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Claudin 11 stops the leaks in neuronal myelin sheaths
Devaux and Gow demonstrate how a tight junction protein called claudin 11 makes the neuronal myelin sheath a snug fit.   view more (2008-12-01)

A scientific breakthrough on the control of the bad cholesterol
A study performed by the team of Dr. Nabil G. Seidah, Director of the Biochemical Neuroendocrinology Research Unit at the IRCM, shows for the very first time that the degradation by PCSK9 of the LDLR receptor   view more (2008-11-25)

Heart patients are often not treated in accordance with guidelines
Many patients with cardiovascular disease are not given adequate drug therapy. This is the result of an international study. In the current edition of Deutsches Ärzteblatt International, Uwe Zeimer et al. present the German results of this prospective, one-year survey.   view more (2008-11-24)

Nature Medicine study shows Peregrine's bavituximab can cure lethal virus infections
Peregrine Pharmaceuticals, Inc. (NASDAQ: PPHM) today reported publication of data in Nature Medicine that supports the broad anti-viral potential of the company's novel anti-phosphatidylserine (anti-PS) antibody platform, showing that its PS-targeting drug bavituximab can cure lethal virus... view more (2008-11-24)

UT Southwestern researchers develop new strategy for broad spectrum anti-viral drugs
Bavituximab, an anti-viral drug developed by UT Southwestern Medical Center researchers, shows promise as a new strategy to fight viral diseases, including potential bioterrorism agents.   view more (2008-11-24)

Long-term antibiotics reduce COPD exacerbations, raise questions
Long-term use of a macrolide antibiotic may reduce the frequency of exacerbations in patients with moderate to severe chronic obstructive pulmonary disease (COPD) by as much as 35 percent, according to a London-based study.   view more (2008-11-21)

Systems biology brings hope of speeding up drug development
Almost every day brings news of an apparent breakthrough against cancer, infectious diseases, or metabolic conditions like diabetes, but these rarely translate into effective therapies or drugs, and even if they do clinical development usually takes well over a decade.   view more (2008-11-20)

Garlic chemical tablet treats diabetes I and II
A drug based on a chemical found in garlic can treat diabetes types I and II when taken as a tablet, a study in the new Royal Society of Chemistry journal Metallomics says.   view more (2008-11-20)

New platinum-phosphate compounds kill ovarian cancer cells
A new class of compounds called phosphaplatins can effectively kill ovarian, testicular, head and neck cancer cells with potentially less toxicity than conventional drugs, according to a new study published this week in the journal Proceedings of the National Academy of Sciences.    view more (2008-11-20)

Stopping germs from ganging up on humans
Keeping germs from cooperating can delay the evolution of drug resistance more effectively than killing germs one by one with traditional drugs such as antibiotics, according to new research from The University of Arizona in Tucson.   view more (2008-11-20)

Conference report highlights new research into drug delivery to treat eye disease
Researchers are investigating microneedles, nanoparticles and polymer carriers as potential new techniques to combat the leading cause of visual impairment and blindness in the United States, according to a report from the Third Annual ARVO/Pfizer Ophthalmics Research Institute Conference.   view more (2008-11-18)

Biomedical engineers' detective work reveals antibiotic mechanism
A series of genetic clues led a team of Boston University biomedical engineers to uncover exactly how certain antibiotics kill bacteria. The findings could help rejuvenate the efficacy of older antibiotics and reveal new antibiotic targets within bacterial cells.   view more (2008-11-18)

Simple new method detects contaminants in life-saving drug
The blood-thinning drug heparin is highly effective when used to prevent and treat blood clots in veins, arteries and lungs, but earlier this year its reputation as a lifesaver was sullied when contaminated heparin products caused serious allergic reactions that led to a large number of deaths.   view more (2008-11-18)

Hope for treating relapse to methamphetamine abuse
A new study at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory suggests that vigabatrin (a.k.a. gamma vinyl-GABA, or GVG) blocks drug-seeking behavior in animals previously trained to associate methamphetamine with a particular environment.   view more (2008-11-13)

OHSU Knight Cancer Institute researcher: study may result in more targeted drugs for GIST
According to Oregon Health & Science University Knight Cancer Institute researchers, there is strong evidence that patients can have varying clinical responses to medications depending on the specific makeup of their cancer.   view more (2008-11-13)

Novel 4-drug combination proves safe for lung cancer treatment
The four drug-combination of carboplatin and paclitaxel, with the targeted therapies bevacizumab (Avastin) and cetuximab (Erbitux), is safe and may improve survival for patients with advanced lung cancer, according to a cooperative group study led by The University of Texas M. D. Anderson Cancer... view more (2008-11-13)

Lead-flapping objects experience less wind resistance than their trailing counterparts
It is commonly known that racing cars and bicyclists can reduce air resistance by following closely behind a leader, but researchers from New York University and Cornell University have found the opposite is true with flapping objects, such as flags.   view more (2008-11-11)

Forced evolution: Can we mutate viruses to death?
It sounds like a science fiction movie: A killer contagion threatens the Earth, but scientists save the day with a designer drug that forces the virus to mutate itself out of existence. The killer disease? Still a fiction. The drug? It could become a reality thanks to a new study by Rice University... view more (2008-11-11)

Montana State University researchers find gene that regulates mold's resistance to drugs
Montana State University scientists concerned about lethal mold infections have found a gene that regulates the mold's resistance to drugs.   view more (2008-11-07)

Study reveals continued damage from banned obesity drug
Fenfluramine, the appetite suppressant drug banned in the US in 1997 due to fears over its links to heart conditions, has been shown to have serious long-term effects.   view more (2008-11-06)

Drug mimics low-cal diet to ward off weight gain, boost running endurance
A drug designed to specifically hit a protein linked to the life-extending benefits of a meager diet can essentially trick the body into believing food is scarce even when it isn't, suggests a new report in the November Cell Metabolism.   view more (2008-11-05)

Apelin hormone injections powerfully lower blood sugar
By injecting a hormone produced by fat and other tissues into mice, researchers report in the November Cell Metabolism that they significantly lowered blood sugar levels in normal and obese mice.   view more (2008-11-05)

An Anti-Frailty Pill for Seniors?
Researchers at the University of Virginia Health System report that a daily single oral dose of an investigational drug, MK-677, increased muscle mass in the arms and legs of healthy older adults without serious side effects, suggesting that it may prove safe and effective in reducing age-related... view more (2008-11-05)

Iowa State researcher develops new treatment method for canine eye diseases
An Iowa State University researcher is exploring a new method of getting medicine to the eyes of infected dogs that is more effective and reliable than using eye drops.   view more (2008-10-29)

Researchers find new chemical key that could unlock hundreds of new antibiotics
Chemistry researchers at The University of Warwick and the John Innes Centre, have found a novel signalling molecule that could be a key that will open up hundreds of new antibiotics unlocking them from the DNA of the Streptomyces family of bacteria.   view more (2008-10-29)
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