.   view more (2008-02-04)

Scripps research scientists find new genetic mutation that halts the development of lupus
The lupus-suppressing action is the result of what is known as a nonsense mutation of the Coronin-1A gene (Coro1a) required for the development of the disease.   view more (2008-01-18)

Glue inside the cell: Ubiquitin builds up an immune response
Ubiquitin is a small protein, which can be attached to other cellular proteins, a process known as ubiquitination. Discoveries in the 1980 th on a key function of ubiquitination in the regulation of protein degradation where awarded with the Nobel Prize for chemistry in 2004.   view more (2007-10-22)

Immune cells fighting chronic infections become progressively 'exhausted,' ineffective
A new study of immune cells battling a chronic viral infection shows that the cells, called T cells, become exhausted by the fight in specific ways, undergoing profound changes that make them progressively less effective over time.   view more (2007-10-19)

M.D. Anderson-led team reports possible key to autoimmune disease
A human peptide that acts as a natural antibiotic against invading microbes can also bind to the body's own DNA and trigger an immune response in the absence of an infection, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports in an early online... view more (2007-09-17)

Reducing inflammation plays key role in type 1 diabetes therapy
Researchers at Beth Israel Deaconess Medical Center (BIDMC) have found that a triple combination therapy consisting of both tolerance-inducing and anti-inflammatory properties is successful in abolishing adverse autoimmunity against insulin-producing cells in a mouse model of Type 1 diabetes.   view more (2007-08-01)

Antibody-altering protein found in developing B cells
In order for the B cells of the immune system to identify and fight disease pathogens, they produce a protein called activation-induced cytidine deaminase (AID).   view more (2007-07-20)

Study tests oral insulin to prevent type 1 diabetes
University of Florida researchers have begun a clinical study of oral insulin to prevent or delay type 1 diabetes in people at risk for the disease.   view more (2007-06-04)

Protein may be linked to melanoma recurrence
Higher levels of a protein called S-100 in patients with melanoma may correlate with a higher risk of having the disease return.   view more (2007-06-04)

Scientists Develop Method to Track Immune System Enzyme in Live Animals
Scientists supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) at the National Institutes of Health have created two mouse strains that will permit researchers to trace, in a live animal, the activity of an enzyme believed to play a crucial role both in... view more (2007-05-18)

Glucosamine-like supplement inhibits multiple sclerosis, type 1 diabetes
A glucosamine-like dietary supplement has been found to suppress the damaging autoimmune response seen in multiple sclerosis and type 1 diabetes mellitus, according to University of California, Irvine health sciences researchers.   view more (2007-05-15)

Animal Study Identifies Promising New Target for Brain Tumor Therapy
A drug that targets the body's immune cells may be effective in treating malignant brain tumors, according to a new study led by researchers at Duke's Preston Robert Tisch Brain Tumor Center. In animal models, the drug re-engaged the body's cancer-damaged immune system.   view more (2007-05-09)

Researchers find that later-life diseases resulting from fetal and infant toxicity have common immune pattern
A Cornell researcher and his wife have conducted the first comprehensive review of later-life diseases that develop in people who were exposed to environmental toxins or drugs either in the womb or as infants. They have found that most of the diseases have two things in common: They involve an... view more (2007-05-03)

Minuscule molecules pack a powerful punch
A role for a microRNA in the immune system has been shown by study of one of the world's first microRNA knockout mouse, reported Friday 27 April in Science.   view more (2007-04-27)
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