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Study finds genomic changes in the brains of people who commit suicide
Are genes destiny? Alternatively, are we simply the products of our environment? There is a growing sense that neither of these two possibilities fully captures the essence of the risk for psychiatric disorders.   view more (2008-10-23)

Our genome changes over lifetime, Johns Hopkins experts say
Researchers at Johns Hopkins have found that epigenetic marks on DNA-chemical marks other than the DNA sequence-do indeed change over a person's lifetime, and that the degree of change is similar among family members.   view more (2008-06-25)

Child abuse may 'mark' genes in the brains of suicide victims
A team of McGill University scientists has discovered important differences between the brains of suicide victims and so-called normal brains. Although the genetic sequence was identical in the suicide and non-suicide brains, there were differences in their epigenetic marking - a chemical coating... view more (2008-05-07)

'Destruct' triggers may be jammed in tumor cells, UF geneticists say
Tumor cells living in the cross hairs of radiation or chemotherapy may be able to escape death because their self-destruct mechanisms are jammed, say University of Florida scientists writing in a recent issue of Developmental Cell.   view more (2008-05-01)

Epigenetic research uncovers new targets for modification enzymes
Enzymes regulating genetic expression can be just as important as the genome itself, increasing evidence shows. The expanding field of epigenetics focuses on the multiple influences on DNA and surrounding molecules that determine whether genes are turned on or off during development and disease... view more (2008-04-28)

Scientists Clarify a Mechanism of Epigenetic Inheritance
Although letters representing the three billion pairs of molecules that form the "rungs" of the helical DNA "ladder" are routinely called the human "genetic code," the DNA they comprise transmits traits across generations in a variety of ways, not all of which depend... view more (2008-04-23)

Computation to unravel how genes are regulated and shed light on how cells become different
A closer alliance between computational and experimental researchers is needed to make progress towards one of biology's most challenging goals, understanding how epigenetic marks contribute to regulation of gene expression.   view more (2008-04-11)

USC researchers explore genetic causes for male infertility
Researchers at the University of Southern California (USC) suggest epigenetics, or the way DNA is processed and expressed, may be the underlying cause for male infertility. The study will be published in the Dec. 12 issue of Public Library of Science One.   view more (2007-12-12)

Duke scientists map imprinted genes in human genome
Scientists at Duke University have created the first map of imprinted genes throughout the human genome, and they say a modern-day Rosetta stone - a form of artificial intelligence called machine learning - was the key to their success.   view more (2007-11-30)

New molecules discovered that block cancer cells from modifying cell DNA
Researchers have discovered new small molecules that may prevent prostate cancer cells from turning off normal genes in a process that transforms normal cells into cancer cells.   view more (2007-10-12)

Human embryonic stem cells remain embryonic because of epigenetic factors
A human embryonic stem cell is reined in - prevented from giving up its unique characteristics of self-renewal and pluripotency - by the presence of a protein modification that stifles any genes that would prematurely instruct the cell to develop into heart or other specialized tissue.   view more (2007-10-05)

UD leads $5.3-million research project on rice epigenetics
Using a novel "deep sequencing" technology that can in one fell swoop decode 50 million sequences representing well over a billion bases of DNA, a research team led by University of Delaware scientists is working to unmask where, why and how certain genes are switched on or off in rice--a... view more (2007-09-11)

Scientists find clue to mechanisms of gene signaling and regulation
Scientists have discovered a pattern in the DNA sequence of the mouse genome that may play a fundamental part in the way DNA molecules regulate gene expression.   view more (2007-08-23)

Negative effects of plastic's additive blocked by nutrient supplements
Experiments in animals have provided additional and tantalizing evidence that what a pregnant mother eats can make her offspring more susceptible to disease later in life.   view more (2007-07-31)

Turn-ons and turn-offs for neurons
Our brain consists of billions of nerve cells enabling to learn, remember and reason. Every time we think and experience, touch, smell or fear, millions of neurons in our brain becomes active.   view more (2007-06-20)

Exploring the Dark Matter of the Genome
Not so long ago, the difficult-to-sequence, highly repetitive, gene-poor DNA found in regions of chromosomes known as heterochromatin was called "junk." Like dark matter in the universe, the true nature of heterochromatin was unknown.   view more (2007-06-18)

Liposuctioned fat stem cells to repair bodies
Expanding waistlines, unsightly bulges: people will gladly remove excess body fat to improve their looks. But unwanted fat also contains stem cells with the potential to repair defects and heal injuries in the body.   view more (2007-02-23)

Epigenetics to shape stem cell future
Everyone hopes that one day stem cell-based regenerative medicine will help repair diseased tissue.   view more (2007-02-20)

Mice cloned from skin cells
Healthy and viable mice that survive until adulthood have, for the first time, been cloned from adult stem cells. Scientists from Rockefeller University, including Howard Hughes Medical Institute investigator Elaine Fuchs, used cells called keratinocyte stem cells, which represent a new model... view more (2007-02-13)

USC study in Nature Genetics supports a stem cell origin of cancer
Researchers at the University of Southern California (USC) recently made significant strides toward settling a decades-old debate centering on the role played by stem cells in cancer development.   view more (2007-01-10)

Regulating the Nuclear Architecture of the Cell
An organelle called the nucleolus resides deep within the cell nucleus and performs one of the cell's most critical functions: it manufactures ribosomes, the molecular machines that convert the genetic information carried by messenger RNA into proteins that do the work of life.   view more (2006-12-11)

American research finds twins more likely to have premature menopause
In a study of more than 800 Australian and UK twin pairs, lead by Dr Roger Gosden, Professor of Reproductive Biology at Weill Medical College of Cornell University in New York, premature ovarian failure was between three and five times greater when measured at age 40 and age 45 than in the general... view more (2006-10-25)

In a technical tour de force, Salk scientists take a global view of the epigenome
A collaboration between researchers at the Salk Institute for Biological Studies and the University of California at Los Angeles captured the genome-wide DNA methylation pattern of the plant Arabidopsis thaliana-the "laboratory rat" of the plant world-in one big sweep.   view more (2006-09-01)

Researchers find protein that silences genes
A team of researchers, including biologists at Washington University in St. Louis, has discovered the key role one protein plays in a major turn-off - in this case, the turning off of thousands of nearly identical genes in a hybrid plant.   view more (2006-05-08)

Cancer cells suppress large regions of DNA by a reversible process that can be tackled
Cancer researchers at Sydney's Garvan Institute, in collaboration with Spanish scientists, have formulated a new concept for how cancer cells can escape normal growth controls, which may have far-reaching implications for the new generation of cancer therapies.   view more (2006-04-24)

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