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A potential route for human tumor gene therapy
The type 1 Na+/H+ exchanger (NHE1) is a transmembrane protein found in all eukaryotic cells. One of its functions is to evacuate excessive H+ in the cytoplasm by means of Na+-H+ exchange, resulting in stable intracellular pH value.   view more (2008-05-21)

Bone drug could help prevent the spread of breast cancer
Maintaining bone density could be a key to decreasing the spread of cancer in women with locally advanced breast cancer, according to research at Washington University School of Medicine in St. Louis.   view more (2008-05-19)

New Mount Sinai research tracks effects of addictive drugs on brain
Mount Sinai researchers may have unlocked the key to better understanding the effect addictive drugs have on the human brain.   view more (2008-05-16)

Vitamin D protects cells from stress that can lead to cancer
By inducing a specific gene to increase expression of a key enzyme, vitamin D protects healthy prostate cells from the damage and injuries that can lead to cancer, University of Rochester Medical Center researchers report.   view more (2008-05-14)

How embryonic stem cells develop into tissue-specific cells demonstrated
While it has long been known that embryonic stem cells have the ability to develop into any kind of tissue-specific cells, the exact mechanism as to how this occurs has heretofore not been demonstrated.   view more (2008-05-13)

Suspected cause of type 1 diabetes caught
Scientists at Washington University School of Medicine in St. Louis working with diabetic mice have examined in unprecedented detail the immune cells long thought to be responsible for type 1 diabetes.   view more (2008-05-12)

New Cancer Gene Discovered
Researchers at the OU Cancer Institute have identified a new gene that causes cancer. The ground-breaking research appears Monday in Nature's cancer journal Oncogene.   view more (2008-05-09)

Immune system pathway identified to fight allergens, asthma
For the first time, researchers from the University of Pittsburgh School of Medicine have identified genetic components of dendritic cells that are key to asthma and allergy-related immune response malfunction.   view more (2008-05-08)

Researchers find way to make tumor cells easier to destroy
Tumors have a unique vulnerability that can be exploited to make them more sensitive to heat and radiation, researchers at Washington University School of Medicine in St. Louis report.   view more (2008-05-07)

Immune exhaustion in HIV infection
As HIV disease progresses in a person infected with the HIV virus, a group of cells in the immune system, the CD8+ T lymphocytes, become "exhausted," losing many of their abilities to kill other cells infected by the virus.   view more (2008-05-06)

Nixing immaturity in red blood cells
A process of self-digestion called autophagy prompts the maturation of red blood cells. Without a protein called Nix, the cells would not effectively rid themselves of organelles called mitochondria and consequently become short-lived, leading to anemia, said researchers at Baylor College of... view more (2008-05-05)

'Destruct' triggers may be jammed in tumor cells, UF geneticists say
Tumor cells living in the cross hairs of radiation or chemotherapy may be able to escape death because their self-destruct mechanisms are jammed, say University of Florida scientists writing in a recent issue of Developmental Cell.   view more (2008-05-01)

UCLA stem cell researchers create heart and blood cells from reprogrammed skin cells
Stem cell researchers at UCLA were able to grow functioning cardiac cells using mouse skin cells that had been reprogrammed into cells with the same unlimited properties as embryonic stem cells.   view more (2008-04-30)

Clumps of red and white blood cells may contribute to sickle cell disease
It's long been known that patients with sickle cell disease have malformed, "sickle-shaped" red blood cells - which are normally disc-shaped - that can cause sudden painful episodes when they block small blood vessels.   view more (2008-04-29)

Two suppressor molecules affect 70 genes in leukemia
By restoring two small molecules that are often lost in chronic leukemia, researchers were able to block tumor growth in an animal model.   view more (2008-04-25)

Specialized white blood cells coordinate first responders to viral infection
Just as fire engines arrive quickly at the scene to save people and property, the cells that fight viruses have to reach the site of an infection promptly to mount a protective response.   view more (2008-04-25)

Heart derived stem cells develop into heart muscle
Dutch researchers at University Medical Center Utrecht and the Hubrecht Institute have succeeded in growing large numbers of stem cells from adult human hearts into new heart muscle cells.   view more (2008-04-24)

Menstrual blood -- a valuable source of multipotential stem cells?
Researchers seeking new and more abundant sources of stem cells for use in regenerative medicine have identified a potentially unlimited, noncontroversial, easily collectable, and inexpensive source - menstrual blood.   view more (2008-04-23)

A stem cell type supposed to be crucial for angiogenesis and cancer growth does not exist?
Angiogenesis, the growth of new blood vessels, is a central process in diverse physiological and pathological situations such as healing of wounds and traumas, cardiovascular disorders, inflammatory conditions such as rheumatoid arthritis, and in cancer growth.   view more (2008-04-23)

Ovarian cancer stem cells identified, characterized
Researchers at Yale School of Medicine have identified, characterized and cloned ovarian cancer stem cells and have shown that these stem cells may be the source of ovarian cancer's recurrence and its resistance to chemotherapy.   view more (2008-04-18)

Drug compound leads to death of ovarian cancer cells resistant to chemotherapy
In a discovery that may be useful for maintaining remission in chemo-resistant ovarian cancer, Yale scientists report that pre-clinical studies have shown the drug compound NV-128 can induce the death of ovarian cancer cells by halting the activation of a protein pathway called mTOR.   view more (2008-04-18)

New type of drug shrinks primary breast cancer tumors significantly in just 6 weeks
A drug that targets the cell surface receptors that play an important role in many types of cancer can bring about significant tumour regression in breast cancer after only six weeks of use.   view more (2008-04-17)

A potential sugar fix for tumors
Researchers at the Duke School of Medicine apparently have solved the riddle of why cancer cells like sugar so much, and it may be a mechanism that could lead to better cancer treatments.   view more (2008-04-16)

How smoking encourages infection
Now new research published in the open access journal BMC Cell Biology shows that nicotine affects neutrophils, the short-lived white blood cells that defend against infection, by reducing their ability to seek and destroy bacteria.   view more (2008-04-15)

Human vascular system in mice
The formation of new blood vessels, or angiogenesis, is an Achilles' heel of tumor growth, because tumors depend on the supply of oxygen and nutrients for survival.   view more (2008-04-15)
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