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Imiquimod, an immune response modifier, is dependent on the OGF-OGFr signaling pathway
Researchers at The Pennsylvania State University College of Medicine, Hershey, Pennsylvania have discovered that the efficacy of imiquimod, a clinically important immune response modifier with potent antiviral and antitumor activity, is dependent on the Opioid Growth Factor (OGF)-OGF receptor... view more (2008-07-28)

Angiotensin receptor blockers are lower incidence, progression of Alzheimer's disease
Researchers at Boston University School of Medicine (BUSM) have, for the first time, found that angiotensin receptor blockers (ARBs)-a particular class of anti-hypertensive medicines-are associated with a striking decrease in the occurrence and progression of dementia. Data from this study will be... view more (2008-07-28)

1 missing gene leads to fruitless mating rituals
Male fruit flies missing a gene for one particular odor receptor become clueless in matters of love, scientists at Duke University Medical Center have discovered.   view more (2008-07-24)

Gene variant found in those with African ancestry increases odds of HIV infection
A variant of a gene found only in people of African ancestry increases the odds of becoming infected with the human immunodeficiency virus (HIV-1) by 40 percent, according to a long-term study of African Americans reported in the journal Cell Host & Microbe, a publication of Cell Press.   view more (2008-07-17)

Turning on hormone tap could aid osteoporosis fight
A potential new drug that 'opens the taps' for the release of useful hormones could stimulate new bone growth - and may eventually bring relief to osteoporosis sufferers.   view more (2008-07-16)

Myostatin inhibitors may improve recovery of wartime limb injuries
Inhibiting a growth factor that keeps muscles from getting too big may optimize recovery of injured soldiers, researchers say.   view more (2008-07-09)

Schizophrenia linked to dysfunction in molecular brain pathway activated by marijuana
Alterations in a molecular brain pathway activated by marijuana may contribute to the cognitive symptoms of schizophrenia, according to a report in the July issue of Archives of General Psychiatry, one of the JAMA/Archives journals.   view more (2008-07-08)

Treatment delays result in poor outcomes for men with breast cancer
Men who develop breast cancer are often not treated until the disease has spread to the point that treatment becomes difficult, new results show.   view more (2008-07-07)

Researchers identify cancer preventive properties in common vitamin supplement
Early laboratory research has shown that resveratrol, a common dietary supplement, suppresses the abnormal cell formation that leads to most types of breast cancer, suggesting a potential role for the agent in breast cancer prevention.   view more (2008-07-07)

Integrins as receptors give insight into rotavirus and diarrhea
Eleven years ago, Dr. Mary Estes of Baylor College of Medicine and her colleagues discovered the first viral enterotoxin, rotavirus NSP4, a toxic protein that affects the intestines, causing diarrhea.   view more (2008-07-01)

Zinc finger proteins put personalized HIV therapy within reach
Researchers at the University of Pennsylvania School of Medicine and collaborators are using minute, naturally occurring proteins called zinc fingers to engineer T cells to one day treat AIDS in humans.   view more (2008-07-01)

Crucial Factors in Lymphoma Development and Survival Discovered
Researchers at National Jewish Medical and Research Center have discovered an important factor in the development of B-cell lymphomas, one of the fastest growing forms of cancer.   view more (2008-06-24)

Mayo researchers discover how measles virus spreads (in its host)
Measles, one of the most common contagious diseases, has been thought to enter the body through the surface of airways and lungs, like many other major viruses.   view more (2008-06-23)

Opioids and cannabinoids influence mobility of spermatozoids
A PhD thesis from the University of the Basque Country has concluded that there are opioid and cannabinoid receptors in human sperm and that these influence the mobility of spermatozoid.   view more (2008-06-23)

Risk of death after cancer diagnosis; shift in stage of breast cancer diagnosis
Cancer patients with low socioeconomic status (SES) have more advanced cancers at diagnosis, receive less aggressive treatment, and have a higher risk of dying in the five years following cancer diagnosis, according to a new study.   view more (2008-06-23)

Stroke study reveals key target for improving treatment and suggests that Gleevec may help
For over a decade, the drug called tPA has proven its worth as the most effective emergency treatment for the most common kind of stroke. But its promise is blemished by two facts: tPA can cause dangerous bleeding in the brain, and its brain-saving power fades fast after the third hour of a stroke.   view more (2008-06-23)

Systems properties of insulin signaling revealed
A team of Swedish researchers has characterized novel systems properties of insulin signaling in human fat cells. Their mathematical modeling, described in an article published June 20th in the open-access journal PLoS Computational Biology, provides further insight into energy level maintenance... view more (2008-06-20)

Neuroscientists Show Insulin Receptor Signaling Regulates Structure and Function of Brain Circuits
A team of neuroscientists at Cold Spring Harbor Laboratory (CSHL) has demonstrated for the first time in living animals that insulin receptors in the brain can initiate signaling that regulates both the structure and function of neural circuits.   view more (2008-06-19)

Immune molecule that plays a powerful role in avoiding organ rejection identified
When a mouse's immune system is deciding whether to reject a skin graft, one powerful member of a molecular family designed to provoke such a response can effectively reduce the visibility of the mouse's own cells and help the graft survive, researchers say.   view more (2008-06-17)

Complex Changes in the Brain's Vascular System Occur after Menopause
Many women experience menopausal changes in their body including hot flashes, moodiness and fatigue, but the changes they don't notice can be more dangerous.   view more (2008-06-17)

30 percent RA patients refractory to anti-TNFs achieve disease remission with tocilizumab plus metho
Tocilizumab plus methotrexate showed significant clinical improvements in efficacy and safety in patients with moderate to severe rheumatoid arthritis (RA), who had not adequately responded to anti-tumour necrosis factor (anti-TNF) therapy.   view more (2008-06-16)

Estrogen therapy helps or hurts the brain depending on reproductive status
Estrogen therapy may limit stroke damage if started close to, but not long after reproductive cycles are over, according to a new animal study. The results were presented Sunday, June 15, at The Endocrine Society's 90th Annual Meeting in San Francisco.   view more (2008-06-16)

Cell surface receptors are all 'talk' in T cell stimulation
Understanding the mechanisms that drive healthy immune responses is important when it comes to combating autoimmune diseases, which occur when cells that should attack invading organisms turn on the body instead.   view more (2008-06-13)

QBI neuroscientists make Alzheimer's disease advance
Queensland Brain Institute (QBI) neuroscientists at UQ have discovered a new way to reduce neuronal loss in the brain of a person with Alzheimer's disease.   view more (2008-06-10)

Common bowel problem linked to chili pepper pain receptor
People with irritable bowel syndrome have a higher than usual number of chilli pepper pain receptors, according to a new study published tomorrow (Wednesday 11 June).   view more (2008-06-10)
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