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Double binding sites on tumor target may provide future combination therapy
Researchers from the University of Pennsylvania School of Medicine and colleagues at Merck Serono Research in Germany have found that two drugs bind to receptor sites on some tumors in different places at the same time, suggesting the possibility of a new combination therapy for certain types of... view more (2008-04-09)

Nano-sized technology has super-sized effect on tumors
Anyone facing chemotherapy would welcome an advance promising to dramatically reduce their dose of these often harsh drugs. Using nanotechnology, researchers at Washington University School of Medicine in St. Louis have taken a step closer to that goal.   view more (2008-04-03)

Stanford researcher criticizes FDA plans to reduce oversight of off-label drug use
Proposed guidelines from the U.S. Food and Drug Administration would allow companies to market more drugs for unapproved uses and are a step in the wrong direction, said a researcher from the Stanford University School of Medicine.   view more (2008-04-03)

Scientists solve mystery of polyketide drug formation
Many top-selling drugs used to treat cancer and lower cholesterol are made from organic compounds called polyketides, which are found in nature but historically difficult for chemists to alter and reproduce in large quantities.   view more (2008-04-02)

Prednisone tablets less variable than marketed drugs
The U.S. Pharmacopeial (USP) Convention today announced results of a study comparing the dissolution variability of USP Prednisone Lot P Reference Standard tablets to two marketed drugs.   view more (2008-04-02)

Are blood thinners post-op killers?
New study shows that the use of powerful anticoagulants to prevent pulmonary embolism may actually lead to more deaths after surgery   view more (2008-04-01)

Restrictive drug policies often cause schizophrenic patients to discontinue medication
Policies requiring authorization before physicians can prescribe newer medications to schizophrenic patients may be counter-productive. According to a new study, patients in Maine's Medicaid program who found themselves in this situation were 29% more likely to stop or disrupt medication use than... view more (2008-04-01)

NSAIDs: Painkillers, inflammation inhibitors, anti-cancer drugs and new de-methylating agents
Researchers at the National Sun Yat-Sen University and Kaohsiung Medical University, Kaohsiung, Taiwan have revealed a new mechanism by which nonsteroidal anti-inflammatory drugs (NSAIDs) attenuate tumor invasion and metastasis.   view more (2008-03-27)

OHSU Cancer Institute researchers identify new approach to help control drug resistance in leukemia
Oregon Health & Science University Cancer Institute researchers have found that an experimental drug known as SGX393 is effective against Gleevec-resistant chronic myeloid leukemia (CML). The results of their study will be published the week of March 24th in the Proceedings of the National... view more (2008-03-25)

Promising new drug targets identified for Huntington's disease
Research funded by the Wellcome Trust has provided a number of promising new drug targets for Huntington's disease, a neurodegenerative disease. Scientists at the University of Cambridge have identified a number of candidate drugs to investigate further which encourage cells to "eat" the... view more (2008-03-24)

Solving the drug price crisis
The mounting U.S. drug price crisis can be contained and eventually reversed by separating drug discovery from drug marketing and by establishing a non-profit company to oversee funding for new medicines, according to two MIT experts on the pharmaceutical industry.   view more (2008-03-18)

Researchers develop method to rapidly ID optimal drug cocktails
UCLA researchers have developed a feedback control scheme that can search for the most effective drug combinations to treat a variety of conditions, including cancers and infections. The discovery could play a significant role in facilitating new clinical drug-cocktail trials.   view more (2008-03-18)

Pain Receptor in Brain May Be Linked to Learning and Memory
Scientists have long known that the nervous system receptor known as TRPV1 can affect sensations of pain in the body. Now a group of Brown University scientists has found that these receptors - a darling of drug developers - also may play a role in learning and memory in the brain.   view more (2008-03-14)

Arthritis medications reduce the risk of heart attacks and strokes
Patients prescribed drugs to treat rheumatoid arthritis could be at a reduced risk of heart attacks and strokes, according to a study published today in the open access journal Arthritis Research & Therapy.   view more (2008-03-06)

Mouse model tightly matches pediatric tumor syndrome, will speed drug hunt
Frustrated by the slow pace of new drug development for a condition that causes pediatric brain tumors, a neurologist at Washington University School of Medicine in St. Louis decided to try to fine-tune the animal models used to test new drugs.   view more (2008-03-03)

Columbia geneticists uncover new gene involved in determining hair texture and density in humans
A Columbia University Medical Center research team has discovered a new gene involved in determining hair texture in humans.   view more (2008-02-26)

Do patients with inflammatory bowel disease receive optimal care?
Inflammatory bowel disease (IBD) is a chronic recurrent gastrointestinal disease. The disease has a relatively higher morbidity in young adults, in whom growth, education, employment and wellbeing all are adversely influenced.   view more (2008-02-25)

Researchers explore the antidepressant effects of ketamine
Drug treatments for depression can take many weeks for the beneficial effects to emerge. The excruciating and disabling nature of depression highlights the urgency of developing treatments that act more rapidly.   view more (2008-02-22)

Heart attack prescription drug strategy may save lives and reduce healthcare costs
Full prescription coverage of heart drugs could help heart attack survivors live longer, better lives and lower the nation's healthcare costs, according to a new analysis reported in Circulation: Journal of the American Heart Association.   view more (2008-02-19)

Scientists move closer to developing a new class of asthma and allergy drugs
A team of Biotechnology and Biological Sciences Research Council (BBSRC) funded scientists has moved a step closer to developing a new class of effective asthma and allergy drugs.   view more (2008-02-15)

New findings show additional similarity between opiate and nicotine addiction
"That was good!" "Do it again." This is what the brain says when people use tobacco, as well as 'hard drugs' such as heroin.   view more (2008-02-13)

Fake antimalarial drugs analysis highlights threat to global health
A unique collaboration between scientists, public health workers and police has led to the arrest by the Chinese authorities of alleged traders of fake anti-malarial drugs in southern China and the seizure of a large quantity of drugs.   view more (2008-02-12)

MIT develops thin-film 'micro pharmacy'
A new thin-film coating developed at MIT can deliver controlled drug doses to specific targets in the body following implantation, essentially serving as a "micro pharmacy."   view more (2008-02-12)

HIV drugs, Abacavir and Didanosine, increase the risk of heart attack
A study to assess the adverse effects of anti-retroviral drugs shows that two of the widely used HIV drugs are associated with an increased risk of heart attack/the formation of blood clots in the heart. With the use of Didanosine; the risk of developing a heart attack increases by 49%, with... view more (2008-02-11)

Study reveals why certain ovarian cancers develop resistance to platinum-based chemotherapy
A team of researchers led by Fred Hutchinson Cancer Research Center has identified a new mechanism that explains why some recurrent ovarian tumors become resistant to treatment with commonly used platinum-based chemotherapy drugs such as cisplatin and carboplatin. They describe their research... view more (2008-02-11)
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